Volume 101 ·  Issue 32 ·  2021

Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare clinical diseases, accounting for about 4%-5% of all primary pancreatic tumors, and 60% of patients had had distant metastases when pNENs were diagnosed, with liver being the most frequently involved metastatic organ. Currently, treatment options for pNENs with liver metastasis include surgery, local embolization and ablation, chemotherapy, targeted therapy represented by everolimus and bevacizumab, somatostatin receptor therapy and immunotherapy. However, how to accurately evaluate the condition of patients at different stages of the disease, choose the above-mentioned treatment methods and optimize the treatment effect is a hot and difficult research topic. As a new tumor treatment concept in the era of intelligent medicine recently proposed by the author, the concept of multivariate saturation treatment used artificial intelligence technology to integrate existing tumor treatment methods, combined with the individual heterogeneity of patients; used the deep learning technology of artificial intelligence to accurately assess disease stages and predict the possible response of the corresponding treatment; used the robotic surgery platform to adopt the most suitable surgical method for the patient, which was dynamically adjusted at different stages of tumor treatment to maximize and optimize the treatment effect. Multivariate saturation treatment can provide the possibility to achieve the optimal prognosis of the patient.

The number of patients suffering from both dry eye and mental disorders (especially anxiety and depression) has risen rapidly in ophthalmic clinics. However, the mental disorders related dry eye has not received enough attention. At present, it lacks related information of basic data, and there is no standard for the clinical diagnosis and treatment. To this end, this article aims to determine the role of mental factors in the pathogenesis of dry eye, to strengthen the relevant basic and clinical research, to standardize its clinical diagnosis and treatment, and thus to promote the prevention and treatment of the mental disorder related dry eye in China.

On December 26, 2020, 38 experts from professional public health institutions, university research institutes, medical institutions, professional journals and societies conducted in-depth discussions on "innovative medical prevention coordination mechanism, strategy and implementation path", and put forward expert suggestions on innovative medical prevention coordination mechanism: (1) improve the guarantee mechanism for medical prevention coordination investment; (2) Implement the medical and prevention collaborative resource sharing mechanism; (3) Improve the cooperative division of labor and cooperation mechanism between medical and prevention; (4) Reform the training mechanism of medical and prevention collaborative talents; (5) Innovate the financing and payment mechanism of medical prevention collaborative medical insurance; (6) Establish a collaborative performance appraisal mechanism for medical and prevention. At the same time, 13 specific suggestions were put forward.

To evaluate the clinical efficacy of dietary supplement Licofor in the treatment of dry eye associated with meibomian gland dysfunction (MGD).

This was a prospective, randomized controlled clinical trial. Sixty patients [25 males, 35 females, aged (42±13) years] who had dry eye associated with MGD were recruited in Xiangya Hospital of Central South University from December 2018 to October 2019. The patients were equally divided into two groups: 30 cases (60 eyes) in the experimental group and 30 cases (60 eyes) in the control group. All subjects were treated with eye hot compress, artificial tears and antibiotic ointment. After that, the experimental group and control group were received dietary supplementary Licofor or placebo daily for 12 weeks. The symptoms and signs of dry eye, morphology and function of meibomian gland, and inflammatory response were assessed at the beginning, 4^th, 8^th and 12^th week of treatment.

After 12 weeks of treatment, statistically significant improvements in ocular surface disease index (OSDI) scores, tear break-up time (TBUT), corneal fluorescein staining (CFS), the morphology of eyelid margin, meibomian gland orifice, meibomian gland expressibility, meibum quality, and periglandular inflammatory cell density were determined in both groups (all P<0.05). In the Licofor group, the improvement of OSDI scores [16.7 (12.5, 20.8) vs 20.8 (18.8, 22.9),P<0.001], the morphology of eyelid margin, meibomian gland orifice and periglandular inflammatory cell density [443 (318, 513) vs 553 (415, 676)/mm², P=0.002] were more significant (all P<0.05).

The combined treatment of licofor and conventional treatment can significantly improve symptoms of dry eye, the morphology of eyelid margin, meibomian gland orifice, meibum quality, and eyelid inflammation response of dry eye associated with MGD.

To evaluate the association of meibomian gland dysfunction (MGD) and body mass index (BMI) in Chinese adults.

A total of 2 419 patients were retrospectively recruited between May and October 2013 from 33 ocular surface disease clinic in China. There were 780 males (32.2%) and 1 639 females (67.8%), aged 18-89 (46±16) years. BMI value of each patient was respectively calculated, and the patients were divided into underweight, normal weight, overweight and obesity groups accordingly. Meibomian gland-related examinations were performed in right eyes.

The number of the patients in four groups were 196, 1 556, 567 and 100, respectively. Compared with normal weight group, the rates of moderate to severe MGD (59.1%, 71.0% vs 49.9%) in overweight group and obesity group were higher, and the differences were statistically significant (both P<0.05). The scores of change in eyelid margin, meibomian gland dropout and meibum expressibility were significantly higher in overweight group and obesity group, compared with normal weight group (allP<0.05). Additionally, after stratified by age, all the above-mentioned three scores of obese patients were significantly higher than those of non-obese patients in young adult group. Multivariate logistic regression analysis showed that moderate to severe MGD was correlated with overweight (OR=2.19, 95%CI: 1.06-4.50, P=0.033) and obesity (OR=3.70, 95%CI: 2.57-5.04, P=0.008).

Moderate to severe MGD significantly correlates with high BMI in Chinese adults.

To investigate the accommodation and vergence (AV) function of patients with mild to moderate refractory dry eye symptoms, and determine the impact of relevant interventions on subjective symptoms.

A total of 103 patients with dry eye disease (DED) in Zhongshan Ophthalmic Center between December 2017 and June 2019 were included. After 3-month conventional treatment, the patients entered the treatment-responsive group if ocular surface disease index (OSDI) decreased ≥12.5, and others were recruited into the refractory symptoms group. Binocular AV function, OSDI, tear break-up time (TBUT), Schirmer′s test (ST) and fluorescein staining (FL) were determined in all the patients. Corrective therapy on the AV dysfunction was added in the refractory symptoms group besides the conventional therapy. The above-mentioned indexes were reexamined 8 weeks later. The incidence of AV dysfunction was compared between the refractory symptoms group and the treatment-responsive group. Moreover, the differences of OSDI and tear film stability were compared before and after the corrective therapy in the refractory symptoms group.

Sixty of 103 DED patients were classified into the refractory symptoms group [mean age: (27±6) years; 18 males and 25 females] and 43 into the treatment-responsive group [mean age: (30±6) years; 32 males and 28 females]. The incidence of AV dysfunction in the refractory symptom group (100%) was higher than that of the treatment responsive group (72.1%) (P<0.001). Forty patients with refractory symptoms accomplished the 8-week corrective therapy, and the OSDI score was significant improved (23.4±16.0 vs 40.6±15.7,P<0.001). However, further changes in ST, TBUT and FL were not detected in these patients (allP>0.05).

There is a high prevalence of AV dysfunction in patients with refractory symptomatic DED. The corrective therapy on AV may improve the subjective symptoms in these patients.

To explore the effect of androgen replacement therapy in a rabbit dry eye model characterized by androgen deficiency and meibomian gland dysfunction (MGD).

Thirty 6-month-old male Chinchilla rabbits were randomly divided into the treatment group, model group and control group, with 10 rabbits in each group. In the treatment and model groups, 2/3 of the meibomian gland openings were closed by cauterization with electric coagulation pen, and bilateral testes were removed. One gram gel containing 1% testosterone was applied for 28 days on the skin of rabbits in the treatment group since day 28 after the surgery. The model group and control group received transdermal petrolatum instead. Tear secretion, tear breakup time (TBUT), corneal fluorescein staining, and serum free testosterone level were monitored throughout the study period. The globes and eyelids were collected for hematoxylin-eosin staining and periodic acid-Schiff staining. Conjunctival tissue was tested for the expression of miRNA-744-5p and interleukin-6. Meibum was collected for fatty acid analysis.

Animals presented with typical dry eye signs and androgen deficiency. After 28-day androgen replacement therapy, compared with the model group, the treatment group had a significantly higher tear secretion rate [(14.7±5.2) vs (10.3±3.6) mm, P=0.001], higher TBUT [(15.0±4.2) vs (10.2±3.6) s, P=0.003], lower fluorescein staining score [0 (0, 1) vs 2 (1, 4), P<0.001], and higher goblet cell density at conjunctival fornix (27.2±7.6 vs 10.7±4.8,P<0.001). Additionally, compared with the model group, the conjunctiva of the treatment group expressed a significantly lower level of miRNA-744-5p (1.67±0.24 vs 2.63±0.58,P<0.001) and interleukin-6 [2.38 (1.84, 4.61) vs 4.82 (3.99, 6.36),P=0.022]. Meanwhile, the treatment group showed significantly increased level of 16∶1, Δ⁹ fatty acid [(10.31±1.00)% vs (3.87±0.45)%, P<0.001] andiso-18∶0 fatty acid [(7.09±0.93)% vs (2.44±0.70)%, P<0.001], but decreased level ofiso-26∶0 fatty acid [(5.72±1.07)% vs (8.02±0.65)%, P<0.001] in the meibum compared with the model group.

Androgen replacement therapy can alleviate dry eye signs in rabbits presented with combined androgen deficiency and MGD.

To evaluate the effectiveness and safety of functional axillary dissection based on lymphatic drainage (FUND) in decreasing breast cancer-related lymphedema (BCRL) events.

A total of 168 eligible patients in Zhongnan Hospital of Wuhan University from July 2018 to February 2019 were randomly assigned to the FUND group or axillary lymph node dissection (ALND) group using random number table generated by SPSS. In the FUND group, methylene blue (MB) was adopted to reveal the sentinel lymph node (SLN) for all patients; 0.1 ml MB was injected into the SLNs before resection to reveal the efferent lymphatic channels and subsequent-echelon lymph node. The blue-stained lymphatic channels were mapped by bluntly dissecting along the lymphatic drainage channels from the breast to the axilla. Then, the SLNs were removed and pathologically analyzed by immediate frozen sectioning (FS); if the SLNs were positive, the blue-stained bALNs in breast lymphatic level (BLL) Ⅱ were removed and sent for immediate FS; if the blue-stained ALNs in BLL Ⅱ were confirmed negative, the tissues in BLL Ⅱ were removed'en bloc′. Clinicopathologic information for all the patients in the two groups were collected. The fixed-point circumference volume measurement method and the Norman questionnaire scoring method were used to evaluate the arm lymphedema between the two groups. Clinicopathological characteristics, incidences of arm lymphedema, locoregional recurrence, and distant metastasis between the two groups were compared.

The mean age were (50.3±8.0) in the FUND group and (51.1±9.0) in the ALND group. Seventy-four cases (88.1%) in the FUND group successfully underwent FUND surgery, and patients whose breast lymphatics failed to be stained blue underwent standard ALND. There was no statistically significant difference in terms of age, BMI, histological types, surgical approaches and adjunct therapy between the FUND group (n=74) and ALND group (n=84) (P>0.05). The average operation time of the FUND group and the stand ALND group were (169±15) and (123±12) min respectively (range: 145-198, 103-146 min) (P<0.001), and the number of lymph nodes removed [M (Q₁, Q₃)] were 8.3 (6, 15) and 12.9 (7, 18) (P=0.019). The cumulative BCRL rate, within a median follow-up of 24 months and 23 months respectively for FUND and ALND group, were 10.8% (8/74) vs 23.8% (20/84) (P=0.033) measured by fixed-point circumference volume measurement method, and was 12.2% (9/74) vs 27.4% (23/84) by Norman questionnaire (P=0.018). There were no local regional recurrence events during the follow-up period between the two groups.

For breast cancer patients with clinically node-positive axilla or positive SLN, FUND based on lymphatic drainage was a less radical axillary surgery, with which eliminating the risk of BCRL might be achieved.

To compare the diagnostic performance of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and high-resolution ultrasound (HRUS) in euthyroid Hashimoto′s thyroiditis (HT).

From January 2016 to January 2019, patients with complete data of preoperative thyroid function, TPOAb, TgAb and HRUS who had undergone thyroid surgery treatment at the First Affiliated Hospital with Nanjing Medical University were reviewed. The diagnostic value of different diagnostic methods was compared using histopathology (HP) examination result as the gold standard.

The data of 792 patients (217 males and 575 females) was retrospectively collected. The M(Q₁,Q₃)of patients′ age was 41(32,52)years and the range was 16-75 years. With HP as the diagnostic gold standard, TPOAb exhibited similar sensitivity (59.3% vs 61.2%, P=0.752), accuracy (85.0% vs 83.6%, P=0.379), area under the receiver operating characteristic curve (AUC) (0.767 vs 0.764, P=0.886) and higher specificity (94.2% vs 91.6%, P=0.033) when compared with TgAb in diagnosing euthyroid HT. They both exhibited a higher sensitivity (59.3% vs 44.5%, P = 0.002; 61.2% vs 44.5%, P<0.001), accuracy (85.0% vs 79.7%, P = 0.001; 83.6% vs 79.7%, P = 0.013) and AUC (0.767 vs 0.684, P<0.001; 0.764 vs 0.684, P<0.001) than HRUS. Compared with each method alone, the sensitivity and AUC of TPOAb combined with TgAb or HRUS were improved. The combination of three methods showed the greatest sensitivity. Concordance analysis demonstrated that TPOAb and HP had a moderate agreement (Kappa=0.580, 95%CI:0.513-0.647,P<0.001).

The combination of thyroid antibodies, TPOAb and TgAb, can improve sensitivity, accuracy and AUC of diagnosis in euthyroid Hashimoto′s thyroiditis. The two antibodies combined with HRUS exhibited the highest diagnostic performance. Elevated TPOAb showed moderate diagnostic consistency with histopathologic evidence of HT.

To evaluate the cost-effectiveness of anti-tumor associated antigen autoantibody (TAAb) for hepatocellular carcinoma (HCC) screening in cirrhosis population with chronic hepatitis B (CHB).

A simulated cohort of 40-year-old patients with CHB cirrhosis was established with a sample size of 10 000. Using TAAb screening alone or TAAb and AFP screening in parallel (TAAb + AFP) as the research strategy, and liver ultrasound and AFP screening in parallel (liver ultrasound + AFP) as the control strategy, the decision analysis Markov model was constructed and the model validity was evaluated. The 6-month cycle was simulated using TreeAge Pro 2020 software. Cost and quality-adjusted life years (QALY) were calculated. Incremental cost-effectiveness ratio (ICER) was used to compare the two strategies, and sensitivity analysis was used to evaluate the uncertainty of results.

The Markov model had a total of 11 outcomes, of which 7 were natural outcomes and 4 wereclinical intervention outcomes, and the goodness of fit was 0.969. The lifetime screening cost of TAAb+AFP strategy for HCC screening was 249 612 yuan/case, and the QALY per capita was 7.704 years. Compared with liver ultrasound +AFP strategy (247 805 yuan/case), the total health cost increased by 1 807 yuan/case, and the QALY obtained was 0.014. The ICER was 127 635 yuan /QALY. When the TAAb screening fee was higher than 889.552 yuan, or the discount rate was higher than 0.068, or the antiviral treatment compliance was lower than 45.1%, ICER > 212 676 yuan /QALY. When the single TAAb screening fee was 400-600 yuan, the TAAB+AFP strategy had cost effective value. When the willingness to pay was 70 892, 141 784 and 212 676 yuan /QALY, the probability of cost-effectiveness of TAAb+AFP strategy was 70.6%, 75.3% and 77.8%, respectively.

It is cost-effective to use TAAb+AFP for early screening of liver cancer in Chinese population with CHB cirrhosis.

To analyze the related factors affecting the success of frozen-thawed embryo transfer (FET).

A total of 563 couples treated in the Reproductive Medicine Center of Guangdong Hospital of Traditional Chinese Medicine from January 2017 to March 2020 were selected as subjects. A total of 736 FET cycles were included to analyze the live birth outcomes of FET. Pregnancy outcomes, pregnancy complications and embryo status of patients between the live birth group and the non-live birth group were compared. A multivariate logistic regression model was used to evaluate the association between the 15 candidate factors and live birth outcomes for identifying independent factors associated with the live birth outcomes of the FET.

Among the enrolled subjects, the men were (33±5) years old at sperm extraction while the women were (31±4) years old at ovum pick-up (OPU) and (32±4) years old at embryo transfer (ET) and their infertility duration were (3.5±2.6) years. There were 333 (45.2%) live birth cycles and 403 (54.8%) non-live birth cycles in the 736 FET cycles. Pregnancy complications occurred in 49 cases (14.7%) of the live birth group. The age of the women at ET ((31±4) vs (32±4) years), the age of the women at OPU ((30±4) vs (32±4) years) and the age of the men at sperm extraction ((33±4) vs (34±5) years) in the live birth group were all lower than those in the non-live birth group. The infertility duration was shorter ((3.2±2.2) vs (3.6±2.8) years), and the proportion of primary infertility was higher ((63.1%, 210 cases) vs (49.6%, 200 cases)) in the live birth group (P<0.05) than those in the non-live birth group. Multivariate logistic regression analyses showed that the age of woman at ET (OR (95%CI): 0.50 (0.27-0.92), P=0.026), the types of infertility (0.62 (0.43-0.88), P=0.008), the numbers of optimal embryos transferred (1.60(1.11-2.31), P=0.012), and the types of embryos transferred (2.43 (1.46-4.01), P=0.001) were statistically significant related factors for live birth outcome of FET.

The age of the woman at ET, the types of infertility, the numbers of optimal embryos transferred and the types of embryos transferred are associated factors for the outcomes of live birth after FET.

The clinical data of 18 patients with biopsy-proven IgG4-related kidney disease (IgG4-RKD) in Peking University First Hospital from Jananuary 2012 to Jananuary 2017 were analyzed retrospectively. The prevalence of elevated IgG4 and hypocomplement C3 were commonly found. Acute kidney disease accounted for 9 cases. Pathological examination showed IgG4 associated tubulointerstitial nephritis, with IgG4-ANCA or anti-PLA2R associated crescentic nephritis in 3 cases, and membranous nephropathy in 2 cases. Patients with erythrocyte sedimentation rate>60 mm/1 h had higher acute tubulointerstitial injury scores. Improved renal function was observed in 15 patients under immunosuppressive therapy. But 3 patients relapsed during follow-up. IgG4-RKD with concurrent glomerulopathy is not uncommon. Biopsy-based kidney examination is recommended.

Islet transplantation after kidney transplantation has become one of the ideal solutions for the treatment of adult diabetes mellitus complicated with end-stage renal disease, but its application in children is rarely reported. This paper reports a 4-year-old child with type 1 diabetes mellitus complicated with renal failure who underwent allogeneic islet transplantation 3 months after renal transplantation. After islet transplantation, the blood glucose of the children was stable, no hypoglycemia occurred again, the C-peptide level returned to normal, the insulin dosage was reduced by 2/3 when discharged from hospital 4 weeks after transplantation, and no related complications such as liver puncture bleeding occurred.

Acute respiratory distress syndrome (ARDS) is the most important pathological process in patients with novel coronavirus pneumonia (COVID-19). Coagulation dysfunction is an important feature in COVID-19 patients. Low molecular weight heparin (LMWH) has multiple effects such as anticoagulant, anti-inflammatory and antioxidant. Although the application of LMWH to prevent and treat thrombotic complications in COVID-19 patients has become a consensus, the therapeutic effect of LMWH on ARDS remains to be further explored. Starting with the pathological and clinical characteristics of COVID-19, this paper reviews the evidence of LMWH in the treatment of ARDS, and analyzes the current application and existing problems of LMWH in COVID-19.

This study compared the cost-effectiveness value of using MRI and ultrasound for semi-annual liver cancer surveillance in patients with liver cirrhosis by constructing a decision analysis Markov model, and identified the population that achieved the best cost-effectiveness through MRI surveillance. The study compares cost and quality-adjusted life years (QALYs) between the two surveillance strategies mentioned above from a healthcare system perspective. The model simulated a cohort of cirrhotic patients with a starting age of 50 years. 71% of them were infected with hepatitis B virus. The cycle length was 6 months and the operation period was 20 years. The transition probability and cost in the model parameters were mainly from a prospective cohort study, and the other parameters were from the literature. The cost-effectiveness value of MRI monitoring strategies was evaluated by calculating the incremental cost-effectiveness ratio (ICER) between strategies, and the stability of the results was evaluated by sensitivity analysis. The results showed that if the annual incidence of liver cancer was 3%, the cost of MRI surveillance compared with ultrasound surveillance strategy was $5,562 more, the QALY increased by 0.221, and the ICER was $25,202/QALY. The ICER was less than $50 000/QALY when the incidence of liver cancer was>1.81%. With the increasing incidence of liver cancer, even if the cost ratio of MRI and ultrasound increases, MRI monitoring strategies still have cost-effective value. The results of this study suggest that, despite the high cost of MRI monitoring strategies, for patients with hepatitis B virus-associated compensated cirrhosis with a sufficiently high risk of liver cancer, the use of MRI for semi-annual liver cancer monitoring may be more cost-effective than ultrasound.

Sleep problems can seriously affect physical health and quality of life. Previous studies have suggested that patients with dry eye generally have shorter sleep time and poorer sleep quality, while individuals with sleep problems are more likely to suffer from dry eye, but the sample size is small. To prevent sampling bias and interference from multiple factors, the study used large population-based cohorts to elucidate the association between dry eye and sleep quality. From the health and health-related behavior database of 167 729 people in the north of the Netherlands, the researchers screened for analysis the data of 71 761 people who completed data collection between 2014 and 2018, aged (50.2±12.3) years, of which 59.4% were women. Dry eye was diagnosed using the self-reported Women's Health Study Dry Eye Questionnaire (WHS), and dry eye was defined by those who reported dry and/or irritating feelings as frequent or persistent or who had been diagnosed with dry eye in the past. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), with a PSQI>5 defined as poor sleep quality and a PSQI ≤5 defined as good sleep quality. Dry eye was diagnosed in 6 414 (8.9%) participants and 18 563 (25.9%) participants were evaluated as having poor sleep quality. The proportion of poor sleep quality was significantly higher in the dry eye group than in the non-dry eye group (36.4% vs 24.8%), and the results of multivariate logistic regression analysis showed that dry eye and poor sleep quality were associated after adjustment for sex and age (OR=1.52，95%CI：1.44~1.60，P<0.000 1）； After adjusting for 51 possible confounding factors such as sex, age, BMI, education, and income, dry eye remained an associated factor for poor sleep quality (OR=1.20，95%CI：1.11~1.28，P<0.001), and this correlation was present in different genders and in all age groups. Therefore, dry eye is closely related to the quality of sleep in patients.

In modern society, the prevalence of dry eye and depression continues to rise. This study used a mobile App (DryEyerRhythm) to investigate the association between dry eye and depressive symptoms. From September 2, 2016 to January 12, 2018, data were collected and statistically analyzed for 4 454 Japanese users who downloaded and used DryEyeRhythm, aged (27.9 ± 12.6) years, of which 2 971 were female, accounting for 66.7%. The ocular surface disease index (OSDI) and Zung self-rated depression scale (SDS) were used to evaluate dry eye symptoms and depressive symptoms. The OSDI score ≥13 was defined as dry eye, of which 13-22 were classified as mild dry eye, 23-32 were classified as moderate dry eye, and 33-100 were classified as severe dry eye; Those with SDS ≥40 were defined as having depressive symptoms. The SDS scores were (42.4±9.3), (45.5±9.7), (47.8±9.6), and (50.5±10.4) in 1 160, 1 139, 778, and 1 377 patients with mild, moderate, and severe dry eyes, respectively. Compared with the normal control group, the SDS scores of patients with mild, moderate, and severe dry eyes were all higher (allP<0.001）。 The number of patients with SDS ≥40 accounted for 58.2%, 70.9%, 79.4% and 85.0% of the normal control group and mild, moderate and severe dry eye groups, respectively. The proportion of depressive symptoms in mild, moderate and severe dry eye patients was significantly higher than that in the normal control (allP<0.001）。 The results of multivariate logistic regression analysis showed that compared with normal controls, mild, moderate and severe dry eye were correlated with depressive symptoms.ORValues were 1.62 (95%CI：1.35~1.95，P<0.001）、2.39（95%CI：1.92~2.97，P<0.001) and 3.29 (95%CI：2.70~4.00，P<0.001）。 Depressive symptoms are more common in patients with severe dry eye, and DryEyeRhythm can play a corresponding role in early prevention or prediction of depressive symptoms in patients with dry eye.

The effectiveness of alcohol use treatments such as medication-assisted therapy (MAT) and physician consultations to promote alcohol abstinence has been demonstrated, but the cost-effectiveness of alcohol use treatment for patients with alcohol-associated compensated cirrhosis remains to be explored. Therefore, this study simulated 1 group of patients with alcohol-related compensated cirrhosis who received liver disease clinic care throughout their lives by constructing a decision analysis Markov model and predicted the costs to be paid and quality-adjusted life years (QALY) obtained throughout their lives after receiving different alcohol use therapies from a healthcare and social perspective. The parameters of conversion probability, cost, and health utility value in the model of this study were taken from the literature. The study used FDA-approved MAT (acamboxylic acid and naltrexone), non-FDA-approved MAT (baclofen, gabapentin and topiramate) and physician consultation as the research strategy, and did not perform any interventions as the control strategy. The incremental cost-benefit ratio (ICER) between strategies was calculated. From a healthcare perspective, MAT provides cost savings and more health outputs compared to the non-intervention strategy, with an ICER of $3,724/QALY for the physician consultation strategy, which is below the cost-effectiveness threshold ($50,000/QALY). Among them, the acamboxylic acid and naltrexone strategies were the lowest cost and obtained the most QALY compared to other intervention strategies. At the same time, one-dimensional and probabilistic sensitivity analysis were carried out to evaluate the parameter uncertainty, and the results suggest that the results of this study are stable and reliable. The results of this study suggest that interventions such as MAT and physician consultation for patients with alcohol-related compensated cirrhosis have extremely high cost-effectiveness value, can be used to prevent decompensated cirrhosis and improve patient health, and should be encouraged to be widely used. Furthermore, health policies should emphasize appropriate subsidies for these interventions.