2016年 · 第39卷第10期

Pre-eclampsia (PE) is a kind of hypertensive disease during pregnancy, which is unique to pregnant women. The incidence rate is about 2% ~8%. It usually occurs after 20 weeks of pregnancy. The clinical manifestations are hypertension, proteinuria, edema, convulsions, coma, and even maternal and infant death in severe cases. It is an important cause of maternal and perinatal death^[1]。 Up to now, the etiology and pathogenesis of PE have not been fully elucidated. It was found that placental microthrombosis of varying degrees is one of the most common pathological changes in PE^[2,3]。 Among these pathological changes, vascular endothelial cell activation or damage is closely related to the pathogenesis of PE^[4]。 At the same time, it also manifests as platelet activation, dysfunction of coagulation and fibrinolysis, and hypercoagulability or pre-thrombotic state^[5,6]。 In order to further clarify the significance of vascular endothelial cell function changes in the pathogenesis of PE and screen the early diagnostic indexes of PE, so as to more effectively prevent and treat hypertension during pregnancy, this study investigated the plasma soluble endothelial protein C receptor (sEPCR), von willebrand factor antigen (vWF: Ag) in PE patients And soluble thrombomodulin (sTM) were detected and analyzed.

Cis-AB (cisAB) blood group is a special and relatively common phenotype of ABO subtype. It is an AB subtype whose epigenetics of ABO blood group do not conform to Mendelian law, and can be manifested as father (mother) of type O and children of type AB^[1]。 The stereotype can be manifested as the positive and negative stereotypes of ABO blood group, which leads to the difficulty of ABO blood group identification and blood matching, as well as paternity disputes. There have also been reports of ABO neonatal hemolytic disease caused by cisAB blood group in fetal-maternal immunity^[2]。 The study of the molecular mechanism of cisAB blood group is beneficial to the correct understanding of cisAB blood group and the improvement of its detection methods, and plays an important role in safe blood transfusion, organ transplantation, prenatal fetal ABO-HDN prediction and paternity testing. There are 9 alleles registered in the Blood Group Antigen Gene Mutation Database (BGMUT) of NCBI for cisAB blood group^[3], the molecular mechanism of which has not been fully elucidated.

The patient, a 19-year-old male from Qinghai, was admitted to hospital mainly for "repeated fever for more than 10 months, accompanied by chills and chills". His body temperature fluctuated between 38 and 40 ℃. The patient began to have fever 10 months ago, which improved after anti-inflammatory treatment in the local county hospital (details unknown). Seven months ago, he had fever again, but the local hospital still gave anti-inflammatory treatment and improved. Five months ago, he had irregular fever again and was transferred to the local provincial people's hospital for hospitalization.