MedNexus
2024年 · 第137卷第03期
出版日期 2024-02-05电子版 ￥0.00元
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Editorial
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介绍香港医学杂志及其在及时传播新冠肺炎相关知识方面的重要作用Rashid N Lui, Kenneth KW Li, Martin CS Wong
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000003003
摘要
香港医学杂志（HKMJ）是中国香港特别行政区的旗舰全科医学期刊，具有国际视野。我们致力于发表和推广高质量的研究。我们的编辑委员会在总编辑黄志光教授的带领下，很高兴能与中华医学杂志（CMJ），以及CMJ的编辑，以提高我们各自期刊的知名度，并营造一个合作环境，为我们的读者带来想法和知识。
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超微创经口胆道镜鉴别诊断不确定型胆道狭窄的新标准Wengang Zhang, Ningli Chai, Qingzhen Wu, Enqiang Linghu
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002827
摘要
不确定胆道狭窄(IBS)是指组织学诊断不确定的胆道狭窄[
Review Article
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主动脉夹层的生物标志物：临床研究的诊断和预后价值Yufei Zhao, Weiguo Fu, Lixin Wang
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002719
摘要
Aortic dissection is a life-threatening condition for which diagnosis mainly relies on imaging examinations, while reliable biomarkers to detect or monitor are still under investigation. Recent advances in technologies provide an unprecedented opportunity to yield the identification of clinically valuable biomarkers, including proteins, ribonucleic acids (RNAs), and deoxyribonucleic acids (DNAs), for early detection of pathological changes in susceptible patients, rapid diagnosis at the bedside after onset, and a superior therapeutic regimen primarily within the concept of personalized and tailored endovascular therapy for aortic dissection.
Viewpoint
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慢性肾脏病患者的血压目标：评论与争议Ying Zheng, Guangyan Cai, Xiangmei Chen
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002892
摘要
根据2017年全球疾病负担研究，中国有1.32亿慢性肾脏病（CKD）患者，[
Original Article
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1990-2019年中美哮喘死亡率长期趋势Xiaochen Li, Mingzhou Guo, Yang Niu, Min Xie, Xiansheng Liu
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002855
摘要
Background:
Asthma imposes a large healthcare burden in China and the United States (US). However, the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the countries. The aim of this study was to compare the mortality and risk factors between China and the US.
Methods:
The deaths, and mortality rates of asthma in China and the US during 1990–2019 were obtained from the Global Burden of Disease Study 2019. The age–period–cohort model was used to estimate these mortality rates based on a log-linear scale with additive age, period, and cohort effects. The population attributable fractions of risk factors for asthma were estimated.
Results:
In 1990–2019, the asthma mortality rate was higher in China than in the US. The crude and age-standardized asthma mortality rates trended downward in both China and the US from 1990 to 2019. The decline in mortality was more obvious in China. Mortality gap between the two countries was narrowing. A sex difference in asthma mortality was observed with higher mortality in males in China and females in the US. The age effects showed that mortality increased with age in adults older than 20 years, particularly in the elderly. Downward trends were generally observed in the period and cohort rate ratios in both countries, with China experiencing a more obvious decrease. Smoking and high body mass index (BMI) were the leading risk factors for asthma mortality in China and the US, respectively. Mortality attributable to occupational asthmagens and smoking decreased the most in China and the US, respectively.
Conclusions:
In 1990–2019, the asthma mortality rate was higher in China than in the US; however, the mortality gap has narrowed. Mortality increased with age in adults. The improvements in asthma death risk with period and birth cohort were more obvious in China than in the US. Smoking, high BMI, and aging are major health problems associated with asthma control. The role of occupational asthmagens in asthma mortality underscores the importance of management and prevention of occupational asthma.
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REDH：造血分化和恶性肿瘤RNA编辑组数据库Jiayue Xu, Jiahuan He, Jiabin Yang, Fengjiao Wang, Yue Huo, Yuehong Guo, Yanmin Si, Yufeng Gao, Fang Wang, Hui Cheng 等
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002782
摘要
Background:
The conversion of adenosine (A) to inosine (I) through deamination is the prevailing form of RNA editing, impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic species. Millions of high-confidence RNA editing sites have been identified and integrated into various RNA databases, providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic targets. However, the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still lacking.
Methods:
We downloaded RNA sequencing (RNA-seq) data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also used. We performed sequence alignment, identified RNA editing sites, and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic diseases.
Results:
We established a new database, "REDH", represents RNA editome in hematopoietic differentiation and malignancy. REDH is a curated database of associations between RNA editome and hematopoiesis. REDH integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts (human). Through the Differentiation, Disease, Enrichment, and knowledge modules, each A-to-I editing site is systematically integrated, including its distribution throughout the genome, its clinical information (human sample), and functional editing sites under physiological and pathological conditions. Furthermore, REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy control.
Conclusions:
REDH is accessible at http://www.redhdatabase.com/. This user-friendly database would aid in understanding the mechanisms of RNA editing in hematopoietic differentiation and malignancies. It provides a set of data related to the maintenance of hematopoietic homeostasis and identifying potential therapeutic targets in malignancies.
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1990-2019年子宫内膜癌发病率和死亡率负担的全球和区域趋势：2019年全球疾病负担研究的最新结果Jianyang Feng, Rongjin Lin, Haoxian Li, Jiayan Wang, Hong He
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002841
摘要
Background:
The disease burdens for endometrial cancer (EC) vary across different countries and geographical regions and change every year. Herein, we reported the updated results of the Global Burden of Disease Study 2019 on EC with respect to age-standardized incidence and mortality from 1990 to 2019.
Methods:
The annual percentage change (APC) of incidence and mortality was evaluated using joinpoint regression analysis to examine the temporal trends during the same timeframe in terms of the global landscape, different sociodemographic indices (SDI), and geographic regions. The relationship between Human Development Index (HDI) and incidence and mortality was additionally explored.
Results:
The age-standardized incidence rates (ASIRs) revealed a significant average global elevation by 0.5% per year (95% confidence interval [CI], 0.3–0.7; P <0.001). The age-standardized mortality rates (ASMRs), in contrast, fell by an average of 0.8% per year (95% CI, −1.0 to −0.7; P <0.001) worldwide. The ASIRs and ASMRs for EC varied across different SDIs and geographical regions. We noted four temporal trends and a significant reduction by 0.5% per year since 2010 in the ASIR, whereas we detected six consecutively decreasing temporal trends in ASMR during the entire period. Notably, the estimated APCs were significantly positively correlated with HDIs (ρ = 0.22; 95% CI, 0.07–0.35; P = 0.003) with regard to incident cases in 2019.
Conclusions:
Incidence rates for EC reflected a significant increase overall (although we observed a decline since 2010), and the death rates declined consecutively from 1990 to 2019. We posit that more precise strategies can be tailored and then implemented based on the distinct age-standardized incidence and mortality burden in different geographical areas.
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IgG4相关疾病增殖型、纤维化型和混合型的临床特征和预后比较：一项回顾性队列研究Linyi Peng, Xinlu Zhang, Jiaxin Zhou, Jieqiong Li, Zheng Liu, Hui Lu, Yu Peng, Yunyun Fei, Yan Zhao, Xiaofeng Zeng 等
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002755
摘要
Background:
Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized immune-mediated disorder that can affect almost any organ in the human body. IgG4-RD can be categorized into proliferative and fibrotic subtypes based on patients’ clinicopathological characteristics. This study aimed to compare the clinical manifestations, laboratory findings, and treatment outcomes of IgG4-RD among different subtypes.
Methods:
We prospectively enrolled 622 patients with newly diagnosed IgG4-RD at Peking Union Medical College Hospital from March 2011 to August 2021. The patients were divided into three groups according to their clinicopathological characteristics: proliferative, fibrotic, and mixed subtypes. We compared demographic features, clinical manifestations, organ involvement, laboratory tests, and treatment agents across three subtypes. We then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with immunosuppressants. Moreover, risk factors of relapse were revealed by applying the univariate and multivariate Cox regression analysis.
Results:
We classified the 622 patients into three groups consisting of 470 proliferative patients, 55 fibrotic patients, and 97 mixed patients, respectively. We found that gender distribution, age, disease duration, and frequency of allergy history were significantly different among subgroups. In terms of organ involvement, submandibular and lacrimal glands were frequently involved in the proliferative subtype, while retroperitoneum was the most commonly involved site in both fibrotic subtype and mixed subtype. The comparison of laboratory tests revealed that eosinophils (P = 0.010), total IgE (P = 0.006), high-sensitivity C-reactive protein (P <0.001), erythrocyte sedimentation rate (P <0.001), complement C4 (P <0.001), IgG (P = 0.001), IgG1 (P <0.001), IgG4 (P <0.001), and IgA (P <0.001), at baseline were significantly different among three subtypes. Compared with proliferative and mixed subtypes, the fibrotic subtype showed the lowest rate of relapse (log-rank P = 0.014).
Conclusions:
Our study revealed the differences in demographic characteristics, clinical manifestations, organ involvement, laboratory tests, treatment agents, and outcomes across proliferative, fibrotic, and mixed subtypes in the retrospective cohort study. Given significant differences in relapse-free survival among the three subtypes, treatment regimens, and follow-up frequency should be considered separately according to different subtypes.
Trial Registration:
ClinicalTrials. gov, NCT01670695.
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替奈普酶与阿替普酶治疗急性ST段抬高型心肌梗死的随机非劣效性试验Xingshan Zhao, Yidan Zhu, Zheng Zhang, Guizhou Tao, Haiyan Xu, Guanchang Cheng, Wen Gao, Liping Ma, Liping Qi, Xiaoyan Yan 等
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002731
摘要
Background:
A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator (rhTNK-tPA) has previously shown its preliminary efficacy in ST elevation myocardial infarction (STEMI) patients. This study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase (rt-PA) in Chinese patients with STEMI.
Methods:
In this multicenter, randomized, open-label, non-inferiority trial, patients with acute STEMI were randomly assigned (1:1) to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42 mg in 90 min. The primary endpoint was recanalization defined by thrombolysis in myocardial infarction (TIMI) flow grade 2 or 3. The secondary endpoint was clinically justified recanalization. Other endpoints included 30-day major adverse cardiovascular and cerebrovascular events (MACCEs) and safety endpoints.
Results:
From July 2016 to September 2019, 767 eligible patients were randomly assigned to receive rhTNK-tPA (n = 384) or rt-PA (n = 383). Among them, 369 patients had coronary angiography data on TIMI flow, and 711 patients had data on clinically justified recanalization. Both used a –15% difference as the non-inferiority efficacy margin. In comparison to rt-PA, both the proportion of patients with TIMI grade 2 or 3 flow (78.3% [148/189] vs. 81.7% [147/180]; differences: –3.4%; 95% confidence interval [CI]: –11.5%, 4.8%) and clinically justified recanalization (85.4% [305/357] vs. 85.9% [304/354]; difference: –0.5%; 95% CI: –5.6%, 4.7%) in the rhTNK-tPA group were non-inferior. The occurrence of 30-day MACCEs (10.2% [39/384] vs. 11.0% [42/383]; hazard ratio: 0.96; 95% CI: 0.61, 1.50) did not differ significantly between groups. No safety outcomes significantly differed between groups.
Conclusion:
rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery, a validated surrogate of clinical outcomes, among Chinese patients with acute STEMI.
Trial registration:
www.ClinicalTrials.gov (No. NCT02835534).
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中国人群腹腔镜袖状胃切除术对术后5年2型糖尿病影响的不同预测模型比较Chengyuan Yu, Liang Wang, Guangzhong Xu, Guanyang Chen, Qing Sang, Qiqige Wuyun, Zheng Wang, Chenxu Tian, Nengwei Zhang
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002718
摘要
Background:
The effect of bariatric surgery on type 2 diabetes mellitus (T2DM) control can be assessed based on predictive models of T2DM remission. Various models have been externally verified internationally. However, long-term validated results after laparoscopic sleeve gastrectomy (LSG) surgery are lacking. The best model for the Chinese population is also unknown.
Methods:
We retrospectively analyzed Chinese population data 5 years after LSG at Beijing Shijitan Hospital in China between March 2009 and December 2016. The independent t-test, Mann–Whitney U test, and chi-squared test were used to compare characteristics between T2DM remission and non-remission groups. We evaluated the predictive efficacy of each model for longterm T2DM remission after LSG by calculating the area under the curve (AUC), sensitivity, specificity, Youden index, positive predictive value (PPV), negative predictive value (NPV), and predicted-to-observed ratio, and performed calibration using Hosmer–Lemeshow test for 11 prediction models.
Results:
We enrolled 108 patients, including 44 (40.7%) men, with a mean age of 35.5 years. The mean body mass index was 40.3 ± 9.1 kg/m2, the percentage of excess weight loss (%EWL) was (75.9 ± 30.4)%, and the percentage of total weight loss (% TWL) was (29.1 ± 10.6)%. The mean glycated hemoglobin A1c (HbA1c) level was (7.3 ± 1.8)% preoperatively and decreased to (5.9 ± 1.0)% 5 years after LSG. The 5-year postoperative complete and partial remission rates of T2DM were 50.9% [55/108] and 27.8% [30/108], respectively. Six models, i.e., "ABCD", individualized metabolic surgery (IMS), advanced-DiaRem, DiaBetter, Dixon et al’s regression model, and Panunzi et al’s regression model, showed a good discrimination ability (all AUC >0.8). The "ABCD" (sensitivity, 74%; specificity, 80%; AUC, 0.82 [95% confidence interval [CI]: 0.74–0.89]), IMS (sensitivity, 78%; specificity, 84%; AUC, 0.82 [95% CI: 0.73–0.89]), and Panunzi et al’s regression models (sensitivity, 78%; specificity, 91%; AUC, 0.86 [95% CI: 0.78–0.92]) showed good discernibility. In the Hosmer–Lemeshow goodness-of-fit test, except for DiaRem (P <0.01), DiaBetter (P <0.01), Hayes et al (P = 0.03), Park et al (P = 0.02), and Ramos-Levi et al’s (P <0.01) models, all models had a satifactory fit results (P >0.05). The P values of calibration results of the "ABCD" and IMS were 0.07 and 0.14, respectively. The predicted-to-observed ratios of the "ABCD" and IMS were 0.87 and 0.89, respectively.
Conclusion:
The prediction model IMS was recommended for clinical use because of excellent predictive performance, good statistical test results, and simple and practical design features.
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使用便携式手持双光子显微镜对病理性疤痕进行无创成像Yang Han, Yuxuan Sun, Feili Yang, Qingwu Liu, Wenmin Fei, Wenzhuo Qiu, Junjie Wang, Linshuang Li, Xuejun Zhang, Aimin Wang 等
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002715
摘要
Background:
Pathological scars are a disorder that can lead to various cosmetic, psychological, and functional problems, and no effective assessment methods are currently available. Assessment and treatment of pathological scars are based on cutaneous manifestations. A two-photon microscope (TPM) with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in vivo. This study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar patients.
Methods:
Fifteen patients with pathological scars and three healthy controls were recruited. Imaging was performed using a portable handheld TPM. Five indexes were extracted from two dimensional (2D) and three dimensional (3D) perspectives, including collagen depth, dermo-epidermal junction (DEJ) contour ratio, thickness, orientation, and occupation (proportion of collagen fibers in the field of view) of collagen. Two depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D images. We assessed index differences between scar and normal skin and changes before and after treatment.
Results:
Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen fibers. Five indexes were employed to distinguish between normal skin and scar tissue. Statistically significant differences were found in average depth (t = 9.917, P <0.001), thickness (t = 4.037, P <0.001), occupation (t= 2.169, P <0.050), orientation of collagen (t = 3.669, P <0.001), and the DEJ contour ratio (t = 5.105, P <0.001).
Conclusions:
Use of portable handheld TPM can distinguish collagen from skin tissues; thus, it is more suitable for scar imaging than reflectance confocal microscopy. Thus, a TPM may be an auxiliary tool for scar treatment selection and assessing treatment efficacy.
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雌激素受体β抑制雄激素受体在三阴性乳腺癌中的致癌作用Feng Xu, Kun Xu, Lingling Fan, Xintong Li, Yiqiu Liu, Fang Yang, Chengjun Zhu, Xiaoxiang Guan
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002930
摘要
Background:
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options. The androgen receptor (AR) has emerged as a potential therapeutic target for luminal androgen receptor (LAR) TNBC. However, multiple studies have claimed that anti-androgen therapy for AR-positive TNBC only has limited clinical benefits. This study aimed to investigate the role of AR in TNBC and its detailed mechanism.
Methods:
Immunohistochemistry and TNBC tissue sections were applied to investigate AR and nectin cell adhesion molecule 4 (NECTIN4) expression in TNBC tissues. Then, in vitro and in vivo assays were used to explore the function of AR and estrogen receptor beta (ERβ) in TNBC. Chromatin immunoprecipitation sequencing (ChIP-seq), co-immunoprecipitation (co-IP), molecular docking method, and luciferase reporter assay were performed to identify key molecules that affect the function of AR.
Results:
Based on the TNBC tissue array analysis, we revealed that ERβ and AR were positive in 21.92% (32/146) and 24.66% (36/146) of 146 TNBC samples, respectively, and about 13.70% (20/146) of TNBC patients were ERβ positive and AR positive. We further demonstrated the pro-tumoral effects of AR on TNBC cells, however, the oncogenic biology was significantly suppressed when ERβ transfection in LAR TNBC cell lines but not in AR-negative TNBC. Mechanistically, we identified that NECTIN4 promoter –42 bp to –28 bp was an AR response element, and that ERβ interacted with AR thus impeding the AR-mediated NECTIN4 transcription which promoted epithelial–mesenchymal transition in tumor progression.
Conclusions:
This study suggests that ERβ functions as a suppressor mediating the effect of AR in TNBC prognosis and cell proliferation. Therefore, our current research facilitates a better understanding of the role and mechanisms of AR in TNBC carcinogenesis.
Correspondence
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内镜筛查人群中食管癌可改变危险因素的模型研究Qian Zhang, Fan Wang, Hao Feng, Jie Xing, Shengtao Zhu, Hao Zhang, Yang Li, Wenqiang Wei, Shutian Zhang
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002878
摘要
致编辑：食管癌是中国最常见的癌症类型之一，预计2022年新增病例346,633例，死亡病例323,600例，正成为日益严重的临床和公共卫生问题。[
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FEF降低50作为慢性鼻窦炎伴鼻息肉患者并发哮喘和持续气流受限的指标：一项横断面研究Xuechen Wang, Fangyuan Li, Chengshuo Wang, Kai Huang, Shen Shen, Ming Wang, Jianmin Jin, Luo Zhang
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002925
摘要
致编辑：虽然20-60%的慢性鼻窦炎伴鼻息肉(CRSwNP)患者患有共病哮喘（称为难治性哮喘），但在25-48%的患有共病哮喘的CRSwNP患者中哮喘未被诊断。[
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组学方法预测慢性阻塞性肺疾病预后及治疗疗效Yan Huang, Juanjuan Xu, Guanzhou Ma, Sufei Wang, Xiaojuan Yan, Yang Jin, Jiafu He
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002929
摘要
致编辑：慢性阻塞性肺疾病（COPD）是一种严重危害人类健康的疾病。2018年，王等人[
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大剂量氨甲环酸输注在初次全膝关节置换术中的随机多中心临床试验Jinwei Xie, Qiang Huang, Zeyu Huang, Fei Wang, Jun Liu, Hua Tian, Wei Huang, Fuxing Pei
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002952
摘要
致编辑：在全膝关节置换术（TKA）中，显著的纤溶亢进总是伴随着手术创伤和止血带的使用，导致相当大的隐性失血、炎症和疼痛，从而阻碍恢复过程。近几十年来，增强术后恢复（ERAS）促进了患者血液管理的发展。并且已经研究了许多血液保存方法，包括氨甲环酸(TXA)，一种纤溶酶和纤溶酶原的赖氨酸类似物竞争性抑制剂。[
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去甲肾上腺素对宿主免疫和细菌感染的影响Jia Wang, Zhiyao Fang, Xue Dong, Wenwen Li, Xianyao Wan
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002931
摘要
致编辑：去甲肾上腺素（NE）属于儿茶酚胺家族，当宿主处于应激状态时，交感神经系统和肾上腺髓质会越来越多地产生。已经证明NE具有显著的抗炎作用。此外，越来越多的证据表明应激激素直接参与细菌和宿主之间的相互作用。多种细菌可以通过高浓度的NE表现出生长、毒力和生物膜的变化。因此，本文旨在总结NE对宿主免疫和细菌感染的影响及其分子机制的主要研究进展[
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心脏淀粉样变性患者QRS波电压与淀粉样蛋白负荷的关系Jing-Hui Li, Changcheng Li, Yucong Zheng, Kai Yang, Yan Huang, Huixin Zhang, Xianmei Li, Xiuyu Chen, Linlin Dai, Tian Lan 等
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002965
摘要
致编辑：心脏淀粉样变性（CA）是一种浸润性心肌病，其特征是错误折叠的不溶性淀粉样原纤维的细胞外沉积。[
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催乳素/睾酮比值与中国女性乳腺癌的关系Qian Cai, Xiaohan Tian, Yuyi Tang, Han Cong, Jie Liu, Song Zhao, Rong Ma, Jianli Wang, Jiang Zhu
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002942
摘要
致编辑：乳腺癌是一种常见的恶性肿瘤，在全球范围内是癌症相关死亡的第二大原因。[
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使用iTRAQ LC-MS/MS技术鉴定精索静脉曲张的新生物标志物Xianfeng Lu, Na Li, Lufang Li, Yongai Wu, Xuefeng Lyu, Yingli Cao, Jianrong Liu, Qin Qin
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002798
摘要
致编辑：精索静脉曲张（VC）是一种血管疾病，被认为是男性不育的主要原因。[
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神经精神型系统性红斑狼疮患者的磁共振成像特征Yanli Huang, Shuoqi Zhang, Shaozhe Cai, Bingxia Ming, Rongfen Gao, Ziwei Hu, Lingli Dong
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002864
摘要
致编辑：神经精神系统性红斑狼疮（NPSLE）是系统性红斑狼疮（SLE）的一组严重并发症，预后差，死亡率高。[
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甲状旁腺肿瘤的分子遗传学研究进展Liwei Zhao, Xianghui He
中华医学杂志英文版2024年 137卷 03期
DOI: 10.1097/CM9.0000000000002935
摘要
致编辑：甲状旁腺肿瘤是一种内分泌肿瘤，可导致钙、磷代谢紊乱，累及多个器官系统。在过去，甲状旁腺肿瘤的遗传学已经很好地建立，并且基因的重要作用，例如男人1,CDC73，和CCND1在甲状旁腺肿瘤发生过程中已被鉴定和证实[
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