2024年 · 第47卷第12期

Time goes by, and time goes by. In the blink of an eye, a year has flown by, and the 12th issue of this magazine in 2024 is here to meet you readers.

Systematic mediastinal lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration biopsy (EBUS-TBNA) improves staging accuracy in patients with early stage non-small cell lung cancer (NSCLC). However, patients with locally advanced NSCLC usually have only selective lymph node sampling. This study aimed to determine the recognition rate of systematic endoscopic mediastinal staging for positron emission computed tomography (PET) occult lymph node metastasis in patients with locally advanced NSCLC and the impact of lymph node metastasis recognition on radiotherapy regimens.

Idiopathic pulmonary fibrosis (IPF) is a rare progressive disease that can cause progressive cough, exertion dyspnea, impaired quality of life, and death. Bexotegrast (PLN 74809) is a newly developed drug for the treatment of IPF.

Presence of KRT13 in the airway⁺Cells, distributed in the pseudo-stratified columnar airway epithelium, are named airway hillocks. They are columns produced by proliferating basal cells, which express squamous marker genes compared to classical basal stem cells of the rest of the airway epitheliumKrt13, and presents a unique hierarchical structure. Single cell sequencing results showed that airway collicular cells expressed regulators of cell adhesion and squamous epithelial differentiation (Ecm1、S100a11AndCldn3) and genes associated with immunomodulation and asthma. The study explored the composition and spatial location of airway hillocks in mouse and human airways in an attempt to elucidate the function of airway hillocks.