2015年 · 第38卷第11期

The precursor substance for the formation of A and B antigens on erythrocytes is H antigen. The ABO locus determines the production of A and B antigens, whereas the α 1,2 – fucosyltransferase geneFUT1(orH) andFUT2(orSe) determines the production of H antigens, the precursors of A and B antigens^[1]。 In Bombay-like blood group, ABH antigen is not normally expressed on the surface of red blood cells, but the secretion may contain ABH substance^[2]Serum contains strong anti-H antibodies, so Bombay-like blood group can lead to ABO typing discrepancy and blood transfusion difficulty. Studies on the molecular mechanisms of Bombay-like blood groups are beneficial for correct identification of blood groups and clinical safety of blood transfusion. Individuals with Bombay-like blood typically have a defective FUT1 gene and a normal or weakly expressed FUT2 gene.

Omega – 3 (also known as Omega – 3 or n – 3) polyunsaturated fatty acids (PUFAs) mainly include linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Numerous studies have shown that omega – 3 PUFAs may protect cardiovascular^[1,2]antidepressant^[3]anti-tumor^[4]Promote brain and retina development^[5]Promote bone health^[6]anti-inflammatory^[7]And other biological functions, among which the cardiovascular protective effect has been clearly defined.

The problem of whether and when patients treated with nucleoside (acid) analogues can be withdrawn has been a difficult and hot issue. According to the prevention and treatment guidelines of chronic hepatitis B (CHB) in China, the discontinuation criteria of nucleoside (acid) analogues were discontinued^[1]Some patients still have recurrence. Therefore, it is urgent to study the monitoring indicators to judge whether relapse after drug withdrawal is not. The purpose of this study was to analyze the relationship between serum dynamic HBsAg level and relapse after discontinuation of entecavir (ETV) in e antigen-positive CHB patients, and to explore the predictive value of HBsAg level on relapse after discontinuation of entecavir.

According to the requirements of ISO 15189:2012^[1]quality indicator (QI) is a measure of the extent to which a set of intrinsic characteristics meet requirements. QI can not only monitor and evaluate the degree to which the performance of each key step in the whole inspection process meets the requirements, but also monitor the laboratory non-inspection process, including laboratory safety and environment, equipment performance, personnel capability, and the effectiveness of document control system.