At present, the incidence of coronary artery disease (CAD) is increasing year by year. For patients with suspected stable CAD, international guidelines recommend non-invasive examination as the first-line examination. Non-invasive coronary CT angiography (CCTA) has a high negative predictive value but overestimates the degree of coronary stenosis, especially in the presence of extensive calcified plaque. Previous studies have demonstrated that the fractional flow reserve (CT-FFR) diagnostic accuracy of coronary CT angiography is high with invasive fractional flow reserve (FFR) as the reference standard, but there are few studies on the diagnostic performance of CT-FFR in patients with extensive coronary artery calcification. This study aimed to explore the diagnostic performance and short-term prognostic effect of CT-FFR in patients with chest pain with calcification score>399.
