MedNexus
2021年 · 第101卷第23期
MedNexus
- 全部
- 述评
- 标准与规范
- 动脉自旋标记在神经系统病变的应用
- 临床研究
- 疑难病例析评
- 综述
- 文献速览
Internal carotid artery stenosis has a higher risk of stroke. At present, many studies have focused on plaque vulnerability: plaque structure and composition, but few studies have analyzed intracerebral hemodynamic changes as a risk factor for stroke in patients with internal carotid artery stenosis. The study used magnetic resonance contrast-enhanced angiography, carotid plaque imaging, and arterial spin labeling (ASL) to distinguish between asymptomatic and symptomatic patients with carotid stenosis. The enrolled patients with carotid stenosis were derived from two prospective studies (ECST-2, SHIP) in which ASL and carotid plaque imaging were acquired on the same 3T magnetic resonance imaging (MRI) between 2014 and 2018. Enrolled patients were divided into symptomatic and asymptomatic groups according to clinical assessment of recent transient ischemic attack or stroke. Without the knowledge of clinical symptoms, the degree of stenosis of carotid plaque, plaque surface structure and intraplaque hemorrhage (IPH), collateral branches of Willis ring, and the presence and severity of superior arterial passage artifacts (ATAs) in ASL images were analyzed. A total of 44 patients were enrolled in the study. Sixteen of the 28 patients with more than 70% carotid stenosis were shown to have ATAs, and ATAs was associated with absence of the anterior communicating artery. There was no significant correlation between cerebral ischemic symptoms and the degree of stenosis, IPH and plaque surface structure. Patients with ATAs are more likely to develop symptoms than those without ATAs. Cerebral ischemic symptoms were also associated with ATAs severity. Therefore, it is concluded that ATAs is the only factor associated with ischemic symptoms in patients with recent carotid stenosis, and the degree of carotid stenosis, plaque ulcers and IPH are not associated with cerebral ischemic symptoms.
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