中华心血管病杂志
2019年 · 第132卷第02期
出版日期 2019-01-20电子版 ￥0.00元
中华心血管病杂志
- 全部
- Original Article
- Clinical Guideline
- Review Article
- Correspondence
- Corrigendum
Original Article
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在一个中国结蛋白病家系中发现一种新的剪接突变表型Peng Fan, Chao-Xia Lu, Xue-Qi Dong, Di Zhu, Kun-Qi Yang, Ke-Qiang Liu, Di Zhang, Ying Zhang, Xu Meng, Hui-Qiong Tan 等
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000001
摘要
Background:
Desminopathy, a hereditary myofibrillar myopathy, mainly results from the desmin gene (DES) mutations. Desminopathy involves various phenotypes, mainly including different cardiomyopathies, skeletal myopathy, and arrhythmia. Combined with genotype, it helps us precisely diagnose and treat for desminopathy.
Methods:
Sanger sequencing was used to characterize DES variation, and then a minigene assay was used to verify the effect of splice-site mutation on pre-mRNA splicing. Phenotypes were analyzed based on clinical characteristics associated with desminopathy.
Results:
A splicing mutation (c.735+1G>T) in DES was detected in the proband. A minigene assay revealed skipping of the whole exon 3 and transcription of abnormal pre-mRNA lacking 32 codons. Another affected family member who carried the identical mutation, was identified with a novel phenotype of desminopathy, non-compaction of ventricular myocardium. There were 2 different phenotypes varied in cardiomyopathy and skeletal myopathy among the 2 patients, but no significant correlation between genotype and phenotype was identified.
Conclusions:
We reported a novel phenotype with a splicing mutation in DES, enlarging the spectrum of phenotype in desminopathy. Molecular studies of desminopathy should promote our understanding of its pathogenesis and provide a precise molecular diagnosis of this disorder, facilitating clinical prevention and treatment at an early stage.
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能量代谢酶异常表达与腹泻型肠易激综合征的密切关系Chun-Yan Zhang, Xin Yao, Gang Sun, Yun-Sheng Yang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000003
摘要
Background:
Irritable bowel syndrome (IBS) is one of the most common functional intestinal diseases, but its pathogenesis is still unknown. The present study aimed to screen the differentially expressed proteins in the mucosa of colon between IBS with diarrhea (IBS-D) patients and the healthy controls.
Methods:
Forty-two IBS-D patients meeting the Rome III diagnostic criteria and 40 control subjects from July 2007 to June 2009 in Chinese PLA General Hospital were enrolled in the present study. We examined the protein expression profiles in mucosa of colon corresponding to IBS-D patients (n= 5) and controls (n= 5) using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). Secondly, Western blot and immunohistochemical analysis were carried out to validate the screened proteins in 27 IBS-D patients and 27 controls. Thirdly, high-performance liquid chromatography (HPLC) was further carried out to determine ATP concentration in the mucosa of colon between 10 IBS-D patients and 8 controls. Comparisons between 2 groups were performed by Student’s t-test or Mann-Whitney U-test.
Results:
Twelve differentially expressed proteins were screened out. The α-enolase (ENOA) in the sigmoid colon (0.917 ± 0.007 vs. 1.310 ± 0.100, t= 2.643, P= 0.017) and caecum (0.765 ± 0.060 vs. 1.212 ± 0.122, t= 2.225, P= 0.023), Isobutyryl-CoA dehydrogenase (ACAD8) in the sigmoid colon (1.127 ± 0.201 vs. 1.497 ± 0.392, t= 7.093, P= 0.008) of the IBS-D group were significantly lower while acetyl-CoA acetyltransferase (CT) in the caecum (2.453 ± 0.422 vs. 0.931 ± 0.652, t= 8.363, P= 0.015) and ATP synthase subunit d (ATP5H) in the sigmoid (0.843 ± 0.042 vs. 0.631 ± 0.042, t= 8.613,P= 0.007) of the IBS-D group was significantly higher, compared with the controls. The ATP concentration in the mucosa of the sigmoid colon in IBS-D group was significantly lower than that of control group (0.470 [0.180, 1.360] vs. 5.350 [2.230, 7.900], U= 55, P < 0.001).
Conclusions:
Many proteins related to energy metabolism presented differential expression patterns in the mucosa of colon of the IBS-D patients. The abnormalities in energy metabolism may be involved in the pathogenesis of IBS which deserves more studies to elucidate.
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成骨不全患者大型队列的基因型-表型关系COL1A1新评分系统揭示的突变Lu-Jiao Li, Fang Lyu, Yu-Wen Song, Ou Wang, Yan Jiang, Wei-Bo Xia, Xiao-Ping Xing, Mei Li
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000013
摘要
Background:
Osteogenesis imperfecta (OI), a heritable bone fragility disorder, is mainly caused by mutations in COL1A1 gene encoding α1 chain of type I collagen. This study aimed to investigate the COL1A1 mutation spectrum and quantitatively assess the genotype-phenotype relationship in a large cohort of Chinese patients with OI.
Methods:
A total of 161 patients who were diagnosed as OI in Department of Endocrinology of Peking Union Medical College Hospital from January 2010 to December 2017 were included in the study. The COL1A1 mutation spectrum was identified by next generation sequencing and confirmed by Sanger sequencing. A new clinical scoring system was developed to quantitatively assess the clinical severity of OI and the genotype-phenotype relationship was analyzed. The independent sample t-test, analysis of variance, Mann-Whitney U-test, Chi-squared test, Pearson correlation, and multiple linear regression were applied for statistical analyses.
Results:
Among 161 patients with OI, 32.9% missense mutations, 16.8% non-sense mutations, 24.2% splice-site mutations, 24.8% frameshift mutations, and 1.2% whole-gene deletions were identified, of which 38 variations were novel. These mutations led to 53 patients carrying qualitative defects and 67 patients carrying quantitative defects in type I collagen. Compared to patients with quantitative mutations, patients with qualitative mutations had lower alkaline phosphatase level (296 [132, 346] U/L vs. 218 [136, 284] U/L, P= 0.009) and higher clinical score (12.2 ± 5.3 vs. 7.4 ± 2.4, P < 0.001), denoting more severe phenotypes including shorter stature, lower bone mineral density, higher fracture frequency, more bone deformity, vertebral compressive fractures, limited movement, and dentinogenesis imperfecta (DI). Patients would not present with DI if the glycine substitutions happened before the 79th amino acid in triple helix of α1 chains .
Conclusions:
This presented distinctive COL1A1 mutation spectrum in a large cohort of Chinese patients with OI. This new quantitative analysis of genotype-phenotype correlation would be helpful to predict the prognosis of OI and genetic counseling.
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妊娠期糖尿病：妊娠期体重增加及其与妊娠结局的关系Bao-Hua Gou, Hui-Min Guan, Yan-Xia Bi, Bing-Jie Ding
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000036
摘要
Background:
Weight gain during pregnancy reflects the mother’s nutritional status. However, it may be affected by nutritional therapy and exercise interventions used to control blood sugar in gestational diabetes mellitus (GDM). This study aimed to evaluate weight gain during gestation and pregnancy outcomes among women with GDM.
Methods:
A retrospective study involving 1523 women with GDM was conducted between July 2013 and July 2016. Demographic data, gestational weight gain (GWG), blood glucose, glycated-hemoglobin level, and maternal and fetal outcomes were extracted from medical records. Relationships between GWG and pregnancy outcomes were investigated using multivariate logistic regression.
Results:
In total, 451 (29.6%) women showed insufficient GWG and 484 (31.8%) showed excessive GWG. Excessive GWG was independently associated with macrosomia (adjusted odds ratio [aOR] 2.20, 95% confidence interval [CI] 1.50–3.52, P < 0.001), large for gestational age (aOR 2.06, 95% CI 1.44–2.93, P < 0.001), small for gestational age (aOR 0.49, 95% CI 0.25–0.97, P= 0.040), neonatal hypoglycemia (aOR 3.80, 95% CI 1.20–12.00, P= 0.023), preterm birth (aOR 0.45, 95% CI 0.21–0.96, P= 0.040), and cesarean delivery (aOR 1.45, 95% CI 1.13–1.87, P= 0.004). Insufficient GWG increased the incidence of preterm birth (aOR 3.53, 95% CI 1.96–6.37, P < 0.001).
Conclusions:
Both excessive and insufficient weight gain require attention in women with GDM. Nutritional therapy and exercise interventions to control blood glucose should also be used to control reasonable weight gain during pregnancy to decrease adverse pregnancy outcomes.
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DNMT3A/3B过表达可能与患者生存率低、高甲基化和低表达相关ESR1/PCR子宫内膜样癌：癌症基因组图谱分析Dan He, Xiao Wang, Yan Zhang, Jian Zhao, Rui Han, Ying Dong
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000054
摘要
Background:
DNA methylation is involved in numerous biologic events and associates with transcriptional gene silencing, playing an important role in the pathogenesis of endometrial cancer. ESR1/PGR frequently undergoes de novo methylation and loss expression in a wide variety of tumors, including breast, colon, lung, and brain tumors. However, the mechanisms underlying estrogen and progesterone receptors (ER/PR) loss in endometrial cancer have not been studied extensively. The aims of this study were to determine the expression of DNA (cytosine-5)-methyltransferase 3A/3B (DNMT3A/3B) in endometrial cancer to investigate whether the methylation catalyzed by DNMT3A/3B contributes to low ER/PR expression.
Methods:
The clinicopathologic information and RNA-Seq expression data of DNMT3A/3B of 544 endometrial cancers were derived from The Cancer Genome Atlas (TCGA) uterine cancer cohort in May 2018. RNA-Seq level of DNMT3A/3B was compared between these clinicopathologic factors with t-test or one-way analysis of variance.
Results:
DNMT3A/3B was overexpressed in endometrioid carcinoma (EEC) and was even higher in non-endometrioid carcinoma (NEEC) (DNMT3A, EEC vs. NEEC: 37.6% vs. 69.9%, t=－7.440, P < 0.001; DNMT3B, EEC vs. NEEC: 42.4% vs. 72.8 %, t= －6.897, P < 0.001). In EEC, DNMT3A overexpression was significantly correlated with the hypermethylation and low expression of the ESR1 and PGR (P < 0.05). The same trend was observed in the DNMT3B overexpression subgroup. In the ESR1/PGR low-expression subgroups, as much as 83.1% of ESR1 and 59.5% of PGR were hypermethylated, which was significantly greater than the ESR1/PGR high-expression subgroups (31.3% and 11.9%, respectively). However, the above phenomena were absent in NEEC, while DNMT3A/3B overexpression, ESR1/PGR hypermethylation, and low ER/PR expression occurred much more often. In univariate analysis, DNMT3A/3B overexpressions were significantly correlated with worse prognosis. In multivariate analysis, only DNMT3A was an independent predictor of disease-free survival (P < 0.05).
Conclusions:
DNMT3A/3B expression increases progressively from EEC to NEEC and is correlated with poor survival. The mechanisms underlying low ER/PR expression might be distinct in EEC vs. NEEC. In EEC, methylation related to DNMT3A/3B overexpression might play a major role in ER/PR downregulation.
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孤独感对健康科学专业学生创新行为影响的研究Fadime Çinar, Kerem Toker
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000031
摘要
Background:
Contributing to the innovative behavior of individuals in the health management process is a desirable condition for increased health institution performance. The relationship between the sense of loneliness and individual innovation behaviors has not been studied and relevant literature is extremely limited. The purpose of this research was to examine the effect of an individual’s sense of loneliness on their innovative behavior.
Methods:
The research was performed between January and October 2018. The effects of loneliness feelings on the individual innovative behaviors of 451 health science faculty students were measured. The data were collected using the "Individual Information Form," the "individual innovation scale," and the "University of California Los Angeles loneliness scale." The reliability and validity of the scales were tested with Structural Equation Modeling.
Results:
It was found that the female participants showed exhibited more innovative behavior than the men. However, there was no significant difference in the loneliness status of participants by gender. A group of 23-year-old individuals showed a significant difference in the risk taking dimension compared to other age groups. First-grade students had more points in the experimental openness and opinion leadership sub-dimension than the other classes. It was observed that the behavior is molded as the education level increases. The regression models showed that loneliness has a negative effect of －0.254 on experiential openness and the leadership of ideas, and has a negative effect of －0.216 on risk taking. There was no effect of the sub-dimensions of loneliness on change resistance. Moreover, on the individualistic behavior of physical loneliness, a －0.267 negative effect was observed. Emotional loneliness has no effect on the sub-dimensions of individual innovation. Finally, the total sense of loneliness was found to have a negative effect on total individual innovation.
Conclusions:
The study results clearly show that physical loneliness has a negative effect on individual innovation. It can be said that individuals living in social environments exhibit more innovative behaviors. However, emotional loneliness has no significant effect on innovative behavior. In this context, designing social spaces in health institutions will stimulate individuals’ innovative behaviors.
Clinical Guideline
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前庭偏头痛评估和治疗的多学科专家共识Stroke and Vertigo Association of Chinese Stroke Association
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000064
摘要
前庭偏头痛（VM）是一种具有熟悉易感性的常见疾病，其特征是反复发作的头晕或眩晕以及伴随的恶心、呕吐和/或头痛症状。VM患者可能需要神经、急诊或耳鼻喉科服务，并且该疾病经常被误诊为后循环缺血（PCI）或短暂性脑缺血发作（TIA）、周围性前庭眩晕、梅尼埃病（MD）和多发性（腔隙性）脑梗死。基于人群的研究报告显示，VM的患病率高达1%，[
Review Article
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His-Purkinje系统起搏的最新方法Li-Ting Cheng, Jun-Meng Zhang, Ze-Feng Wang, Hui-Kuan Gao, Yong-Quan Wu
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000038
摘要
Objective:
Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades. His bundle pacing (HBP) has been long considered the most physiologic pacing method; however, with the widespread implementation of this method, its disadvantages have become apparent. In this context, left bundle branch pacing (LBBP)—directly engaged in the His-Purkinje system—has been foreseen as the best pacing method to mimic physiologic activation patterns. This review aimed to summarize recent approaches to physiologic cardiac pacing.
Data sources:
This review included fully peer reviewed publications up to July 2018, found in the PubMed database using the keywords "His bundle branch pacing," "right ventricular pacing," and "physiologic pacing."
Study selection:
All selected articles were in English, with no restriction on study design.
Results:
The HBP has been studied worldwide, and is currently considered the most physiologic pacing method. However, it has disadvantages, such as high pacing threshold, unsatisfactory sensing and long procedure times, among others. Although LBBP is theoretically superior to HBP, the clinical relevance of this difference remains under debate, as few large randomized clinical trials with LBBP have been published.
Conclusions:
Although HBP indeed appears to be the most physiologic pacing method, it has certain shortcomings, such as high pacing threshold, difficult implantation due to specific anatomic features, and others. Further studies are required to clarify the clinical significance of LBBP.
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接受经皮冠状动脉介入治疗的急性冠状动脉综合征患者抗血小板治疗降级：一项叙述性综述Ya-Ling Han
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000047
摘要
Objective:
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary intervention (PCI). In current clinical situation, availability of different oral P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor) has enabled physicians to switch among therapies owing to specific clinical scenarios. Although optimum time, loading dose and interval of transition between P2Y12 inhibitors is still controversial and needs further evidence, switching between oral inhibitors frequently occurs in clinical practice for several reasons.
Data sources:
This review was based on data in articles published in PubMed up to June 2018, with the following keywords "antiplatelet therapy" , "ACS" , "PCI" , "ticagrelor" and "clopidogrel" .
Study selection:
Original articles and critical reviews on de-escalation strategy in ACS patients after PCI were selected. References of the retrieved articles were also screened to search for potentially relevant papers.
Results:
Safety concerns associated with switching between antiplatelet agents, has prompted the use of clopidogrel for patients with ACS especially after PCI as a de-escalation strategy. Practical considerations for de-escalating therapies in patients with ACS such as reducing dose of P2Y12 inhibitors or shortening duration of DAPT (followed by aspirin or P2Y12 receptor inhibitor monotherapy) as potential options are yet to be standardized and validated.
Conclusions:
Current review will provide an overview of the pharmacology of common P2Y12 inhibitors, definitions of deescalation and different de-escalating strategies and its outcomes, along with possible direction to be explored in de-escalation.
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唇撕裂的诊断与治疗Tiao Su, Guang-Xing Chen, Liu Yang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000020
摘要
Objective:
To review the literature regarding diagnosis and treatment of labral tear.
Data sources:
A systematic search was performed in PubMed using various search terms and their combinations including hip, labrum, acetabular labral tear, arthroscopy, diagnosis, and anatomy.
Study selection:
For each included study, information regarding anatomy, function, etiology, diagnosis, and management of acetabular labral tear was extracted.
Results:
Five hundred and sixty abstracts about anatomy, function, etiology, diagnosis, and management of acetabular labral tear were reviewed and 66 selected for full-text review. The mechanism of labral tear has been well explained while the long-term outcomes of various treatment remains unknown.
Conclusions:
Labral tear is generally secondary to femoroacetabular impingement, trauma, dysplasia, capsular laxity, and degeneration. Patients with labral tear complain about anterior hip or groin pain most commonly with a most consistent physical examination called positive anterior hip impingement test. Magnetic resonance arthrography is a reliable radiographic examination with arthroscopy being the gold standard. Conservative treatment consists of rest, non-steroidal anti-inflammatory medication, pain medications, modification of activities, physical therapy, and intra-articular injection. When fail to respond to conservative treatment, surgical treatment including labral debridement, labral repair, and labral reconstruction is often indicated.
Correspondence
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持续性左上腔静脉伴右上腔静脉异常引流、房间隔缺损和心房颤动1例Lei Li, Ke-Qiang Ji, Chun-Yuan You
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000044
摘要
致编辑：患者男，53岁，近日来我院就诊，近半月有心悸、头晕、呼吸困难、胸闷等病史。此外，患者自幼易活动性疲劳，有呼吸道感染易感史。体检后，检测到脉搏不规则和心脏杂音。肺动脉瓣听诊发现胸骨左侧、第一和第二肋骨之间的第二心音加重，3/6级收缩期杂音。基本的实验室检查并不显著。心电图（ECG）显示心房颤动（AF）。胸片显示轻度心脏增大。经胸超声心动图（TTE）提示房间隔缺损（ASD）由左向右分流；左心房、右心房和右心室扩张；中度三尖瓣反流；持续性左上腔静脉（PLSVC）导致轻度肺动脉高压和冠状窦明显扩张。考虑心脏计算机断层扫描（CT）以更好地描绘静脉异常并确定分流的位置。CT在Philips Brilliance 64层多层CT（MDCT）扫描仪上进行，证实了PLSVC的TTE发现[
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原发性肺淋巴上皮瘤样癌合并全反位Tao Zhu, Zhi-Hong Chen, Shuo Tang, Xian-Jun Yang, Shun Fang, Huo-Jin Deng
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000039
摘要
致编辑：根据世界卫生组织（WHO）肺肿瘤组织学分类，原发性肺淋巴上皮瘤样癌（LELC）属于其他未分类癌，被认为是肺癌变异的罕见亚型。[
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综合组织学评估和基因检测在同步多灶性肺腺癌中的应用及进一步的生存分析Fei Xiao, Zhen-Rong Zhang, Xiao-Wei Wang, De-Ruo Liu, Yong-Qing Guo, Bin Shi, Zhi-Yi Song, Chao-Yang Liang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000055
摘要
致编辑：多原发性肺腺癌（MPLAs）与转移瘤的鉴别对于正确的临床治疗和预后预测非常重要。自2003年以来，美国胸科医师学会（ACCP）提出的目前修订的MPLAs诊断标准一直被普遍应用。[
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腹膜透析患者血清碱性磷酸酶与死亡率相关性的年龄差异Juan Wu, Xin-Hui Liu, Rong Huang, Hai-Shan Wu, Qun-Ying Guo, Chun-Yan Yi, Xue-Qing Yu, Xiao Yang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000019
摘要
致编辑：血清碱性磷酸酶（ALP）是慢性肾脏病（CKD）患者的重要骨转换标志物，研究表明较高的血清ALP水平与血液透析（HD）患者的死亡率增加相关。[
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一例中国脂蛋白肾小球病患者载脂蛋白E新突变(p.Arg 150Cys)Ming Ku, Cai Tao, An-An Zhou, Yuan Cheng, Qi-Jun Wan
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000050
摘要
致编辑：脂蛋白肾小球病（LPG）是一种罕见的遗传性肾脏疾病，其特征是受累肾小球毛细血管腔中的脂蛋白血栓明显扩张、血浆载脂蛋白E（apoE）浓度高和蛋白尿。[
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同步原发性甲状旁腺功能亢进、甲状腺滤泡癌和甲状腺乳头状癌Dong-Jun Dai, Dan-Feng Peng, Ming-Gao Guo, Jun Yin, Yu-Qian Bao, Jian Zhou
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000018
摘要
致编辑：自1956年以来，偶尔有原发性甲状旁腺功能亢进（pHPT）和非髓样甲状腺癌（NMTC）共存的报道；[
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中国青少年活体供体纯三维腹腔镜左全肝切除术Jiu-Lin Song, Hong Wu, Jia-Yin Yang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000052
摘要
致编辑：活体供体肝移植（LDLT）扩大了尸体器官捐献率低的国家的供体库。一般来说，左侧同种异体肝移植对于儿童和青少年接受者是足够和安全的。[
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模仿盆腔肿块的创伤性脾切除术后15年道格拉斯窝脾Zhong Jia, Shi-Jie Li, Jia-Qing Huang
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000075
摘要
致编辑：一名49岁女性，因意外创伤接受脾切除术15年，在常规产科检查中表现为道格拉斯窝无症状小肿块。她随即住进浙江大学医学院附属杭州市第一人民医院接受进一步评估。腹部触诊和实验室检查未发现特殊发现。阴道超声显示，除子宫外，有几个大小不等的未连接肿块，范围从1厘米到4厘米。计算机断层扫描显示多发性软组织阴影，无增强[
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腺样囊性癌转移至甲状腺的多模式声像图特征是什么？Hai-Na Zhao, Bu-Yun Ma
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000033
摘要
致编辑：腺样囊性癌（ACC）是一种罕见的肿瘤，约占所有头颈部恶性肿瘤的1%。[
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一种类似乳腺癌的良性病变Yan Zhao, Wen-Chao Wang, Ting Lu
中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000041
摘要
致编辑：我们在此报告一例于2018年2月2日通过冰冻切片快速病理检查发现的乳腺病变。该病变在大体观察和组织学特征方面与乳腺癌非常相似。免疫组织化学和磷脂酰肌醇-3-激酶（PIK3CA）进行基因测序。详细报告了病变的临床病理特征。
Corrigendum
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勘误：气滞胃通颗粒治疗餐后窘迫综合征为主的功能性消化不良的随机、双盲、多中心、安慰剂对照试验中华医学杂志英文版2019年 132卷 02期
DOI: 10.1097/CM9.0000000000000091
摘要
在题为“气脂胃通颗粒对餐后窘迫综合征-为主的功能性消化不良的随机、双盲、多中心、安慰剂对照试验”的文章中，发表于第131卷第13期第1549-1556页中华医学杂志,[
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