2014年 · 第52卷第01期

In the past 2013, the Chinese Journal of Pediatrics successfully completed its 51st volume. All the editorial board members and colleagues in the editorial department have worked hard and achieved fruitful results. The latest citation report of scientific and technological journals in China shows that the total score of comprehensive evaluation of Chinese Journal of Pediatrics reaches 92.8, ranking first among its peers, but also among the best among 1,994 core scientific and technological journals in China, showing the high level and high influence of comprehensive academic quality of Chinese Journal of Pediatrics in the whole country. In 2013, "Chinese Journal of Pediatrics" was awarded the honorary title of "China's Top 100 Newspapers and Periodicals" by the State Administration of Press, Publication, Radio, Film and Television.

Chinese Journal of Pediatrics is a magazine that we have been familiar with since our student days. There, we have known many respectable teachers, drawn a serious and rigorous scholarship spirit, and learned the life perception of devoting ourselves to science and pursuing truth. The Chinese Journal of Pediatrics has accompanied the growth of several generations of pediatricians in China, and we are grateful for the grace of the Chinese Journal of Pediatrics. I remember Dean Zhu Futang said to me: "When I went to France 30 years ago, I thought how can I promote the development of pediatrics in our country? Running a good academic journal is a very important way. Now, you have to actively submit manuscripts, and in the future, you have to actively review manuscripts and work hard for running a good academic journal." Now I have retired from my post on the editorial board and entered the academic steering committee. I have been thinking about how can I live up to my teacher's teachings and do my best to run the Chinese Journal of Pediatrics?

A male child was admitted to hospital 6 days after birth due to "poor postnatal response with hypotonia for 6 days". The child was the first birth, the first birth, with a gestational age of 35 weeks. He was delivered by vaginal lateral incision 15 h due to premature rupture of membranes, and his birth weight was 2.5 kg. Apgar score unknown. After birth, due to "poor response, weak crying, accompanied by moaning and hypotonia", he was monitored and treated in the neonatology department of the local hospital, and his parents were admitted to our hospital for further treatment. Her mother was 27 years old. She had regular prenatal check-ups and found thrombocytopenia during pregnancy, with the lowest level of 46×10.⁹/L, without special treatment, deny the history of diabetes and hypertension, deny the history of heart disease, kidney disease and connective tissue disease, deny the history of infectious diseases, blood products and radiation exposure. His father is 26 years old and in good health. The parents are not intimate married, and there is no history of genetic diseases and infectious diseases in the family.

A 4-month-old girl was admitted for "moaning with dyspnea for 3 days". Three days before admission, the child suddenly developed moaning, dyspnea, shortness of breath, poor eating, lethargy, no fever, cough, diarrhea, and no convulsions.

Twin A, the second birth of twin, female, was 1 year and 2 months old at the onset of the disease. She was admitted to hospital for 1 month due to loss of appetite and intermittent fever. WBC 181.36×10⁹/L, naive cells accounted for 66%, hemoglobin 70 g/L, platelets 44×10⁹/L. acute lymphoblastic leukemia (ALL) was confirmed by bone marrow cytology. Karyotype analysis of G-banding chromosomes showed: 46, XX. Twin B, the first of the twins, is a female. Twins A and B share a placenta. They were 2 years and 6 months old at the time of onset. They were admitted to hospital for more than half a month due to yellow face for 2 months, abdominal distension and repeated fever. WBC 22.76×10⁹/L, naive cells accounted for 67.5%, hemoglobin 76 g/L, platelets 154×10⁹/L. Bone marrow cytology examination showed that the bone marrow blast + naive lymphocytes were 64%, and the peroxidase staining was negative, and the diagnosis was ALL. Karyotyping of G-banding chromosomes revealed: 46, XX, t (4; 11) (a21; q23). Real-time quantitative polymerase chain reaction (RT-qPCR) detection showed that both children had mixed lineage leukemia (MLL) -AF4Fusion gene positive. Results of immunoglobulin heavy chain gene (IgH) rearrangement analysis showed that both children were positive. Immunotyping was all earlierBCellularALL，CD10 negative. Cerebrospinal fluid series examinations showed no obvious abnormalities.

Child male, 1 d, due to "gestational age 35^＋4Zhou, postpartum skin blues with moaning 10 min "admitted to the Department of Pediatrics of Zhongnan Hospital of Wuhan University. The child was the first birth of the mother, and the birth examination showed" fetal edema cause to be investigated: fetal cardiac insufficiency? ", and was delivered naturally after 3 days of induction of labor. Apgar scores at birth were 1 min 5 points, 5 min 8 points and 10 min 8 points.

Child girl, 34 d. The child developed fever without obvious trigger 10 days ago, with the highest body temperature of 38.9 ℃. Other hospitals had given intravenous infusion of "amoxicillin" for 2 days and "cefepime" for 3 days. The child still had fever, poor mental diet, slight cough and drowsiness. The outpatient clinic was admitted to our hospital for treatment on January 24, 2010 with "fever to be examined? Sepsis?". The child had red eyes and red lips at the beginning of the disease, and the parents denied that the child had a rash and cervical lymphatic swelling.

fetal cardiac intervention (FCI) refers to the treatment of fetuses with congenital heart disease in the second trimester of pregnancy when the embryonic heart and blood vessels have not yet appeared irreversible disease. The first balloon aortic valvuloplasty was performed by Maxwell and Allan since 1989^[1]Later, 12 such cases were reported worldwide between 1991 and 1997, with a gestational age of 27 to 33 weeks at the time of treatment, of which 7 were technically successful, but 6 of these 7 cases died in the neonatal period^[2]。 In 2004, Tworetzky et al.^[3]Twenty-four cases of aortic stenosis fetuses underwent balloon aortic valve dilatation. The gestational age of the treatment was advanced to 21~29 weeks of gestation, and the success rate of the operation was 70%. Follow-up studies after surgery confirmed that early intervention in fetal congenital heart disease can prevent the progressive aggravation of fetal heart disease and help to restore the normal anatomical structure and function of the heart after birth. At present, many domestic medical centers have also begun to explore the related research on fetal interventional heart surgery in the middle and third trimester of pregnancy, and have achieved certain results. However, there are still many unknown areas in FCI technology, such as how to screen FCI cases, how to choose the timing of treatment, how to assess the risk-benefit of treatment, and how to change the pathophysiology of the fetus caused by the treatment measures^{[4,5,6,7,8,9,10]}。

––––––

Child, male, 6 years and 4 months old. He was admitted to hospital on March 9, 2013 due to "intermittent fever for more than 20 days and cough for 2 days".

On May 4 – 7, 2013, the 2013 Annual Meeting of the Pediatric Academic Societies (PAS) was held at the Convention and Exhibition Center in Washington, D.C., USA. The PAS Annual Conference is a high-level international academic conference on child health and related research. The purpose of the conference is to summarize the past, base on the present, look forward to the future, and pay attention to original research and clinical application transformation for global child health research. The PAS Annual Meeting is different in form, rich in content, large in scale, and sponsored in ways. It is hereby briefly introduced by American scholars as follows.