2023年 · 第103卷第26期

Spontaneous abortion is usually defined as intrauterine pregnancy loss before survival. The incidence of spontaneous abortions has been reported to be as high as 15%. Recurrent spontaneous abortion (RM) is defined as two or more pregnancy losses before 24 weeks of gestation. RM occurs in 1% to 3% of women who attempt to conceive. Relevant studies have clarified the risk factors associated with RM and the risk of subsequent pregnancy resulting in miscarriage, but the impact on other perinatal outcomes remains to be clarified. The purpose of this study was to determine whether a history of RM is a risk factor for adverse obstetric and perinatal outcomes in pregnancies beyond 24 weeks.

Preimplantation genetic testing (PGT) is a technique that selects normal embryos for transfer during intracytoplasmic sperm injection (ICSI) and is suitable for genetic defects, chromosomal abnormalities, older women, recurrent miscarriages, repeated implantation failures, and severe teratospermia. It has been more than 30 years since the success of the first case of PGT. PGT technology has made great progress in clinical application, bringing hope for healthy offspring for patients with genetic diseases and infertility. This study aimed to explore a single freeze-thaw blastocyst transfer cycle to determine whether PGT is associated with a higher risk of adverse perinatal outcomes compared to IVF/ICSI.