May 2017J Am Soc NephrolThe study on gene susceptibility and its mechanism of primary membranous nephropathy by Professor Zhao Minghui, Department of Nephrology, Peking University First Hospital, was published in the journal-"Major histocompatibility complex (MHC) class II gene and its encoded amino acids are associated with the susceptibility to primary membranous nephropathy" [Cui Z, Xie LJ, Chen FJ, et al. MHC Class Ⅱ risk alleles and amino acid residues in idiopathic membranous nephropathy. J Am Soc Nephrol, 2017, 28 (5): 1651 – 1664]. A review by Professor Kiryluk, an expert in renal genetics at Columbia University in the United States, was also issued in the current issue[1]。 This study explored the susceptible HLA genotypes and the key amino acids encoded by them in primary membranous nephropathy, predicted the T cell epitopes presented by risk HLA molecules, and helped elucidate the presentation mechanism of autoantigens in primary membranous nephropathy.
