1983年 · 第96卷第09期

The incidence of absent dorsalis pedis (12.5%) and posterior tibial pulsation (2.8%) in 3,456 feet of 1,728 healthy young Chinese is surveyed. Sex, racial and geographic deviations are noted and an evaluation of the clinical significance attempted.

Analysis of 60 pituitary adenomas with acromegaly is made. All 60 surgical specimens are studied by both light and electron microscopy. By light microscopy we classified the adenomas into strong acidophilic cell (16 cases) and weak acidophilic cell (20 cases), stem cell (2 cases) and mixed cell type adenomas (22 cases). By electron microscopy we classified them into densely granulated (14 cases) and sparsely granulated growth hormone (GH) cell adenomas (22 cases) in which there are fibrous bodies near the indented part of the nucleus which are of diagnostic value, corresponding to the round lucent area near the indented nucleus seen by light microscopy. The densely granulated and sparsely granulated GH cells may coexist within 1 adenoma (4 cases). Some adenomas may contain 2-3 kinds of secretory granules and are called multiple functional adenomas, in this series 18 had GH+PRL prolactin), 1 GH+ACTH and 1 GH+PRL+ACTH. Strong acidophilic cells correspond to densely granulated GH cells while weak acidophilic cells correspond to sparsely granulated GH cells. The number of strong or weak acidophilic cells and number of secretory granules are not directly proportional to the GH blood level. By electron microscopy GH, PRL and ACTH secretory granules have characteristic features which are not absolute. Correct diagnosis is based upon combining the clinical symptoms and signs, blood hormone levels and secretory granule morphology. Fibrous body diagnostic value and their genesis and development are dis- cussed.

Based on the survey data of 1,512 hospital staff members and 34 chronic hepatitis patients the author notes increased tumor and tumor-like hyperplasia in patients with chronic hepatitis. Traditionally, early surgery is often advised for benign tumors to prevent malignant changes, but a serious hunt for concomitant hepatitis is not made. Therefore, whenever we come across a case of tumor or tumor-like hyperplasia, we should bear in mind the possibility of coexisting chronic hepatitis. A detailed history and thorough physical examination with varied liver function tests should be made. Sometimes. even liver biopsy is needed. In this condition, we suggest using traditional Chinese medicine first, postponing consideration of surgery.

This paper deals with the parasitology, epidemiology, clinical manifestations, laboratory diagnosis, treatment, prevention and control of human infection with Macracanthorhychus hirudinaceus in China. The disease involves many provinces, and at times assuming epidemic proportions in certain areas. Obviously it is very much more prevalent than was previously known, especially in pigs. So far, this is the first finding occasioned by demonstrating both mature and immature eggs obtained through a fine needle from a mature female worm.

By fusing NS-1 mouse myeloma cells with spleen cells from immunized BALB/c mice with MEF 1 strain type 2 poliovirus, 7 hybridoma cell lines secreting type 2 poliovirus monoclonal antibodies are established in our laboratory. These hybrid cells possess many of their parents' properties as chromosome number and morphology producing cancer nodules by intraperitoneal injection and stable production of specific antibodies. The titer of neutralizing antibodies secreted by hybrid cell in vitro cultured is 1:80-5120 and of antibodies in BALB/c mice ascitic fluid 1:20480-327680. The monoclonal antibodies are strictly type-specific, some have different neutralizing activities to different strains of the same type poliovirus.

In 1978, we detected 20 cases of polyps with cancerous changes in mass screening for colorectal cancer in Haining county. The earliest stage cases did not fit Dukes' classification or the then extant Dukes' modified classification. We suggested a new modification of Dukes' classification (the Hangzhou classification) based upon anatomicopathologic changes in 165 cases (73 colon, 92 rectal) treated in our hospital and surviving more than 5 years postoperatively from 1961 to 1975. We combined the Hangzhou classification with the internationally adopted TNM classification.

Chromosome changes are studied in 21 cases of chronic benzene poisoning, both hypodiploid and hyperdiploid cells are significantly increased. Among the hypodiploid cells, deletion of Group C, E and G chromosomes is observed. Analysis of hyperdiploid cells reveals extra Group C and E chromosomes. The chromatid gaps and breaks are mostly found in poisoned cases, but fragments and minutes are less common. The chromosome abnormalities induced by chronic benzene intoxication may be considered further proof of benzene metabolite acting chiefly through changes in the nucleic acid metabolism.

The authors suggest that the critical lethal freezing temperature of monolayer cells is -40 C 3 minutes, but 3 of these freeze-thaw cycles are required for S-180 sarcoma suspension lethality.

From 1973 to 1981 50 cases of disseminated lung cancer were treated by direct liquid nitrogen freezing technic. All these patients were unsuitable for either radiation therapy or pulmonary resection. By using this technic half of them survive over 2 years. To further evaluate cryosurgery in these patients the authors suggest the following types of lung cancer be considered for trial cryosurgery: those with poor pulmonary or cardiac function or large tumor with cavitation, where pulmonary lobectomy or radio-therapy is contraindicated; those with unilateral or bilateral metastatic lung cancer with the primary tumor under control; when the tumor found during thoracotomy is too extensive for resection, cryosurgery can be used as a palliative measure or as adjuvant therapy; cryosurgery combined with anaerobic corynebacterium vaccine is more effective than cryosurgery alone in disseminated lung cancer with pleural effusion or multiple lesions.

10 cases of WPW syndrome are diagnosed by repeated episodes of tachycardia, electrocardiogram, vectocardiogram and electrophysiologic studies. Two are associated with other cardiac diseases (atrial septal defect in 1 and mitral stenosis in the other). Interruption of the anomalous conduction pathway between the atrium and ventricle is guided by epicardial mapping, anomalous conduction pathways are cut in 7 cases, injected with alcohol in 1 and both technics are used in 2. Good results are obtained in 8, there is persistent delta wave but symptom relief in 1 and recurrence of tachycardia in 2. One unsuccessful case was reoperated upon with good results.