1987年 · 第100卷第07期

Mean atmospheric humidity, pressure and temperature were taken as meteorological indices and computer analyzed for correlation with cerebral hemorrhage and thrombosis among 110000 persons for 3 consecutive years. It was found that low humidity and temperature are inversely proportional to the incidence of cerebral hemorrhage while high atmospheric pressure is proportional. On the other hand, cerebral thrombosis incidence is proportional to high humidity and temperature but inversely pro-portional to low atmospheric pressure. This suggests that these meteorological factors are not negligible forces influencing incidence of stroke (cerebral hemorrhage and thrombosis).

Astragalus membranaceus (AM) injecta protects rat beating heart cells experimentally infected with Coxsackie B-2 virus as evaluated for changes in release of cardiac enzymes (lactate dehydrogenase and aspartate aminotransferase). Heart beat rate, cytopathic effects, cardiac cellular damage as measured by cytotoxicity assay, virus titer, and ultra structure were monitored. Significant protective effects were demonstrated when AM was given l-9 hours post-infection. The results suggest that AM may be valuable in prophylaxis and treatment of acute Coxsackie virus caused myocarditis.

In 1957, a new tsutsugamushi disease vector, Leptotrombidium (L) Gaohuensis SP. Nov. was discovered during an investigation of the disease in Gaohu Village, Zhejiang Province. An overall study of its epidemiology, ecology and etiology was conducted to determine the insect in function as a tsutsu-gamushi disease vector. The authors conducted an insect bite test on themselves, showing that the larvae had the ability to bite humans and cause the infection. The second generation larvae were divided int0 5 groups of 5-20 larvae each and allowed to bite healthy mice. Two groups of the mice contracted the disease and died. Two strains of Rickettsia tsutsugamushi were isolated from them, and by electron microscopy, large quantities of rickettsia parasites were found in the ovum with the ability to transmit Rickettsia tsutsugamushi. Isolation of Rickettsia Gaohuensis indicated that under suitable conditions. tsutsugamushi from L natural infection occurs L Gaohuensis is distributed throughout 10 counties in Zhejiang Province. It is a dominant species in the foci disease areas; its seasonal fluctuation conforms to that of the disease and its ecological distribution also conforms with the disease incidence in the infectious areas. The findings indicate that L Gaohuensis fulfils all the criteria for a vector of tsutsugamushi disease, so it is concluded that L Gaohuensis SP. Nov. is a new vector for the disease.

This article reports an animal model showing bulbar conjunctival and pial microcirculatory disturbances produced by infusion of high molecular weight dextran, and the effect of a polysaccharide agent, Naoxinshu, on impaired conjunctival and pial microcirculation and the morphologic and ultrastructural changes of the cerebral tissue. Polysaccharide agent Naoxinshu is proven to amelioratc impaired microcirculation, accelerate blood flow, disaggregate erythrocyte aggregation, relieve arteriolar spasm, increase the number of capillaries, protect arteriole endothelial cells, alleviate brain edema and hemorrhage, and prevent fibrinoid depositition in the capillaries.

This paper reports the morphology of mycosis fungoides (MF) cells observed in 112 specimens of skin lesions of various developmental stages and 3 lymph nodes from 85 cases with MF. After reviewing the tissue imprints, the findings of electron microscope and immunological assays, and the results of clinical follow-up, it seems most likely that MF cells are derived from peripheral helper T cells during the process of transformation and their changes of morphology and size are in the form of a spectrum. The presence of MF cells in MF is a decisive factor for its diagnosis.

This paper reporLs the 1-9 year follow-up results of 133 eyes with herpes simplex keratitis (HSK) treated with penetrating keratoplasty. The overall transparent rate of the graft is 72.18%, the rate of blindness relief is 64.48%, the total visual increase rate 86.47% and the recurrence rate 6.77%. The authors believe that penetrating keratoplasty is the treatment of choice for deep stromal HSK for the time being and it stands to be the only procedure that provides improvement of vision for the patient.

In this paper, 41 cases of clear cell lymphoma are reported. The results of clinical, histopathological, ultrastructural and cell marker study are presented. The characteristics of this subtype,including clinical, histopathological, ultrastructural features, etc. are discussed.

A study of treatment of 304 cases of nonlymphocytic leukemia with the ester alkaloid of harringtonine is reported. Among them, 216 patients were given the ester alkaloid of harringtonine or semisynthetic harringtonine alone. There were 93 acute myelocytic leukemia cases, of whom 22 achieved complete remission (23.7%); 97 chronic myelocytic leukemia cases were treated, of whom 93 attained complete or partial remission (95.9%). The ester alkaloid of harringtonine also appeared to possess a better curative effect in treating 4 APL, 3 AEL, and 9 AMMOL and AMOL cases. 88 ANLL and CML-BC cases were treated with a combined HOAP chemotherapeutic regimen and the curative effects were even better than using ester alkaloid of harringtonine alone. Moreover, its side reactions are less than those of the conventional anti-ANLL drug Ara-C. We believe that harringtonine is a good agent against nonlymphocytic leukemia.