MedNexus
2021年 · 第134卷第08期
出版日期 2021-04-20电子版 ￥0.00元
MedNexus
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- Consensus Statement
- Review Article
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- Ideas and Opinion
- Original Article
- Clinical Observation
- Technical Note
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Editorial
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复杂B型解剖伴足弓的最佳选择Chang Shu, Tun Wang, Ming-Yao Luo, Kun Fang, Quan-Ming Li, Ming Li, Xin Li, Hao He
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001354
摘要
胸主动脉腔内修复术（TEVAR）是B型主动脉夹层（TBAD）的首选方法。[
Clinical Guideline
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早期乳腺癌患者前哨淋巴结活检临床实践指南：中国乳腺外科学会（CSBrS）实践指南2021Jing-Ming Ye, Bao-Liang Guo, Qian Liu, Fei Ma, Hong-Jin Liu, Qian Wu, Ling Xin, Yuan-Jia Cheng, Hong Zhang, Shuang Zhang 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001410
摘要
腋窝淋巴结评估是乳腺癌临床病理分期的重要指标之一。研究表明，前哨淋巴结活检（SLNB）较常规腋窝淋巴结清扫（ALND）具有并发症少、创伤小等优点。[
Consensus Statement
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乳腺癌改良根治术临床实践指南：中国乳腺外科学会（CSBrs）实践指南2021De-Chuang Jiao, Jiu-Jun Zhu, Li Qin, Xu-Hui Guo, Ya-Jie Zhao, Xiu-Chun Chen, Cheng-Zheng Wang, Zhen-Duo Lu, Lian-Fang Li, Shu-De Cui 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001412
摘要
中国接受乳房切除术的早期乳腺癌患者比例超过70%，[
Review Article
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尘肺病：现状与未来展望Xian-Mei Qi, Ya Luo, Mei-Yue Song, Ying Liu, Ting Shu, Ying Liu, Jun-Ling Pang, Jing Wang, Chen Wang
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001461
摘要
Pneumoconiosis refers to a spectrum of pulmonary diseases caused by inhalation of mineral dust, usually as the result of certain occupations. The main pathological features include chronic pulmonary inflammation and progressive pulmonary fibrosis, which can eventually lead to death caused by respiratory and/or heart failure. Pneumoconiosis is widespread globally, seriously threatening global public health. Its high incidence and mortality lie in improper occupational protection, and in the lack of early diagnostic methods and effective treatments. This article reviews the epidemiology, safeguard procedures, diagnosis, and treatment of pneumoconiosis, and summarizes recent research advances and future research prospects.
Medical Progress
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交感神经和副交感神经拮抗作用在胃癌发生中的作用Jing Gao, Shu-Gang Liu
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001348
摘要
已有研究表明，自主神经系统在胃癌（GC）的发生发展中起一定作用。[
Ideas and Opinion
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关于在大流行中开展和实施临床实践指南的一些思考Xiaomei Yao, Ying-Hui Jin, Benjamin Djulbegovic
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001169
摘要
疫情是一种在世界范围内传播的疾病。当疾病是新的，如冠状病毒疾病2019（新冠肺炎），根据定义，预防、诊断和治疗该疾病的证据基础是有限的。然而，迫切需要临床实践指南来帮助政策和卫生保健工作者做出明智的决定。但是，在高质量证据真空中采取行动，也就是说，将指南建立在低质量研究的基础上，可能会适得其反，并可能有害。[
Original Article
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血管内治疗广泛主髂动脉闭塞性疾病（EAIOD）的长期结果及原发性通畅丧失的危险因素Xiao-Lang Jiang, Yun Shi, Bin Chen, Jun-Hao Jiang, Tao Ma, Chang-Po Lin, Da-Qiao Guo, Xin Xu, Zhi-Hui Dong, Wei-Guo Fu
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001229
摘要
Background:
Although endovascular therapy has been widely used for focal aortoiliac occlusive disease (AIOD), its performance for extensive AIOD (EAIOD) is not fully evaluated. We aimed to demonstrate the long-term results of EAIOD treated by endovascular therapy and to identify the potential risk factors for the loss of primary patency.
Methods:
Between January 2008 and June 2018, patients with a clinical diagnosis of the 2007 TransAtlantic Inter-Society Consensus II (TASC II) C and D AIOD lesions who underwent endovascular treatment in our institution were enrolled. Demographic, diagnosis, procedure characteristics, and follow-up information were reviewed. Univariate analysis was used to identify the correlation between the variables and the primary patency. A multivariate logistic regression model was used to identify the independent risk factors associated with primary patency. Five- and 10-year primary and secondary patency, as well as survival rates, were calculated by Kaplan-Meier analysis.
Results:
A total of 148 patients underwent endovascular treatment in our center. Of these, 39.2% were classified as having TASC II C lesions and 60.8% as having TASC II D lesions. The technical success rate was 88.5%. The mean follow-up time was 79.2 ± 29.2 months. Primary and secondary patency was 82.1% and 89.4% at 5 years, and 74.8% and 83.1% at 10 years, respectively. The 5-year survival rate was 84.2%. Compared with patients without loss of primary patency, patients with this condition showed significant differences in age, TASC II classification, infrainguinal lesions, critical limb ischemia (CLI), and smoking. Multivariate logistic regression analysis showed age <61 years (adjusted odds ratio [aOR]: 6.47; 95% CI: 1.47-28.36; P = 0.01), CLI (aOR: 7.81; 95% CI: 1.92-31.89; P = 0.04), and smoking (aOR: 10.15; 95% CI: 2.79-36.90; P < 0.01) were independent risk factors for the loss of primary patency.
Conclusions:
Endovascular therapy was an effective treatment for EAIOD with encouraging patency and survival rate. Age <61 years, CLI, and smoking were independent risk factors for the loss of primary patency.
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累积血压与心血管疾病长期风险的关系：来自26年中国多省队列研究-北京项目的发现Shuai Liu, Dong Zhao, Miao Wang, Yue Qi, Jia-Yi Sun, Jun Liu, Yan Li, Jing Liu
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001383
摘要
Background:
Cumulative blood pressure (BP), a measure incorporating the level and duration of BP exposure, is associated with the risk of cardiovascular disease (CVD). However, the level at which cumulative BP could significantly increase the risk remains unclear. This study aimed to investigate the association of 15-year cumulative BP levels with the long-term risk of CVD, and to examine whether the association is independent of BP levels at one examination.
Methods:
Data from a 26-year follow-up of the Chinese Multi-provincial Cohort Study-Beijing Project were analyzed. Cumulative BP levels between 1992 and 2007 were calculated among 2429 participants free of CVD in 2007. Cardiovascular events (including coronary heart disease and stroke) occurring from 2007 to 2018 were registered. Adjusted hazard ratios (HRs) for CVD incidence associated with quartiles of cumulative systolic blood pressure (SBP) and diastolic blood pressure (DBP) were calculated.
Results:
Of the 2429 participants, 42.9% (1042) were men, and the mean age in 2007 was 62.1 ± 7.9 years. Totally, 207 CVD events occurred during the follow-up from 2007 to 2018. Participants with higher levels of cumulative SBP or DBP exhibited a higher incidence rate of CVD (P < 0.001). Compared with the lowest quartile of cumulative SBP, the HR for CVD was 1.03 (95% confidence interval [CI]: 0.59-1.81), 1.69 (95% CI: 0.99-2.87), and 2.20 (95% CI: 1.21-3.98) for the second to the fourth quartile of cumulative SBP, and 1.46 (95% CI: 0.86-2.48), 1.99 (95% CI: 1.18-3.35), and 2.08 (95% CI: 1.17-3.71) for the second to the fourth quartile of cumulative DBP, respectively. In further cross-combined group analyses with BP measurements in 2007, 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg·year for cumulative SBP/DBP, which were equivalent to maintaining SBP/DBP levels of 131/83 mmHg or above on average in 15 years, were associated with higher risk of CVD in subsequent years independent of BP measurements at one-time point.
Conclusion:
Cumulative exposure to moderate elevation of BP is independently associated with increased future cardiovascular risk.
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当代急性A型主动脉夹层和壁内血肿的临床特征和预后：来自中国首次主动脉夹层登记的经验教训Wei-Xun Duan, Wei-Guang Wang, Lin Xia, Chao Xue, Bo Yu, Kai Ren, Wei Yi, Hong-Liang Liang, Xiao-Chao Dong, Jian Zuo 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001459
摘要
Background:
Acute type A aortic dissection (ATAAD) and acute type A intramural hematoma (ATAIMH) are life-threatening diseases with high mortality. To better understand their clinical features in the Chinese population, we analyzed the data from the first Registry of Aortic Dissection in China (Sino-RAD) to promote the understanding and management of the diseases.
Methods:
All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1, 2012 to December 31, 2016 were involved. The data of patients’ selection, history, symptoms, management, outcomes, and postoperation complications were analyzed in the study. The continuous variables were compared using the Student’s t test for normal distributions and the Mann-Whitney U test for non-normal distributions. Categorical variables were compared using the Chi-square test or Fisher exact test.
Results:
A total of 1582 patients with ATAAD and 130 patients with ATAIMH were included. The mean age of all patients was 48.4 years. Patients with ATAAD were significantly younger than patients with ATAIMH (48.9 years vs. 55.6 years, P < 0.001). For the total cohort, males were dominant, but the male ratio of patients with ATAAD was significantly higher compared to those with ATAIMH (P = 0.01). The time range from the onset of symptom to hospitalization was 2.0 days. More patients of ATAIMH had hypertension than that of ATAAD (82.3% vs. 67.6%, P < 0.05). Chest and back pain were the most common clinical symptoms. Computerized tomography (CT) was the most common initial diagnostic imaging modality. 84.7% received surgical treatment and in-hospital mortality was 5.3%. Patients with ATAAD mainly received surgical treatment (89.6%), while most patients with ATAIMH received medical treatment (39.2%) or endovascular repair (35.4%).
Conclusions:
Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention, achieving early diagnosis and treatment, thereby reducing the mortality rate of patients with aortic dissection in China. We should standardize the procedures of aortic dissection treatment and improve people’s understanding. Meanwhile, the curing and transferring efficiency should also be improved.
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人类肾脏和膀胱中血管紧张素转换酶II表达的单细胞分析揭示了2019新型冠状病毒病毒感染的潜在途径Wei Lin, Jue Fan, Long-Fei Hu, Yan Zhang, Joshua D. Ooi, Ting Meng, Peng Jin, Xiang Ding, Long-Kai Peng, Lei Song 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001439
摘要
Background:
Since 2019, a novel coronavirus named 2019 novel coronavirus (2019-nCoV) has emerged worldwide. Apart from fever and respiratory complications, acute kidney injury has been observed in a few patients with coronavirus disease 2019. Furthermore, according to recent findings, the virus has been detected in urine. Angiotensin-converting enzyme II (ACE2) has been proposed to serve as the receptor for the entry of 2019-nCoV, which is the same as that for the severe acute respiratory syndrome. This study aimed to investigate the possible cause of kidney damage and the potential route of 2019-nCoV infection in the urinary system.
Methods:
We used both published kidney and bladder cell atlas data and new independent kidney single-cell RNA sequencing data generated in-house to evaluate ACE2 gene expression in all cell types in healthy kidneys and bladders. The Pearson correlation coefficients between ACE2 and all other genes were first generated. Then, genes with r values larger than 0.1 and P values smaller than 0.01 were deemed significant co-expression genes with ACE2.
Results:
Our results showed the enriched expression of ACE2 in all subtypes of proximal tubule (PT) cells of the kidney. ACE2 expression was found in 5.12%, 5.80%, and 14.38% of the proximal convoluted tubule cells, PT cells, and proximal straight tubule cells, respectively, in three published kidney cell atlas datasets. In addition, ACE2 expression was also confirmed in 12.05%, 6.80%, and 10.20% of cells of the proximal convoluted tubule, PT, and proximal straight tubule, respectively, in our own two healthy kidney samples. For the analysis of public data from three bladder samples, ACE2 expression was low but detectable in bladder epithelial cells. Only 0.25% and 1.28% of intermediate cells and umbrella cells, respectively, had ACE2 expression.
Conclusion:
This study has provided bioinformatics evidence of the potential route of 2019-nCoV infection in the urinary system.
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中国重症新冠肺炎患者的临床特征和相关危险因素Ning Jiang, Yan-Nan Liu, Jing Bao, Ran Li, Wen-Tao Ni, Xing-Yu Tan, Yu Xu, Li-Ping Peng, Xiao-Rong Wang, Yi-Ming Zeng 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001466
摘要
Background:
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. In this study, we aimed to identify the risk factors for severe COVID-19 to improve treatment guidelines.
Methods:
A multicenter, cross-sectional study was conducted on 313 patients hospitalized with COVID-19. Patients were classified into two groups based on disease severity (nonsevere and severe) according to initial clinical presentation. Laboratory test results and epidemiological and clinical characteristics were analyzed using descriptive statistics. Univariate and multivariate logistic regression models were used to detect potential risk factors associated with severe COVID-19.
Results:
A total of 289 patients (197 nonsevere and 92 severe cases) with a median age of 45.0 (33.0, 61.0) years were included in this study, and 53.3% (154/289) were male. Fever (192/286, 67.1%) and cough (170/289, 58.8%) were commonly observed, followed by sore throat (49/289, 17.0%). Multivariate logistic regression analysis suggested that patients who were aged ≥ 65 years (OR: 2.725, 95% confidence interval [CI]: 1.317-5.636; P = 0.007), were male (OR: 1.878, 95% CI: 1.002-3.520, P = 0.049), had comorbid diabetes (OR: 3.314, 95% CI: 1.126-9.758, P = 0.030), cough (OR: 3.427, 95% CI: 1.752-6.706, P < 0.001), and/or diarrhea (OR: 2.629, 95% CI: 1.109-6.231, P = 0.028) on admission had a higher risk of severe disease. Moreover, stratification analysis indicated that male patients with diabetes were more likely to have severe COVID-19 (71.4% vs. 28.6%, χ2 = 8.183, P = 0.004).
Conclusions:
The clinical characteristics of those with severe and nonsevere COVID-19 were significantly different. The elderly, male patients with COVID-19, diabetes, and presenting with cough and/or diarrhea on admission may require close monitoring to prevent deterioration.
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局部晚期宫颈癌（IIB-IIIB期）同步放化疗后辅助性T细胞17的改变与治疗疗效的相关性：一项为期3年的前瞻性研究Yi Liu, Qiu-Fen Guo, Jin-Long Chen, Xi-Rui Li, Fei Hou, Xiao-Yan Liu, Wen-Jing Zhang, Yan Zhang, Fu-Feng Gao, You-Zhong Zhang 等
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001475
摘要
Background:
Recently, T-helper 17 (Th17) cells have been proved to play an important role in promoting cervical cancer. But, till now, few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor treatments. This study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer (LACC) patients before and after concurrent chemoradiotherapy (cCRT) and to analyze the correlations between the alterations in Th17 cells and treatment efficacy.
Methods:
A prospective study with 49 LACC (International federation of gynecology and obstetrics [FIGO] stage IIB-IIIB) patients and 23 controls was conducted. Patients received the same cCRT schedule and were followed up for 3 years. Circulating Th17 cells (CD3+CD8- interleukin [IL]-17+ T cells) and related cytokines IL-17, transforming growth factor-β (TGF-β), IL-10, IL-23, IL-6, and IL-22 were detected before and after cCRT. Correlations between alterations of circulating Th17 cells and treatment efficacy were analyzed. Kaplan-Meier analysis was used for overall survival (OS) and progression-free survival (PFS).
Results:
We found that 40 patients finished the entire cCRT schedule and met the endpoint of this study. The percentage of circulating Th17 cells in the LACC patients was higher than that in the controls, and it significantly decreased after cCRT (P < 0.05). After cCRT, patients were divided into two groups based on the average of the Th17 cells declined. The subgroup of patients with a prominent decrease in circulating Th17 cells after cCRT had a higher treatment efficacy and longer PFS and OS times. Compared with the control patients, LACC patients had higher IL-6, IL-10, IL-22, TGF-β levels and a lower IL-23 level (P < 0.05). After cCRT, IL-6, IL-10, IL-17, IL-23 level significantly increased and TGF-β level significantly decreased compared with the levels before cCRT (P < 0.05).
Conclusion:
Circulating Th17 cells in the LACC patients (FIGO stage IIB-IIIB) were higher than those in the controls, but they generally decreased after cCRT. A more pronounced decrease in circulating Th17 cells after cCRT was correlated with better therapeutic effect and longer PFS and OS times.
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HDAC4对IL-1 β诱导的基质金属蛋白酶表达的影响，部分通过WNT3A/β-catenin途径调节Qi Ning, Ye-Hua Gan, Rui-Rui Shi, Juan-Hong Meng
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001470
摘要
Background:
Histone deacetylase 4 (HDAC4) regulates chondrocyte hypertrophy and bone formation. The aim of the present study was to explore the effects of HDAC4 on Interleukin 1 beta (IL-1β)-induced chondrocyte extracellular matrix degradation and whether it is regulated through the WNT family member 3A (WNT3A)/β-catenin signaling pathway.
Methods:
Primary chondrocytes (CC) and human chondrosarcoma cells (SW1353 cells) were treated with IL-1β and the level of HDAC4 was assayed using Western blotting. Then, HDAC4 expression in the SW1353 cells was silenced using small interfering RNA to detect the effect of HDAC4 knockdown on the levels of matrix metalloproteinase 3 (MMP3) and MMP13 induced by IL-1β. After transfection with HDAC4 plasmids, the overexpression efficiency was examined using Real-time quantitative polymerase chain reaction (qRT-PCR) and the levels of MMP3 and MMP13 were assayed using Western blotting. After incubation with IL-1β, the translocation of β-catenin into the nucleus was observed using immunofluorescence staining in SW1353 cells to investigate the activation of the WNT3A/β-catenin signaling pathway. Finally, treatment with WNT3A and transfection with glycogen synthase kinase 3 beta (GSK3β) plasmids were assessed for their effects on HDAC4 levels using Western blotting.
Results:
IL-1β downregulated HDAC4 levels in chondrocytes and SW1353 cells. Furthermore, HDAC4 knockdown increased the levels of MMP3 and MMP13, which contributed to the degradation of the extracellular matrix. Overexpression of HDAC4 inhibited IL-1β-induced increases in MMP3 and MMP13. IL-1β upregulated the levels of WNT3A, and WNT3A reduced HDAC4 levels in SW1353 cells. GSK-3β rescued IL-1β-induced downregulation of HDAC4 in SW1353 cells.
Conclusion:
HDAC4 exerted an inhibitory effect on IL-1β-induced extracellular matrix degradation and was regulated partially by the WNT3A/β-catenin signaling pathway.
Clinical Observation
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B型主动脉夹层患者的胸主动脉腔内修复术：来自中国三级中心的11年经验Yuan-Qing Kan, Da-Qiao Guo, Yi Si, Wei-Guo Fu
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001420
摘要
胸主动脉腔内修复术（TEVAR）已逐渐被认为是B型主动脉夹层（TBAD）的主流疗法，尤其是对复杂的急性TBAD，[
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二维和三维超声心动图评价漏斗胸患者手术前后右心室功能Xin Zhang, Cheng-Hao Chen, Ning Ma, Lin Zheng, Pei Li, Qun Wu, Ji-Hang Sun, Qi Zeng, Fang-Yun Wang
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001414
摘要
漏斗胸（PE）是临床实践中观察到的最常见的先天性胸壁畸形之一，在儿童中估计患病率在500分之一至1000分之一的范围内；其特征是胸骨下部和软骨-肋骨附件向后移位。[
Technical Note
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“尖点重叠”技术简化了经导管主动脉瓣植入术中中国国产经导管瓣膜的植入Mi Chen, Li-Zhong Sun
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001405
摘要
目前，经导管主动脉瓣植入术（TAVI）已成为被认为不能手术或手术风险高的严重主动脉瓣狭窄患者的可行介入技术。在中国，TAVI技术始于2010年。到目前为止，两种国产设备J Valve（杰成医疗技术，中国苏州）和Venus A-Valve（Venus MedTech，中国杭州）已于2017年获准进入市场，此后大多数中心开始建立TAVI计划。Venus A-Valve是中国唯一的经股动脉经导管瓣膜，在VitaFlow（MicroPort，中国上海）和SAPIEN 3（Edwards Lifesciences，Irvine，CA，美国）几个月前进入中国市场之前，已植入约4000次。
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急性A型主动脉夹层复杂病例的外科治疗：分支优先主动脉弓置换技术的体会Cun-Hua Su, Wei Qin, Wen Chen, Jian Li, Michael Carmichael, Fu-Hua Huang, Xin Chen
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001436
摘要
涉及主动脉弓的A型夹层仍然是一种固有的致命疾病。太阳等人[
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心肌梗死后室间隔破裂伴血流动力学不稳定的外科新技术Chao Liu, Li-Li Xiao, Lu Wang, Fu-Qiang Sun, Xing-Xing Yao, Yan-Zhou Zhang, Xiao-Yan Zhao, Ling Li, Xiao-Fang Wang, Jian-Zeng Dong
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001442
摘要
室间隔破裂（VSR）是急性心肌梗死（AMI）的一种罕见但致命的并发症。[
Rapid Report
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非酸性咽喉返流的分类Jin-Rang Li, Jia-Sen Wang, Mu-Kun Wu, Jing Zhao, Hong-Guang Guo
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001223
摘要
喉咽反流病（LPRD）目前被定义为与胃十二指肠内容物反流的直接和间接影响相关的上呼吸消化道组织炎症，其可能诱导上呼吸消化道的形态学改变。[
Correspondence
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CD23介导促炎细胞因子白细胞介素-1 β和肿瘤坏死因子-α的诱导烟曲霉角膜炎Hai-Jing Yan, Nan Jiang, Li-Ting Hu, Qiang Xu, Xu-Dong Peng, Hua Yang, Wen-Yi Zhao, Le-Yu Lyu, Li-Mei Wang, Cheng-Ye Che
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001342
摘要
致编辑：真菌性角膜炎主要由致病真菌物种引起，如茄病镰刀菌和烟曲霉.的发生率烟曲霉已在全球范围内增加。[
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减少IV型Mirizzi综合征结石大小的内镜逆行胰胆管造影新技术：避免胆管空肠吻合术Tian-Ya Li, Zi-Xian Chen, Yu-Dong Wang, Ying Liu, Jin-Duo Zhang, Ping Yue, Wen-Bo Meng
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001370
摘要
致编辑：Mirizzi综合征（MS）是一种罕见的胆石症，在所有胆结石病例中发病率为0.1%。[
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孤立性纤维性肿瘤：10年回顾性分析及几例罕见病例Ke Zhang, Hui-Juan Liu, Zhang-Bo Cheng, Mi Deng, Jing Luo, Xin Qi
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001170
摘要
致编辑：孤立性纤维肿瘤（SFT）是间充质肿瘤，最初在胸膜中描述，随后在胸膜外器官中发现，如腹膜、肺、腮腺、鼻窦、眼眶、皮肤和颅内区域。[
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有限的vs.急性I型主动脉夹层延长修复术：北京安贞医院十年来的长期结果Su-Wei Chen, Yu Chen, Wei-Guo Ma, Yong-Liang Zhong, Zhi-Yu Qiao, Yi-Peng Ge, Cheng-Nan Li, Jun-Ming Zhu, Li-Zhong Sun
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001416
摘要
致编辑：对于急性DeBakeyⅠ型主动脉夹层患者，升主动脉或半弓置换术可减少手术时间，危急情况下可挽救生命。然而，残留的远端夹层会增加扩张、破裂和死亡的风险。[
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药物洗脱珠支气管动脉化疗栓塞后机械力介导的错误通道开放致脑梗死Wei Luo, Mao-Gang Wei, Hai-Long Wei, Ya-Lun Li
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001284
摘要
致编辑：对于不符合或拒绝接受标准化疗的非小细胞肺癌（NSCLC）患者，药物洗脱珠支气管动脉化疗栓塞（DEB-BACE）已被证明是一种可行且耐受性良好的治疗选择。[
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颈部半透明测量在产前常规检查中的临床意义Xin-Rong Zhao, Li Gao, Jin-Ling Sun, Ren-Yi Hua, Yi Wu, Yan-Lin Wang
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000000895
摘要
致编辑：颈部半透明性（NT）的测量是非整倍体、胎儿异常和其他病理状况的有效标志物，[
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冠状病毒疾病2019与肾损伤：基于当前证据的简要综述Guang Yang, Hao Wang, Yang Liu, Jie-Bin Hou, Guo-Gang Xu, Feng Cao, Qing-Li Cheng
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001311
摘要
致编辑：2019冠状病毒病（COVID-19）全球大流行尚未得到控制，COVID-19已影响全球数千万人。虽然新冠肺炎的主要特征是弥漫性肺泡损伤和急性呼吸衰竭，但对其他器官的损害也值得关注，因为这些患者往往症状更严重，预后更差。在本文中，我们简要综述了新冠肺炎肾脏受累的特点以及肾损伤对疾病预后的影响，以期从肾内科医生的角度更好地了解新冠肺炎疫情。
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一名年轻男性的复发性重要血栓事件FVIII基因复制Ling-Li Wang, Dan Liu, Na Feng, Mu-Ye Ping, Jiang-Li Han, Wei Gao, Fang-Fang Wang
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001230
摘要
致编辑：凝血系统是人体内一个复杂的调节系统。在该病例中，年轻患者有各种重要的血栓形成，包括脑静脉窦血栓形成（CVST）、冠状动脉血栓形成和左心室血栓。然而，该患者既没有高凝相关疾病，也没有风险，也没有凝血或纤溶蛋白缺乏。[
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托珠单抗成功治疗一例抗黑色素瘤分化相关基因-5抗体阳性的快速进展性间质性肺病患者Fei Teng, Jin-Min Peng, Qian Wang, Xin-Lun Tian, Zhen Huo, Li Weng
中华医学杂志英文版2021年 134卷 08期
DOI: 10.1097/CM9.0000000000001235
摘要
致编辑：抗黑色素瘤分化相关基因5（MDA-5)阳性间质性肺病(ILD)的特征是快速进展的呼吸衰竭和有限的住院生存期。尚未建立或证明有益的标准疗法。在此，我们报告了一例快速进展的患者，其被诊断为抗MDA-5抗体阳性的ILD，正在接受托珠单抗治疗。
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