MedNexus
2024年 · 第137卷第09期
出版日期 2024-05-05电子版 ￥0.00元
MedNexus
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- Editorial
- Consensus Statement
- Review Article
- Meta Analysis
- Original Article
- Correspondence
- Corrigendum
Editorial
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中国炎症性肠病的流行病学研究、负担和临床进展Hong Yang, Jiaming Qian
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003064
摘要
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），是一种慢性、进行性疾病，严重程度波动，涉及复发和缓解的反复期。它已经成为一个全球公共卫生挑战。传统上，IBD主要在西方国家发现，北美和欧洲表现出最高的患病率和发病率。具体而言，UC的患病率和发病率分别为505/100,000和249/100,000，而CD的患病率和发病率分别为322/100,000和319/100,000。[
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经导管主动脉瓣置换术：二十年及以后的历程Tianyuan Xiong, Mao Chen
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003082
摘要
根据2019年全球疾病负担估计，钙化性主动脉瓣狭窄（AS）患者人数为940万，随着人口老龄化，这一数字将继续增加。[
Consensus Statement
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具有致癌驱动突变的晚期非小细胞肺癌免疫治疗中国专家共识（2023年版）The Society of Cancer Precision Medicine of Chinese Anti-Cancer Association, The Lung Cancer Expert Group of Chinese Medical Association Publishing House
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003055
摘要
具有致癌驱动突变的非小细胞肺癌（NSCLC）此前被认为是免疫治疗的“禁区”。[
Review Article
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针对非小细胞肺癌肝转移微环境的治疗进展Lingling Zhu, Xianzhe Yu, Xiaojun Tang, Chenggong Hu, Lei Wu, Yanyang Liu, Qinghua Zhou
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002981
摘要
Liver metastases (LMs) are common in lung cancer. Despite substantial advances in diagnosis and treatment, the survival rate of patients with LM remains low as the immune-suppressive microenvironment of the liver allows tumor cells to evade the immune system. The impact of LMs on the outcomes of immune checkpoint inhibitors in patients with solid tumors has been the main focus of recent translational and clinical research. Growing evidence indicates that the hepatic microenvironment delivers paracrine and autocrine signals from non-parenchymal and parenchymal cells. Overall, these microenvironments create pre- and post-metastatic conditions for the progression of LMs. Herein, we reviewed the epidemiology, physiology, pathology and immunology, of LMs associated with non-small cell lung cancer and the role and potential targets of the liver microenvironment in LM in each phase of metastasis. Additionally, we reviewed the current treatment strategies and challenges that should be overcome in preclinical and clinical investigations. These approaches target liver elements as the basis for future clinical trials, including combinatorial interventions reported to resolve hepatic immune suppression, such as immunotherapy plus chemotherapy, immunotherapy plus radiotherapy, immunotherapy plus anti-angiogenesis therapy, and surgical resection.
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内部m6A和m7造血系统G RNA修饰与急性髓系白血病Xiaoxu Zhang, Yanni Ma, Jia Yu, Rui Su, Xiaoshuang Wang
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003073
摘要
Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene expression. The past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications, as prompted by the emergence of potent analytical approaches. The hematopoietic system provides a lifelong supply of blood cells, and gene expression is tightly controlled during the differentiation of hematopoietic stem cells (HSCs). The dysregulation of gene expression during hematopoiesis may lead to severe disorders, including acute myeloid leukemia (AML). Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis, which has led to the development of small-molecule inhibitors that target N6-methyladenosine (m6A) modification machinery as treatments. Here, we summarize the latest findings and our most up-to-date information on the roles of m6A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic system. Furthermore, we will discuss the therapeutic potential and limitations of cancer treatments targeting m6A.
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线粒体功能障碍在肾脏疾病中的作用：来自cGAS-STING信号通路的见解Lu Li, Fei Liu, Chunyue Feng, Zhenjie Chen, Nan Zhang, Jianhua Mao
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003022
摘要
Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease. However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive. The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in many renal diseases. One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway. Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases. Furthermore, we summarize the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases. This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction.
Meta Analysis
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糖代谢异常患者黄斑厚度和血管密度降低：光学相干断层扫描（OCT）和OCT血管造影研究的荟萃分析Xiangyu Fu, Xiang Ren, Wenyue Chen, Danian Chen
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003052
摘要
Background:
Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy (DR) remain inconclusive. This study aimed to determine whether retinal manifestations in abnormal glucose metabolism (AGM) patients differ from those in the healthy individuals.
Methods:
PubMed, Embase, and Web of Science were searched between 2000 and 2021. The eligibility criteria were AGM patients without DR. Primary and secondary outcomes measured by optical coherence tomography (OCT) and OCT angiography (OCTA) were analyzed and expressed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A random-effects model was used in the data synthesis. The potential publication bias for the variables was evaluated using Egger’s test.
Results:
A total of 86 observational studies involving 13,773 participants and 15,416 eyes were included. OCT revealed that compared to healthy controls, the total macular thickness of AGM patients was thinner, including the thickness of fovea (–0.24, 95% CI [–0.39, –0.08]; P = 0.002, I2 = 87.7%), all regions of parafovea (–0.32, 95% CI [–0.54, –0.11]; P = 0.003; I2 = 71.7%) and the four quadrants of perifovea; the thickness of peripapillary retinal nerve fiber layer (pRNFL), macular retinal nerve fiber layer (mRNFL), and ganglion cell layer (GCL) also decreased. OCTA indicated that the superficial and deep vascular density decreased, the foveal avascular zone (FAZ) area enlarged, and the acircularity index (AI) reduced in AGM individuals.
Conclusions:
Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR; OCT and OCTA may have the potential to detect these preclinical changes.
Registration:
PROSPERO; http://www.crd.york.ac.uk/prospero/; No. CRD42021269885.
Original Article
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使用一系列健康相关生活质量评估识别长期不良预后高风险的冠状动脉旁路移植术患者Juncheng Wang, Hanning Liu, Chao Yue, Limeng Yang, Kai Yang, Yan Zhao, Huan Ren, Ying Zhang, Zhe Zheng
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002806
摘要
Background:
Patients who undergo coronary artery bypass grafting (CABG) are known to be at a significant risk of experiencing long-term adverse events, emphasizing the importance of regular assessments. Evaluating health-related quality of life (HRQoL) serves as a direct method to gauge prognosis. Our objective is to ascertain the prognostic significance of consecutive HRQoL assessments using the Physical Component Summary (PCS) and Mental Component Summary (MCS) derived from the Short-Form 36 (SF-36) health survey in CABG patients.
Methods:
The study population consisted of 433 patients who underwent isolated elective CABG at Fuwai Hospital between 2012 and 2013. SF-36 assessments were conducted during both the hospitalization period and follow-up. The primary endpoint of the study was all-cause mortality, while the secondary outcome was a composite measure including death, myocardial infarction, stroke, and repeat revascularization. We assessed the relationships between the PCS and MCS at baseline, as well as their changes during the first 6 months after the surgery (referred to as ΔPCS and ΔMCS, respectively), and the observed outcomes.
Results:
The patients were followed for an average of 6.28 years, during which 35 individuals (35/433, 8.1%) died. After adjusting for clinical variables, it was observed that baseline MCS scores (hazard ratio [HR] for a 1-standard deviation [SD] decrease, 1.57; 95% confidence interval [CI], 1.07–2.30) and ΔMCS (HR for a 1-SD decrease, 1.67; 95% CI, 1.09–2.56) were associated with all-cause mortality. However, baseline PCS scores and ΔPCS did not exhibit a significant relationship with all-cause mortality. Notably, there was a dose-response relationship observed between ΔMCS and the likelihood of all-cause mortality (HRs for the 2nd, 3rd and 4th quartiles compared to the 1st quartile, 0.33, 0.45 and 0.11, respectively).
Conclusions:
Baseline MCS and changes in MCS were independent predictors for long-term mortality of CABG. Better mental health status and recovery indicated better prognosis.
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强化血压控制对老年高血压患者动脉僵硬度的影响Shuyuan Zhang, Yixuan Zhong, Shouling Wu, Hailei Wu, Jun Cai, Weili Zhang
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002868
摘要
Background:
Arterial stiffening increases with age and blood pressure and is associated with cardiovascular disease (CVD), but the relationship between blood pressure lowering and arterial stiffening is still uncertain, especially in older people. This study aimed to evaluate the effect of intensive blood pressure treatment on the progression of arterial stiffness and risk of CVD in older patients with hypertension.
Methods:
The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial was a multicenter, randomized, controlled trial performed at 42 clinical centers throughout China, and 8511 patients aged 60–80 years with essential hypertension were enrolled and randomly assigned to systolic blood pressure (SBP) target of 110 mmHg to <130 mmHg (intensive treatment) or 130 mmHg to <150 mmHg (standard treatment). Patients underwent repeated examinations of the brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) at baseline, and the arterial stiffness was evaluated at the 3-year follow-up. A total of 5339 patients who had twice repeated measurements were included in this study. Changes in arterial stiffness between the intensive and standard treatment groups were analyzed using a multivariate linear regression model. The Cox proportional hazard regression model was used to evaluate the effect of intensive treatment on primary CVD outcomes.
Results:
The changes in baPWV were 61.5 cm/s (95% confidence interval [CI]: 49.8–73.2 cm/s) in the intensive treatment group and 98.4 cm/s (95% CI: 86.7–110.1 cm/s) in the standard treatment group (P <0.001). Intensive treatment significantly delayed the progression of arterial stiffness, with an annual change of 23.1 cm·s–1·year–1 vs. 36.7 cm·s–1·year-1 of baPWV in the intensive and standard treatment groups, respectively. During a median follow-up period of 3.36 years, primary CVD outcomes occurred in 77 (2.9%) patients in the intensive treatment group compared with 93 (3.5%) in the standard treatment group. Intensive treatment resulted in a significantly lower CVD risk in patients aged 70–80 years or with SBP <140 mmHg.
Conclusion:
Intensive blood pressure control with an SBP target of 110 mmHg to <130 mmHg could delay the progression of arterial stiffness and reduce the risk of CVD in older patients with hypertension.
Clinical trial registration:
http://www.clinicaltrials.gov; No. NCT03015311.
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功能性胃肠疾病、精神健康、遗传易感性和慢性肾病发病率Mengyi Liu, Panpan He, Ziliang Ye, Sisi Yang, Yanjun Zhang, Qimeng Wu, Chun Zhou, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002805
摘要
Background:
Whether functional gastrointestinal disorders (FGIDs) are associated with the long-term risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the association.
Methods:
About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were included. Participants with FGIDs (including irritable bowel syndrome [IBS], dyspepsia, and other functional intestinal disorders [FIDs; mainly composed of constipation]) were the exposure group, and non-FGID participants were the non-exposure group. The primary outcome was incident CKD, ascertained from hospital admission and death registry records. A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD, and the mediation analysis was performed to investigate the mediation proportions of mental health.
Results:
At baseline, 33,156 (8.0%) participants were diagnosed with FGIDs, including 21,060 (5.1%), 8262 (2.0%), and 6437 (1.6%) cases of IBS, dyspepsia, and other FIDs, respectively. During a mean follow-up period of 12.1 years, 11,001 (2.6%) participants developed CKD. FGIDs were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.28–1.44). Similar results were observed for IBS (HR, 1.27; 95% CI, 1.17–1.38), dyspepsia (HR, 1.30; 95% CI, 1.17–1.44), and other FIDs (HR, 1.60; 95% CI, 1.43–1.79). Mediation analyses suggested that the mental health score significantly mediated 9.05% of the association of FGIDs with incident CKD and 5.63–13.97% of the associations of FGID subtypes with CKD. Specifically, the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of CKD.
Conclusion:
Participants with FGIDs had a higher risk of incident CKD, which was partly explained by mental health scores and was more pronounced in those with high genetic susceptibility to CKD.
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鉴别尿酸铵结石与尿酸结石的放射组学模型的建立体内：双能计算机断层扫描诊断陷阱的补救措施Junjiong Zheng, Jie Zhang, Jinhua Cai, Yuhui Yao, Sihong Lu, Zhuo Wu, Zhaoxi Cai, Aierken Tuerxun, Jesur Batur, Jian Huang 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002866
摘要
Background:
Dual-energy computed tomography (DECT) is purported to accurately distinguish uric acid stones from non-uric acid stones. However, whether DECT can accurately discriminate ammonium urate stones from uric acid stones remains unknown. Therefore, we aimed to explore whether they can be accurately identified by DECT and to develop a radiomics model to assist in distinguishing them.
Methods:
This research included two steps. For the first purpose to evaluate the accuracy of DECT in the diagnosis of uric acid stones, 178 urolithiasis patients who underwent preoperative DECT between September 2016 and December 2019 were enrolled. For model construction, 93, 40, and 109 eligible urolithiasis patients treated between February 2013 and October 2022 were assigned to the training, internal validation, and external validation sets, respectively. Radiomics features were extracted from non-contrast CT images, and the least absolute shrinkage and selection operator (LASSO) algorithm was used to develop a radiomics signature. Then, a radiomics model incorporating the radiomics signature and clinical predictors was constructed. The performance of the model (discrimination, calibration, and clinical usefulness) was evaluated.
Results:
When patients with ammonium urate stones were included in the analysis, the accuracy of DECT in the diagnosis of uric acid stones was significantly decreased. Sixty-two percent of ammonium urate stones were mistakenly diagnosed as uric acid stones by DECT. A radiomics model incorporating the radiomics signature, urine pH value, and urine white blood cell count was constructed. The model achieved good calibration and discrimination {area under the receiver operating characteristic curve (AUC; 95% confidence interval [CI]), 0.944 (0.899–0.989)}, which was internally and externally validated with AUCs of 0.895 (95% CI, 0.796–0.995) and 0.870 (95% CI, 0.769–0.972), respectively. Decision curve analysis revealed the clinical usefulness of the model.
Conclusions:
DECT cannot accurately differentiate ammonium urate stones from uric acid stones. Our proposed radiomics model can serve as a complementary diagnostic tool for distinguishing them in vivo.
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的影响COL1A1和SYTL2胸主动脉瘤血管壁炎细胞浸润和细胞外基质不良重塑的研究Xinsheng Xie, Ye Yuan, Yulong Huang, Xiang Hong, Shichai Hong, Gang Chen, Yihui Chen, Yue Lin, Weifeng Lu, Weiguo Fu 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002808
摘要
Background:
Thoracic aortic aneurysm (TAA) is a fatal cardiovascular disease, the pathogenesis of which has not yet been clarified. This study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this disease.
Methods:
Gene expression profiles of the GSE9106, GSE26155, and GSE155468 datasets were acquired from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the "limma" package in R. Least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), random forest, and binary logistic regression analyses were used to screen the diagnostic marker genes. Single-sample gene set enrichment analysis (ssGSEA) was used to estimate immune cell infiltration in TAA.
Results:
A total of 16 DEGs were identified. The enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related diseases. Collagen type I alpha 1 chain (COL1A1) and synaptotagmin like 2 (SYTL2) were identified as diagnostic marker genes with a high diagnostic value for TAA. The expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues, and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall tissues. Additionally, COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall tissue. Single-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation (CD)8+ T cells. In addition, single-cell analysis indicated that fibroblasts and CD8+ T cells in TAA were significantly higher than those in normal arterial wall tissue.
Conclusions:
COL1A1 and SYTL2 may serve as diagnostic marker genes for TAA. The upregulation of SYTL2 and COL1A1 may be involved in the inflammatory infiltration of the vessel wall and poor extracellular matrix remodeling, promoting the progression of TAA.
Correspondence
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地西他滨联合伊达比星在改良白消安/环磷酰胺调理方案中治疗晚期骨髓增生异常综合征：一项前瞻性多中心临床队列研究Yigeng Cao, Mingyang Wang, Fuxu Wang, Wenwen Guo, Yueshen Ma, Xiaoyun Li, Yi He, Aiming Pang, Rongli Zhang, Weihua Zhai 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002963
摘要
致编辑：异基因造血干细胞移植（allo-HSCT）是骨髓增生异常综合征（MDS）和MDS/骨髓增生性肿瘤（MPN）患者唯一的长期生存治疗选择。不幸的是，造血干细胞移植(HSCT)后复发仍然是治疗失败的原因，挽救治疗的结果很差。迫切需要开发更好的调理方案。先前的研究显示地西他滨（DEC）和伊达比星（IDA）之间具有协同抗白血病作用。[
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肺栓塞患者无症状复发Song Hu, Lei Wang, Jiangshan Tan, Wei Fang, Xinghong Ma, Tingting Guo, Xin Gao, Yan Wu, Yuzi Zhou, Li Wang 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003047
摘要
致编辑：肺栓塞（PE）是继中风和心脏病发作之后全球心血管相关死亡的第三大常见原因。由于血流动力学差异，PE患者表现出广泛的临床表现，从无症状到危及生命的情况。PE患者的复发率很高，尽管大多数患者在疾病的初始阶段后存活，但复发的风险贯穿一生。与首次PE发作的患者相似，复发性PE患者可能无症状。迄今为止，我们关于复发性PE的大部分知识来自临床试验或注册研究，其中有症状复发是主要终点，而无症状复发很少报道。此外，目前的指南建议治疗无症状PE患者与有症状PE患者相似，[
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不同程度冠状动脉狭窄患者口腔和肠道微生物群失调及其与代谢物的关系Zekun Wang, Long Li, Chenyang Wang, Qian Wang, Fengzhi Wang, Xin Xu, Xuedong Zhou
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002943
摘要
致编辑：冠状动脉粥样硬化性心脏病（CAD）源于冠状动脉粥样硬化（CAS）斑块堆积，导致冠状动脉狭窄（CS）和闭塞，最终引起心肌缺血、缺氧或坏死。研究表明，高级别CS可能是随后几个月ST段抬高心肌梗死的重要预测因素。[
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西部地区2648例颌骨囊肿临床病理特征、治疗及预后的流行病学分析Hui Li, Zuoqiang Liu, Linli Jiang, Jiangyu Liang, Lei Liu
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003054
摘要
致编辑：颌骨囊肿是口腔颌面部最常见的良性肿瘤之一。[
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主观认知下降域提高血浆A β的准确性42/A β40临床前阿尔茨海默病诊断：SILCODE研究Mingkai Zhang, Xiaoni Wang, Weina Zhao, Yuxia Li, Chao Ying, Jiehui Jiang, Yanning Cai, Jie Lu, Ying Han
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000002851
摘要
致编辑：越来越多的证据表明，阿尔茨海默病（AD）的临床前阶段（即无症状淀粉样变性）在认知症状出现前持续数十年，为早期干预提供了很大的窗口期。淀粉样蛋白病理学，与AD相关的最早病理变化，可以被检测到体内具有脑脊液（CSF）分析或正电子发射断层扫描（PET），其存在对于临床前AD（pre-AD）的诊断是必要的。然而，PET扫描和CSF分析都很昂贵，阻碍了它们在大规模筛查中的应用。因此，基于血液的生物标志物是理想的替代方案，因为它们具有成本效益并且是非侵入性的。血浆β-淀粉样蛋白(A β)生物标志物，特别是A β42/A β40比率，是合理的基于血液的候选者，因为最近的研究表明A β降低42/A β40沿AD连续体的比率。[
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电子健康记录用于真实世界研究的数据适当性的初步评估：对中国一个发展中地区医院的调查Yuelin Yu, Lin Zhuo, Ruogu Meng, Wanqian Guo, Yuanyuan Chen, Yunjing Zhang, Ying Chen, Hongjing Shi, Zhi Lin, Siyan Zhan 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003053
摘要
致编辑：数据适当性评估是一个回答来自常规医疗实践的电子健康记录（EHR）是否符合预期研究目的的过程，例如，可用于进行，具有足够的个人记录，能够从记录中提取相关信息等。[
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过敏性支气管肺曲霉病拟议诊断标准的验证Runjin Cai, Yifei Yang, Huan Ge, Xuemei Chen, Xinyue Hu, Yuanyuan Jiang, Lisha Luo, Shuanglinzi Deng, Jiale Tang, Chendong Wu 等
中华医学杂志英文版2024年 137卷 09期
DOI: 10.1097/CM9.0000000000003058
摘要
致编辑：过敏性支气管肺曲霉病(ABPA)是一种由对抗原过敏引起的过敏性肺病曲霉属，最常见于哮喘或囊性纤维化患者。[
Corrigendum
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勘误表：2022年中国国家临床实践指南幽门螺杆菌根除治疗中华医学杂志英文版2024年 137卷 09期
DOI: 10.3760/cma.j.issn.0366-6999.2024.09.101
摘要
作者声明，在文章中[
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