中华外科杂志
2026年 · 第139卷第14期
出版日期 2026-07-20电子版 ￥100.00元
中华外科杂志
- 全部
- Editorial
- Consensus Statement
- Review Article
- Original Article
- Correspondence
- Corrigendum
Editorial
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这个中华医学杂志中华医学会：百年遗产与学术共同体的制度化Jingjing Su, Daqing Zhang
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004103
摘要
1932年，中华医学杂志(CMJ）是通过合并正式成立的中国医学杂志和英文部分中国医学杂志标志着中国现代医学话语权威从外国传教士医生向中国医学学者的决定性转移。以期刊血统来衡量，这一转变花了近半个世纪才完成；如果说始于彼得·帕克从 1835 年开始在广东的行医，那么它跨越了近一个世纪；如果追溯到西方医学知识的传入，它将深入到更长的三个世纪。值得注意的是CMJ可以追溯到中国医学传教士杂志(CMMJ），于1887年推出，并更名为中国医学杂志1907年——西方医学知识和实践在中国有影响力的渠道。同时，中国医学杂志《中华医学会》于 1915 年由新成立的中华医学会（后来的中华医学会，CMA）创办，以中英文双语出版，标志着中国医学界进入现代医学发展的主流轨道。在正式合并之前，这两个期刊保持着密切的合作，并作为推进全国现代医学研究和诊疗实践的重要学术平台。
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我国整形外科医师执业及生活状况调查分析Xinyi Jiang, Ye Zhang, Shujun Fan, Jinxiu Yang, Leren He
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004032
摘要
整形外科是医学的一个重要分支，在中国发展迅速。随着社会和经济水平的提高，加上对美学增强的日益重视，对整形外科医生的需求大幅增长。从业者的职业和个人环境影响整形美容外科的可持续发展。然而，关于整形外科医生的专业实践和生活条件的全面研究仍然有限，特别是在倦怠、工作与生活平衡、婚姻状况、生殖选择、健康状况和职业发展等领域。此外，公立和私立医院雇用的男女外科医生之间的区别尚未得到彻底调查。在整形外科发达的国家，这种调查研究是优先考虑的。[
Consensus Statement
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2025年成人原发性免疫性血小板减少症诊断和管理指南概要Xinguang Liu, Yu Hu, Ming Hou
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004143
摘要
原发性免疫性血小板减少症（ITP）是一种获得性自身免疫性疾病，会导致孤立性血小板减少症。在新疗法和新临床证据的快速出现的推动下，中国血液学会血栓与止血学组发布了2025年版成人ITP指南。[
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急性左旋多巴激发试验在帕金森病中的临床应用共识（2025）Lingyan Ma, Lijuan Wang, Haibo Chen, Shengdi Chen, Tao Feng, Parkinson’s Disease and Movement Disorders Group from Neurology Branch of Chinese Medical Association, Parkinson’s Disease and Movement Disorders Group from Neurology Branch of Chinese Medical Doctor Association
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000003962
摘要
帕金森病（PD）是第二大常见的神经退行性疾病。PD的病理标志是黑质多巴胺能神经元变性，并伴有α-突触核蛋白的异常聚集。[
Review Article
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从转化角度看肺动脉高压：桥接病理生理学和治疗Taeil Yang, Wook-Jin Chung
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004137
摘要
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder defined by elevated pulmonary arterial pressure and vascular resistance, ultimately leading to right ventricular failure and premature death. Once considered a disease of pure vasoconstriction, PAH is now recognized as a complex vasculopathy involving endothelial dysfunction, inflammation, metabolic dysregulation, and genetic susceptibility. The pulmonary vasculature is dynamically narrowed by vasoconstriction, structurally obstructed by smooth muscle and endothelial proliferation, and pathologically stiffened by fibrosis and extracellular matrix deposition. Multiple cell types including endothelial cells, smooth muscle cells, fibroblasts, and immune cells contribute to this remodeling process. At the molecular level, hyperproliferative, apoptosis-resistant phenotypes emerge through mitochondrial dysfunction, oxidative stress, and endothelial-to-mesenchymal transition, which together drive a Warburg-like metabolic shift favoring glycolysis over oxidative phosphorylation. Chronic immune activation, characterized by cytokine release, T-cell and macrophage infiltration, and disrupted immune regulation, further amplifies vascular injury. Genetic studies have identified mutations in BMPR2, TBX4, SOX17, and other regulators of the bone morphogenic protein (BMP)/transforming growth factor-β (TGF-β) pathway as key contributors to heritable and idiopathic forms of PAH, highlighting impaired endothelial repair and aberrant signaling as central mechanisms. Recent translational breakthroughs have yielded novel therapeutic strategies beyond traditional vasodilators. Agents targeting the BMP/TGF-β axis (e.g., sotatercept), growth factor signaling (seralutinib), inflammatory pathways (tocilizumab, rituximab), and metabolic remodeling (pyruvate dehydrogenase kinases [PDK] and fatty acid oxidation [FAO] modulators) are redefining treatment paradigms. Concurrently, large-scale multi-omics initiatives such as PVDOMICS and PHOENIKS enable deep phenotyping, which unravels molecular endotypes and informs precision medicine approaches. This review summarizes the pathophysiology of PAH and the ongoing clinical trials in the PAH field.
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炎症性肠病中的人工智能：从当前证据、临床转化到精准医学之路Robert Hughes, Antonio Lo Bello, Raymond Fueng-Hin Liang, Cecilia Lina Pugliano, Irene Zammarchi, Subrata Ghosh, Marietta Iacucci
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004170
摘要
Artificial intelligence (AI) is rapidly transforming healthcare, supporting disease management and enabling outcome prediction across multiple clinical settings. Inflammatory bowel diseases (IBD) are complex, heterogeneous conditions whose assessment relies on integrating several modalities, including endoscopy, histology, cross-sectional imaging, and omics data, all of which are critical for evaluating disease activity and predicting long-term outcomes. In recent years, numerous AI-based systems have been developed within each of these domains. In IBD endoscopy, deep learning algorithms have demonstrated high accuracy in objectively assessing mucosal inflammation and detecting colitis-associated dysplasia. In histology, AI applications enable automated, standardized evaluation of disease activity, reducing interobserver variability. Similarly, in cross-sectional imaging, AI models have shown promise in characterizing disease severity, identifying complications, and supporting outcome prediction. Beyond individual modalities, machine learning approaches are increasingly being explored to integrate complex clinical, imaging, and multi-omics data to predict disease trajectories and enable precision medicine strategies in IBD. The present review provides an overview of current AI applications across endoscopy, histology, imaging, and omics in IBD, highlighting its potential clinical impact and ability to advance precision medicine strategies through multimodal and multi-omics integration. Moreover, it discusses the main challenges, unmet needs, and limitations that remain barriers to adoption in clinical trials and routine clinical practice.
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用于癌症治疗的绿色纳米药物Wenhui Liu, Baiyuan Fan, Yu Qian, Hui Shi, Hongbo Zhang, Xu Zhang
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004164
摘要
Nanoparticles derived from various sources have been widely investigated as biological therapeutic agents and drug carriers for cancer treatment. Among them, plant-derived vesicle-like nanoparticles (PDVLNs) have attracted considerable interest because of their wide availability, high yield, and ease of preparation. PDVLNs are primarily produced via active secretory mechanisms in plant cells in response to specific physiological and environmental stimuli. They can cross biological barriers while retaining the bioactive components of their parent plants, thereby exhibiting the dual capabilities of drug delivery and biological regulation. Currently, in the field of cancer treatment, PDVLNs sourced from ginger, grapes, green tea, and Brucea javanica have been successfully applied in monotherapy, combination therapy, and targeted drug delivery. This review systematically summarizes recent advances and the underlying molecular mechanisms of PDVLNs in cancer treatment, with an emphasis on engineering strategies designed to improve their performance as drug delivery systems, including drug loading techniques, surface modification approaches, and membrane fusion methods. Furthermore, the potential applications of PDVLNs in precision medicine and clinical translation are explored. By synthesizing current research progress and outlining future directions, this review provides a systematic theoretical foundation and practical insights to support the development of safe, effective, and clinically feasible antitumor nanotherapeutic platforms.
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内源性糖皮质激素和糖皮质激素受体信号传导：肿瘤微环境中PD-1/PD-L1免疫治疗疗效的双重调节因子Fanyu Guo, Benling Xu, Guangyu Chen, Jiaqi Liu, Quanli Gao
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000003956
摘要
Immunotherapy targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) has significantly improved outcomes for various cancers, yet the emergence of resistance remains a major challenge. This review focuses on the dual role of endogenous glucocorticoids (GCs) and their receptor (GR) within the tumor microenvironment (TME), systematically elucidating the mechanisms by which they regulate responses to PD-1/PD-L1 therapy via the hypothalamic-pituitary-adrenal (HPA) axis, local synthesis and metabolism, and heterogeneity of GR signaling. We elaborate on the regulatory effects of the GC/GR signaling pathway on immune cells (such as cluster of differentiation 8 positive [CD8+] T cells, regulatory T cells [Tregs], dendritic cells, natural killer [NK] cells, and macrophages), and highlight the impact of GCs on PD-L1 expression, cytokine secretion, and the immunosuppressive microenvironment. This review also explores the controversial role of exogenous GCs in managing immune-related adverse events (irAEs) and their potential impact on therapeutic efficacy. The development of tissue-selective GR modulators holds promise for balancing immunosuppression while enhancing anti-tumor activity. A deeper understanding of the role of endogenous GCs in cancer immunotherapy is crucial for optimizing therapeutic strategies, overcoming resistance, and finally achieving precision in cancer immunotherapy.
Original Article
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中国神经系统疾病的患病率和负担：2021年全球疾病负担研究分析Qingyuan Dai, Queran Lin, Jiongxue Chen, Zhenhong Deng, Wenyi Jin, Pengpeng Ye, You Zuo, Yuxin Yang, Songhua Xiao, Yamei Tang
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004051
摘要
Background:
Neurological diseases represent a growing challenge to the Chinese public health system. However, a comprehensive analysis of neurological diseases in China is lacking. This study aimed to analyze disease burden and risk factors of neurological diseases in China to identify priorities for disease control and prevention.
Methods:
Disease burden and risk factors in China were analyzed for 12 neurological disorders using data from the Global Burden of Diseases 2021 study and the Chinese Center for Disease Control and Prevention. Prevalence, deaths, years of life lost, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were used as metrics.
Results:
Intracerebral hemorrhage (ICH) (1930.3 [95% uncertainty interval (UI): 1605.3-2296.7] per 100,000), ischemic stroke (1646.8 [95% UI: 1400.0-1893.1] per 100,000), Alzheimer’s disease and other dementias (dementia) (708.0 [95% UI: 347.7-1561.7] per 100,000) made the greatest contributions to DALY rates in China in 2021. The fastest growing contributors to DALY rates were dementia (208.2% [95% UI: 166.4-255.7%]), Parkinson’s disease (160.7% [95% UI: 121.8-208.3%]), and ischemic stroke (95.2% [95% UI: 56.9-140.6%]). Migraine was the leading contributor to DALY rates among populations aged 10-39 years, ICH for those aged 40-74 years, ischemic stroke for those aged 75-89 years, and dementia for those aged >90 years. Ischemic stroke accounted for the highest age-standardized DALY rates in North and Northeast China, whereas ICH ranked first in other regions. High systolic blood pressure had the highest attributable DALYs for all diseases combined. Metabolic risk factors, alcohol use, secondhand smoke, and low physical activity contributed to higher YLDs in females, whereas alcohol use, smoking, and a high-sodium diet contributed to higher YLDs in males.
Conclusions:
Neurological diseases present a growing public health challenge, characterized by significant disparities in their prevalence and presentation across age, sex, and geographic regions. Addressing these disparities requires coordinated strategies encompassing prevention, treatment, rehabilitation, and supportive care at the national level.
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长期暴露于较低的低密度脂蛋白胆固醇与神经影像学指标的关系：一项基于人群的队列研究Jing Sun, Ying Hui, Jing Li, Xinyu Zhao, Pengfei Zhao, Xiaoshuai Li, Shuohua Chen, Shouling Wu, Zhenchang Wang, Han Lv
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004105
摘要
Background:
Limited evidence exists regarding the relationship between long-term exposure to low concentrations of low-density lipoprotein cholesterol (LDL-C) and brain structural integrity. This study aimed to examine the associations of cumulative low LDL-C exposure with a series of neuroimaging metrics.
Methods:
This study included 987 participants (median age 55 years) from a population-based cohort study in China. Serum circulatory LDL-C concentrations were assessed biennially from 2006 to 2018. Prolonged LDL-C exposure was calculated using a time-weighted average (TWA) approach during that period. Brain MRI examinations were performed during 2020-2022. We used generalized linear model to investigate the multivariate-adjusted associations of TWA LDL-C levels with MRI markers of brain tissue volume, white matter microstructural integrity, and white matter hyperintensity (WMH).
Results:
After full adjustments, TWA LDL-C concentrations of 70-100 mg/dL and less than 70 mg/dL were associated with lower fractional anisotropy value and higher mean diffusivity, axial diffusivity, and radial diffusivity value compared to LDL-C concentrations of 100-130 mg/dL. These associations were particularly prominent in male participants and older participants who were over 50 years. No association was found between relatively lower LDL-C levels and brain tissue volumes or WMH.
Conclusion:
LDL-C concentrations of 70-100 mg/dL and <70 mg/dL are associated with impaired microstructural integrity of brain white matter.
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单胎妊娠妊娠血糖水平与先兆子痫风险之间的剂量反应关系：一项回顾性多中心研究Shang Ma, Tingfei Gu, Huifeng Shi, Yuan Wei, Xiaoli Wang
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004057
摘要
Background:
Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. Whether risks of pre-eclampsia are associated with severity of blood glucose concentrations or glycemic control is still unknown. This study aimed to analyze the association of blood glucose concentrations during pregnancy and the risk of pre-eclampsia.
Methods:
A retrospective cohort study was conducted using data of 53,054 singleton pregnant women aged 18-49 years from 121 maternity hospitals in China between 2015 and 2018. Logistic regression models with restricted cubic splines were performed to reveal a non-linear association of blood glucose concentrations in the first trimester and the gestational change with pre-eclampsia. The association of the categories of blood glucose concentrations with pre-eclampsia was further examined by performing robust Poisson regression.
Results:
A total of 1356 (2.55%, 1356/53,054) participants were diagnosed with pre-eclampsia. Higher risk was observed in those with higher blood glucose in the first trimester and those with greater increase in blood glucose during gestation, with the incidence of pre-eclampsia ranging from 1.27% (24/1883) to 6.03% (29/481). Compared with women with blood glucose (BG) concentrations of <4.4 mmol/L in the first trimester, the risk of pre-eclampsia was significantly increased in women with 4.4 ≤BG <5.1 mmol/L (adjusted relative risk [aRR] = 1.347, 95% confidence interval [CI]: 1.185-1.531), 5.1 ≤BG <5.6 mmol/L (aRR = 1.750, 95% CI: 1.441-2.124), and BG ≥5.6 mmol/L (aRR = 2.431, 95% CI: 1.958-3.019), respectively, after adjusting for basic characteristics of women, including region, age, education, ethnicity, residential status, assisted reproductive technology, primigravida, pre-pregnancy body mass index and categories of gestational change of blood glucose concentrations. The association of gestational change of blood glucose concentrations during gestation with pre-eclampsia was presented as a U-shaped curve after controlling the blood glucose concentrations in the first trimester.
Conclusions:
The findings highlight that higher blood glucose concentration in the first trimester and greater gestational variations of blood glucose contribute to higher risks of pre-eclampsia. Therefore, maintaining optimal blood glucose in early pregnancy and minimizing gestational glucose fluctuations is recommended to reduce the risk of pre-eclampsia.
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pronase提高结肠镜检查可视性和安全性的临床研究Bo Zhang, Tanzhou Chen, Yu Chen, Danian Ji, Guodong Li, Xing Chen, Biguang Tuo, Wen Wang, Peng Li, Weijian Lun 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004114
摘要
Background:
This is a multicenter, randomized, double-blind, placebo-controlled interventional clinical study to evaluate the efficacy and safety of pronase in improving visibility in colonoscopy and to evaluate whether pronase can increase the detection rate of intestinal lesions and the colonoscopist’s satisfaction.
Methods:
From June 2023 to December 2023, a total of 1942 patients undergoing air insufflation colonoscopy in 10 hospitals (The First Medical Center, Chinese PLA General Hospital, et al) were selected as the study subjects. They were randomly divided into two groups: (1) the experimental group (n = 969) was given pronase for flushing in colonoscopy; and (2) the control group (n = 973) was given physiological saline for flushing in colonoscopy. The improvement of the visibility at the target site (region of interest) in colonoscopy was evaluated in two groups to verify the efficacy of pronase in improving visibility in colonoscopy. The safety of pronase for flushing in colonoscopy was evaluated by comparing the incidence of adverse events between the two groups.
Results:
After the use of pronase in colonoscopy, the patient’s vital signs remained stable, without serious adverse reactions. The improvement rate of visibility in the pronase group was significantly higher than that in the physiological saline group (97.21% [942/969] vs. 86.74% [844/973], P <0.0001), and the subgroup analysis (Boston Bowel Preparation Scale ≥6 points) showed similar results to the overall ones. The physician’s satisfaction score in the pronase group was significantly increased. There was no statistically significant difference in the detection rates of adenoma, colorectal cancer, minimal lesions, non-polypoid colorectal lesions, polyps, and precancerous lesions between the two groups.
Conclusions:
Pronase can improve the visibility in colonoscopy and help physicians observe the lesions better. Pronase demonstrates good safety in colonoscopy, with no significant difference compared to physiological saline.
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握力与妊娠期高血压疾病的关系：同济-华西-双流分娩队列的前瞻性分析Yuxiang Wang, Ping Wu, Yi Wang, Yixiang Ye, Yuwei Lai, Junxiang Chen, Yue Li, Jijuan Zhang, Jingyi Wang, Hancheng Yu 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004024
摘要
Background:
Hypertensive disorders of pregnancy (HDP) are leading causes of maternal and fetal morbidity and mortality. Although lower grip strength has been linked to higher cardiovascular risk in the general population, evidence on its relationship with HDP remains limited. We aimed to prospectively investigate this association in a large cohort of pregnant women.
Methods:
Between March 2017 and January 2020, 6802 pregnant women (mean age ± standard deviation: 26.6 ± 3.7 years) enrolled in the Tongji-Huaxi-Shuangliu Birth Cohort were included in this analysis. Grip strength was measured in early pregnancy (mean gestational week ± standard deviation: 10.3 ± 2.0 weeks) and assessed in three ways: absolute grip strength (AGS) and two relative indices (AGS normalized to body mass index or body weight). Logistic regression models were used to assess the associations between grip strength and the risk of HDP (gestational hypertension or preeclampsia). Multiple blood biomarkers (blood lipids, leptin, adiponectin, C-reactive protein, C-peptide, glycated hemoglobin, and homeostatic model assessment of insulin resistance) were measured among 638 women at enrollment.
Results:
A total of 180 women developed HDP during pregnancy. The adjusted odds ratios (95% confidence intervals) of HDP across increasing quartiles of AGS in early pregnancy were 1.00 (reference), 0.93 (0.63-1.35), 0.67 (0.44-1.00), and 0.35 (0.21-0.56). Odds ratios across quartiles of two relative grip strength (RGS) indices showed similar patterns. Restricted cubic spline analyses indicated a nonlinear association between AGS and HDP risk (P for nonlinearity = 0.014). The risk plateaued at lower AGS levels but showed a linear inverse association above a threshold of 18.1 kg. In contrast, the two relative measures showed linear associations with HDP risk (P for nonlinearity ≥0.164). Additionally, higher RGS was generally correlated with favorable metabolic profiles (e.g., lower levels of low-density lipoprotein cholesterol, triglycerides, and C-reactive protein).
Conclusion:
Grip strength in early pregnancy was inversely associated with the risk of HDP, and RGS may serve as a simple and useful measure for risk stratification.
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蛋白质组学分析揭示滤泡性甲状腺癌进展中关键蛋白质的调节Xue Cai, Rui Sun, Liang Yang, Nan Yao, Yaoting Sun, Guangmei Zhang, Weigang Ge, Yan Zhou, Zhiqiang Gui, Yu Wang 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000003645
摘要
Background:
Cytopathology cannot be used to reliably distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC), the second most common form of thyroid cancer, because they exhibit nearly identical cellular morphology. Given the challenges in diagnosis and treatment, this study aims to identify the mechanisms underlying FTC.
Methods:
Using parallel reaction monitoring-mass spectrometry (PRM-MS) assays, we identified and quantified 94 differentially expressed protein candidates from a retrospective cohort of 1085 FTC and FTA tissue samples from 18 clinical centers. Of these targeted proteins, those with the potential for distinguishing FTC from FTA were prioritized using machine learning. Co-immunoprecipitation (co-IP) and immunofluorescence co-localization assays, as well as gene interference, overexpression, and immunohistochemistry (IHC) experiments, were used to investigate the interactions and cellular functions of selected proteins.
Results:
Using machine learning models and feature selection methods, 30 of the 94 candidates were prioritized as key proteins. Co-IP and immunofluorescence co-localization assays using FTC cell lines revealed interactions among insulin-like growth factor 2 receptor (IGF2R), major vault protein (MVP), histone deacetylase 1 (HDAC1), and histone H1.5 (H1-5). Gene interference and overexpression experiments in FTC-133 cells confirmed the promotional role of these proteins in cell proliferation. IHC assays of patient samples further confirmed elevated expression of these four proteins in FTC compared with that in FTA.
Conclusions:
Our findings underscore the utility of advanced proteomic techniques in elucidating the molecular underpinnings of FTC, highlighting the potential significance of IGF2R, MVP, HDAC1, and H1-5 in FTC progression, and providing a foundation for the exploration of targeted therapies.
Correspondence
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抗PD-1单克隆抗体抑制肝癌患者乙型肝炎病毒Chuanhua Zhao, Yanqiao Zhang, Gang Wang, Weiqing Chen, Li Zhuang, Shanzhi Gu, Jinfang Zheng, Lei Han, Zujiang Yu, Chang Liu 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004072
摘要
致编辑：抗程序性死亡1（抗PD-1）抗体治疗晚期肝细胞癌（HCC）的疗效已得到充分证实。鉴于乙型肝炎病毒（HBV）是HCC的主要原因，并且关于抗PD-1抗体与HBV之间相互作用的证据有限，我们探讨了HCC患者接受抗PD-1抗体finotonlimab治疗后HBV的变化。我们证明finotonlimab抑制HBV复制并维持病毒稳定性，可能与临床结果的改善相关。该分析涉及相对较大的样本量，强调了抗PD-1抗体在治疗HCC和并发HBV感染患者中的双重益处。这些发现支持进一步研究PD-1抗体在HBV治疗中的作用和机制，可能有助于开发慢性肝炎和HCC的新治疗策略。
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静息状态脑功能网络与癌症风险之间的遗传关联：一项双向孟德尔随机化研究Sicong Liu, Hao Lin, Bo Ding, Yang Shen
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000003905
摘要
致编辑：静息状态功能性磁共振成像（rsfMRI）能够评估自发神经活动，并揭示了对情绪调节、认知控制和全身稳态至关重要的内在大脑网络。[
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筛选和功能验证应用程序,PSEN1，和PSEN2来自PUMCH痴呆队列的突变Jie Li, Peixin Meng, Liling Dong, Longze Sha, Chenhui Mao, Dan Lei, Xinying Huang, Jie Wang, Li Shang, Shanshan Chu 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004037
摘要
致编辑:PSEN1,PSEN2，和应用程序已被证实是家族性阿尔茨海默病（AD）的致病基因。荟萃分析表明，AD致病突变患者可能在更年轻的年龄出现症状（平均发病年龄为46.2岁）。[
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中度新冠肺炎和肺炎放射学体征门诊患者的糖皮质激素类固醇：一项队列研究Jiuyang Xu, Rongrong Song, Yeming Wang, Hui Zhang, Xiaoying Gu, Jingya Li, Lingxi Guo, Zhengping Liu, Bin Cao
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000004106
摘要
致编辑：2019冠状病毒病（COVID-19）继续在全球传播。严重新冠肺炎的过度炎症反应可能会导致细胞因子风暴，从而诱导多器官衰竭、急性呼吸窘迫综合征和更差的预后。因此，新冠肺炎重症患者的抗病毒单药治疗可能不够，联合免疫调节剂的重要性不言而喻。恢复试验[
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斯拉1,APOA5，和AIFM2通过全外显子组测序确定复发性高甘油三酯血症相关急性胰腺炎的新遗传危险因素Zehua Huang, Li Wen, Chunlan Huang, Junjie Fan, Wenfei Qin, Jing Wang, Wei Zhang, Nuoming Yin, Qixiang Mei, Yang Fu 等
中华医学杂志英文版2026年 139卷 14期
DOI: 10.1097/CM9.0000000000003663
摘要
致编辑:高甘油三酯血症相关性急性胰腺炎（HTG-AP）是中国急性胰腺炎（AP）的第二大常见病因，其特点是与其他病因相比，并发症更多，重症监护室（ICU）入院人数更高，住院时间更长，复发率更高（16.0-49.2%）。[
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更正：角蛋白17通过PI3K/AKT/NF-κB途径调节角质形成细胞中CXCL1的分泌来增强中性粒细胞的趋化性中华医学杂志英文版2026年 139卷 14期
DOI: 10.3760/cma.j.issn.0366-6999.2026.14.101
摘要
作者在信函中声明“角蛋白17通过在银屑病中通过PI3K/AKT/NF-κB途径调节角质形成细胞中的CXCL1分泌来增强中性粒细胞的趋化性”，[
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