MedNexus
2021年 · 第134卷第07期
出版日期 2021-04-05电子版 ￥0.00元
MedNexus
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- Review Article
- Systematic Review
- Medical Progress
- Original Article
- Clinical Observation
- Technical Notes
- Rapid Report
- Correspondence
Review Article
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唾液酸结合免疫球蛋白样凝集素9作为慢性阻塞性肺疾病的潜在治疗靶点Zi Chen, Shuang-Lan Xu, Lin-Yang Ge, Jin Zhu, Tao Zheng, Zhou Zhu, Linfu Zhou
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001381
摘要
Chronic obstructive pulmonary disease (COPD) has become the third-leading cause of death worldwide, which is a severe economic burden to the healthcare system. Chronic bronchitis is the most common condition that contributes to COPD, both locally and systemically. Neutrophilic inflammation predominates in the COPD airway wall and lumen. Logically, repression of neutrophilia is an essential fashion to COPD treatment. However, currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects. Thus, there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease. Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 is a member of the Siglec cell surface immunoglobulin family. It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes. Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils. Furthermore, administration of antibody to Siglec-E, mouse functional ortholog of Siglec-9, restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo. Given the critical role that neutrophils play in chronic bronchitis and emphysema, targeting Siglec-9 could be beneficial for the treatment of COPD, asthma, fibrosis, and related chronic inflammatory lung diseases.
Systematic Review
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长期意识障碍患者的神经调节治疗Yue-Hao Wu, Jie Yu, Li-Rong Hong, Ben-Yan Luo
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001377
摘要
Background:
Reviving patients with prolonged disorders of consciousness (DOCs) has always been focused and challenging in medical research. Owing to the limited effectiveness of available medicine, recent research has increasingly turned towards neuromodulatory therapies, involving the stimulation of neural circuits. We summarised the progression of research regarding neuromodulatory therapies in the field of DOCs, compared the differences among different studies, in an attempt to explore optimal stimulation patterns and parameters, and analyzed the major limitations of the relevant studies to facilitate future research.
Methods:
We performed a search in the PubMed database, using the concepts of DOCs and neuromodulation. Inclusion criteria were: articles in English, published after 2002, and reporting clinical trials of neuromodulatory therapies in human patients with DOCs.
Results:
Overall, 187 published articles met the search criteria, and 60 articles met the inclusion criteria. There are differences among these studies regarding the clinical efficacies of neurostimulation techniques for patients with DOCs, and large-sample studies are still lacking.
Conclusions:
Neuromodulatory techniques were used as trial therapies for DOCs wherein their curative effects were controversial. The difficulties in detecting residual consciousness, the confounding effect between the natural course of the disease and therapeutic effect, and the heterogeneity across patients are the major limitations. Large-sample, well-designed studies, and innovations for both treatment and assessment are anticipated in future research.
Medical Progress
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血清高尔基体蛋白-73在慢性肝病治疗中的应用Ming-Jie Yao, Lei-Jie Wang, Shuang Liu, Feng-Min Lu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001296
摘要
慢性肝病（CLD）每年导致约214万（2.06-2.30）人死亡；因此，代表着沉重的全球健康负担。[
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肺癌免疫治疗相关毒性的临床特点及处理策略Wen-Xin Luo, Lan Yang, Wei-Min Li
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001287
摘要
在世界范围内，肺癌是最常见的恶性肿瘤，也是癌症相关死亡的主要原因。在经历了化疗、放疗、分子靶向治疗时代后，晚期肺癌的治疗进入了以免疫检查点抑制剂（ICIs）为代表的免疫治疗新时代，包括程序性细胞死亡蛋白-1/程序性细胞死亡蛋白配体-1（PD-1/PD-L1）抑制剂和细胞毒性T淋巴细胞相关抗原-4（CTLA-4）抑制剂。[
Original Article
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全球和中国癌症负担的变化：2020年全球癌症统计数据的二次分析Wei Cao, Hong-Da Chen, Yi-Wen Yu, Ni Li, Wan-Qing Chen
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001474
摘要
Background:
Cancer is one of the leading causes of death globally, but its burden is not uniform. GLOBOCAN 2020 has newly updated the estimates of cancer burden. This study summarizes the most recent changing profiles of cancer burden worldwide and in China and compares the cancer data of China with those of other regions.
Methods:
We conducted a descriptive secondary analysis of the GLOBOCAN 2020 data. To depict the changing global profile of the leading cancer types in 2020 compared with 2018, we extracted the numbers of cases and deaths in 2018 from GLOBOCAN 2018. We also obtained cancer incidence and mortality from the 2015 National Cancer Registry Report in China when sorting the leading cancer types by new cases and deaths. For the leading cancer types according to sex in China, we summarized the estimated numbers of incidence and mortality, and calculated China’s percentage of the global new cases and deaths.
Results:
Breast cancer displaced lung cancer to become the most leading diagnosed cancer worldwide in 2020. Lung, liver, stomach, breast, and colon cancers were the top five leading causes of cancer-related death, among which liver cancer changed from the third-highest cancer mortality in 2018 to the second-highest in 2020. China accounted for 24% of newly diagnosed cases and 30% of the cancer-related deaths worldwide in 2020. Among the 185 countries included in the database, China’s age-standardized incidence rate (204.8 per 100,000) ranked 65th and the age-standardized mortality rate (129.4 per 100,000) ranked 13th. The two rates were above the global average. Lung cancer remained the most common cancer type and the leading cause of cancer death in China. However, breast cancer became the most frequent cancer type among women if the incidence was stratified by sex. Incidences of colorectal cancer and breast cancer increased rapidly. The leading causes of cancer death varied minimally in ranking from 2015 to 2020 in China. Gastrointestinal cancers, including stomach, colorectal, liver, and esophageal cancers, contributed to a massive burden of cancer for both sexes.
Conclusions:
The burden of breast cancer is increasing globally. China is undergoing cancer transition with an increasing burden of lung cancer, gastrointestinal cancer, and breast cancers. The mortality rate of cancer in China is high. Comprehensive strategies are urgently needed to target China’s changing profiles of the cancer burden.
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两种升压方案预防剖宫产术腰麻后低血压的比较：一项随机对照试验Qian-Qian Fan, Yong-Hui Wang, Jing-Wen Fu, Hai-Long Dong, Man-Ping Yang, Duo-Duo Liu, Xiao-Fan Jiang, Zhi-Xin Wu, Li-Ze Xiong, Zhi-Hong Lu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001404
摘要
Background:
Norepinephrine infusion decreases hypotension after spinal anesthesia during cesarean section. This study aimed to compare the efficacy of norepinephrine infusion and ephedrine bolus against post-spinal hypotension in parturients.
Methods:
In this double-blinded, randomized controlled clinical trial, parturients scheduled for elective cesarean section were randomly allocated to receive norepinephrine infusion (0.05 μg·kg-1·min-1) just before spinal anesthesia continuing for 30 min or ephedrine bolus (0.15 mg/kg) just before spinal anesthesia. A rescue bolus (5 μg norepinephrine for the norepinephrine group, and 5 mg ephedrine for the ephedrine group) was administered whenever hypotension occurred. Our primary outcome was the incidence of hypotension within 30 min of spinal anesthesia administration. Secondary outcomes included maternal and neonatal outcomes 30 min after spinal block, and neonatal cerebral oxygenation 10 min after birth.
Results:
In total, 190 patients were enrolled; of these patients, 177 were included in the final analysis. Fewer patients suffered hypotension in the norepinephrine group than in the ephedrine group (29.5% vs. 44.9%, odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.28-0.95, P = 0.034). Moreover, the tachycardia frequency was lower in the norepinephrine group than in the ephedrine group (OR: 0.22, 95% CI: 0.11-0.44, P < 0.001), and patients suffered less nausea and vomiting (OR: 0.28, 95% CI: 0.11-0.70, P = 0.004). There was no difference in Apgar scores and umbilical arterial blood gas analysis between the two groups. However, neonatal cerebral regional saturations were significantly higher after birth in the norepinephrine group than in the ephedrine group (mean difference: 2.0%, 95% CI: 0.55%-3.45%, P = 0.008).
Conclusion:
In patients undergoing elective cesarean section with spinal anesthesia, norepinephrine infusion compared to ephedrine bolus resulted in less hypotension and tachycardia, and exhibited potential neonatal benefits.
Trial Registration:
ClinicalTrials.gov, NCT02542748; https://clinicaltrials.gov/ct2/show/record/NCT02542748
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卵母细胞募集期间发热的不孕症患者“全冷冻”策略第一个解冻周期的妊娠结局：一项配对研究Ming-Mei Lin, Zi-Ru Niu, Hua Zhang, Rong Li
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001238
摘要
Background:
It is currently unknown whether patients with a fever after controlled ovulation during egg retrieval could increase the risk of pelvic infection or not, and fever itself may affect endometrial receptivity or embryo quality with poor pregnancy outcomes. The aim of this study was to analyze the outcomes of patients with fever during oocyte retrieval after the first frozen-thawed embryo transfer (FET) cycle.
Methods:
This was a 1:3 retrospective paired study matched for age. In this study, 58 infertility patients (Group 1) had a fever during the control ovulation, and the time of the oocyte retrieval was within 72 hours, they underwent ovum pick up and whole embryo freezing ( "freeze-all" strategy). The control subjects (Group 2) are 174 patients matched for age who underwent whole embryo freezing for other reasons. The baseline characteristics, clinical data of ovarian stimulation, and outcomes, such as the clinical pregnancy rate, ongoing clinical pregnancy rate were compared between the two groups in the subsequent FET cycle.
Results:
All patients had no pelvic inflammatory disease after oocyte retrieval. Anti-Mullerian hormone (AMH) levels (4.2 vs. 2.2, P <0.001) were higher in group 2, and the number of oocytes retrieved, and fertilization rate were lower in group 1 (P < 0.001), but the endometrial thickness, the number of embryo transfers, and the type of luteal support supplementation were similar between the two groups. Regarding pregnancy outcomes in the subsequent FET cycle, the implantation rate, clinical pregnancy rate, early spontaneous rate, ectopic pregnancy rate, and ongoing pregnancy rate were all not significantly different. Further regression analyses showed that the clinical pregnancy rate and ongoing pregnancy rate were also not significantly different.
Conclusions:
Transvaginal ultrasound-guided follicular puncture for oocyte retrieval is a safe and minimally invasive method for patients with fever. Moreover, the fever had almost no effect on embryo quality.
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保留乳头乳房切除术的现状调查：中国大型多中心研究（CSBrs-003）Li Zhu, Yang Yan, Lin Tian, Li Yang, Bao-Shi Bao, Hua Kang, Jian-Dong Wang
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001350
摘要
Background:
Mastectomy techniques have been extended to nipple-sparing mastectomy (NSM). This study aimed to assess the actual application of NSM in China and identify the factors influencing postoperative complications.
Methods:
The clinical data of 615 patients (641 surgeries) undergoing NSM from January 1st, 2018 to December 31st, 2018 at 28 centers nationwide were retrospectively analyzed to obtain the rate of NSM and investigate factors related to NSM surgery.
Results:
The proportion of NSM surgery performed in this study was 2.67% (17/641). Malignant breast tumors accounted for the majority of NSM surgery (559/641, 87.2%). A total of 475 (77.3%) patients underwent NSM combined with reconstructive surgery. The rate of reconstruction decreased with age in our study, and implants were the most common option (344/641, 53.7%) in reconstruction. Radial incision was the most selected method regardless of reconstruction. However, for those who underwent reconstruction surgery, 18.4% (85/462) of cases also chose curvilinear incision, while in the simple NSM surgery group, more patients chose circumareolar incision (26/136, 19.1%). The tumor-to-nipple distance (TND) influenced postoperative complications (P = 0.004). There were no relationships between postoperative complications and tumor size, tumor location, histologic grade, molecular subtype, nipple discharge, and axillary lymph nodes.
Conclusions:
NSM surgery is feasible and only TND influenced postoperative complications of NSM surgery. But the proportion of NSM surgery performed is still low in nationwide centers of China. The selection criteria for appropriate surgical methods are important for NSM in clinical practice. To optimize clinical applications of NSM, further multicenter prospective randomized controlled studies are needed.
Trial Registration:
ChiCTR.org.cn, ChiCTR1900027423; http://www.chictr.org.cn/showprojen.aspx?proj=38739
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2型糖尿病患者血清维生素D水平与糖尿病微血管并发症的关系Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001364
摘要
Background:
Vitamin D deficiency has been reported to be associated with diabetic microvascular complications, but previous studies have only focused on the relationship between vitamin D and specific complications. Therefore, we aimed to explore the relationship between vitamin D level and diabetic microvascular complications in general, including diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic peripheral neuropathy (DPN).
Methods:
This was a cross-sectional study of 815 patients with type 2 diabetes mellitus (T2DM). Clinical information and laboratory results were collected from the medical records. The relationship between vitamin D and the three diabetic microvascular complications was investigated.
Results:
The serum 25-hydroxyvitamin D (25 [OH] D) level of patients with DPN and/or DN was significantly lower than that of T2DM patients without any microvascular complications (P < 0.01). Univariate analysis showed that the 25 (OH) D level was related to DPN and DN, but not DR. After adjustment, the 25 (OH) D level was confirmed to be an independent protective factor for DPN (odds ratio [OR]: 0.968, P = 0.004]) and DN (OR: 0.962, P = 0.006). The prevalence of DPN and DN increased significantly as the serum 25 (OH) D levels decreased. Furthermore, patients with both DPN and DN had the lowest concentration of serum 25 (OH) D (P < 0.001), and the prevalence of macroalbuminuria increased more abruptly than that of microalbuminuria across the 25 (OH) D tertiles. Among the patients with vitamin D insufficiency, those with DPN presented more comorbid macroalbuminuria than those without DPN (15.32% vs. 4.91%; P = 0.001).
Conclusions:
Vitamin D deficiency is independently associated with higher risk of DPN and DN, but not DR, in T2DM patients. Further, it may be a potential predictor for both the occurrence and severity of DPN and DN.
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基于深度神经网络的直肠癌T分期自动诊断平台的建立及临床应用价值Qing-Yao Wu, Shang-Long Liu, Pin Sun, Ying Li, Guang-Wei Liu, Shi-Song Liu, Ji-Lin Hu, Tian-Ye Niu, Yun Lu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001401
摘要
Background:
Colorectal cancer is harmful to the patient’s life. The treatment of patients is determined by accurate preoperative staging. Magnetic resonance imaging (MRI) played an important role in the preoperative examination of patients with rectal cancer, and artificial intelligence (AI) in the learning of images made significant achievements in recent years. Introducing AI into MRI recognition, a stable platform for image recognition and judgment can be established in a short period. This study aimed to establish an automatic diagnostic platform for predicting preoperative T staging of rectal cancer through a deep neural network.
Methods:
A total of 183 rectal cancer patients’ data were collected retrospectively as research objects. Faster region-based convolutional neural networks (Faster R-CNN) were used to build the platform. And the platform was evaluated according to the receiver operating characteristic (ROC) curve.
Results:
An automatic diagnosis platform for T staging of rectal cancer was established through the study of MRI. The areas under the ROC curve (AUC) were 0.99 in the horizontal plane, 0.97 in the sagittal plane, and 0.98 in the coronal plane. In the horizontal plane, the AUC of T1 stage was 1, AUC of T2 stage was 1, AUC of T3 stage was 1, AUC of T4 stage was 1. In the coronal plane, AUC of T1 stage was 0.96, AUC of T2 stage was 0.97, AUC of T3 stage was 0.97, AUC of T4 stage was 0.97. In the sagittal plane, AUC of T1 stage was 0.95, AUC of T2 stage was 0.99, AUC of T3 stage was 0.96, and AUC of T4 stage was 1.00.
Conclusion:
Faster R-CNN AI might be an effective and objective method to build the platform for predicting rectal cancer T-staging.
Trial registration:
chictr.org.cn: ChiCTR1900023575; http://www.chictr.org.cn/showproj.aspx?proj=39665.
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MicroRNA-23a通过Rho相关激酶1/sirtuin-1/核因子-κ B串扰减少脂多糖诱导的细胞凋亡和炎性细胞因子的产生Xiao-Jun Shi, Ye Jin, Wei-Ming Xu, Qing Shen, Jun Li, Kang Chen
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001369
摘要
Background:
MicroRNAs are closely associated with the progression and outcomes of multiple human diseases, including sepsis. In this study, we examined the role of miR-23a in septic injury.
Methods
Lipopolysaccharide (LPS) was used to induce sepsis in a rat model and H9C2 and HK-2 cells. miR-23a expression was evaluated in rat myocardial and kidney tissues, as well as H9C2 and HK-2 cells. A miR-23a mimic was introduced into cells to identify the role of miR-23a in cell viability, apoptosis, and the secretion of inflammatory cytokines. Furthermore, the effect of Rho-associated kinase 1 (ROCK1), a miR-23a target, on cell damage was evaluated, and molecules involved in the underlying mechanism were identified.
Results:
In the rat model, miR-23a was poorly expressed in myocardial (sham vs. sepsis 1.00 ± 0.06 vs. 0.27 ± 0.03, P < 0.01) and kidney tissues (sham vs. sepsis 0.27 ± 0.03 vs. 1.00 ± 0.06, P < 0.01). Artificial overexpression of miR-23a resulted in increased proliferative activity (DNA replication rate: Control vs. LPS vs. LPS + Mock vs. LPS + miR-23a: H9C2 cells: 34.13 ± 3.12 vs. 12.94 ± 1.21 vs. 13.31 ± 1.43 vs. 22.94 ± 2.26, P < 0.05; HK-2 cells: 15.17 ± 1.43 vs. 34.52 ± 3.46 vs. 35.19 ± 3.12 vs. 19.87 ± 1.52, P < 0.05), decreased cell apoptosis (Control vs. LPS vs. LPS + Mock vs. LPS + miR-23a: H9C2 cells: 11.39 ± 1.04 vs. 32.57 ± 2.29 vs. 33.08 ± 3.12 vs. 21.63 ± 2.35, P < 0.05; HK-2 cells: 15.17 ± 1.43 vs. 34.52 ± 3.46 vs. 35.19 ± 3.12 vs. 19.87 ± 1.52, P < 0.05), and decreased production of inflammatory cytokines, including interleukin-6 (Control vs. LPS vs. LPS + Mock vs. LPS + miR-23a: H9C2 cells: 59.61 ± 5.14 vs. 113.54 ± 12.30 vs. 116.51 ± 10.69 vs. 87.69 ± 2.97 ng/mL; P < 0.05, F = 12.67, HK-2 cells: 68.12 ± 6.44 vs. 139.65 ± 16.62 vs. 143.51 ± 13.64 vs. 100.82 ± 9.74 ng/mL, P < 0.05, F = 9.83) and tumor necrosis factor-α (Control vs. LPS vs. LPS + Mock vs. LPS + miR-23a: H9C2 cells: 103.20 ± 10.31 vs. 169.67 ± 18.84 vs. 173.61 ± 15.91 vs. 133.36 ± 12.32 ng/mL, P < 0.05, F = 12.67, HK-2 cells: 132.51 ± 13.37 vs. 187.47 ± 16.74 vs. 143.51 ± 13.64 vs. 155.79 ± 15.31 ng/mL, P < 0.05, F = 9.83) in cells. However, ROCK1 was identified as a miR-23a target, and further up-regulation of ROCK1 mitigated the protective function of miR-23a in LPS-treated H9C2 and HK-2 cells. Moreover, ROCK1 suppressed sirtuin-1 (SIRT1) expression to promote the phosphorylation of nuclear factor-kappa B (NF-κB) p65, indicating the possible involvement of this signaling pathway in miR-23a-mediated events.
Conclusion:
Our results indicate that miR-23a could suppress LPS-induced cell damage and inflammatory cytokine secretion by binding to ROCK1, mediated through the potential participation of the SIRT1/NF-κB signaling pathway.
Clinical Observation
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通过多重连接依赖性探针扩增验证的下一代测序检测杂合子家族性高胆固醇血症儿童的新拷贝数变异Hui Yan, Jian-Hui Qiu, Yi-Nan Ma, Yang Xiao, Jun-Bao Du
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001224
摘要
家族性高胆固醇血症（FH）是一种常见的常染色体显性脂质代谢紊乱。低密度脂蛋白受体基因突变（LDLR）代表了大多数FH病例。LDLR突变是共显性遗传。通常，与杂合突变相关的临床表型相对较轻，而纯合突变、复合杂合突变和双基因突变LDLR导致严重的表型。然而，一些杂合子FH（HeFH）和纯合子FH（HoFH）患者具有相似的脂质水平。由于这些患者的预后和治疗方法差异很大，准确的诊断尤为重要。基因检测在FH的诊断中起着至关重要的作用，但通过基因检测找到合适的突变并不总是简单的。
Technical Notes
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组织扩张器重建先天性小耳畸形的三维扫描技术Shu-Qia Xu, Xian-Lei Jia, Yoonho Choi, Zhao-Wei Zhu, Yang-Bin Xu, Ram Velamuri, Xiang-Xia Liu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001279
摘要
为了解决皮肤移植后颜色、质地不匹配和感觉缺失的问题，Brent于1980年将组织扩张技术应用于小耳畸形重建。最近，来自中国和韩国的几个小组报告了他们成功的软组织扩张技术在小耳畸形重建中的经验，效果良好，并发症发生率低。[
Rapid Report
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天然截短的54aa变异体揭示HIV-Vpr在细胞凋亡中的多因素作用Ling Du, Cui-Song Wu, Jun Sun, Tong Yu, Pan-Pan Lyu, San-Feng Han, Chao Qiu, Zhe-Feng Meng
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001297
摘要
尽管抗逆转录病毒疗法（ART）在抑制人类免疫缺陷病毒1型（HIV-1）复制方面是有效的，但HIV-1感染仍然是一个全球性的公共卫生问题。HIV-1辅助蛋白病毒蛋白R（Vpr）是一种多功能蛋白，在调节细胞凋亡中起主要作用。[
Correspondence
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生物信息学分析确定增殖细胞核抗原(PCNA)在肝细胞癌中的过表达可预测不良预后Dan-Dan Li, Jia-Wei Zhang, Rui Zhang, Jie-Hong Xie, Kuo Zhang, Gui-Gao Lin, Yan-Xi Han, Rong-Xue Peng, Dong-Sheng Han, Jie Wang 等
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001192
摘要
致编辑：目前，在早期诊断和临床治疗方面已经采取了许多方法，但肝细胞癌（HCC）患者的总生存期（OS）仍然不令人满意。[
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局部米诺地尔和纳米微针辅助成纤维细胞生长因子联合治疗男性雄激素性脱发：一项在中国患者中的随机对照试验Cheng-Qian Yu, Hui Zhang, Meng-Er Guo, Xiao-Kun Li, Hong-Duo Chen, Yuan-Hong Li, Xue-Gang Xu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001195
摘要
致编辑：男性雄激素性脱发（MAA）是最常见的脱发疾病，其特征是毛囊小型化和进行性脱发。[
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一例年轻女性患者的早发性痛风和慢性肾脏病Yu Cao, Xin-Xin Han, Xiao-Xue Wang, Yun Zhang, Xue-Jun Zeng
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001174
摘要
致编辑：2018年，一名31岁女性在我院就诊，有10年慢性关节炎和慢性肾病（CKD）病史。她的左脚踝外伤后发生了关节炎。然后给她开了止痛药，症状很快就消失了。她的血清尿酸（sUA）和血清肌酐（SCr）均轻度升高。后来，患者多次出现关节痛；疼痛是由脚踝拉伤或食用海鲜引发的，在夜间最为明显。每次疼痛发作时，症状在24 h内迅速发展，伴有皮肤发红和关节肿胀，一周内减轻。在接下来的几年里，她的右脚踝、手腕以及手脚的多个小关节都经历了类似的攻击，但之前没有外伤。该患者随后在当地诊所被诊断为痛风和慢性肾病。她间歇性服用苯溴马隆和消炎药治疗痛风（苯溴马隆已于8年前停用），申帅宁（中成药）治疗CKD。
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一例罕见异位纵隔支气管动脉动脉瘤的电视胸腔切除术Li Li, Luo Zhao, Ying-Zhi Qin, Jia He, Zhi-Jun Han
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001157
摘要
致编辑：支气管动脉瘤（BAA）是一种罕见但可能致命的疾病。在所有选择性支气管动脉造影中，不到1%报告了BAA。[
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基于深度学习的前列腺癌Gleason分级(GD)系统的临床应用Yun Niu, Can-Cheng Liu, Bing-Lin Zhang, Zhi-Gang Song, Huang Chen, Ping-Ping Liu, Jing-Si Chen, Shu-Hao Wang, Huai-Yin Shi, Ding-Rong Zhong
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001220
摘要
致编辑：前列腺癌是男性生殖系统最常见的恶性肿瘤之一，2012年约有110万新发病例。[
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子宫肌瘤切除术中肌内注射加压素导致严重心动过缓Li-Ping Song, Shi-Miao Feng, Xiao-Qin Jiang
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001314
摘要
致编辑：子宫肌瘤切除术是切除子宫肌瘤的重要治疗选择，同时使用子宫肌层内加压素以减少术中出血。[
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重组CD55-CD46融合蛋白阻断大疱性类天疱疮补体激活Pei Qiao, Yi-Xin Luo, Da-Long Zhi, Gang Wang, Er-Le Dang
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001312
摘要
致编辑：大疱性类天疱疮（BP）是一种自身免疫性水疱性疾病，由自身抗体引起，与补体激活有关。[
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STRONGkids在儿科重症监护室营养风险识别中的应用：中国实践调查Ling-Ying Wang, Lin Hu, Xiao-Ying Huang, Meng-Lin Tang
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001330
摘要
致编辑：在儿童生长过程中，定期监测生长指数，如儿童的体重、身高和其他身体测量，有助于早期诊断营养风险和异常生长。[
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中国冠状动脉斑块早期检测和风险分层登记（C-STRAT）研究的基本原理、设计和基线特征Jun-Jie Yang, Dong-Kai Shan, Lei Xu, Jun-Fu Liang, Zhao-Qian Wang, Mei Zhang, Min Li, Wen-Jie Yang, Jian-Rong Xu, Yong-Gao Zhang 等
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001307
摘要
致编辑：冠状动脉计算机断层血管造影（CCTA）被认为是诊断冠状动脉疾病（CAD）最重要的无创成像方式之一。[
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18F-FDG PET/CT与常规体检套餐在中国无症状患者癌症筛查中的比较Cong Ma, Wei-Hua Zhang, Bing-Xiang Yu, Bai-Xuan Xu
中华医学杂志英文版2021年 134卷 07期
DOI: 10.1097/CM9.0000000000001376
摘要
致编辑：癌症是中国人死亡的主要原因。[
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