Volume 45 ·  Issue 07 ·  2009

The purpose of setting the file of ocular refractive development is to record the process of eye development in children with plan. Set the individual file and begins at 3 years old till 12. Examination is done every 6 months. Parameters are recorded including power of cycloplegic refraction, visual acuity, keratometer , anterior chamber depth, axial length, intraocular pressure, body height and weight. In this way, can provide very important information as to the prompt intervening in myopia control. It is also the effective and practical way in myopia prevention. (Chin J Opbthalmol, 2009,45:577-579)

Objective To investigate the changes of the Modulation Transfer Function (MTF) and its effect on visual and optical quality with or without low and higher order wavefront aberration after conventional and wavefront guild laser in situ keratomileusis. Methods It was a comparative case series. An aberrometer with Hartmann-shark sensor was used to measure the monochromatic aberration of eyes. One hundred and two cases entered the study; 38 cases were randomized to LASIK and 64 were randomized to WFG-LASIK MTFs of optical system were calculated at various pupil size (3, 4, 5 and 6 mm) respectively and compared pre and 3 month postoperatively between conventional and wavefront guide ablation with or without higher order aberration. Results There was a significant increase in MTF positively compared with preoperative values at all spatial frequency (5-60 cycles per degree, c/d), P <0. 05. MTF values got more improvement without spherical aberration than without coma aberration after LASIK surgery and there was significant different at a spatial frequency of 5 c/d. Higher MTFs were showed in the WFG-LASIK group although there were no significant difference between conventional LASIK group and WFG-LASIK group. However, there were apparently changed without high order aberration as compared to that with high order aberration at all spatial frequency (5-60 c/d.) in WFG-LAS1K group and higher MTFs were showed in the WFG-LASIK group compared with conventional LASIK group and there were significant different(P <0. 05) by calculation and evaluation. Conclusion Spherical aberration have more negative role on visual quality than coma aberration after LASIK surgery. With the optical benefits expected from correcting higher aberration,wavefront guide ablation have shown a great benefit for low and high order aberration but it still leave a small amount of high order aberration and need further investigation. MTF is a sensitive and extensive in demonstrating the optical quality in refractive surgery. (Chin J Ophthalmol, 2009, 45: 580-586)

Objective To investigate morphologically the different changes of cornea tissue between thick and thin cornea flap with confocal microscope, and to compare visual function between thick and thin cornea flap after LASIK Methods 70 eases (70 eyes) who had received LASIK were divided into the thin cornea flap group (36eyes, group A) and the thick cornea flap group (34 eyes, group B). The age was (23 ± 5) years old, spherical equivalent diaopter (SE) were (- 4. 76 ± 2. 30) D and (- 3.03 ± 2. 20) D. Inspection items included visual acuity (VA), refraction, wave-front analysis, contrast sensitivity analysis (KONTRASTOMETER BA-4, Germany) during pre-and post-LASIK, at the same time, all eyes were examined by confocal microcopy (HRT Ⅲ, Germany). Using Moria 90 μm and 130 μm keratome with Allegretto Excimer laser machine. Results Refraction: there was no difference between the two groups. Post-LASIK 3 to 6 months: group A (0. 35 ± 0. 21) D; group B (0. 45 ± 0. 69) D (P > 0. 05). Comparison results by confocal microscope. The thickness of cornea flap: group A (107.37 ± 20.5) μm, group B (149 ± 25. 2) μm(P<0. 05). The thickness of wrinkle: group A (63.71 ± 15.8) μm; group B (48. 16 ± 20. 7) μm (P < 0. 05). The thickness of acellular area: group A (69. 93 ± 15.8)wm; group B (55.63 ± 23.7) μm(P < 0. 05). The thickness of activation cornea cells: group A (60. 15 ± 30. 9)mμ; group B (51.86 ± 27. 9) μm (P <0. 05). The density of anterior stromal: group A(825. 14 ± 156. 9)mm2 ; group B (853.54 ± 126. 8) mm2 (P < 0. 05). There were significant differences on the thickness of cornea flap, the thickness of wrinkle, the thickness of acellular area, the thickness of activation cornea cells, the density of anterioer stromal, but there was no difference on posterior stromal(P > 0. 05). Wavefront analysis:there was no difference between two groups in Z3-3, Z3-1, Z31, Z33, Z40, RMS3, RMS4, RMSS, RMS6, RMSh (P >0. 05) pre-and post-operation. Contrast sensitivity analysis: there was also no difference between two groups(P > 0. 05) pre-and post-LASIK 1-6 month. Conclusions From the point of confocal microscope view, morphologic changes of cornea was significant with different thick flap. It is not cicatrical healing between the cornea flap and stromal. The cell injury of cornea tissue in the thin cornea flap was severe than that of in the thick cornea flap even though there was no significant difference between thin and thick cornea flap group in clinical refraction correction, wavefront and contrast sensitivity. (Chin J Ophthalmol, 2009,45: 587-593)

Objective To evaluate the corneal wound-healing response of LASIK with ultra-thin corneal flaps and LASEK in rabbits. Methods It was an experimental study. Thirty-two adult New Zealand rabbits were divided into 2 groups with 16 each. Two surgical procedures, LASIK with ultra-thin corneal flaps and LASEK were performed on the right eye of each group, with the left eye as control. A myopic ablation of 10 diopters was performed in each group. Corneal wound-healing and histopathological changes of the ablation zone were studied through slit lamp, hght microscope and transmission electronic microscope. The expression levels of collagen Ⅰ , collagen Ⅲ, fibronectin (FN) and transforming growth factor beta-1 (TGF-β1) were investigated by immunohistochemistry and RT-PCR assays. Results In the group of LASIK with ultra-thin corneal flaps, the corneas were clear without haze followed by slight wound healing and fast recovery. While in the group of LASEK, corneal wound healing was obviously delayed. There was haze in grade 1 (62. 5%) and grade 2 (37.5%) in 1 month, with grade 0. 5 (43. 75%) and grade 1 (56. 25%) in 3 months. 1 month and 3 months after surgery, proteins and mRNA of collagen Ⅲ, FN and TGF-β1 were expressed in the anterior corneal stromal layer in each group. But the expression was much higher in the group of LASEK (t=18.47, 11.98, P<0.05). The protein and mRNA expression of coflagen Ⅰ had no difference between the two groups (t = 0. 72,0. 36,0. 47,2. 38, P > 0. 05). The mRNA expression of collagen Ⅰ, collagen Ⅲ, FN and TGF-β1 had no statistical difference between the groups of control and LASIK with ultra-thin flap in 3 months (t = 2. 42,1.54, - 0. 83, P > 0. 05). Conclusion According to the animal experiments, it was suggested that the corneal wound-healing response of LASIK with ultra-thin corneal flaps was much better than that of LASEK. (Chin J Opbthalmol, 2009,45:594-600)

Objective To investigate a new clinical grading scale of diffuse lamellar keratitis (DLK) following laser in situ keratomileusis (LASIK) and to observe the clinic outcomes of eyes treated with corresponding classified therapy. Methods It was a prospective case-control study. Eyes that developed DLK after LASIK were diagnosed by a new criterion of clinical grading scale based on both severity and scope of inflammatory cells infiltrations in the corneal interface. Dose and frequency of topical or systemic corticosteroid were determined by the classified profiles according to each grade. Clinical symptoms, corneal inflammatory cells infiltrations, visual acuity, refractive error and intraocular pressure (IOP) were evaluated on 1, 3, 5, 7, 10 days and 1 month after diagnosis as well as at the time of diagnosis. Results Among the 35 eyes of 29 patients that developed DLK, mild inflammatory cells infiltrations were mostly seen. Thirty eyes had degree Ⅰ DLK and 3 had degree Ⅱ DLK. One eye had degree ⅢDLK and one had degree Ⅳ DLK Inflammatory cells infiltrations in 20 eyes invaded peripheral zone (zone 1) and those in 11 eyes invaded mid-peripheral zone (zone 2). Inflammatory cells infiltrates in 4 eyes invaded central zone (zone 3). Nineteen eyes had degree Ⅰ zone 1 DLK. Thirty three eyes were diagnosed between the 1st day and the 3rd day after surgery. Uncorrected visual acuity (UCVA) was worse than preoperative best spectacle corrected visual acuity (BSCVA). Inflammatory cells infiltrations retreated within 6. 06 ± 2.04 days after classified corticosteroid therapy. One month after the treatment, UCVA had improved to the level of preoperative BSCVA. BSCVA in 30 eyes were equal to or better than those before surgery. Spherical equivalent of the refractive error was (-0. 21 ± 1.16)D. There was no statistic difference in the retreat time of inflammatory cells infiltrations, recovery of visual acuity and refractive error among the different grades of DLK or among the DLK treated with different therapy profiles. No eye suffered from high intraocular pressure during the treatments. Conclusions Clinical grading scale and corresponding classified therapy were proved to be effective in the treatment for DLK (Chin J Ophthalmo], 2009,45:601-606)

Objective To understand the development of the refractive status in premature infants during their early life. Methods It was a cross-sectional study. Two hundred fifty-three premature infants without retinopathy of prematurity (BOP) were screened for BOP at 4-6 weeks after born. Refraction with cycloplegic retinoscopy was determined. The refractions of 38 infants were compared with those of mature infants at 40-44 weeks' correct gestational age (CGA). Results The spherical equivalent (SE) increased progressively (become more hypermetropic) along with increasing gestational age (GA), birth weight (BW) and CGA at test. BW was the main factor for SE. The incidence of myopia and astigmatism was 14. 43% (73eyes) and 10. 28% (52eyes). The former decreased and the latter did not change along with increasing CGA. The median of astigmatism was 1.00DC, while Percentile 25 (P25) and Percentile 75 (P75) were 0. 50DC and 1.13DC, respectively. The degree of astigrnatism increased along with increasing CGA and did not change along with GA or BW. The median of axis of astigmatism (AX) was 90°, while P25 and P75 were 90°and 100° ,respectively. The AX was not correlated with CGA, GA or BW. Five observations, including SE, incidence of myopia and astigmastism, the degree and axis of astigmatism between premature and mature infants at 40 to 44 weeks' CGA, were compared. It shows that there was no statistical difference between the two groups in all items mentiond above but SE, which indicating that there was more myopic in premature infants. Conclusions The refraction of premature infants shifts towards hypermetropia along with development, but is still more myopic than mature infants at 40 to 44 weeks' CGA. Further studies on the underlying mechanisms of myopia and the subsequent refractive development are needed. (Chin J Ophthalmol , 2009,45:507-511)

：Objectives This study isdesigned to analyze the accommodative hysteresis, accommodative responses between two eyesof anisometropes. The difference of the shape and slope of the accommodative responsecurves under closed-loop state is evaluated. A comparison study between emmetropes andanisometropes was assessed as well. Methods It was a ease-control study. Forty volunteers,(age from 20 to 31 years)participated in the research. 20 subjects hademmetropia(spherical equivalent + 0.37D to -0.25D in both eyes), 20 subjects badanisometropia with spherical power difference ranging from 2. 50D to 7.00D between theirtwo eyes. Accommodation taken by objective methods: RE and accommodative response (AR) to1.00D, 2.00D, 3.00D, 4.00D stimulus were measured objectively by WV-500 binocular infraredoptometer (Grand Seiko Co. Japan). The slope of the AR/AS was calculated and comparedbetween different groups. Results Under closed-loop state, the higher refractive error eyeof anisemetropia had most accommodation lag followed by lower eye and emmetropic eye. Instimulus of 3.00D and 4. 00D, the differences between higher eye and emmetrepic eye weresignificant (t= 2.055, 2.410; P < 0.05). The differences of the slopes between two eyesof ainisometropes under all conditions were without significant difference (P > 0. 05).But the slopes of higher refractive error were lower than that of emmetropoes (t = 2. 550,P < 0. 05) . Conclusions The accommodative responses of two eyes of anisometropia aredifferent, the higher eye of anisometropia shows higher accommodation lag. Every nonaccommodation balance phenomenon showed by anisometropia may be associated either withdifferent accommodation controller gain, or with higher threshold of"cilliary-lens" system or both. It is needed further study to clarify. (Chin JOpbthalmol, 2009,45:612-615)

Objective To investigate the reproducibility and repeatability of anterior segment optical coherence tomography (AS-OCT) for measuring the tear meniscus height (TMH) and to evaluate its clinical application in the diagnosis of dry eye diseases. Methods Evaluation of diagnostic test. The inferior tear meniscus height of 36 eyes of 36 patients with dry eyes and 38 eyes of 38 normal volunteers were measured by AS-OCT and slit lamp marker lens in Zhongshan Ophthalmic Center, Sun Yat-sen University from November 2007 to August 2008. Then the paired t test, intra-class correlation coefficiency test, ANOVA and Spearman test were used for comparing TMH values between normal subjects and dry eye patients, two different examiners, two analysts, the repeated examines within a week, and AS-OCT group and slit lamp reticle lens group. Results There are no significant differences between different observers for the same 22 subjects [t = 1.881, P =0.074; TMH: (0.256 ± 0.052) mm and (0.265 ± 0.066) mm], the same observer in different check-points for 20 subjects [t = 1. 306, P =0. 207 ; TMH : (0. 265 ± 0. 056) mm and (0. 272 ± 0. 052) mm]as well as different analyzers for the same 20 AS-OCT pictures [t = 2. 048, P = 0.065; TMH: (0.266±0.059) mm and (0.259 ±0.062) mm]. There is a positive correlation between AS-OCT and reticule reading in measuring TMH (r =0. 713,P =0. 000) ; there are significant differences between normal subjects and patients with dry eye (t = 9. 368, P = 0. 000), and between groups of dry eye at different degree (F=55.763,P=0.000) [TMH: grade Ⅱ, (0.228 +0.036) ram; grade Ⅲ, (0. 145 ± 0. 056) mm; and grade Ⅳ, (0. 084 ± 0. 048) mm]. The sensitivity and specificity of TMH value with AS-OCT for dry eye diagnosis was 77.8% and 71.7%, when the diagnostic value was set to be 0. 213 mm under the instruction of receptor operating characteristics curve (ROC). Conclusion AS-OCT has excellent reproducibility and repeatability for measuring the inferior tear meniscus height, and can be taken as an objective clinical imaging method for the diagnosis of aqueous deficiency dry eye. (Chin J Ophthalmol,2009,45:616-620)

Objective To investigate the effect of gene screening on forewarning and monitoring of familial open-angle glaucoma pedigree. Methods Comprehensive ophthalmic examinations were performed in all available family members. The genomic DNA was extracted from peripheral blood. The myocilin gene was amplified and screened for mutations using direct sequencing. All family members were followed up. Results Among 12 family members, 5 individuals carry a C to T transition in exon 3 resulting in the substitution of proline to leucine (Pro370Leu), and the other 7 individuals did not carry this mutation. Ophthalmic examinations did not show any abnormality in the optic disc, the thickness of RNFL, and visual field parameters in mutation-carriers. During the follow-up, all carriers were diagnosed as open-angle glaucoma. The mean time of presentation of the defect of visual field was 21.6 months and 14.4 months after the changes in RNFL thickness. Conclusion Genetic diagnosis was proven to be a method with high specificity and sensitivity; and can be used for presymptom diagnosis and forewarning in familial open-angle glaucoma pedigree. (Chin J Ophthalmol , 2009,45:621-624)

Objective To compare the difference of the antibody profile between the primary open angle glaucoma (POAG) and the healthy controls (CTRL). Methods It was a case-control study. Sera from 44 POAG and 48 CTRL were added to tubes containing pre-washed Protein G beads, which can capture IgGs. These IgG-Protein G-complexes were used to capture target antigens (homogenized bovine retina). After elution, the antigenic proteins were measured through surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. By t-test and multivariate statistical analysis, the spectra, the age and the gender between the two groups were compared; subsequently, the antigenic mass spectra data combined with the type of protein chips and the energy of laser desorption/ionization between these two groups were also compared, which indirectly reflect the antibody profiles of these two groups. Results The mean intensity of spectra were 4244.427 ± 4721. 115 in CTRL and 4049.864 ± 4083. 819 in POAG, which showed statistical difference(F = 1. 340, P < 0.01) ; complex antibody profiles were found in both groups. Significantly different immunoreactive spectra were detected between POAG patients and control subjects. Some up-, but mainly down-regulated immunoreactivities were present in POAG patients. Conclusions A significant different pattern of antibody profile is present between the POAG and CTRL. Down-regulated immunoreactivities present in POAG might mean an association between the "aberrant autoimmunity" and the primary open angle glaucoma. (Chin J Ophthalmol , 2009,45:625-630)

Objective To investigate the methylation status of RASSF1A or DAPK promoter in retinoblastoma tissue or peripheral blood from retinoblastoma patients. Methods It was an experimental study on the parafin-embeded retinoblastoma tissue sections, and a case-control study on retinoblastoma cases and normal control people. Methylation status of RASSF1A and DAPK promoter in 28 RB tissues and 9 available peripheral blood samples of RB patients were detected by methylation specific polymerase chainreaction (MSP). Normal retinal tissues from five donor cadaver eyes and normal-peripheral blood samplesfrom five healthy volunteers matched on age and sex were used as controls. The differences of methylation rate among different groups were analyzed statistically by Fisher's exact probability test. Results The percentage of RASSF1A hypermethylation in RB tissues (60. 7%) was statisticantly higher than in normal retinal tissue 0% (0/5) and adjacent non-neoplastic retinal tissue 17. 9% (5/28) (P < 0. 01), the hypermethylation percentage in unilateral RB group was higher than bilateral RB group either. Meanwhile, RASSF1A hypermethylatian in peripheral blood was detected in 2 of 9 RB cases, showing no statistics difference compared with that of normal person. However, no DAPK promoter hypermethylation was found in all RB tissues and peripheral blood from retinoblastoma patients. Conclusion RASSFIA promoter hypermethylation was frequently present in retinoblastoma, which may play an important role during the pathogenesis of retinoblastoma. (Chin J Ophthalmol , 2009,45: 631-635)

lymphocytic hypophysitis (LyH), also known as autoimmune hypophysitis, is a rare disease characterized by inflammatory infiltration of pituitary lymphocytes, which is currently considered to be an autoimmune-related disease [1]. The clinical manifestations are similar to pituitary tumors, with symptoms such as headache, visual loss, visual field defect and hypopituitary function. Cases of abducent nerve paralysis caused by LyH are rarely reported in China. The author encountered one case during his study in PLA General Hospital, and the report is as follows.

keratitis ichthyosis deafness syndrome (KID) is a rare hereditary disease, which was first described by Burns in 1951 and is characterized by diffuse skin hyperkeratosis, vascular keratitis and moderate to severe sensory deafness [1-2].

Stem cells, such as limbal stem cells, oral mucosal cells, embryonic stem cells, mesenchymal stem cells, amniotic epithelial cells and skin stem cells, have shown to be able to repair many types of ocular surface damages. Based on the structural, functional and biological characteristics of corneal epithelium, the differentiation of embryonic and adult stem cells into corneal epithelial cells, the influences on the corneal wound healing and their respective clinical prospects and problems are reviewed. (Chin J Ophthalmol , 2009,45:658-662)

Glaucoma is characterized by progressive loss of retinal ganglion cell (RGCs), optic nerve atrophy, cupping of the optic disc, and specific visual field deficits. Elevated intraocnlar pressure (IOP) is considered to be a major risk factor associated with the development of this neuropathy, therefore, elevated IOP has been induced in animals to simulate key aspects of human glaucoma, in order to unlock the mechanism of this disease and seek out new therapeutic strategies. In the following review: (1) models used for the study of hypertensive glaucomatous neuropathy in rodents, (2) assessment of these animal models and (3) their usage will be described. (Chin J Ophtbalmol, 2009,45:663-668)

The patient was a 43-year-old male, whose visual acuity decreased gradually for 1 month, accompanied by dyspnea. The whole body examination showed that CD4 cells were 26/μ L, and the lung was infected with Pneumocystis carinii.

Runshi Eye Hospital is a regular medical insurance designated hospital approved and registered by Beijing Municipal Health Bureau, with total fixed assets of more than 30 million yuan. It mainly treats refractive errors, cataract, strabismus, amblyopia and other ophthalmic diseases. The hospital is equipped with advanced surgical equipment and a complete set of examination equipment, such as American VISX S4 excimer laser host and wavefront aberration system, French MORIA M2 microscopic lamellar knife, German ZEISS surgical microscope and optical examination system, etc. After several years of development, it has become one of the faster developing ophthalmology hospitals in China. The hospital has advanced management philosophy, which will provide every employee with broad room for growth. For the needs of business development, we sincerely recruit professionals, and welcome professionals who love ophthalmology to join.

Beijing People's Eye Hospital is a tertiary eye hospital in Beijing invested by People's Group. It has carried out femtosecond laser and excimer laser for myopia and fundus surgery. Our hospital has not only introduced the internationally advanced corneal refractive surgery equipment-femtosecond laser system, but also equipped with Swiss Lycra M844 ophthalmic surgery microscope and American Visx S4 excimer laser system, and has a laminar flow purification operating room built according to national standards.

In order to improve the writing level of authors' medical papers, especially English medical papers, the English edition of Chinese Medical Journal of Chinese Medical Association is scheduled to hold a "National Medical Paper Writing Seminar" in Jinan from August 28 to 30, 2009. The seminar invites domestic experts with rich experience in reviewing, submitting and writing in English to teach the following contents: (1) How to write Chinese (English) medical papers (treatises, reviews, case reports) that are easily accepted by magazines; (2) The production of figures and tables in medical papers; (3) How to report clinical randomized controlled trials; (4) Management of medical paper references; (5) Ethical issues in essay writing; (6) Copyright knowledge, repeated publication and secondary publication issues; (7) Precautions for submitting articles to domestic and foreign medical journals; (8) Manuscript processing procedures of world-class medical journals; (9) Clinical trial registration.

In order to promote the scientific and technological journals sponsored by CAST and its affiliated national societies to better serve the independent innovation of science and technology, strengthen the function of academic exchange, promote the implementation of the strategy of fine scientific and technological journals, improve the core competitiveness of scientific and technological journals, and improve the ability of national societies to serve the strategy of rejuvenating the country through science and education and strengthening the country through talents, CAST has organized and implemented the application and evaluation of fine scientific and technological journals project funding projects since 2006. This journal has been successively awarded the first phase of fine scientific and technological journals project funding project of CAST from 2006 to 2008, and again won the second phase of 2009 fine scientific and technological journals project Class B project funding project of CAST in 2009. There are 45 kinds of journals supported this time. Among them, there are 5 types of Class A (subsidized by 250,000 yuan), 40 types of Class B (subsidized by 150,000 yuan), and 100 types of non-subsidized journals.

Huaxi-Alcon Eye Surgery Skills Training Center, jointly organized by West China Hospital of Sichuan University and Alcon (China) Ophthalmic Products Co., Ltd., was officially inaugurated in West China Hospital of Sichuan University on April 24th, 2009. The center aims to train high-level phacoemulsification surgeons and is equipped with Infiniti phacoemulsification system (6 sets) and advanced equipment such as 6 sets of twisting ultrasound handles, surgical microscope and camera system. The students of the center will be ophthalmologists from hospitals all over the country, and the teachers will be composed of well-known phacoemulsification surgery experts in China, providing students with systematic and practical theoretical and professional technical guidance on phacoemulsification cataract aspiration surgery.

As a journal with strong academic strength and extensive academic influence in ophthalmology in China, in order to better serve the majority of ophthalmologists in China, strengthen clinicians' cognition of various ophthalmology surgical concepts, surgical standards and surgical effects, and thus promote the development and improvement of clinical surgical skills in China, Chinese Journal of Ophthalmology will hold a series of select activities of Chinese Journal of Ophthalmology for ophthalmologists all over the country. The participating materials are surgical videos, and the evaluation committee of the activity is composed of the editorial board of relevant majors of Chinese Journal of Ophthalmology. Based on the principle of fairness and justice, the academic level is the leading factor, and the participating materials are evaluated according to the standardization of operation, skills, difficulty, excitement and other items. The results of the selection will be announced and awarded at the National Academy of Ophthalmology, and published in Chinese Journal of Ophthalmology in written form. Some or all of the selected surgical videos will be included in the CD-ROM of Chinese Journal of Ophthalmology for distribution.

China Medical Electronic Audiovisual Publishing House is a medical professional electronic audiovisual publishing unit with independent legal personality under the supervision of the Ministry of Health and sponsored by Chinese Medical Association. Our society gives full play to the advantages of the Chinese Medical Association and uses electronic audio and video products as the medium to spread new medical technologies, popularize medical and health knowledge, promote academic exchanges and raise public health awareness. China Medical Electronic Audio and Video Publishing House will provide a platform for doctors at all levels to exchange experience and promote technology, deeply promote the development of medical continuing education for clinical medical workers, and improve the diagnosis and treatment technology level of clinicians in China. Physicians at all levels are welcome to actively submit films.

In order to strengthen the academic exchange of ophthalmology at home and abroad, expand the international vision of domestic ophthalmologists, and promote the integration of domestic ophthalmology with international standards as soon as possible, the Health Express Training Network (www.lxieam.com) has been specially established, which will serve all domestic ophthalmologists in the form of public welfare.

With the development of society and economy, visual quality has obviously affected the quality of life of patients, which is increasingly concerned by the society. The rapid development of science and technology has laid the foundation for the continuous renewal of ophthalmic equipment and drugs, and improved the level of clinical diagnosis and treatment. Bausch & Lomb Eye Surgery Products Company of the United States continues to provide professional medical equipment for ophthalmology clinics. Among them, the excimer laser 217Z100 refractive correction system has a relatively comprehensive individualized treatment technology, and its clinical effect has been recognized by ophthalmologists and patients; Akreos AO (Advanced Optic Adapt) aspherical acrylate folding intraocular lenses are uniquely designed and, in addition to the traditional benefits of Akreos, their aspherical zero-aberration design and consistent refractive power from edge to center and further improved steeper front surface design deliver better visual results for patients.

If the topic involved in the thesis is a national or ministerial or provincial fund or key project, the name of the fund project should be indicated with "Fund Project:" as the logo at the foot of the front page of the article, and the project number should be indicated in parentheses.

In order to implement the policy of combining popularization and improvement, Chinese Journal of Ophthalmology, while reporting major clinical and basic research results at home and abroad, pays attention to the actual needs of the majority of ophthalmologists and strengthens the practicality of the journal. In 2009, it continued to open the column "Test Questions Analysis".

In order to comply with the development trend of network and digitalization of journals and provide high-quality services for authors and readers, the Journal of Chinese Medical Association has developed a remote manuscript management system. The system is designed according to the business requirements of manuscript processing process, editing and processing specification, manuscript review system and management specification of Chinese Medical Association series magazines. It adopts advanced database and network technology, and has strong data processing and analysis ability.

With the extensive application of excimer laser refractive corneal surgery in clinical practice, more and more ophthalmologists and researchers not only pay attention to the evaluation of its clinical effect, but also focus on the research of its basic theory. In recent years, ophthalmologists have gained rich experience in excimer laser treatment of ocular refractive errors. In order to further promote the development of excimer laser treatment technology, the Ministry of Continuing Education of Chinese Medical Association plans to hold the "2009 7th Excimer Laser Refractive Keratophysical Surgery Symposium of Chinese Medical Association" in Guangzhou in early October, 2009. During the conference, a training course on excimer laser certification renewal and assessment of large-scale medical equipment will be held. It is hoped that relevant professionals from all hospitals will actively contribute and participate in the conference. The relevant matters are hereby notified as follows.

Founded in 1989, Tianjin Medical University Eye Center celebrated her 20th birthday in 2009. In order to celebrate the 20th anniversary of its founding and the 66th anniversary of Professor Yuan Jiaqin, the founder of the Ophthalmology Center, the 8th International Conference of Tianjin Medical University Ophthalmology Center, Cross-Strait Neuroophthalmology Symposium and Fundus Disease Study Class will be held in Tianjin Saixiang Hotel from September 24 to 28, 2009. The conference was jointly sponsored by Tianjin Medical University Ophthalmology Center, Cross-Strait Medical and Health Exchange Association, Ophthalmology Group of Ophthalmology Branch of Chinese Medical Association, Chinese Journal of Ophthalmology, Taiwan Province Neuroophthalmology Research Association and International Retina Foundation.

In order to improve the practical operation skills of basic Research of ophthalmologists, and to provide the general direction and urgent Research objectives of basic Research of ophthalmology, Tianjin Medical University Ophthalmology Center and Overseas Chinese Association for Vision and Eye Research will hold a training course on basic Research of ophthalmology from August 31 to September 1, 2009. This training course is mainly aimed at graduate students, young clinicians and researchers. The conference invites to the Doheny Ophthalmology Institute of the University of Southern California, USA,

The patient was a 3-year-old male who went to Beijing Tongren Eye Center of Beijing Tongren Hospital affiliated to Capital Medical University on December 6, 2005 due to intermittent redness and pain in his left eye, decreased vision accompanied by headache and vomiting for more than 1 year. He was diagnosed with glaucoma in a local hospital and was treated with timolamide eye solution, but the symptoms did not improve significantly.

Chinese Journal of Ophthalmology is a professional academic journal of ophthalmology sponsored by Chinese Medical Association. It targets ophthalmologists as the main readers, reporting leading scientific research achievements, clinical diagnosis and treatment experience in the field of ophthalmology, and basic theoretical research that has a guiding role in ophthalmology clinical practice and is closely integrated with ophthalmology clinical practice. The purpose of this journal is to implement the principles and policies of the Party and the state on health work, implement the principle of combining theory with practice, popularization and improvement, reflect the significant progress of clinical and scientific research in ophthalmology in China, and promote academic exchanges in ophthalmology at home and abroad.