2012年 · 第45卷第11期

cerebral venous sinus thrombosis (CVST) is a special type of cerebrovascular disease caused by various causes, which is characterized by obstruction of cerebral venous return, often accompanied by cerebrospinal fluid absorption disorder leading to intracranial hypertension. It accounts for 0.5% ~1.0% of cerebrovascular diseases^[1]。 In a Canadian report, the incidence rate for children under the age of 18 is 0.67 per 100,000, of which 43 percent are newborns^[2]； The peak age of incidence in adults is 20-30 years old, and the ratio of male to female is 1:1.5-5 per year. The exact incidence rate is still unknown^[3]The incidence of CVST in puerperium is high among women of childbearing age in China. The lesion site can be primarily from superficial vein, deep vein or venous sinus in the brain, among which simple superficial vein thrombosis is rare, mostly due to the extension of cerebral venous sinus thrombosis; Deep vein thrombosis is more common in internal cerebral veins and great cerebral veins. In more than 60% of patients, the lesions involved multiple venous sinuses, among which the incidence of above sagittal sinuses ranked first. In terms of the nature of the lesion, it can be distinguished as infectious and non-infectious. The former is often secondary to suppurative infection or non-specific inflammation of the head, face or other parts; The latter is mostly related to hypercoagulability, blood stasis and tube wall damage, some of which are unknown. Due to the anatomical anastomosis and communication between cerebral veins and venous sinuses, between venous sinuses and venous sinuses, and between venous sinuses and extracranial veins, when venous or venous sinus thrombosis is formed, the difference factors of thrombosis involvement and collateral circulation lead to complex and diverse clinical manifestations, ranging from no clinical symptoms to severe illness and even death; Due to the fluctuation of coagulation and fibrinolysis, the patient's condition alternated with remission and aggravation. The disease is mostly subacute or chronic with prolonged onset. Except for cavernous sinus thrombosis, its clinical symptoms lack specificity, so it is easy to misdiagnose and misdiagnose. The missed diagnosis rate can reach 73%, and the average diagnosis time of 40% patients is more than 10 days^[4,5]。

painful peripheral neuropathy is a peripheral neuropathy characterized by neuropathic pain, usually referring to painful sensory peripheral neuropathies or painful sensory and motor peripheral neuropathies. Herein refers to painful sensory peripheral neuropathies as well as peripheral neuropathies generalized to painful symptoms, including hybrids that may have motor-sensory coexistence. Painful peripheral neuropathy may be a single disease subject or a manifestation of a systemic disease. The lesions mainly involve small or unmyelinated nerve fibers (class C fibers), and may be with or without large fiber lesions.