Volume 43 ·  Issue 02 ·  2007

The emergence of a new type of intraocular lens provides the possibility of individualized selection. According to the condition of the patient's eyeball, combined with his economy, occupation, habit and medical condition, some suggestions are put forward to make the patient obtain satisfactory postoperative visual quality. (Chinese Journal of Ophthalmology, 2007, 43: 97-98)

Ophthalmic pathology has been considered to be a subject that relies on images to study the morphological changes of ocular tissues and cells caused by pathogenic factors. With the progress of science, medical research has been deepened to the molecular level, and the research methods of pathology on diseases have been more diversified, and the research scope has been more extensive, microscopic and detailed.

1. The results of wavefront aberration detection of aspheric intraocular lens [1-3] show that the decrease of functional vision is closely related to the increase of spherical aberration of the lens. With the continuous improvement of wavefront aberration detection technology, it is clinically recognized that contrast sensitivity and functional vision quality are closely related to higher order aberration. With the increase of age, the spherical aberration of the aging lens increases gradually due to nuclear sclerosis and the change of refractive index, and it loses the ability to compensate the positive spherical aberration of the cornea.

Objective to compare the visual function of adjustable intraocular lens and multifocal intraocular lens implantation after phacoemulsification cataract aspiration.Methods Thirty-two patients with age-related cataract were divided into two groups according to the principle of voluntary.Thirteen patients (24 eyes) in the experimental group were implanted with 1CU adjustable intraocular lens, and 19 patients (30 eyes) in the control group were implanted with Array multifocal intraocular lens. The best corrected visual acuity and the near vision, near point and adjustment amplitude and stereoscopic vision obtained on the basis of the best corrected visual acuity were measured by standard logarithmic vision chart 3 months after surgery. The examination results were taken as the covariate of age, and univariate covariance analysis of group design quantitative data was performed. Results There were no obvious postoperative complications in all patients during the follow-up period.The best corrected visual acuity was 4.96±0.15 in the experimental group and 5.02±0.08 in the control group 3 months after surgery, and the difference between the two groups was not statistically significant (P =0.085). The near vision obtained on the basis of the best corrected visual acuity was 4.65±0.15 in the experimental group and 4.60±0.10 in the control group. There was no statistically significant difference between the two groups (P =0.398). The postoperative subjective proximal point was (56±9) cm in the experiment group and (61±11) cm in the control group, and there was no statistically significant difference between the two groups (P =0.80). The postoperative adjustment range was (1.30±0.40) D in the experiment group and (1.20±0.36) D in the control group, and there was no statistically significant difference between the two groups (P =0.093). The postoperative stereoscopic vision was 43.24″±18.25″ in the experiment group and 60.00″±23.09″ in the control group, and there was no statistically significant difference between the two groups (P =0.543). Conclusion Patients implanted with 1CU adjustable intraocular lens can obtain a certain near vision while maintaining the best distance vision after operation. The two intraocular lenses were not statistically significant in the correction of far vision, near vision under distal correction, subjective proximal point, postoperative adjustment range and stereoscopic vision examination based on proximal correction. (Chinese Journal of Ophthalmology, 2007, 43: 104-107)

Objective to investigate the efficacy and safety of iris pull hook combined with suturable capsular bag tension ring (MCTR) in patients with lens subluxation in Marfan's syndrome.Methods Five patients (7 eyes) with lens subluxation in Marfan's syndrome.After 3.2 mm transparent corneal tunnel incision and continuous annular capsulorhexis,2~4 disposable nylon iris pull hooks were used to hook the edge of capsulorhexis to stabilize the lens capsular bag and center it, and the lens aspiration,MCTR implantation and suture fixation were completed.Folded intraocular lenses were implanted in the lens capsular bag.Results The best corrected visual acuity was ≥0.8 in 6 eyes and 0.7 in 1 eye at 12 months postoperative.Scheimpflug images obtained by anterior segment analysis system showed good intraocular lens centering. Ultrasound bioscopy showed that intraocular lens haptics and MCTR were located in the lens capsular bag, The fixation hook of MCTR is stably located between the iris and the lens capsule. Photographic analysis of reflective slit lamp microscope showed that the posterior lens capsule was obviously opaque in one eye. There were no intraoperative and postoperative complications such as vitreous prolapse and retinal detachment. Conclusion the use of iris hook can maintain the stability of the lens capsule during operation and the operation safety of the operation. MCTR implantation can maintain the long-term stability of the postoperative intraocular lens, and safely and effectively avoid the postoperative intraocular lens dislocation caused by progressive aggravation of suspensory ligament abnormality of the lens in patients with Marfan syndrome. (Chinese Journal of Ophthalmology, 2007, 43: 108-111)

Objective to evaluate the safety, effectiveness, predictability and stability of excimer laser in situ keratomileusis (LASIK) in the treatment of high hyperopic anisometropia in children, and to explore its influence on the treatment effect of postoperative amblyopia. Methods 42 children with high hyperopic anisometropia were observed by prospective self-control method, ranging from 6 to 14 years old. The visual acuity, diopter and binocular visual function were analyzed after operation. The follow-up time was 6 to 24 months. Results the correction diopter was +3.00~ +7.50 D, and the residual diopter of 66.6% of the eyes was within the range of the predicted correction diopter ± 1.00 D at 2 years after operation. The fluctuation range of the equivalent spherical diopter was +0.99 Conclusion LASIK is safe, effective, predictable and stable for children suffering from high hyperopic anisometropia and cannot tolerate wearing glasses, and it is helpful to improve the cure rate of high hyperopic anisometropic amblyopia. (Chinese Journal of Ophthalmology, 2007, 43: 112-117)

Objective to investigate the surgical methods, clinical efficacy and prevention and management of complications of small incision and seamless deep lamellar keratoplasty. Methods 9 patients (9 eyes) with bullous keratopathy were treated with small incision and seamless deep lamellar keratoplasty, 6 of them combined with anterior segment vitrectomy. The adhesion between graft and graft bed, the occurrence and management of graft displacement were observed after operation. The visual acuity, graft transparency, corneal curvature, corneal astigmatism and corneal endothelial cell density were observed after 3~5 months of follow-up. Results 8 patients had good adhesion between graft and graft bed, 1 patient had graft displacement on the first day after operation, and the adhesion was good after re-positioning. 6 patients had different degrees of visual acuity improved, 3 patients had long-term preoperative hypertension, but postoperative visual acuity did not improve. 9 patients had clear graft, corneal curvature (43.96±3.38) D, corneal astigmatism (3.32±1.20) D, corneal endothelial cell density (2124±278) /mm2, and no serious complications occurred. Small incision deep lamellar endothelial transplantation is more advantageous in the treatment of bullous keratopathy, and it is expected to be one of the surgical methods for the treatment of this disease. (Chinese Journal of Ophthalmology, 2007, 43: 118-123)

Objective to observe the expression changes of type Ⅰ collagen and fibronectin in human eyeball fascial sac fibroblasts (HTFs) transfected with Smad7 gene.Methods the eukaryotic expression plasmid containing Smad7 was transfected into HTFs by NucleofectorTM nucleic acid transfection instrument.The expression changes of type Ⅰ collagen and fibronectin mRNA were detected by real-time quantitative reverse transcription polymerase chain reaction method.The concentration changes of type Ⅰ procollagen carboxyterminal peptiden (PICP) in culture medium were detected by radioimmunoassay, and the changes of the above indexes were detected after the treatment of transforming growth factor β 2 (TGF-β 2,10 ng/ml). The untransfected HTFs and the empty HTFs were used as controls.Results the plasmid containing Smad7 gene was successfully transfected into HTFs, and the mRNA expression of Smad7 gene was significantly increased. The mRNA expression rate of type Ⅰ collagen in HTFs transfected with Smad7 was (89.53±9.37) %, which was 40.47% of the control group and 37.94% of pCMV5-HTFs The expression of fibronectin mRNA of HTFs transfected with Smad7 was not significantly different from that of the control group regardless of the effect of TGF-β 2 (P>0.05). Conclusion Smad7 can decrease the expression of type Ⅰ collagen mRNA and the synthesis of type Ⅰ collagen in HTFs, but has no significant effect on the expression of fibronectin mRNA (Chinese Journal of Ophthalmology, 2007, 43: 124-128)

Objective to investigate the effect of scleral flap stent implantation under scleral flap with methyl methacrylate (PMMA) material.Methods Thirty-two normal small-tailed Han sheep were divided into experimental group or control group by random number table method.The experimental group underwent scleral flap stent implantation, while the control group underwent simple trabeculectomy.The changes of intraocular pressure and anterior segment were observed before and after surgery for 1 consecutive year.Results the decrease of intraocular pressure in the experimental group was significantly greater than that in the control group.The intraocular pressure in the control group basically returned to the original level at 4 weeks after surgery, and the intraocular pressure in the experimental group returned to the original level at least 3 months after surgery. Three months after surgery, the filtering vesicles were still loose; Four weeks after surgery, the filtering vesicles in the control group were low and flat, and the filtering tract was occluded. In the experimental group, the filtration tract healed delayed after operation, and there was still a gap between the stent and the surrounding tissues at 3 months; At 6 months, this space disappeared, and the stent and surrounding tissues all healed, showing good histocompatibility and no rejection phenomenon. The pathological examination results were completely consistent with the results of UBM. One year after operation, no obvious toxic or side effects were observed in the experimental group. Conclusion The effect of filteroplasty with PMMA stent implanted under the scleral flap is safe and effective, and the effect of lowering intraocular pressure is more significant and lasting than that of traditional trabeculectomy. (Chinese Journal of Ophthalmology, 2007, 43: 129-133)

Objective to study the biological characteristics of human limbal epithelial cells, and to explore the clinical application value and prospect of human limbal epithelial cells transplanted in vitro for ocular surface reconstruction. Methods Human limbal epithelial cells were cultured in vitro, and their phenotypes were analyzed by immunofluorescence staining and reverse transcription polymerase chain reaction (RT-PCR), and slow-cycling cells were detected by BrdU doping method. Rat corneal alkali burn model was established and randomly divided into control group, amniotic membrane transplantation (AMT) group and amniotic membrane carrier limbal epithelial cell transplantation (LSAT) group. The recovery of ocular surface in each group was evaluated by slit lamp microscopy, HE staining of corneal sections and immunofluorescence staining. Results Most limbal epithelial cells were positive for p63 and K19 staining, and only a few cells were positive for K3 staining. RT-PCR showed that both p63 and K12 were positive in cultured limbal epithelial cells, while only K12 was positive in corneal epithelial cells. Slow cycle cells were detected by BrdU incorporation. Animal experiments showed that LSAT could significantly alleviate corneal lesions and restore corneal integrity and transparency. The differences of ocular surface scores were statistically significant compared with those of AMT group and control group. Most of the epithelial cells in LSAT group were positive for anti-human nucleus and K3 staining. The presence of slow-cycle cells confirmed the existence of limbal stem cells in cultured limbal epithelial cells, and the cells with p63 and K19 positive and K3 negative were limbal stem cells; Transplantation of human limbal epithelial cells cultured in vitro with amniotic membrane as carrier can effectively reconstruct ocular surface, and has high clinical application value and development prospect. (Chinese Journal of Ophthalmology, 2007, 43: 134-141)

Objective to observe the inhibitory effect of histone deacetylase inhibitor FK228 on retinal neovascularization. Methods C57BL/6J pups aged 7 days were placed in 75% oxygen for 5 days continuously to establish a model of hyperoxia-induced angioproliferative retinopathy. The pups were randomly divided into normal control group, oxygen control group and treatment group (the pups were injected with FK228250 ng in vitreous cavity and the same volume of dimethyl sulfoxide solution in the opposite eye as control). The number of endothelial cell nuclei that broke through the inner limiting membrane of retina was observed and counted by tissue sections, and the inhibition of retinal neovascularization by FK228 was observed. Results The distribution of retinal blood vessels was disordered and the density was increased, and a large number of retinal neovascularization was observed in the oxygen-administered control group (rat age 17 d), and more endothelial cell nuclei that broke through the inner limiting membrane of retina were observed on tissue sections. The distribution of retinal blood vessels was regular and the density was decreased, and the number of endothelial cell nuclei that broke through the inner limiting membrane was decreased significantly in the treatment group, and the difference between the two groups was statistically significant (P<0.01). Conclusion FK228 can inhibit retinal neovascularization and is expected to be an effective method for preventing and treating angioproliferative retinopathy. (Chinese Journal of Ophthalmology, 2007, 43: 142-145)

Objective to study the differentiation of bone marrow mesenchymal stem cells (MSCs) in the microenvironment of rat choroidal neovascularization (CNV). Methods MSCs from BN rats were implanted into the subretinal space of CNV model rats induced by argon laser. The MSCs were tracked by immunofluorescence labeling and the differentiation of MSCs in the microenvironment of CNV was observed at 1, 2, 3, 4 and 5 weeks after operation. Results MSCs were found on the surface of CNV at the first week after operation, but the CD31 label was negative. MSCs expressed CD31 positive in CNV at the second week, and MSCs migrating to photoreceptor expressed rhodopsin at the fifth week. Conclusion MSCs can survive after implantation into the subretinal space of CNV model rats, and can differentiate into endothelial cells and photoreceptor cells. (Chinese Journal of Ophthalmology, 2007, 43: 146-150)

Objective to investigate the amino acid sequence of human apolipoprotein A [apo (a)] kringle V (KV) in anti-neovascularization and to evaluate its inhibitory effect on vascular endothelial growth factor (VEGF) -induced corneal neovascularization in mice. Methods The structure and biological characteristics of the amino acid sequence of apo (a) KV were analyzed by bioinformatics method from the aspects of sequence alignment, antigenicity, surface contact and hydrophilicity prediction, and the possible active peptides were screened. The effect of small peptide on VEGF-induced neovascularization was detected by corneal microcapsule model in mice. According to the random number table method, 40 C57BL/6 mice (40 eyes) were divided into 4 groups: control group, group A, group B and group C, 10 eyes in each group. 160 ng VEGF was implanted in the corneal stromal layer of each group, and 0.0, 0.5, 1.0 and 1.5 μ g small peptide sustained-release granules were implanted in sequence. Compared with other peptides in apo (A) KV, the longest vessel length, number of hours and area of corneal neovascularization in groups B and C were significantly different from those in the control group (P<0.01), while the difference between group C and group B was not statistically significant (P>0.05). The above three indexes were not significantly different between group A and control group (P>0.05). Conclusion The selected small peptides have obvious inhibitory effect on VEGF-induced corneal neovascularization in mice at a certain dose, and their amino acid sequences may be located in the anti-neovascularization active site of apo (A) KV. (Chinese Journal of Ophthalmology, 2007, 43: 151-157)

The current corneal curvature measurement method is not accurate in measuring corneal refractive power after corneal refractive surgery, which leads to low calculation of intraocular lens power during cataract surgery, and severe hyperopia after surgery. With the increase of the number of patients undergoing excimer laser corneal refractive surgery, this problem will become increasingly prominent in the future. Around this problem, many scholars have put forward various correction schemes to improve the accuracy of intraocular lens power calculation after corneal refractive surgery. This article reviews this problem. (Chinese Journal of Ophthalmology, 2007, 43: 188-192)

Approved by China Association for Science and Technology and the Ministry of Science and Technology, the "7th International (Shanghai) Academic Conference on Ophthalmology and Optometry", co-sponsored by Ophthalmology Branch of Chinese Medical Association in six provinces and one city in East China, and co-sponsored by Eye, Ear, Nose and Throat Hospital affiliated to Fudan University, School of Optometry of Wenzhou Medical College and China International Science and Technology Conference Center, will be held at Shanghai Everbright Convention and Exhibition Center International Hotel (No.66 Caobao Road, Xuhui District, Shanghai) from April 12 to 15, 2007. Experts, scholars and well-known manufacturers in the fields of ophthalmology and optometry from the United States, European countries, South Korea, Japan, India and other countries in China will be invited to attend this conference. Delegates who attend this conference and meet the relevant conditions will receive national class I continuing medical education credits. Conference website: http: / /www.cooc.cn. Thesis consultation: Ms. Lu Ping, Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai (No.83 Fenyang Road, Shanghai 200031); Phone or fax: 021-64318258; Email: luping@cooc.cn. Registration Consultation:

Ophthalmic diseases can significantly affect the quality of life of patients, and have been paid more and more attention by the society. The rapid development of science and technology has laid the foundation for the continuous renewal of ophthalmic equipment and drugs, and improved the level of clinical diagnosis and treatment.

The 14th Asian-African Ophthalmology Congress will be held in Marrakech, Morocco, near the Atlantic Ocean, from 20 to 25 June 2007. The conference covers all professional fields of ophthalmology, including cataract and refractive surgery, corneal and external eye diseases, glaucoma, retinal and vitreous diseases, plastic surgery, pediatric ophthalmology, neuro-ophthalmology, ocular trauma, pharmacology, etc. The conference will arrange 45 thematic seminars and lectures, and also live surgical broadcasts. Preferential registration fee and submission deadline is February 28, 2007. Contact Methods: Fax: +212-22-430628; Email: smosa@menara.ma. Details can be found at www.aaco2007.org.

The 17th International Congress of Eye Research (ICER) was held in Buenos Aires, Argentina, from October 29 to November 3, 2006. International Eye Research Congress is an International event hosted by The International Society for Eye Research, aiming at exchanging and improving The level of International research in The field of ophthalmology. At present, it is The largest and representative International conference in The field of ophthalmology research. This conference is based on cornea, lens, glaucoma, retinal cell biology, retinal neuroscience, eye immunity and infection, eye physiology and pharmacology, comprehensive ophthalmology and young researchers forum as sub-venues for communication. The meeting was also preceded by a satellite conference on retinal degeneration.

Call for papers for the National Academic Symposium on Diabetic Retinopathy, and the book "Digital Stereoscopic Visual Examination Chart" was published.

To celebrate the 55th anniversary of the founding of Chinese Journal of Ophthalmology, the CD-ROM of the full-text retrieval system of Chinese Journal of Ophthalmology from 1950 to 2004, edited by the editorial board of Chinese Journal of Ophthalmology, produced by Beijing Zhitong Blueprint Medical Information Technology Co., Ltd. and published by Tsinghua Tongfang CD-ROM Electronic Publishing House, has now been officially released by Beijing Zhitong Blueprint Medical Information Technology Co., Ltd. The CD-ROM commemorating the 55th anniversary of Chinese Journal of Ophthalmology produced this time contains the full text of the journal for 55 years from its founding in October 1950 to 2004, and truthfully reproduces the pictures and tables attached to the text. Searching and collecting documents supports a variety of retrieval methods and their combinations, so that ophthalmologists can consult the required information conveniently and quickly.

Ophthalmologists at home and abroad are welcome to submit their contributions. In 2007, this journal presented a full-text retrieval CD with it.

The main characteristics of primary open angle glaucoma are increased intraocular pressure and optic nerve damage, the pathogenesis of which has not been completely defined so far. Trabecular meshwork is the main site of obstruction of aqueous humor discharge, and the physiological function and pathological changes of trabecular cells directly affect aqueous humor circulation.

Cataract is the most common eye disease causing blindness, although it cannot be prevented but can be treated. Economical and effective surgical treatment can reduce cataract blindness. According to preliminary statistics, out of the 5 million cataract patients in China, nearly 400,000 people become blind every year. According to the latest eye disease sampling survey results of Tibet Autonomous Region, cataract is the most common eye disease causing blindness in our region, with a prevalence rate of 14.6%. According to the latest census data, there are about 30,000 blind people, of which cataract blindness accounts for 46.8%, that is, there are about 14 040 cataract blind patients in the whole region. With the aging of the population, the newborn cataract patients are increasing year by year, and the task of preventing and treating blindness in our region will be very arduous.

With the development of phacoemulsification cataract aspiration, soft intraocular lens (IOL) has become the development trend of IOL because of its foldability, small surgical incision and good postoperative effect. Commonly used soft IOL can be roughly divided into two categories: hydrophilic and hydrophobic, each with its own advantages and disadvantages. Clinical observation shows that the pathological changes related to the anterior surface of hydrophilic IOL are milder after surgery, such as inflammatory reaction and opacity of anterior capsule of lens, but the pathological changes related to the posterior surface are heavier, that is, the opacity of posterior capsule is heavier; Hydrophobic IOL is the opposite of hydrophilic IOL [1]. Silicone gel soft IOL is the main material of hydrophobic soft IOL, which has excellent bulk properties [2]. It has been clinically proved that its hydrophobic posterior surface and right-angled edge can reduce the occurrence of posterior capsule opacity [3].

A 60-year-old male patient came to our outpatient clinic on October 29, 2003 due to "red eye, pain and visual loss for 22 days". He complained of red eye, pain and visual loss before 22 days, and was diagnosed as "iritis" in another hospital. After drug treatment (specific medication unknown), the red eye and pain were relieved, but the visual acuity did not improve. Eye examination: the best corrected visual acuity of the right eye was 0.6 (international standard vision chart), the cornea was clear, and there was no floating object in the anterior chamber; The crystalline lens was transparent, and the vitreous body was mildly opaque; The color, shape and boundary of the optic papilla were normal; There are scattered white milky droplet-like cloudy spots in the retina around the optic papilla; There is no lesion in the macular center; A cotton wool spot with a diameter of about twice the diameter of the blood vessel was seen at a distance of 1.5DD above the temporal retina from the optic head, and a Roth spot was seen at a distance of 3DD from the optic head (Figure 1). The visual acuity of the left eye was manual in front of the eye, the cornea was clear, there was no floating object in the anterior chamber, there was annular pigmentation on the surface of the anterior capsule of the lens, and the vitreous body was severe milky white silky turbidity, some of which were like cotton wool, and the fundus could not be seen clearly.

Ophthalmic artery occlusion is one of the diseases that seriously endanger the visual acuity of patients, and it is rare in clinic. One case was encountered in our department in the consultation work, and the report is as follows.

A 9-year-old male patient came to our hospital on August 23, 2005 because of blurred vision in both eyes and obvious at night. The child was obese since childhood, with medium intelligence, poor logical thinking ability and habitual nail gnawing. The parents were not intimate relatives, and the child was an only child with no family genetic history. He delivered naturally at full term, and the mother denied the history of infection, medication and radiation exposure during pregnancy. Whole body examination: obese, height 129 cm, weight 42 kg, body mass index [weight/height square (kg/m2)] was 25.24 (9-year-old boy greater than 22.5 was obese). There was no abnormality in heart and lung, and the development of penis and testis was smaller than that of children of the same age (Figure 1). Both fingers and toes were short and thick, and surgical scars were visible on the outside (Figures 2~4).

Primary hyperparathyroidism is a systemic disease caused by excessive secretion of parathyroid hormone by the parathyroid gland, which causes calcium, phosphorus and bone metabolism disorders [1]. Blindness caused by this disease is rare, and one case was treated in our hospital. The report is as follows.

A 52-year-old man came to the ophthalmology department of our hospital on September 28, 2005 due to pain in his right eye with unbearable ipsilateral headache. The patient fainted on the ground due to heatstroke on July 15, 2005, and his head landed on the ground at that time. He woke up about 2 hours later, without general discomfort or head surface trauma. On the 17th, his right eye appeared red and painful, and he went to the ophthalmology department of another hospital the next day. The medical record at that time recorded: IOP (type of tonometer unknown): 28 mm Hg (1 mm Hg =0.133 kPa) in the right eye and 14 mm Hg in the left eye; CT examination of the head reported "cavernous sinus enlargement and vascular fistula". Only local intraocular pressure lowering drugs were given for treatment, and no other treatment was performed.

The child was a 6-month-old male who went to the ophthalmology department of our hospital on December 12, 2005 due to redness and swelling of the left eyelid, congestion of the bulbar conjunctiva and tearing for 20 days, and peristalsis of small worms on the conjunctival surface for 7 days. The parents of the child found that the child was tearing and peristalsis of small worms in the left eye 20 days ago, so they picked it out with a cotton swab. The child kept a cat and a dog at home. Eye examination: moderate redness and swelling of the left eyelid, congestion of the bulbar conjunctiva, congestion and thickening of the palpebral conjunctival surface, white linear worms peristalsis in the conjunctival sac, mostly moving on the conjunctiva and corneal surface; The cornea is clear, the anterior chamber is clear, and the pupil responds normally directly and indirectly to light. 　　

The patient was a 64-year-old female who came to our hospital on April 21, 2006 because of difficulty in vision in her left eye for more than 1 year. Six years ago, the patient underwent phacoemulsification and cataract aspiration and intraocular lens implantation in an external hospital because of senile cataract in her right eye. Five years ago, the patient underwent phacoemulsification cataract aspiration and intraocular lens implantation in an external hospital due to senile cataract in his left eye. H60M hydrogel intraocular lens was implanted during the operation, and the naked eye visual acuity of his left eye was 0.8 after operation. One year ago, the patient came to our hospital with visual deformation in his right eye with fixed black circle in front of his eye, and was diagnosed as macular choroidal neovascularization in his right eye, which was treated by photodynamic therapy; At the same time, the left eye was examined, and the intraocular lens was found to be opaque, but because the naked eye and the corrected visual acuity were 0.7, it was not treated.

The patient was a 20-year-old male with redness and pain in both eyes and visual acuity decrease for 1 week after wearing orthokeratology lens. He came to our hospital on December 5, 2006. He wore orthokeratology lens for 5 years. Ocular examination showed that the visual acuity was 0.4 in the right eye and 0.2 in the left eye. Slit lamp microscopy showed radial neuritis of the cornea in both eyes (Quintessential Picture 1). Laboratory examination showed that the corneal scrapes and amoeba culture in both eyes were positive, and the amoeba culture in the lens box fluid was positive.