Carbapenem antibiotics have a broad antibacterial spectrum, strong antibacterial activity, and are stable to most beta-lactamases including extended spectrum beta-lactamases (ESBLs), and have become one of the main antibacterial drugs for the treatment of severe bacterial infections. However, in recent years, the widespread use of carbapenem antibiotics has led to the gradual increase of bacterial drug resistance, and the detection rate of carbapenemase-producing strains has increased year by year. Moreover, the gene encoding carbapenemase is located on the mobile gene element such as plasmid, which is easy to transfer horizontally between bacteria, resulting in the outbreak of drug-resistant strains[1]。 Therefore, the rapid and accurate detection of carbapenemase-producing strains has become a hot issue in the field of antibacterial therapy[2]。 The carbapenem inactivation method (CIM) was proposed in the middle of the CLSI meeting in January 2016, which is simple, cheap, easy to generalize, high sensitivity and specificity, and compensates for the limitations of applying traditional methods. The purpose of this study was to explore the application value of CIM in the detection of carbapenemase, and to compare and analyze the differences between traditional methods and CIM, so as to provide reference for clinical infection monitoring.
