Volume 129 · Issue 01 · 2016

《中华医学杂志》（CMJ）创刊于1887年，是中国历史最悠久的医学期刊，是我们喜爱的期刊之一。我们从学医的时候就开始读这本杂志了。

Evaluating a change in the screening rate for hepatocellular carcinoma (HCC) is critical for understanding screening implementation, and whether targeted population groups are receiving proper screening. This study examined recent nationwide changes in HCC screening use among hepatitis B virus (HBV)-infected populations after the introduction of the Korean National Cancer Screening Program and predictors of screening adherence.　

We analyzed 165 and 276 participants ≥40 years of age who were hepatitis B surface antigen-positive from 2001 (14,936 participants) to 2010–2011 (9159 participants) Korea National Health and Nutrition Examination Surveys, respectively. Demographic data, socioeconomic factors, and HCC screening use were collected by means of self-reported questionnaires.　

The rate of HCC screening within the previous 2 years increased significantly from 17.5% in 2001 to 40.3% in 2010– 2011 (P < 0.0001). The rate of HCC screening use increased from 2001 to 2010–2011 in all study populations. Subjects who had a higher income status and were aware of their infection were more likely to have undergone recent HCC screening.　

This study showed a substantial increase in HCC screening in high-risk HBV-infected subjects from 2001 to 2010–2011. However, the HCC screening participation rate remained suboptimal despite the introduction of the nationwide screening program. Efforts should be made to identify high-risk individuals and increase attendance at HCC screening events among high-risk groups.

Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. This study was to investigate the different prevalence of PIM use in elderly inpatients between 65–79 years of age and 80 years or older, who were discharged from Geriatric Department in West China Hospital.　

A large-scale cohort of 1796 inpatients aged 65 years or over was recruited. Respectively, 618 patients were 65–79 years and 1178 patients were 80 years or older. Updated 2012 Beers Criteria by the American Geriatric Society was applied to assess the use of PIM among the investigated samples.　

A review of the prescribed medications identified 686 patients aged 80 years or older consumed at least one PIM giving a rate of 58.2%. Conversely, 268 (43.4%) patients aged 65–79 years consumed at least one PIM (χ² = 40.18, P < 0.001). Patients aged 80 years or older had higher hospitalization expenses, length of stay, co-morbidities, medical prescription, and mortality than patients aged 65–79 years (all with P < 0.001). Patients aged 80 years or older were prescribed with more benzodiazepines, drugs with strong anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin. In multiple regression analysis, PIM use was significantly associated with female gender, age, number of diagnostic disease, and number of prescribed medication.　

The finding from this study revealed that inpatients aged 80 years or older encountered more PIM use than those aged 65–79 years. Anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin are medications that often prescribed to inpatients aged 80 years or older. Doctors should carefully choose drugs for the elderly, especially the elderly aged 80 years or older.

Mitochondrial dysfunction plays an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). We aimed to demonstrate mitochondrial dysfunction in ALS using a lactate stress test and to examine the relationship between mitochondrial dysfunction with motor deterioration.　

We enrolled 116 patients and observed clinical variables, including the survival state.　

Patients with a rapid slope of revised ALS functional rating scales (ALSFRS-r) (>20 U/year) exhibited the slowest elimination rate (median −4.67 × 10⁻³ mmol∙L⁻¹∙min⁻¹, coefficient of variation, 590.15%), the shortest duration (0.63 ± 0.28 years) and the worst ALSFRS-r (32.59 ± 4.93). Patients with a moderate slope of ALSFRS-r (10–20 U/year) showed a moderate elimination rate (median −11.33 × 10⁻³ mmol∙L⁻¹∙min⁻¹, coefficient of variation, 309.89%), duration (1.16 ± 0.45 years), and ALSFRS-r (34.83 ± 6.11). The slower progressing (<10 U/year group) patients exhibited a rapid elimination rate (median: −12.00 × 10⁻³ mmol∙L⁻¹∙min⁻¹, coefficient of variation: 143.08%), longer duration (median: 3 years, coefficient of variation: 193.33%), and adequate ALSFRS-r values (39.58 ± 9.44). Advanced-phase ALS patients also showed slower elimination rate (ER, quartiles −17.33, −5.67, 4.00) and worse ALSFRS-r (34.88 ± 9.27), while early-phase patients showed a more rapid ER (quartiles −25.17, −11.33, −3.50) and better ALSFRS-r (39.28 ± 7.59). These differences were statistically significant. Multiple linear regression analysis revealed strong direct associations among ER, ALSFRS-r slope (standard beta = 0.33, P = 0.007), and forced vital capacity (predict %) (standard beta = −0.458, P = 0.006, adjusted for ALSFRS-r, course and onset region). However, the data obtained from 3 years of follow-up showed no statistically significant difference in the survival rates between the most rapid and slowest ER groups.　

There is a potential linear relationship between ER and motor deterioration in ALS. Slower ER might be associated with faster disease progression.

The factors affecting the outcome of patients referred for lung transplantation (LTx) still have not been investigated extensively. The aim of this study was to characterize the patient outcomes and identify the prognostic factors for death while awaiting the LTx.　

From January 2003 to November 2013, the clinical data of 103 patients with end-stage lung disease that had been referred for LTx to Department of Thoracic Surgery, Shanghai Pulmonary Hospital were analyzed retrospectively. The relationship between predictors and survival was evaluated using the Kaplan–Meier method and the Cox proportional hazards model.　

Twenty-five patients (24.3%) died while awaiting the LTx. Fifty patients (48.5%) underwent LTx, and 28 patients (27.2%) were still on the waitlist. Compared to the candidates with chronic obstructive pulmonary disease (COPD), patients with idiopathic pulmonary fibrosis (IPF) had a higher mortality while awaiting the LTx (40.0% vs. 12.3%, P = 0.003). Patients requiring mechanical ventilation (MV) had a higher mortality while waiting than others (50.0% vs. 20.2%, P = 0.038). Two variables, using MV and IPF but not COPD as primary disease, emerged as significant independent risk factors for death on the waitlist (hazard ratio [HR]= 56.048, 95% confidence interval [CI]: 3.935–798.263, P = 0.003 and HR = 14.859, 95% CI: 2.695–81.932, P = 0.002, respectively).　

The type of end-stage lung disease, pulmonary hypertension, and MV may be distinctive prognostic factors for death while awaiting the LTx.

The dyschromatoses are a group of disorders characterized by simultaneous hyperpigmented macules together with hypopigmented macules. Dyschromatosis universalis hereditaria (DUH) and dyschromatosis symmetrica hereditaria are two major types. While clinical and histological presentations are similar in these two diseases, genetic diagnosis is critical in the differential diagnosis of these entities.　

Three patients initially diagnosed with DUH were included. The gene test was carried out by targeted gene sequencing. All mutations detected on ADAR1 and ABCB6 genes were analyzed according to the frequency in control database, the mutation types, and the published evidence to determine the pathogenicity.　

Family pedigree and clinical presentations were reported in 3 patients from two Chinese families. All patients have prominent cutaneous dyschromatoses involving the whole body without systemic complications. Different pathogenic genes in these patients with similar phenotype were identified: One novel mutation on ADAR1 (c. 1325C>G) and one recurrent mutation in ABCB6 (c. 1270T>C), which successfully distinguished two diseases with the similar phenotype.　

Targeted gene sequencing is an effective tool for genetic diagnosis in pigmentary skin diseases.

Laparoscopic liver resection (LLR) has been considered to be safe and feasible. However, few studies focused on the comparison between the anatomic and nonanatomic LLR. Therefore, the purpose of this study was to compare the perioperative factors and outcomes of the anatomic and nonanatomic LLR, especially the area of liver parenchymal transection and blood loss per unit area.　

In this study, surgical and oncological data of patients underwent pure LLR procedures for malignant liver tumor were prospectively collected. Blood loss per unit area of liver parenchymal transection was measured and considered as an important parameter. All procedures were conducted by a single surgeon.　

During nearly 5 years, 84 patients with malignant liver tumor received a pure LLR procedure were included. Among them, 34 patients received anatomic LLR and 50 received nonanatomic LLR, respectively. Patients of the two groups were similar in terms of demographic features and tumor characteristics, despite the tumor size was significantly larger in the anatomic LLR group than that in the nonanatomic LLR group (4.77 ± 2.57 vs. 2.87 ± 2.10 cm, P = 0.001). Patients who underwent anatomic resection had longer operation time (364.09 ± 131.22 vs. 252.00 ± 135.21 min, P < 0.001) but less blood loss per unit area (7.85 ± 7.17 vs. 14.17 ± 10.43 ml/cm², P = 0.018). Nonanatomic LLR was associated with more blood loss when the area of parenchymal transection was equal to the anatomic LLR. No mortality occurred during the hospital stay and 30 days after the operation. Moreover, there was no difference in the incidence of postoperative complications. The disease-free and overall survival rates showed no significant differences between the anatomic LLR and nonanatomic LLR groups.　

Both anatomic and nonanatomic pure LLR are safe and feasible. Measuring the area of parenchymal transection is a simple and effective method to estimate the outcomes of the liver resection surgery. Blood loss per unit area is an important parameter which is comparable between the anatomic LLR and nonanatomic LLR groups.

Etomidate (R-1-[1-ethylphenyl] imidazole-5-ethyl ester) is a widely used anesthetic drug that had been reported to contribute to cognitive deficits after general surgery. However, its underlying mechanisms have not been fully elucidated. In this study, we aimed to explore the neurobiological mechanisms of cognitive impairments that caused by etomidate.　

A total of 30 Sprague-Dawley rats were used and divided into two groups randomly to receive a single injection of etomidate or vehicle. Then, the rats’ spatial memory ability and neuronal survival were evaluated using the Morris water maze test and Nissl staining, respectively. Furthermore, we analyzed levels of oxidative stress, as well as cyclic adenosine 3’,5’-monophosphate response element-binding (CREB) protein phosphorylation and immediate early gene (IEG, including Arc, c-fos, and Egr1) expression levels using Western blot analysis.　

Compared with vehicle-treated rats, the etomidate-treated rats displayed impaired spatial learning (day 4: 27.26 ± 5.33 s vs. 35.52 ± 3.88 s, t = 2.988, P = 0.0068; day 5: 15.84 ± 4.02 s vs. 30.67 ± 4.23 s, t = 3.013, P = 0.0057; day 6: 9.47 ± 2.35 s vs. 25.66 ± 4.16 s, t = 3.567, P = 0.0036) and memory ability (crossing times: 4.40 ± 1.18 vs. 2.06 ± 0.80, t = 2.896, P = 0.0072; duration: 34.00 ± 4.24 s vs. 18.07 ± 4.79 s, t = 3.023, P = 0.0053; total swimming distance: 40.73 ± 3.45 cm vs. 27.40 ± 6.56 cm, t = 2.798, P = 0.0086) but no neuronal death. Furthermore, etomidate did not cause oxidative stress or deficits in CREB phosphorylation. The levels of multiple IEGs (Arc: vehicle treated rats 100%, etomidate treated rats 86%, t = 2.876, P = 0.0086; c-fos: Vehicle treated rats 100%, etomidate treated rats 72%, t = 2.996, P = 0.0076; Egr1: Vehicle treated rats 100%, etomidate treated rats 58%, t = 3.011, P = 0.0057) were significantly reduced in hippocampi of etomidate-treated rats.　

Our data suggested that etomidate might induce memory impairment in rats via inhibition of IEG expression.

Trichophyton rubrum represents the most common infectious fungus responsible for dermatophytosis in human, but the mechanism involved is still not completely understood. An appropriate model constructed to simulate host infection is the prerequisite to study the pathogenesis of dermatophytosis caused by T. rubrum. In this study, we intended to develop a new T. rubrum infection model in vitro, using the three-dimensional reconstructed epidermis - EpiSkin^®, and to pave the way for further investigation of the mechanisms involved in T. rubrum infection.　

The reconstructed human epidermis (RHE) was infected by inoculating low-dose (400 conidia) and high-dose (4000 conidia) T. rubrum conidia to optimize the infection dose. During the various periods after infection, the samples were processed for pathological examination and scanning electron microscopy (SEM) observation.　

The histological analysis of RHE revealed a fully differentiated epidermis with a functional stratum corneum, which was analogous to the normal human epidermis. The results of hematoxylin and eosin staining and the periodic acid-Schiff staining showed that the infection dose of 400 conidia was in accord with the pathological characteristics of host dermatophytosis caused by T. rubrum. SEM observations further exhibited the process of T. rubrum infection in an intuitionistic way.　

We established the T. rubrum infection model on RHE in vitro successfully. It is a promising model for further investigation of the mechanisms involved in T. rubrum infection.

Vascular endothelial growth factor (VEGF) in the thymus was mainly produced by the thymic epithelial cells (TECs), the predominant component of the thymic microenvironment. The progression of TECs and the roles of VEGF in the neonatal thymus during sepsis have not been reported. This study aimed to explore the alterations of TECs and VEGF level in the neonatal thymus involution and to explore the possible mechanisms at the cellular level.　

By establishing a model of clinical sepsis, the changes of TECs were measured by hematoxylin-eosin staining, confocal microscopy, and flow cytometry. Moreover, the levels of VEGF in serum and thymus were assessed based on enzyme-linked immunosorbent assay and Western blotting.　

The number of thymocytes and TECs was significantly decreased 24 h after lipopolysaccharide (LPS) challenge, (2.40 ± 0.46)×10⁷ vs. (3.93 ± 0.66)×10⁷ and (1.16 ± 0.14)×10⁵ vs. (2.20 ± 0.19)×10⁵, P < 0.05, respectively. Cortical TECs and medullary TECs in the LPS-treated mice were decreased 1.5-fold and 3.9-fold, P < 0.05, respectively, lower than those in the controls. The number of thymic epithelial progenitors was also decreased. VEGF expression in TECs was down-regulated in a time-dependent manner.　

VEGF in thymic cells subsets might contribute to the development of TECs in neonatal sepsis.

Postmastectomy pain syndrome (PMPS) is defined as a chronic (continuing for 3 or more months) neuropathic pain affecting the axilla, medial arm, breast, and chest wall after breast cancer surgery. The prevalence of PMPS has been reported to range from 20% to 68%. In this study, we aimed to determine the prevalence of PMPS among mastectomy patients, the severity of neuropathic pain in these patients, risk factors that contribute to pain becoming chronic, and the effect of PMPS on life quality.　

This cross-sectional study was approved by the Sakarya University, Medical Faculty Ethical Council and included 146 patients ranging in age from 18 to 85 years who visited the pain clinic, general surgery clinic, and oncology clinic and had breast surgery between 2012 and 2014. Patients were divided into two groups according to whether they met PMPS criteria: pain at axilla, arm, shoulder, chest wall, scar tissue, or breast at least 3 months after breast surgery. All patients gave informed consent prior to entry into the study. Patient medical records were collected, and pain and quality of life were evaluated by the visual analog scale (VAS) for pain, a short form of the McGill Pain Questionnaire (SF-MPQ), douleur neuropathique-4 (DN-4), and SF-36.　

Patient mean age was 55.2 ± 11.8 years (33.0–83.0 years). PMPS prevalence was 36%. Mean scores on the VAS, SF-MPQ, and DN-4 in PMPS patients were 1.76 ± 2.38 (0–10), 1.73 ± 1.54 (0–5), and 1.64 ± 2.31 (0–8), respectively. Of these patients, 31 (23.7%) had neuropathic pain characteristics, and 12 (9.2%) had phantom pain according to the DN-4 survey. Patients who had modified radical mastectomy were significantly more likely to develop PMPS than patients who had breast-protective surgery (P = 0.028). Only 2 (2.4%) of PMPS patients had received proper treatment (anticonvulsants or opioids).　

PMPS seriously impacts patients’ emotional situation, daily activities, and social relationships and is a major economic burden for health systems. We conclude that the rate of PMPS among patients receiving breast cancer surgery in Turkey is 64.1% and that challenges to the proper treatment of these patients deserve further investigation.

Despite the rapid growth in the incidence of acute myocardial infarction (AMI) in China, there is limited information about patients’ experiences after AMI hospitalization, especially on long-term adverse events and patient-reported outcomes (PROs).　

The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)-Prospective AMI Study will enroll 4000 consecutive AMI patients from 53 diverse hospitals across China and follow them longitudinally for 12 months to document their treatment, recovery, and outcomes. Details of patients’ medical history, treatment, and in-hospital outcomes are abstracted from medical charts. Comprehensive baseline interviews are being conducted to characterize patient demographics, risk factors, presentation, and healthcare utilization. As part of these interviews, validated instruments are administered to measure PROs, including quality of life, symptoms, mood, cognition, and sexual activity. Follow-up interviews, measuring PROs, medication adherence, risk factor control, and collecting hospitalization events are conducted at 1, 6, and 12 months after discharge. Supporting documents for potential outcomes are collected for adjudication by clinicians at the National Coordinating Center. Blood and urine samples are also obtained at baseline, 1- and 12-month follow-up. In addition, we are conducting a survey of participating hospitals to characterize their organizational characteristics.　

The China PEACE-Prospective AMI study will be uniquely positioned to generate new information regarding patient’s experiences and outcomes after AMI in China and serve as a foundation for quality improvement activities.

To examine the efficacy and safety of dual blockade of the renin-angiotensin-aldosterone system (RAAS) among patients with type 2 diabetic kidney disease.　

We searched the major literature repositories, including the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE, for randomized clinical trials published between January 1990 and October 2015 that compared the efficacy and safety of the use of dual blockade of the RAAS versus the use of monotherapy, without applying any language restrictions. Keywords for the searches included "diabetic nephropathy," "chronic kidney disease," "chronic renal insufficiency," "diabetes mellitus," "dual therapy," "combined therapy," "dual blockade," "renin-angiotensin system," "angiotensin-converting enzyme inhibitor," "angiotensin-receptor blocker," "aldosterone blockade," "selective aldosterone blockade," "renin inhibitor," "direct renin inhibitor," "mineralocorticoid receptor blocker," etc.　

The selected articles were carefully reviewed. We excluded randomized clinical trials in which the kidney damage of patients was related to diseases other than diabetes mellitus.　

Combination treatment with an angiotensin-converting enzyme inhibitor supplemented by an angiotensin II receptor blocking agent is expected to provide a more complete blockade of the RAAS and a better control of hypertension. However, existing literature has presented mixed results, in particular, related to patient safety. In view of this, we conducted a comprehensive literature review in order to explain the rationale for dual blockade of the RAAS, and to discuss the pros and cons.　

Despite the negative results of some recent large-scale studies, it may be immature to declare that the dual blockade is a failure because of the complex nature of the RAAS surrounding its diversified functions and utility. Further trials are warranted to study the combination therapy as an evidence-based practice.

成骨不全症（OI），也称为脆性骨病或洛布斯坦综合征，其特征是蓝色或灰色巩膜、可变身材矮小、牙本质形成不全症、听力损失和复发性骨折。基于临床、遗传学和放射学特征，沉默等人.^[1]将OI分为四种亚型，包括I型：轻度、普通型、巩膜蓝色；II型：围产期致死型；Ⅲ型：重度及年龄相关性进行性畸形，巩膜正常；IV型：中度严重，巩膜正常。基于突变基因和遗传模式，将这四种亚型进一步分为人类在线孟德尔遗传中的15种OI类型。超过90%的OI患者存在I型胶原α突变（COL1A）1和第1A2栏。^[2]

传统的全膝关节置换术（TKA）是晚期关节炎患者缓解疼痛和改善不良功能最成功的外科手术。然而，术后疼痛和延迟康复是传统方法的最大抱怨。最近，已经开发了各种微创手术（MIS）TKA技术来解决该问题。MIS-TKA显示术后疼痛更少，住院时间更短，术后恢复更快。

迄今为止，人工气管假体的实践一直是全世界整个外科领域的重大挑战。以前应用的假体是“内支架”型，不能用天然气管进行生物学愈合。^[1]新开发的设计，赵氏人工气管，使用记忆合金网结合传统操作程序。经过2年的实验，该装置已应用于7名患者，结果令人满意。我们认为这是一种成功的人工气管，能够与天然气管完全生物学愈合。7例患者均未出现排斥反应、感染或重大并发症，赵氏人工气管可视为气管的真实部分。

胆汁酸合成缺陷（BASD）是一种罕见的遗传性疾病，约占婴儿持续性胆汁淤积的2%。^[1]迄今为止，已经鉴定了四种导致胆汁酸合成先天性缺陷（CBAS）的酶。3 β-羟基-Δ 5-C27-类固醇脱氢酶(3 β-HSD），其缺乏可导致CBAS1（OMIM编号607765），由基因编码HSD3B7并且在将类固醇转化为初级胆汁酸的第二步中起作用。

在目前的导管研究中，关于血流储备分数（FFR）有3个主要方向，包括瞬时无波比、FFR的无创测量以及FFR从冠状动脉循环转移到其他缺血诱导循环。最近，发表了一项有趣的研究，其中进行了FFR来诊断和指导慢性肠系膜缺血（CMI）支架植入术。^[1]我们在此强调了FFR从冠状动脉到肾动脉和肠系膜动脉的意义和局限性，分别用于未来的研究。

青少年特发性脊柱侧凸（AIS）是青少年中最常见的疾病之一，全球发病率为1-3%，至少0.02%的患者需要手术治疗。^[1]“金标准”手术是10个或更多椎骨的器械和融合，并强力矫正畸形。^[2]尽管自体骨移植是脊柱融合的“金标准”，^[3]在发现骨移植替代物方面取得了重大进展，包括冻干同种异体移植物、脱矿质骨基质（DBM）、triosite陶瓷和骨髓抽吸物（BMA），它们已被用作AIS手术中髂嵴的替代物。^[4,5,6,7]结果表明，这些替代品可以获得类似的脊柱融合益处，而其他证据无法复制。骨科医生陷入了一个两难的境地，即哪种替代品最适合并发症更少的AIS手术，同时实现更高的融合率。在这篇文章中，我们提出了我们对这个问题的看法。

致编辑：一位20岁的女性主诉她的左手食指上有两个疼痛瘙痒的病变。一个月前，她的食指被一只羔羊咬了；两天后羔羊死了。被咬五天后，她注意到左手食指上有两个逐渐增大的丘疹。体格检查发现两个直径分别为8毫米和10毫米的硬结结节，每个结节都有中央脐部，周围有红色光环[图1a].患者无发热、呼吸道症状或淋巴结肿大。知情同意书是书面的。

编者：SAPHO综合征是一种以滑膜炎、痤疮、脓疱病、骨质增生和骨炎为特征的异质性疾病。如果没有典型的皮肤表现，其诊断可能很困难。我们报告了一例SAPHO综合征，该综合征也符合强直性脊柱炎（AS）的当前诊断标准。

致编者：双主动脉弓（DAA）是一种罕见的先天性心血管疾病，通常因气管或食道阻塞引起的呼吸困难或吞咽困难而在早期被诊断并进行手术矫正。^[1]在此，我们报告一例DAA和夹层动脉瘤的病例，通过支架辅助弹簧圈成功完成。

致编辑：诺卡氏菌种属革兰氏阳性，部分耐酸芽孢杆菌存在于土壤和水中。诺卡菌脑脓肿很罕见，但死亡率很高，文献中对这些病变是否应该常规切除或简单抽吸存在争议。^[1]第一例克拉苏诺卡氏菌本文报告了一名31岁免疫功能正常男性的脑脓肿，以强调这种新出现的病原体和抗菌药物敏感性。他有1周的进行性右侧轻偏瘫病史。他经常在公海上游泳，游泳时右大脚趾被割伤。他的体温是36.2摄氏度。他是警觉和定向的，右上肢为4级医学研究委员会无力，右下肢为2级，反射活跃（3+）。脑部磁共振成像(MRI)显示脓肿[图1a].他的白细胞计数（包括有差异的淋巴细胞）正常，血培养阴性。他的胸片正常。

致编辑：在他们的荟萃分析中，Ma等人.^[1]目的确定脓毒症患者羟乙基淀粉130/0.4或0.42（HES）的死亡率与HES剂量和每日液体平衡的关系。进行敏感性试验以分析死亡率数据异质性的原因。这些测试侧重于“偏倚风险”。

Wiedermann博士评论了我们的系统综述和荟萃回归，这些综述和荟萃回归报告了脓毒症患者HES 130/0.4或0.42相关超额死亡率的试验中的异质性来源^[1]死亡率的汇总分析既没有显示益处也没有显示危害，可能会受到低质量试验的影响。从统计学上来说，如果排除了两项被判断为中度偏倚风险的招募试验，我们同意这一结论。

在题为“口服更昔洛韦预防和治疗复发性单纯疱疹性角膜炎的临床疗效”的文章中，第1期，第128卷，第46-50页中华医学杂志^[1]，第二作者“Linnong Wang”和第三作者“Xinjun Ma”的隶属关系被错误地写成“南京市第一人民医院眼科，江苏南京210006，中国”，而不是“南京医科大学第一医院眼科，江苏南京210006，中国”。