2026年 · 第139卷第17期

Congenital heart disease (CHD) is the most prevalent cardiac anomaly in children and a leading cause of birth defect-related morbidity and mortality in China. Since the 1980s, minimally invasive interventional techniques have become a cornerstone of CHD management. Over the past decade, advances in materials and methodologies have led to significant updates in clinical indications, contraindications, and technical protocols. Therefore, the guideline was developed to standardize and promote interventional treatment for CHD in children.

Hyperuricemia (HUA) is a common chronic condition diagnosed when serum uric acid (SUA) exceeds 420 µmol/L (7.0 mg/dL) on two separate occasions. The prevalence of HUA in China has shown a marked upward trend, increasing from 11.1% in 2015–2016 to 14.0% in 2018–2019.^[1,2]Although established recommendations are available for urate-lowering therapy (ULT) in gout, substantial controversy remains regarding ULT strategies for high-risk hyperuricemia (HrHUA), especially HrHUA with nephrolithiasis, chronic kidney disease, cardiovascular disorders, and metabolic comorbidities.^[3,4,5]To address these challenges, the Chinese Rheumatology Association and the Committee for Rheumatologists and Immunologists of Chinese Primary Health Care Foundation convened national experts to develop this consensus. The consensus aimed to define HrHUA, optimize ULT strategies for this population, and provide evidence-based guidance for comorbidity-specific management.

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurrent abdominal pain and altered stool patterns, with diarrhea-predominant IBS (IBS-D) having the highest morbidity and increasing prevalence. The pathophysiological mechanisms of IBS-D remain unclear, hindering the development of effective treatments.^[1]Capsaicin, the active compound in chili peppers, acts as a transient receptor potential vanilloid 1 (TRPV1) agonist. Although capsaicin has shown various beneficial effects, its potential for treating IBS remains understudied. A recent study published inCellindicated that the absence of TRPV1 led to weight loss, colon shortening, and disruption of the gut barrier.^[2]This study suggests that capsaicin, a TRPV1 agonist, may have the potential to treat IBS. Therefore, we aimed to investigate the therapeutic effects of capsaicin on IBS mice.

To the Editor: In China, about 10.4% of patients with psoriasis (PsO) have concomitant psoriatic arthritis (PsA).^[1]In this population with PsA, polyarticular involvement is the most common feature, along with substantial disease severity and comorbidities,^[2]suggesting a significant unmet need in the optimal management of PsA in China.^[3]Biologics have considerably changed the treatment landscape for PsA by targeting multiple signaling pathways. Interleukin (IL)-17A antagonism is one such therapeutic approach that selectively targets the predominant pro-inflammatory cytokine of the T-helper 17 (Th17) cell subset.^[4]Secukinumab (AIN457) is a high-affinity fully human monoclonal antibody that neutralizes IL-17A activity and an approved therapeutic agent for PsO, PsA, and axial spondyloarthritis (axSpA) in more than 100 countries.^[5,6]Secukinumab has demonstrated a sustained long-term efficacy and a consistent safety profile in patients with PsA.^[7]In this work, we aimed to report the efficacy and safety of secukinumab versus placebo in Chinese participants with active PsA, intending to compare whether the clinical benefits in these participants are consistent with those observed in global studies (FUTURE 2, FUTURE 3, FUTURE 4, and FUTURE 5).^[8,9,10,11]

To the Editor: Clinical trials have confirmed the efficacy and safety of ustekinumab for treating Crohn’s disease (CD). The international guidelines of the European Crohn’s Colitis Organization also strongly recommend ustekinumab as a first-line biologic agent for treating moderate-to-severe CD.^[1]Ustekinumab was approved for treating moderate-to-severe CD in March 2020 in China.

To the Editor: Alcohol consumption is a critical public health challenge in China, impeding progress toward achieving both the Sustainable Development Goals and the Healthy China 2030 initiative.^[1]The Global Burden of Disease Study 2021 identifies alcohol as China’s 10th leading risk factor (6th for males) in terms of disability-adjusted life years and the primary cause of death among adolescents.^[2]Given that a substantial proportion of Chinese adolescents engage in alcohol consumption, investigating the risk factors underlying this behavior is essential. Using nationally representative data, this study examines how parental and peer behavior and perspectives influence adolescent drinking behaviors.

To the Editor: Primary hyperparathyroidism (PHPT), the third most frequent endocrine disorder in Western countries, is a metabolic bone disease caused by autonomous excessive parathyroid hormone (PTH). Classic symptoms include bone resorption, nephrolithiasis, and symptoms associated with hypercalcemia.

To the Editor: Tooth eruption is a physiological process essential for establishing proper occlusion. The gubernacular canal (GC), a bony tract connecting the dental follicle to the gingiva, has been recognized as a crucial anatomical pathway guiding eruptive movement. Previous studies have suggested that GC absence or structural disruption may be associated with eruption disturbances or tooth impaction, highlighting their potential importance.^[1]Despite this theoretical significance, the distribution and developmental characteristics of GCs under physiological conditions remain poorly understood. To address these, the present study analyzed erupting permanent premolars using cone-beam computed tomography (CBCT), described the dynamic detection patterns of GCs, and identified differences of detection rate between the maxilla and mandible, providing evidence for their facilitating role in tooth eruption.

To the Editor: Major depressive disorder (MDD) is a pervasive global public health challenge, affecting approximately 300 million people worldwide and representing the leading cause of disability globally.^[1]In addition to genetic factors, various lifestyle and environmental factors are strongly associated with MDD, including sleep status and physical activity (PA). Previous studies have reported a U-shaped association between sleep duration and depressive symptoms,^[2]whereas increasing evidence indicates that adequate PA is associated with a lower risk of MDD. However, despite their individual benefits, the interdependence between sleep duration and PA and their potential joint effects on MDD have been largely overlooked, limiting the translation of existing findings into clinical practice.

The article entitled "Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism" (Chin Med J 2019;132:948–956. doi: 10.1097/CM9.0000000000000162) by Li Hua, Ruan Wen-Jing, Liu Li-Qiao, Wan Hui-Fang, Yang Xiao-Hong, Zhu Wei-Feng, Yu Le-Han, Zhang Xia-Li, Wan Fu-Sheng^[1]has been retracted by the Publisher and the Editor on behalf of the authors. Following receipt of a notification letter from a reader, alerting the Editorial Office to the similarities between the results presented in Figure 6A in this article and the results in a previously published article by the authors,^[2]the Editors contacted the authors and their institution. The corresponding author requested to retract this article. After communication with the institution, the Editor decided to retract this article.