Volume 42 ·  Issue 06 ·  2006

To objectively evaluate the efficacy and complications of radial optic nerve incision (RON) in the treatment of central retinal vein occlusion (CRVO), aiming at the limitation of indication, uncertainty of efficacy and safety of operation, emphasize the importance of carrying out prospective and controlled clinical research, establishing an evaluation system based on evidence-based medicine, and correctly evaluating the clinical efficacy with a scientific attitude.

Radial optic nerve incision (RON) is one of the surgical methods that has attracted much attention and intense debate. The author puts forward several focal issues for discussion, hoping that the treatment effect of RON should not be negated completely, but that RON should be carried out cautiously. The key problem is that the indication must be selected reasonably and the scope of indication should not be blindly expanded.

Objective to investigate the clinical characteristics, long-term prognosis and related factors of non-ischemic central retinal vein occlusion (CRVO) patients. Methods the visual acuity, fundus color image and fluorescein fundus angiography of non-ischemic CRVO patients were retrospectively analyzed. Results A total of 35 patients (37 eyes) with non-ischemic CRVO were followed up for 3~15 years, with an average of 4.5 years, 14 males (40%) and 21 females (60%). 28 eyes (75%) had a final visual acuity of 0.1 or less; The prognosis of visual acuity of patients was related to the visual acuity at first diagnosis and age (P<0.05). 9 eyes (24%) changed to ischemic CRVO, of which 5 eyes had secondary neovascular glaucoma. The macular complication is the main cause of poor visual acuity prognosis. Two cases of CRVO with primary chronic angle closure glaucoma and partial optic nerve atrophy have a relatively good visual acuity prognosis. Conclusion CRVO seriously impairs the visual acuity of patients, and the main cause is macular complication. Partial optic nerve atrophy may have a protective effect on CRVO.

Objective to investigate the clinical characteristics of patients with central retinal vein occlusion complicated with exudative retinal detachment.Methods the general conditions of patients with central retinal vein occlusion complicated with exudative retinal detachment and the data of visual acuity, intraocular pressure, fundus, fluorescein fundus angiography and ocular ultrasound were retrospectively analyzed.Results Among 15 patients, 8 were males and 7 were females; Five patients had neovascular glaucoma, their visual acuity was 0.05. Fundus examination showed scattered hemorrhage, tortuous retinal veins, obvious edema and hemorrhage in the macular area, and large exudation at the edge of edema and detachment area. Retinal detachment in the sitting position ranged from 2 to 5 hours. No anastomotic branch of papilla vascular was seen in all patients. Fluorescein fundus angiography showed large hemorrhage obscuring fluorescence or capillary without perfusion in the posterior pole. The average axial length of 5 eyes measured by ultrasound was 22.98 mm. Conclusion Exudative retinal detachment is a rare and serious complication of central retinal vein occlusion. It is more common in young patients and is prone to neovascular glaucoma, and its fundus and fluorescein fundus angiography are characteristic.

Objective to study the incidence of retinopathy (ROP) in premature infants and evaluate the therapeutic effect of the threshold stage of ROP. Methods 108 premature infants were screened for ROP by binocular indirect ophthalmoscope, and the screening results were statistically analyzed. The children with threshold lesions were timely performed retinal laser photocoagulation or transcleral and retinal condensation. Results In 108 premature infants, ROP was found in 23 cases, the incidence rate was 21.3%. There were 3 cases of ROP stage 2 (13.0%); The birth weight of the children with ROP was (1.43±0.25) kg (t =4.059, P<0.001). The gestational age was (31.0±2.3) weeks (t =2.637, P =0.013); The oxygen inhalation time ranged from 1 to 49 days, with an average of 17 days (n =23, Z = -3.630, P<0.001); 18 children requiring mechanical assisted respiration (x2=12.009, P =0.001); Compared with non-ROP children, the differences of the above indexes were statistically significant; Logistic regression analysis showed that children with low birth weight (β = -2.542, OR =0.079, P =0.032) and mechanical assisted respiration (β =1.341, OR =3.823, P =0.025) were the associated high risk factors for ROP. Among the 7 children with threshold stage lesions, 6 patients underwent laser photocoagulation OR condensation therapy. After 2 months to 2 years of follow-up, there was no abnormality in the structure and visual function of the operated eye. One child with threshold stage lesions was not treated, but developed retinal detachment after 1 month. Conclusion Premature infants with light birth weight, short gestational age, long oxygen inhalation and mechanical assisted respiration had a higher risk of ROP.

Objective to investigate the clinical characteristics of patients with optic neuritis and the correlation with human leukocyte antigen (HLA). Methods Clinical data of 42 patients with optic neuritis were collected, and HLA-DRB1 allele genotyping was performed by flow polymerase chain reaction-reverse sequence-specific oligonucleotide probe technique. Results Among 42 patients, 2 male patients were excluded from Leber hereditary optic neuropathy according to the genetic test results; 31 cases were accompanied by rotational eye pain; The visual field damage in 17 eyes was diverse, with more central dark spots or paracentral dark spots; 20 cases of brain MR examination showed abnormal signals mainly with multiple spots and patchy lesions in the white matter area of the brain; Optic nerve STIR sequence was detected in 38 cases, and 26 cases (68.4%) showed abnormal optic nerve signal; Twenty-six patients underwent lumbar puncture, and 21 cases (80.8%) showed inflammatory demyelinating changes in cerebrospinal fluid; There were 29 cases (72.5%) with abnormal brain MR and/or cerebrospinal fluid; The HLA-DRB1*15 gene frequency (gene frequency = number of cases of a certain genotype/total number of cases) accounted for 35.0%, and the difference was statistically significant compared with the control group (19.4%) (x2=4.2328, P =0.0397). Group analysis found that the HLA-DRB1*15 gene frequency in 26 female patients accounted for 42.3%, and the difference was statistically significant compared with the control group (x2=6.4260, P =0.0113, RR =2.18); The frequency of HLA-DRB1*15 gene increased in patients with cerebrospinal fluid abnormality, and the difference was statistically significant compared with that in normal patients (corrected x2=4.4499, P =0.0349); However, the frequency of HLA-DRB1*15 gene was not related to the number of diseases, the results of head MR detection and the abnormality of optic nerve signal; Patients in the acute phase are sensitive to high-dose methylprednisolone or human immunoglobulin therapy. Conclusion Most patients with optic neuritis have the clinical features of inflammatory demyelinating disease; HLA-DRB1*15 gene may be a genetic susceptibility gene in some female patients with optic neuritis.

Objective to investigate the effect of cumulative oxidative damage on the growth of human retinal pigment epithelium (RPE) cells and its mechanism. Methods 600 μ mol/L hydrogen peroxide (H2O2) was added to human RPE cells in vitro and cultured for 1, 6, 12, 24 and 72 h, respectively. The effect of H2O2 on the growth of human RPE cells at different time periods was detected by tetramethylazole salt colorimetric (MTT) assay. The apoptosis of human RPE cells was determined by fluorescein-labeled annexin V-fluorescein isothiocyanate-propidium iodium (Av-FITC-PI) double staining flow cytometry. The expression of aging-related protein Clusterin was detected by immunoblotting. Results (1) MTT assay: The growth of human RPE cells was inhibited by 600 μ mol/L H2O2 for 6 h, and the action time of H2O2 was extended to 24 h, which was proportional to the growth inhibition rate of human RPE cells. (2) Av-FITC-PI assay (3) Immunoblotting results showed that Clusterin protein was weakly expressed in normal human RPE cells, and the expression of Clusterin protein was enhanced after 12 hours of H2O2 treatment, but the expression of Clusterin protein was weakened in 24 hours group, but only weakly in 72 hours group. Conclusion 600 μ mol/L of H2O2 could inhibit the growth and induce apoptosis of human RPE cells for a long time; Simultaneously induced the expression of senescence-related protein Clusterin; However, the accumulated damage for a longer period of time caused the necrosis of human RPE cells. The oxidative damage of H2O2 can mimic the aging changes of human RPE cells.

Objective to design and assemble an open pressure-controlled culture system, to study the effects of the system on the Ph value of culture solution, the concentration of bicarbonate (HCO3-), the partial pressure of oxygen (Po2), the partial pressure of carbon dioxide (Pco2) and the proliferation of retinal pigment epithelial cells, and to evaluate the feasibility of the application of the system in basic research of glaucoma.Methods An open pressure-controlled culture system was designed and assembled by dynamic circulating gas-controlled pressure.The effects of normal pressure cell culture system (37℃ constant temperature incubator, 5% CO2 concentration), open pressure-controlled culture system and closed pressure-controlled culture system on the Ph value, HCO3-concentration, Po2 and Pco2 of DMEM/F-12 culture solution were compared by MTF method.The effects of the three culture systems on the proliferation ability of human retinal pigment epithelial cells were compared by MTF method.Results The open pressure-controlled culture system was successfully assembled, and the pressure in the culture flask could be controlled between 0~100 mm Hg (1 mm Hg =0.133kPa) by adjusting the inlet and outlet airflow velocity.The results of 24 h culture: There were no significant differences in Ph value (P =0.927), HCO3-concentration (P =0.887), Po2 (P =0.818), Pco2 (P =0.770) and A value (P =0.719). Compared with the normal pressure cell culture system group, the Ph value of the former increased (P =0.001), the concentration of HCO3- (P =0.000), and the value of Po2 (P =0.000), Pco2 (P =0.000) and A (P =0.000) decreased in the closed group. Conclusion The successful design and assembly of the open pressure controlled culture system can achieve the balanced regulation of the culture environment pressure, the Ph value of the culture solution, the concentration of HCO3-, Po2 and Pco2. Compared with the closed pressure controlled culture system, the system can exclude the influence of the difference of culture conditions on the research results.

Objective to investigate the efficacy and safety of excimer laser in situ keratomileusis (LASIK) and excimer laser sub-epithelial keratomileusis (LASEK) with ultrathin corneal flap in the treatment of high myopia with central corneal thickness<500 μ m. Methods Two methods of ultrathin flap LASIK and LASEK were randomly used to treat myopic patients with myopia>-6.00 D and corneal thickness 450~500 μ m. Among them, 23 patients and 39 eyes in ultrathin flap LASIK group had myopia degree of-6.00~ -9.50 D, with an average of-7.51 D. In 37 eyes of 19 patients in LASEK group, the myopia was-6.00~ -11.50 d, with an average of-7.50 d. The naked eye visual acuity, corrected visual acuity, equivalent spherical degree, and the degree of haze under corneal epithelium were examined and compared at 1, 3, 6 and 12 months after treatment. Results the postoperative reaction was milder in ultrathin flap LASIK group, the average time of corneal epithelium intact was 4 d in LASEK group, and the naked eye visual acuity recovered faster in ultrathin flap LASIK group. The naked eye visual acuity was above 1.0 at 1, 3, 6 and 12 months after operation in 64.1%, 87.2%, 87.2% and 79.3%, respectively, and in LASEK group in 37.8%, 75.7%, 67.6% and 71.4%, respectively. The equivalent spherical degree between ±0.50 d was 48.7%, 51.3%, 61.5% and 82.8% in ultrathin flap LASIK group, and 51.4%, 45.9%, 45.9% and 57.1% in LASEK group. There were no serious complications during and after operation. The main complications in ultrathin flap LASIK group were fine corneal flap stripes and over-correction, while the main complications in LASEK group were refractive regression and mild

Objective to explore the clinical value of comprehensive factor assessment before cataract surgery in elderly patients with cardiovascular diseases.Methods The clinical data of 218 elderly patients with cardiovascular diseases (255 eyes) who performed cataract surgery in our department in the past 5 years were retrospectively analyzed.Results 13 elderly patients with cardiovascular diseases (14 eyes) abandoned surgery because preoperative evaluation found contraindications, intolerance to surgery or inability to improve visual acuity after surgery; 205 elderly patients with cardiovascular diseases (241 eyes) underwent phacoemulsification or small incision cataract extraction combined with intraocular lens implantation safely. Among them, 56 patients with obvious symptoms of cardiac disease were operated under ECG monitoring and continuous low flow oxygen inhalation with medication adjusted by internal medicine. 32 cases (39 eyes) ranged from 0.05 to<0.3, accounting for 15.6%; There were 165 cases (193 eyes) ≥0.3, accounting for 80.5%. The disability rate was 78.1%, and the blindness rate was 91.8%. No serious systemic or local complications occurred during the operation, and the expected results were achieved. One case was transferred to respiratory medicine department for rescue treatment due to aspiration pneumonia after operation. Conclusion The comprehensive factors evaluation before operation should be strengthened in the performing of cataract extraction combined with intraocular lens implantation in the elderly patients with cardiovascular diseases, and the general hospital should give full play to its advantages. The application of sedative, epinephrine and glucocorticoid drugs should be individualized; ECG monitoring and continuous bottom flow oxygen inhalation were used in the operation of special types of patients, so as to minimize the operation risk; Non-phacoemulsification small incision cataract extraction combined with intraocular lens implantation is better than phacoemulsification combined with intraocular lens implantation for grade IV and above.

Objective to evaluate the immunological characteristics and specific binding and killing effects of 5-fluorouracil (5-FU) polylactic acid nanosphere PLA (5-FU) -NP and anti-human lens epithelial cell monoclonal antibody HILE6 by carbodiimide method to prepare immunodrugloaded nanospheres. The activity of monoclonal antibody HILE6 after ligation was detected by ELISA. The immune nanosphere group, the mixed group of HILE6 and drug-loaded nanosphere, the drug-loaded nanosphere group and the blank control group were set up to detect the inhibitory effect on the proliferation of lens epithelial cells by MTT assay. The adhesion and internalization of monoclonal antibody HILE6, immune nanosphere and drug-loaded nanosphere to rabbit lens epithelial cells were observed by indirect immunofluorescence assay. The results showed that the ratio of 5-FU to HILE6 in immune nanosphere was about 1809:1, and the retention of immune activity of monoclonal antibody HILE6 could reach 84% of that of original antibody. The half-inhibitory dose IC50 of immune nanosphere on lens epithelial cells for 2 h was 5.0 μ g/ml, which was significantly higher than that of drug-loaded nanosphere group and monoclonal antibody and microsphere mixed group. 2 h into the cytoplasm evenly distributed; Conclusion HILE6-PLA (5-FU) -NP can carry a large number of drugs, maintain specific immune activity, recognize and enter lens epithelial cells in vitro and effectively inhibit their proliferation.

Objective to investigate the corneal permeability of different formulations of pirenzepine eye drops and provide evidence for clinical application. Methods: 2% pirenzepine eye drops (pirenzepine alone group), 2% pirenzepine +0.1% sodium hyaluronate eye drops (sodium hyaluronate group) and 2% pirenzepine +0.1% azone eye drops (azone group) were prepared. Sixty-three New Zealand white rabbits were divided into three groups, and the above eye drops were dripped into the conjunctival sac of both eyes of each group. About 0.2 ml of anterior aqueous humor was extracted at 0.5, 1.0, 2.0, 4.0, 8.0, 12.0 and 24.0 h after the last eye drop. The concentration of pirenzepine in anterior aqueous humor was analyzed by high performance liquid chromatography, and the general conditions of the eyes of the three groups were observed by slit lamp microscope before and after each eye drop and before the puncture and aspiration of aqueous humor. Results The concentrations of pirenzepine in anterior aqueous humor of the pirenzepine alone group were (0.40 ± 0.06), (0.53 ± 0.03), (1.52 ± 0.33) and (0.15 ± 0.02) μ g/ml at 0.5, 1.0, 2.0 and 4.0 h after the last eye drop, respectively. The pirenzepine could not be detected by high performance liquid chromatography after 8.0 h. The concentrations of pirenzepine in anterior chamber of the azone group and the sodium hyaluronate group were significantly higher than those of the pirenzepine alone group at each time point (P<0.01), and the bioavailability was about 23.0 times and 3.4 times, respectively. Moreover, there was no irritation symptom in rabbits' eyes in each group during the experiment. Conclusion The corneal permeability of the azone group was the best, followed by the sodium hyaluronate group, which was significantly higher than that of the pirenzepine alone group.

Diabetic retinopathy is one of the complications of diabetes, which seriously affects human health and quality of life. It is the main problem to explore and actively seek methods of prevention and treatment. After a large number of epidemiological investigations, it is found that the occurrence and development of diabetic retinopathy is not only related to the disease course and blood sugar control, but also the individual differences in the population are very important. Some patients have a long course of diabetes and poor blood sugar control, but there is no diabetic retinopathy or its degree is very mild during follow-up; Although the course of the disease is short and the blood glucose is well controlled, some patients still develop severe proliferative diabetic retinopathy, and the lesions show obvious family aggregation tendency. After excluding the interference of external factors, it is considered that the main reason for this phenomenon is due to the different genetic susceptibility.

In order to promote the healthy development of academic activities of ophthalmology in China, it is necessary to maintain academic morality and standardize academic behavior<Copyright Law of the People's Republic of China,<Patent Law of the People's Republic of China>,<General Principles of Civil Law of the People's Republic of China>and other national laws and the Ministry of Education<In the spirit of Several Opinions on Strengthening the Construction of Academic Morality, and in combination with the actual situation of the Ophthalmology Branch of Chinese Medical Association and the national ophthalmology community, these regulations are specially formulated.

Trachoma is an ancient eye disease, which is widely prevalent all over the world. It used to be the leading cause of blindness and seriously endanger human health. Since the beginning of the 19th century, the pathogen of trachoma has been paid great attention to by the microbiology and ophthalmology circles.

On October 18, 2001, the National Committee for the Approval of Scientific and Technological Terms and the National Language and Character Working Committee held a "Seminar on the Usage of 'Xiang' and 'Xiang'" at the Chinese Academy of Sciences. The meeting carefully analyzed the reasons for the confusion between the usage of "like" and "like" in the scientific and technological circles. The National Committee on Science and Technology Terms and the State Language Commission considered it necessary to make a clear definition of the usage of this word again. Experts at the meeting believed that: elephant refers to the form and appearance of nature, people or things; Image refers to the image of a person or object made by imitation, comparison, etc., and also includes the image that is the same or similar to the original object formed by reflection and refraction of light.

In order to reflect the innovative scientific research achievements and clinical experience of ophthalmology in China as soon as possible, this journal has opened up a "fast track" to publish excellent academic papers in 2002, simplifying the procedure from review to official publication of papers, and shortening the publication cycle. In view of the increasing number of authors applying for the "fast track" at present, the editorial board of this journal has supplemented and improved the specific conditions for applying for the "fast track" on the basis of the operation of some time ago, and reiterated the relevant regulations of the "fast track" once again, so that academic papers with innovative content can be published as soon as possible.

The abstract must include four parts: purpose, method, result (main data should be given) and conclusion. Each part shall be titled accordingly. It is written in the third person, without "this article" or "author" as the subject. Chinese abstracts can be more refined (about 400 words), while English abstracts are relatively detailed and specific (about 800 content words). The English abstract should include the title of the article, the name of the author (in Chinese Pinyin, the letters of his surname are capitalized), the name of the unit, the name of the city where it is located and the postal code, followed by the name of the country.

The statutory unit of measurement of this journal implements the "Statutory Unit of Measurement of the People's Republic of China" promulgated by the State Council in February 1984, and is represented by unit symbols. For specific use, refer to the book "Application of Statutory Unit of Measurement in Medicine" edited by the Editorial and Publishing Department of Chinese Medical Association in 1991. Note that the unit name and the unit symbol should not be mixed. For example, ng·kg^-1·day^-1 should be changed to ng·kg^-1·d^-1; If there is more than one oblique line indicating division in the symbol of the combination unit, it should be expressed in the form of negative powers. For example, ng/kg/min should be expressed in the form of ng·kg^-1·min_^-1.

in order to promote cooperation and exchange in vision and Ophthalmology Research between China and the United States, under the arrangement of the Organizing Committee of the 2006 Congress of the Association for Research in Vision and Ophthalmology (ARVO), the first China-United States Symposium on Vision and Ophthalmology Research was held in Flaudal, Florida, USA on May 1, 2006. In line with the theme of "Building International Collaborations" at the 2006 ARVO Annual Meeting, this conference provided a platform for mutual exchange in vision and ophthalmology research work between China and the United States, and an opportunity to seek further cooperation.

The 2006 National Continuing Education Program "Eye Plastic Surgery Progress Study Class" will be held in Shenzhen from June 25 to July 1, 2006. This study class was approved by the National Committee on Continuing Medical Education and jointly sponsored by the Department of Ophthalmology of the Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine and Shenzhen Eye Hospital. The study class adopts three forms of learning and exchange: theoretical lecture, surgical teaching and special discussion. The theoretical lectures were delivered by Professor Xu Naijiang and Professor Fan Xianqun, experts in ophthalmoplastic surgery, focusing on new theories, technologies and methods in the field of ophthalmoplastic surgery.

The "National Symposium on New Progress of Retinal Detachment and Diabetic Retinopathy and Minimally Invasive Vitreous Surgery and Continuing Medical Education Study Class", approved by the First Affiliated People's Hospital of Shanghai Jiaotong University, will be held in Shanghai from July 7 to 13, 2006.

Professor Zhao Dongsheng, an honorary editorial member of Chinese Journal of Ophthalmology, a famous expert in fundus diseases in China, a pioneer in the research of retinal detachment surgery, the founder of the Department of Ophthalmology of the First Affiliated People's Hospital of Shanghai Jiaotong University, a member of the Communist Party of China, a recipient of special government allowance from the State Council, a first-class and second-class professor of national health technology, the director and chief physician of the Department of Ophthalmology of the First Affiliated People's Hospital of Shanghai Jiaotong University, and a returned overseas Chinese, died in the First Affiliated People's Hospital of Shanghai Jiaotong University on April 19, 2006 at the age of 93.

Schwann cells (SC) are the main glial cells in the peripheral nervous system. Recent studies have shown that SC can produce several neurotrophic factors necessary for photoreceptor cells, such as basic fibroblast growth factor (bFGF) [1], ciliary neurotrophic factor [2], brain-derived neurotrophic factor [3], etc.

With the widespread application of small incision phacoemulsification cataract aspiration and folding intraocular lenses (IOL) with different materials in China, long-term opacity of IOL has been reported one after another. Recently, 3 patients with long-term opacity of hydrogel folding IOL after small incision phacoemulsification cataract aspiration were treated in our hospital, and IOL replacement was performed on them, and the extracted IOL was analyzed by clinical, pathological, scanning electron microscopy and energy spectrum; The extracted lens capsule was examined by histopathology to understand the causes of IOL opacity and its effect on the adjacent tissues.

When the xanthoma of the medial canthus and the upper eyelid is resected simultaneously with the skin laxity of the upper eyelid, if the xanthoma is too large, it is predicted that the tension may cause the eyelid deformity, we use the loose skin of the resected eyelid to make skin slips or skin flaps for transplantation, and obtain good clinical results.

duralcavernous fistula (DCF), also known as dural shunt syndrome (DSS), duralcavernous arteriovenous shunts (DCAVS), dural arteriovenous fistula (DAVF), red eye short circuit syndrome, etc., is a group of neuroophthalmic syndromes caused by direct or indirect communication between the dura branches of the internal, external and/or vertebrobasilar arteries and the cavernous sinus [1]. Because they are mostly spontaneous, small fistula, low flow, and accidental onset, patients often have no obvious self-conscious symptoms in the early stage, and are not diagnosed until complications or aggravation of symptoms in the late stage. Nowadays, the improvement of imaging technology, especially the birth of digital subtraction angiography (DSA), can clearly show the whole process of DCF, which makes us have a further understanding and understanding of the clinical manifestations, diagnosis and treatment of this disease.

Congenital posterior lens cone is a rare ocular structural dysplasia disease, with an incidence rate of one in 100,000 [1,2]. This disease not only leads to visual loss, but also seriously affects the visual development of children, resulting in amblyopia. There are few reports on its clinical characteristics and treatment [3,4]. The author treated 3 children with lens aspiration combined with intraocular lens (IOL) implantation from August to September 2005. The diagnosis and treatment are reported as follows.

Case 1: A 35-year-old patient came to our hospital in February 2004 due to left eyeball protrusion for 3 months. No abnormalities were found in the whole body examination. Eye examination: The visual acuity of the right eye was 0.5 by the international standard logarithmic visual acuity chart, which could not be corrected. The left eyeball protruded 4 mm forward, there was no obvious restriction of movement in all directions, and no abnormalities were found in the fundus. Laboratory examination: Serum immunoglobulin and urinary Bence Jones protein were negative.

The patient was an 8-year-old woman who came to our hospital on March 30, 2005 because of the discovery of a mass in her left eye for half a year. The patient discovered a mass at the edge of the cornea of her left eye without any inducement six months ago, which was the size of a rice grain at first, with a smooth surface and gradually increasing with red eyes. She did not complain of other discomfort. She had a local biopsy in another hospital on February 1, 2005, and was diagnosed as "hemangioma" by pathological examination, but no treatment was given. No obvious abnormality was found in physical examination.

Coracophyllospora is a fungus of the family Dendrosporaceae, which is characterized by obvious black pigment bands at two ends of its conidia, long beak and an obvious prominent umbilicus at one end of the spores. The fungus is widely distributed on soil and plants in nature, mainly saprophytic fungi of decaying plants, and can also cause skin, mucosa and system infections. In 2003, we diagnosed and treated a patient with fungal keratitis caused by Coracophyllospora, and he has recovered.

The patient was a 22-year-old female who came to the ophthalmology department of our hospital on August 14, 2004 due to tear, pus and visual loss after left eye trauma. On September 30, 2001, the patient was injured in the medial canthus of her left eye by a chair leg. After the injury, she was diagnosed and treated in another hospital. After CT examination, she was diagnosed as a fracture of left orbital wall, and she underwent debridement and suture of left eyelid and rupture and anastomosis of lower lacrimal canaliculus.

The author reported a case of syndrome consisting of short stature, polydactyly, knee valgus and cataract, and discussed it with fellow ophthalmologists.