MedNexus
2024年 · 第137卷第21期
出版日期 2024-11-05电子版 ￥0.00元
MedNexus
- 全部
- Editorial
- Consensus Statement
- Review Article
- Medical Progress
- Viewpoint
- Original Article
- Clinical Observation
- Correspondence
- Corrigendum
Editorial
开放获取
急慢性肝功能衰竭定义和分类的新观点Manman Xu, Yu Chen
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003289
摘要
术语“急性慢性肝功能衰竭”（ACLF）最初是在近30年前提出的。[
Consensus Statement
开放获取
2019（2023）冠状病毒病患者肺部康复共识声明更新Wenqiao Wang, Ye Wang, Danye Li, Xinqi Ma, Tairan Dong, Qing Zhao, Hongmei Zhao, Chen Wang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003296
摘要
冠状病毒疾病2019（新冠肺炎）的全球爆发始于2019年底，并持续到2024年。[
Review Article
开放获取
在医疗人工智能中利用基金会和大语言模型Io Nam Wong, Olivia Monteiro, Daniel T. Baptista-Hon, Kai Wang, Wenyang Lu, Zhuo Sun, Sheng Nie, Yun Yin
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003302
摘要
Recent advancements in the field of medical artificial intelligence (AI) have led to the widespread adoption of foundational and large language models. This review paper explores their applications within medical AI, introducing a novel classification framework that categorizes them as disease-specific, general-domain, and multi-modal models. The paper also addresses key challenges such as data acquisition and augmentation, including issues related to data volume, annotation, multi-modal fusion, and privacy concerns. Additionally, it discusses the evaluation, validation, limitations, and regulation of medical AI models, emphasizing their transformative potential in healthcare. The importance of continuous improvement, data security, standardized evaluations, and collaborative approaches is highlighted to ensure the responsible and effective integration of AI into clinical applications.
开放获取
急性髓系白血病中的B7-H3：从预后生物标志物到免疫治疗靶点Xiao Tan, Xiangyu Zhao
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003099
摘要
B7-H3 (CD276), an immune checkpoint protein of the B7 family, exhibits significant upregulation in solid tumors and hematologic malignancies, exerting a crucial role in their pathophysiology. The distinct differential expression of B7-H3 between tumors and normal tissues and its multifaceted involvement in tumor pathogenesis position it as a promising therapeutic target for tumors. In the context of acute myeloid leukemia (AML), B7-H3 is prominently overexpressed and closely associated with unfavorable prognoses, yet it has remained understudied. Despite various ongoing clinical trials demonstrating the potential efficacy of immunotherapies targeting B7-H3, the precise underlying mechanisms responsible for B7-H3-mediated proliferation and immune evasion in AML remain enigmatic. In view of this, we comprehensively outline the current research progress concerning B7-H3 in AML, encompassing in-depth discussions on its structural attributes, receptor interactions, expression profiles, and biological significance in normal tissues and AML. Moreover, we delve into the protumor effects of B7-H3 in AML, examine the intricate mechanisms that underlie its function, and discuss the emerging application of B7-H3-targeted therapy in AML treatment. By juxtaposing B7-H3 with other molecules within the B7 family, this review emphasizes the distinctive advantages of B7-H3, not only as a valuable prognostic biomarker but also as a highly promising immunotherapeutic target in AML.
开放获取
RNF213烟雾病：基因型-表型关联及其潜在机制Jianxun Fang, Xinzhuang Yang, Jun Ni
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000002985
摘要
Moyamoya disease (MMD) is a cerebrovascular disorder characterized by a steno-occlusive internal carotid artery and compensatory vascular network formation. Although the precise pathogenic mechanism remains elusive, genetic association studies have identified RNF213 as the principal susceptibility gene for MMD, with the single nucleotide polymorphism p.R4810K recognized as the founder variant predominantly in the Asian populations. Distinct genotype-phenotype correlations are observable in RNF213-related MMD. The clinical manifestations linked to p.R4810K bear commonalities within Asian cohort, including familial predisposition, earlier age of onset, ischemic episodes, and involvement of the posterior cerebral artery (PCA). However, despite these shared phenotypic characteristics, there is significant heterogeneity in RNF213-related MMD presentations. This diversity manifests as variations across ethnic groups, inconsistent clinical symptoms and prognosis, and occurrence of other vasculopathies involving RNF213. This heterogeneity, in conjunction with the observed low disease penetrance of RNF213 mutations, suggests that the presence of these mutations may not be sufficient to cause MMD, underscoring the potential influence of other genetic or environmental factors. Although the current research might not have fully identified these additional contributors, experimental evidence points toward the involvement of RNF213 in angiogenesis, lipid metabolism, and the immune response. Future research is required to unveil the molecular mechanisms and identify the factors that synergize with RNF213 in the pathogenesis of MMD.
Medical Progress
开放获取
急性脑小血管病的分类、机制和治疗意义Yuying Yan, Yajun Cheng, Shuai Jiang, Mangmang Xu, Chen Ye, William Robert Kwapong, Wendan Tao, Shuting Zhang, Joanna M. Wardlaw, Ming Liu 等
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003304
摘要
脑小血管疾病（CSVD）是中风和痴呆的重要原因。CSVD导致高达30%的缺血性中风和80%的自发性脑实质内出血。[
Viewpoint
开放获取
感觉神经病学：一个新的神经病学亚专业和机遇Hongxing Wang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003305
摘要
感觉异常是临床神经病学中普遍存在的主诉，这是神经病学中一个重要但被忽视的领域。这个个体子集对临床诊断和治疗提出了实质性的挑战。因此，迫切需要关注感觉异常患者的临床诊断和治疗。
Original Article
开放获取
2022年全球甲状腺癌负担：GLOBOCAN的发病率和死亡率估计Zhangyan Lyu, Yu Zhang, Chao Sheng, Yubei Huang, Qiang Zhang, Kexin Chen
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003284
摘要
Background:
Thyroid cancer (TC) is the most common malignancy of the endocrine system. This study aimed to assess the global distribution of TC incidence and mortality in 2022, as well as to predict the burden for the year 2050.
Methods:
Data from the GLOBOCAN 2022 database were used to analyze the age-standardized incidence and mortality rates of TC by sex, age group (<55 years and ≥55 years), country, world region, and level of Human Development Index (HDI) for 185 countries. The predicted incidence and mortality burden for 2050 was calculated based on demographic projections.
Results:
In 2022, an estimated 821,214 new TC cases and 47,507 TC-related deaths occurred worldwide. The age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were higher in women (ASIR: 13.60 per 100,000; ASMR: 0.53 per 100,000) than in men (ASIR: 4.60 per 100,000; ASMR: 0.35 per 100,000). The ASIR in high HDI countries was approximately ten times higher than that in low HDI countries for both sexes, with relatively similar ASMR across regions. Among 185 countries, China had the largest number of TC cases (accounting for 56.77% of total cases) and TC-related deaths (accounting for 24.35% of global TC-related deaths), with the highest ASIR in men (13.30 per 100,000). Worldwide, approximately 64.63% of TC cases occurred in populations under 55 years old, while nearly 82.99% of TC-related deaths occurred in populations aged 55 years and above. If the rates stay the same as in 2022, it is projected that approximately 1,100,000 new TC cases and 91,000 TC-related deaths will occur in 2050, indicating a 34.15% and 89.58% increase, respectively.
Conclusions:
TC is a highly frequent cancer worldwide with disparities across regions, genders, and age groups. Our results provide light on the worldwide TC disease burden and facilitate regionally customized prevention measures.
开放获取
2022年全球肺癌负担和2050年预计负担Lanwei Guo, Chenxin Zhu, Lin Cai, Xinglong Zhang, Yi Fang, Hongda Chen, Haiyan Yang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003268
摘要
Background:
Lung cancer is the most common cancer and a leading cause of cancer-related deaths globally. The aim of this study was to evaluate the incidence and mortality of lung cancer worldwide in 2022 and to project the number of new cases and deaths due to lung cancer in China and the United States in 2050.
Methods:
In this study, data from the GLOBCAN 2022 database were used to analyze lung cancer incidence and mortality. The current status of lung cancer incidence and deaths was described by country/region, sex, age, and the human development index (HDI), and future lung cancer incidence and deaths in China and the United States were projected for 2050.
Results:
Globally, an estimated 2,480,675 new lung cancer cases and 1,817,469 lung cancer-related deaths occurred in 2022, with age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) of 23.6/100,000 and 16.8/100,000, respectively. In China, the ASIR and ASMR for male lung cancer patients were approximately 1.7 times and 2.7 times greater than those for female lung cancer patients, respectively. The ASIR and ASMR in high-HDI countries were approximately 8.5 times and 6.5 times those in low-HDI countries, respectively. It is estimated that in 2050, there will be approximately 1120 thousand new cases and 960 thousand deaths among Chinese men, 680 thousand new cases and 450 thousand deaths among Chinese women, approximately 170 thousand new cases and 110 thousand deaths among American men, and 160 thousand new cases and 90 thousand deaths among American women.
Conclusions:
There are significant differences in the incidence and mortality of lung cancer among different regions and sexes. Therefore, sex factors need to be considered in the prevention, screening, and treatment strategies of lung cancer, and the implementation of tertiary prevention measures for lung cancer, especially primary and secondary prevention, needs to be actively promoted.
开放获取
2010-2019年国家层面子宫肌瘤发病率和患病率及归因危险因素的全球和区域趋势：一项全球数据库研究Yuxin Dai, Hongda Chen, Jing Yu, Jie Cai, Bin Lu, Min Dai, Lan Zhu
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000002971
摘要
Background:
Uterine fibroids (UFs), the most common tumors in women worldwide, may reduce quality of life and daily activities and even lead to adverse fertility and general health events in patients, causing significant societal health and financial burdens. The objective of this study was to evaluate the global burden through epidemiological trends and examine the potential risk factors for UFs at the national level.
Methods:
Data on the incidence, prevalence, disability-adjusted life years (DALYs), age-standardized incidence rates (ASIRs), age-standardized prevalence rates (ASPRs), and age-standardized DALY rates for UFs were collected, and the associations with the Human Development Index (HDI) and fertility were evaluated. The age trends in the average annual percent change (AAPC) of the incidence and prevalence rates of UFs were evaluated by joinpoint regression analysis. The associations between lifestyle, metabolic, and socioeconomic factors and the ASIRs of UFs were examined using multivariable linear regression analysis.
Results:
The worldwide incidence and prevalence of UFs have been increasing in the past decade, with AAPCs of 0.27% in the incidence rate and 0.078% in the prevalence rate. During 2010-2019, significant increasing trends in UF ASIR were observed in 52 of 88 countries. The age-specific incidence and prevalence of UFs in most age groups showed increasing trends except for 45-54-year-old women which showed no significant trend. Ecological analysis demonstrated no relationship between the incidence of UFs and the HDI but an inverse association with fertility. The incidence of UFs was positively correlated with alcohol intake, hypertension, overweight, and obesity and negatively correlated with smoking.
Conclusion:
With the increasing incidence and prevalence worldwide, effective targeted prevention and control of relevant risk factors at the national level should be encouraged to reduce the disease burden of UFs.
开放获取
具有可控增殖和增强抗肿瘤功效的新型HER2-CAR单核细胞疗法的开发Bing Yang, Xiaoxue Wang, Xundong Wei, Jie Ma
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000002944
摘要
Background:
One of the significant challenges for cell therapies, such as chimeric antigen receptor (CAR)-T cell therapy, is the poor infiltration of immune cells into tumor tissues. CAR-monocytes/macrophages (CAR-M) are promising therapies because of their enrichment in the tumor microenvironment. Thus, we constructed a novel CAR-M to facilitate the infiltration of T cells and other immune cells.
Methods:
The suicide gene inducible caspase-9 (iCasp9) and anti-erb-b2 receptor tyrosine kinase 2 (HER2) CAR elements were transfected into THP1 (an immortalized human monocyte cell line) by lentivirus. The suicide efficiency and specific anti-tumor efficacy were assessed using flow cytometry, inCucyte, and tumor-bearing BALB/c-nude mouse models. The activation of related signaling pathways in CAR-THP1 activation was explored by transcriptome sequencing. Finally, the synergistic therapeutic efficacy of CAR-THP1 combined with RAK cell treatment was demonstrated in tumor-bearing NOD.CB17-Prkdcscid Il2rgtm1/Bcgen mouse models.
Results:
We developed a novel CAR-THP1, which incorporated iCasp9, CD3ζ, and CD147 intracellular segments, based on the first-generation HER2-CAR backbone. By constructing and comparing a series of CARs with different permutations, CAR-CD3ζ-CD147-iCasp9-THP1 was selected as the optimal combination. CAR-CD3ζ-CD147-iCasp9-THP1 initiated suicide quickly and efficiently under the control of iCasp9 gene, which enabled us to achieve controlled proliferation of CAR-THP1. CAR-THP1 also exhibited robust specific anti-tumor efficacy independently of T cells in vitro and in vivo. Through transcriptional sequencing, we found that CAR-THP1 tended to differentiate into the M1 phenotype and bridged innate and adaptive immunity. A combination of CAR-THP1 and Retronectin actived killer cells (RAKs) showed better therapeutic efficiency, as the metalloproteinases (MMPs) secreted by CAR-THP1 facilitated the degradation of the dense tumor matrix. This further assisted intratumoral infiltration of T cells and augmented the anti-tumor immune response.
Conclusion:
CAR-THP1 might be effective against HER2-positive tumor cells and has great potential for combination therapy with other immune cells.
开放获取
保护Ndrg2激活PINK1/Parkin介导的线粒体自噬对肾缺血再灌注损伤的影响Min Liu, Jianwen Chen, Miao Sun, Lixia Zhang, Yao Yu, Weidong Mi, Yulong Ma, Guyan Wang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000002957
摘要
Background:
Renal ischemia-reperfusion (R-I/R) injury is the most prevalent cause of acute kidney injury, with high mortality and poor prognosis. However, the underlying pathological mechanisms are not yet fully understood. Therefore, this study aimed to investigate the role of N-myc downstream-regulated gene 2 (Ndrg2) in R-I/R injury.
Methods:
We examined the expression of Ndrg2 in the kidney under normal physiological conditions and after R-I/R injury by immunofluorescence staining, real-time polymerase chain reaction, and western blotting. We then detected R-I/R injury in Ndrg2-deficient (Ndrg2-/-) mice and wild type (Ndrg2+/+) littermates in vivo, and detected oxygen and glucose deprivation and reperfusion (OGD-R) injury in HK-2 cells. We further conducted transcriptomic sequencing to investigate the role of Ndrg2 in R-I/R injury and detected levels of oxidative stress and mitochondrial damage by dihydroethidium staining, biochemical assays, and western blot. Finally, we measured the levels of mitophagy in Ndrg2+/+ and Ndrg2-/- mice after R-I/R injury or HK-2 cells in OGD-R injury.
Results:
Ndrg2 was primarily expressed in renal proximal tubules and its expression was significantly decreased 24 h after R-I/R injury. Ndrg2-/- mice exhibited significantly attenuated R-I/R injury compared to Ndrg2+/+ mice. Transcriptomics profiling showed that Ndrg2 deficiency induced perturbations of multiple signaling pathways, downregulated inflammatory responses and oxidative stress, and increased autophagy following R-I/R injury. Further studies revealed that Ndrg2 deficiency reduced oxidative stress and mitochondrial damage. Notably, Ndrg2 deficiency significantly activated phosphatase and tensin homologue on chromosome ten-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy. The downregulation of NDRG2 expression significantly increased cell viability after OGD-R injury, increased the expression of heme oxygenase-1, decreased the expression of nicotinamide adenine dinucleotide phosphate oxidase 4, and increased the expression of the PINK1/Parkin pathway.
Conclusion:
Ndrg2 deficiency might become a therapy target for R-I/R injury by decreasing oxidative stress, maintaining mitochondrial homeostasis, and activating PINK1/Parkin-mediated mitophagy.
Clinical Observation
开放获取
新辅助信迪利单抗和阿帕替尼联合围手术期FLOT化疗治疗局部晚期胃癌：一项前瞻性、单臂、II期研究Huinian Zhou, Bo Long, Zeyuan Yu, Junmin Zhu, Hanteng Yang, Changjiang Luo, Wenjuan Zhang, Chi Dong, Xiaoying Guan, Long Li 等
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003303
摘要
对于局部晚期胃癌（LAGC）患者，在新辅助期加入程序性细胞死亡蛋白1（PD-1）抑制剂可显著提高围手术期化疗的有效性。然而，很大比例的程序性死亡-配体1联合阳性评分（PD-L1 CPS）的患者<1或微卫星稳定（MSS）状态可能仍不会受益。抗血管生成剂阿帕替尼可以促进血管正常化，这由神经/胶质抗原2(NG2)标记的周细胞与血小板内皮细胞粘附分子(CD31)标记的内皮细胞的比率指示，[
开放获取
司库奇尤单抗在中国银屑病关节炎患者中的疗效和安全性：来自真实世界研究的证据Xiaohui Zhang, Yuan Chen, Yan Geng, Xuerong Deng, Zhuoli Zhang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003316
摘要
银屑病关节炎(PsA)是一种慢性全身性炎性疾病，影响外周和中轴关节、附着点、皮肤和指甲。它严重降低了生活质量和心理社会功能。尽管肿瘤坏死因子抑制剂（TNFi）显著改善了PsA的患者结局，但仍有显著的未满足需求。
Correspondence
开放获取
降级管理后学生新冠肺炎感染的流行病学调查及危险因素：一项横断面研究Durong Chen, Sitian Li, Yifei Ma, Shujun Xu, Ali Dong, Zhibin Xu, Jiantao Li, Lijian Lei, Lu He, Tong Wang 等
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003158
摘要
致编辑：在2019冠状病毒病（COVID-19）大流行期间，严重急性呼吸综合征冠状病毒2（新型冠状病毒）的奥密克戎变种在全球传播。专家一致认为，奥密克戎变异株致病性较低，潜伏期较短，更容易引起上呼吸道感染。经综合考虑，中国国家卫生健康委员会已于2022年12月26日将COVID-19的术语由“新型冠状病毒肺炎”更名为“新型冠状病毒感染”，并于2023年1月8日将管理由A级降为B级。[
开放获取
2010-2022年中国西部系统性轻链(AL)淀粉样变性患者临床特征、治疗和预后的变化：一项多中心、回顾性、真实世界研究Hongbin Yu, Lei Zhao, Jiawei Li, Chunlan Zhang, Qinyu Liu, Jie Zhou, Fang Xu, Jian Xiao, Ying Yuan, Siyu Yan 等
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003290
摘要
致编辑：全身性轻链(AL)淀粉样变性是一种罕见且致命的疾病，全世界每年每百万人中约有10人受到影响，其特征是由危险的浆细胞或B细胞克隆产生的错误折叠、聚集的免疫球蛋白轻链。由于非特异性症状，AL淀粉样变性的诊断经常面临障碍。由于对AL淀粉样变性的更深入了解和治疗进展，患者的总生存期（OS）在全球范围内显著改善。[
开放获取
免疫学特性探讨试剂盒/PDGFRA野生型胃肠道间质瘤及新抗原疫苗接种的潜在应用Yishan Li, Qin Wang, Lin Li, Shaohua Yuan, Hui Chen, Rutian Li, Fangcen Liu
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003294
摘要
致编辑：胃肠道间质瘤（GISTs）是胃肠道最常见的间叶肿瘤。胃肠道间质瘤多发生在40-60岁左右患者的胃或小肠，对化疗或放疗不敏感。分别约有10%和85%的成人和儿童胃肠道间质瘤患者不携带任何一种突变成套工具或者PDGFRA，从而定义为试剂盒/PDGFRA野生型。[
开放获取
肝细胞癌分子靶向药物临床应用中国专家共识（2022年版）Juxian Sun, Qiu Li, Xueli Bai, Jianqiang Cai, Yajin Chen, Minshan Chen, Chaoliu Dai, Chihua Fang, Weidong Jia, Xiangcheng Li 等
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003301
摘要
致编辑：原发性肝癌是我国最常见的恶性肿瘤之一。2020年，中国报告了410038例肝癌新发病例和391152例肝癌死亡病例，这使得肝癌成为中国第二大常见癌症相关死亡原因；在这些癌症中，肝细胞癌（HCC）占85-90%。[
开放获取
HIV感染者中针对奥密克戎XBB.1.5的中和抗体产生减少Jiaying Zhang, Jiming Yin, Wenjing Wang, Juanli Gao, Tongzeng Li, Danlei Mou, Lianchun Liang, Qinghua Meng, Yingmei Feng
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003139
摘要
致编辑：自2021年11月以来，奥密克戎的出现引起了全球的关注。在奥密克戎菌株中，奥密克戎XBB.1.5是最近发现的。它携带缺失和30多个突变，改变了严重急性呼吸综合征冠状病毒-2（新型冠状病毒）的生物学特征，以增强传播性和免疫逃逸能力。[
开放获取
基于全球疾病负担的1990-2019年中国黑色素瘤流行病学负担变化Qiong Tian, Li Hu, Ruimin Bai, Rui Ge, Jian Zhang
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003213
摘要
致编辑黑色素瘤是一种高度侵袭性的恶性肿瘤，其发病率与社会发展水平有关，发达国家的发病率高于发展中国家。[
开放获取
可降解支架治疗食管狭窄的现状及未来趋势Huan Jiang, Liansong Ye, Yuhang Zhang, Cenqin Liu, Liuxiang Chen, Yuan Gao, Jiachen Yang, Bing Hu
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003300
摘要
致编辑：食管狭窄可以是良性的，也可以是恶性的。良性狭窄通常由食管反流、放射治疗、腐蚀性摄入或早期食管肿瘤内镜粘膜下剥离（ESD）或内镜粘膜切除术后的手术吻合引起。恶性狭窄是由晚期癌症引起的。食管狭窄常导致吞咽困难、营养不良、误吸和呼吸衰竭，使保守治疗具有挑战性。支架植入是缓解吞咽困难、控制狭窄相关并发症和改善患者生活质量的主要选择。
开放获取
心包交感神经副神经节瘤伴副神经节瘤综合征3：多模态影像学表现Shuting Zhang, Entao Liu, Shuiqing Lai, Jian Kuang, Haixia Guan
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003315
摘要
致编辑：心包交感神经副神经节瘤少见，可危及生命。它表现为症状，如难治性高血压、心悸和其他激素相关的表现。本研究介绍了一例起源于纵隔的3型副神经节瘤的独特病例，伴有多模态影像学表现，包括计算机断层扫描(CT)扫描，18F-氟脱氧葡萄糖正电子发射断层扫描/CT（18F-FDG PET/CT），68Ga-DOTA-1-Nal3-奥曲肽正电子发射断层扫描/CT（68Ga-DOTANOC PET/CT)，以及18F-氟二羟基苯丙氨酸正电子发射断层扫描/CT（18F-FDOPA PET/CT)。
开放获取
DcR 3抑制痛风炎症中NF-κ B通路和NLRP 3炎症小体激活Yi Jiang, Xin Tu, Jianwei Guo, Jianxiong Zheng, Xia Liao, Yixi He, Yan Xie, Quanbo Zhang, Yufeng Qing
中华医学杂志英文版2024年 137卷 21期
DOI: 10.1097/CM9.0000000000003274
摘要
致编辑：痛风性关节炎是一种自身炎症性疾病，表现出快速发作的临床症状，但通常在7-10天内自发消退。在急性痛风炎症反应中，尿酸单钠（MSU）晶体被巨噬细胞膜上的Toll样受体（TLRs）识别为损伤相关的分子模式。随后，TLR-NF-κ-B抑制剂α（I κ B α）/核因子κ B（NF-κ B）途径被激活，产生许多炎症因子、中性粒细胞趋化因子和组织蛋白酶并参与核苷酸结合寡聚化结构域受体蛋白3（NLRP3）炎症小体的组装。[
Corrigendum
开放获取
勘误表：黄连素可能通过抑制B细胞功能的调节来阻断结直肠癌的发生小韦荣氏菌中华医学杂志英文版2024年 137卷 21期
DOI: 10.3760/cma.j.issn.0366-6999.2024.21.101
摘要
作者声明，在第136卷第22期发表的文章中中华医学杂志,[
本期目次
下载本期封面 下载本期目录
