Over the past decades, total knee arthroplasty (TKA) has been recognized as an effective solution to reduce pain and restore their joint function in patients such as severe osteoarthritis, so TKA has become increasingly common. However, about 20% of patients are still unsatisfied after TKA. The accuracy of prosthesis placement is still considered to be one of the key factors to improve patient clinical function after surgery and improve patient satisfaction after surgery. Among them, computer navigation assisted (CAS) TKA is considered to assist clinicians in more accurate prosthesis placement. However, current studies on the evaluation of the effect of CAS application in TKA have mixed conclusions and the follow-up time is too short. Therefore, the aim of this study was to compare the differences between CAS-assisted TKA and traditional TKA in perioperative conditions, postoperative clinical functional conditions and prosthetic imaging measures.