glucose-6-phosphate dehydrogenase deficiency (G6PDd) is caused by the mutation of the gene that regulates glucose-6-phosphate dehydrogenase (G6PD), which leads to the reduction of its G6PD activity. It is an X-linked incomplete dominant genetic disease. Its onset is often induced by accidental eating of faba beans, so it is also called "faba bean disease"[1]。 Patients can develop acute hemolytic anemia and hyperbilirubinemia in cases of infection, oxidative stress, food or drug induction, and in severe cases, it can cause kernel jaundice and even life-threatening[2]。 The main measures to prevent this disease are to detect G6PDd patients in time through neonatal disease screening and to avoid contact with food, drugs and other inducing factors[3]。 The disease has a high incidence in Guangdong, Guangxi, Hainan and other southern regions of China, and the incidence rate of male is higher than that of female[4]。
