MedNexus
2023年 · 第136卷第05期
出版日期 2023-03-05电子版 ￥0.00元
MedNexus
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- Review Article
- Meta Analysis
- Perspective
- Commentary
- Original Article
- Clinical Observation
- Correspondence
Review Article
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临床前阿尔茨海默病主观认知功能下降的血液生物标志物研究进展Xianfeng Yu, Kai Shao, Ke Wan, Taoran Li, Yuxia Li, Xiaoqun Zhu, Ying Han
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002566
摘要
Alzheimer' s disease (AD) is a neurodegenerative disease that gradually impairs cognitive functions. Recently, there has been a conceptual shift toward AD to view the disease as a continuum. Since AD is currently incurable, effective intervention to delay or prevent pathological cognitive decline may best target the early stages of symptomatic disease, such as subjective cognitive decline (SCD), in which cognitive function remains relatively intact. Diagnostic methods for identifying AD, such as cerebrospinal fluid biomarkers and positron emission tomography, are invasive and expensive. Therefore, it is imperative to develop blood biomarkers that are sensitive, less invasive, easier to access, and more cost effective for AD diagnosis. This review aimed to summarize the current data on whether individuals with SCD differ reliably and effectively in subjective and objective performances compared to cognitively normal elderly individuals, and to find one or more convenient and accessible blood biomarkers so that researchers can identify SCD patients with preclinical AD in the population as soon as possible. Owing to the heterogeneity and complicated pathogenesis of AD, it is difficult to make reliable diagnoses using only a single blood marker. This review provides an overview of the progress achieved to date with the use of SCD blood biomarkers in patients with preclinical AD, highlighting the key areas of application and current challenges.
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时间在范围中的应用研究进展：超过百分之一Jintao Wan, Jingyi Lu, Cheng Li, Xiaojing Ma, Jian Zhou
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002582
摘要
Glucose monitoring is an important part of medical care in diabetes mellitus, which not only helps assess glycemic control and treatment safety, but also assists with treatment adjustment. With the development of continuous glucose monitoring (CGM), the use of CGM has increased rapidly. With the wealth of glucose data produced by CGM, new metrics are greatly needed to optimally evaluate glucose status and guide the treatment. One of the parameters that CGM provides, time in range (TIR), has been recognized as a key metric by the international consensus. Before the adoption of TIR in clinical practice, several issues including the minimum length of CGM use, the setting of the target range, and individualized TIR goals are summarized. Additionally, we discussed the mounting evidence supporting the association between TIR and diabetes-related outcomes. As a novel glucose metric, it is of interest to compare TIR with other conventional glucose markers such as glycated hemoglobin A1c. It is anticipated that the use of TIR may provide further information on the quality of glucose control and lead to improved diabetes management.
Meta Analysis
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非治愈性内镜粘膜下剥离术后早期胃癌额外手术与非胃切除术治疗的长期结果：一项荟萃分析Sixuan Li, Xueli Tian, Jingyao Wei, Yanyan Shi, Hua Zhang, Yonghui Huang
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002605
摘要
Background:
Endoscopic resection is increasingly used in the treatment for early gastric cancer (EGC); however, about 15% of endoscopic submucosal dissection (ESD) cases report non-curative resection. The efficacy of different remedial interventions after non-curative ESD for EGC remains controversial. This meta-analysis aimed to compare the long-term outcomes of additional surgery and non-gastrectomy treatment for EGC patients who underwent non-curative ESD.
Methods:
All relevant studies published up to October 2021 were systematically searched in the PubMed, Web of Science, and Embase databases. The medical subject headings terms "early gastric cancer," "gastrectomy," "endoscopic submucosal dissection," and their related free keywords were used to search relevant articles without restrictions on regions, publication types, or languages. The Newcastle–Ottawa Quality Assessment Scale was used to evaluate the quality of the included studies. Odds ratios (ORs) with 95% confidence intervals (CIs) of 5-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS) and hazard ratios (HRs) with 95% CIs of OS were calculated using a random- or fixed-effects model.
Results:
This meta-analysis included 17 retrospective cohort studies with 5880 patients, of whom 3167 underwent additional surgery and 2713 underwent non-gastrectomy. We found that patients receiving additional gastrectomy had better 5-year OS (OR = 3.63, 95% CI = 3.05–4.31), DSS (OR = 3.22, 95% CI = 2.22–4.66), and DFS (OR = 4.39, 95% CI = 1.78–10.82) outcomes than those receiving non-gastrectomy treatments. The pooled HR also showed that gastrectomy following non-curative ESD significantly improved OS (HR = 0.40, 95% CI = 0.33–0.48). In addition, elderly patients benefited from additional surgery in consideration of the 5-year OS (HR = 0.54, 95% CI= 0.41–0.72).
Conclusions:
Compared with non-gastrectomy treatments, additional surgery offered better long-term survival outcomes for patients with EGC who underwent non-curative ESD.
Perspective
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机器学习在慢性阻塞性肺疾病中的应用Bochao Zhang, Jiping Wang, Jing Chen, Zongquan Ling, Yuhao Ren, Daxi Xiong, Liquan Guo
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002247
摘要
世界卫生组织预测，到2030年，慢性阻塞性肺病(COPD)将成为全球第三大死亡原因和第七大发病原因。[
Commentary
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对“良性前列腺增生的综合多平台分子图谱识别不同亚型”的评论Zhemin Lin, Yinong Niu
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002594
摘要
良性前列腺增生（BPH）常见于老年男性，其患病率随年龄线性增加，在60岁和90岁男性中分别达到约50%和80%。[
Original Article
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小剂量阿司匹林预防移植肾动脉狭窄的有效性和安全性：一项前瞻性随机对照试验Xiangyong Tian, Bingqing Ji, Xiaoge Niu, Wenjing Duan, Xiaoqiang Wu, Guanghui Cao, Chan Zhang, Jingge Zhao, Zhiwei Wang, Yue Gu 等
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002574
摘要
Background:
Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS.
Methods:
After kidney transplantation, patients were enrolled from January 2018 to December 2020 in Henan Provincial People’s Hospital. A total of 351 enrolled recipients were randomized to an aspirin group with low-dose intake of aspirin in addition to standard treatment (n = 178), or a control group with only standard treatment (n = 173). The patients was initially diagnosed as TRAS (id-TRAS) by Doppler ultrasound, and confirmed cases were diagnosed by DSA (c-TRAS).
Results:
In the aspirin and control groups, 15.7% (28/178) and 22.0% (38/173) of the recipients developed id-TRAS, respectively, with no statistical difference. However, for c-TRAS, the difference of incidence and cumulative incidence was statistically significant. The incidence of c-TRAS was lower in the aspirin group compared with the control group (2.8% [5/178] vs. 11.6% [20/173], P = 0.001). Kaplan–Meier estimates and Cox regression model identified the cumulative incidence and hazard ratio (HR) of TRAS over time in two groups, showing that recipients treated with aspirin had a significantly lower risk of c-TRAS than those who were not treated (log-rank P = 0.001, HR = 0.23, 95% confidence interval [CI]: 0.09–0.62). The levels of platelet aggregation rate (P < 0.001), cholesterol (P = 0.028), and low-density lipoprotein cholesterol (P = 0.003) in the aspirin group were decreased compared with the control group in the third-month post-transplantation. For the incidence of adverse events, there was no statistical difference.
Conclusion:
Clinical application of low-dose aspirin after renal transplant could prevent the development of TRAS with no significant increase in adverse effects.
Trial Registration:
Clinicaltrials.gov, NCT04260828.
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低剂量阿司匹林在中国预防先兆子痫中的应用：根据妇女亚组的产后出血特征和潜在出血风险Jiahui Chen, Jing Huai, Li Lin, Boya Li, Yuchun Zhu, Huixia Yang
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002545
摘要
Background:
The APPEC study is a large-population randomized controlled trial in China evaluating the role of low-dose aspirin prophylactic treatment for pre-eclampsia. There was no statistically significant difference in postpartum hemorrhage (PPH) incidence between the aspirin and control groups. This study aimed to evaluate the potential bleeding risk of 100 mg aspirin in high-risk pregnant women and the difference in the incidence of PPH according to maternal characteristics.
Methods:
This is a secondary data analysis of the APPEC study. Platelet counts and coagulation test results were collected at five follow-up visits. Subgroups defined by maternal age (<35 years and ≥35 years), pre-pregnancy body mass index (pre-BMI, <28 kg/m2 and ≥28 kg/m2), parity, gestational age at enrollment, and medical history, including pre-eclampsia, chronic hypertension, and diabetes mellitus, were analyzed. Logistic regression analysis was used to determine the statistical significance of the difference in the incidence of PPH after aspirin administration in pregnant women in each subgroup. Adjustment using multiple logistic regression models followed these analyses. Binary logistic regression was used to determine the relationship between pre-BMI and PPH.
Results:
There was no significant difference between the aspirin and control groups in bleeding risk (3.4% [16/464] vs. 3.0% [13/434], T = 0.147, P = 0.701). No significant difference was found in the incidence of PPH in total (relative risk = 1.220, 95% confidence interval [CI] = 0.720–2.067, P = 0.459; aspirin group vs. control group, 6.5% [30/464] vs. 5.3% [23/434], P = 0.459) or in subgroup analysis. A significant correlation between pre-BMI and PPH was found in the aspirin group, while in the control group there was no significant correlation (aspirin group, odds ratio [OR] = 1.086, 95% CI = 1.004–1.175, P = 0.040; control group, OR= 1.060, 95% CI = 0.968–1.161, P = 0.209).
Conclusions:
A dosage of 100 mg of aspirin per day, initiated from 12 to 20 gestational weeks until 34 weeks of gestation, did not increase the risk of potential bleeding and PPH regardless of the maternal characteristic. In the aspirin group, the positive correlation between BMI and PPH was significant.
Trial Registration:
ClinicalTrials.gov, NCT01979627.
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CD5分子样在肝细胞癌中的作用Zhaowei Gao, Xianan Wu, Lan Yang, Chong Liu, Xi Wang, Huiping Wang, Ke Dong
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002576
摘要
Background:
CD5L (CD5 molecular-like) plays an important role in lipid metabolism and immune regulation. This study aimed to investigate the roles of CD5L on liver hepatocellular carcinoma (LIHC).
Methods:
We analyzed the CD5L mRNA expression and its potential prognostic value based on The Cancer Genome Atlas and Gene Expression Omnibus databases. Immunohistochemical analysis was used to investigate the CD5L levels in LIHC tissues. Serum CD5L levels in LIHC were detected by enzyme-linked immunosorbent assay. Cell Counting Kit-8 (CCK-8) assay was used to investigate the effect of CD5L treatment on HepG2 and QSG-7701 cell proliferation. CD5L expression correlated genes were exhumed based on the LinkedOmics. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses for CD5L associated genes were performed. The correlation between CD5L and tumor immune infiltration was analyzed by using Tumor Immune Estimation Resource (TIMER) 2.0.
Results:
CD5L mRNA and protein levels were significantly decreased in LIHC tumor tissue compared with non-tumor control tissues. Moreover, serum CD5L levels were significantly lower in LIHC patients than that in healthy subjects. Gene Expression Profiling Interactive Analysis 2 and Kaplan-Meier plotter analysis showed that a high-CD5L expression was correlated with favorable overall survival in LIHC patients, except the LIHC patients with hepatitis virus. CCK-8 results showed that CD5L treatment significantly decreased HepG2 cell proliferation in a concentration-dependent manner, and CD5L treatment had no effect on the proliferation of non-tumor hepatocyte line QSG-7701. CD5L associated genes were enriched in the immune response biological process, and CD5L expression levels were positively correlated with the immune infiltrates of CD8+ T cell and M1 macrophage cells but negatively correlated with CD4+ T cells and M0 macrophage cell infiltration.
Conclusions:
Exogenous CD5L inhibits cell proliferation of hepatocellular carcinoma. CD5L may act as a role of prognostic marker.
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心脏脂肪瘤的外科治疗：单中心20年经验Linlin Li, Jian Meng, Xingtong Zhou, Chang Liu, Hongwei Guo, Hongguang Fan
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002585
摘要
Background:
Primary cardiac lipoma is very rare, and no consensus has been developed regarding its ideal treatment strategy. This study reviewed the surgical treatment of cardiac lipomas in 20 patients over 20 years.
Methods:
Twenty patients with cardiac lipomas were treated at Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College from January 1, 2002, to January 1, 2022. The patients' clinical data and pathological reports were retrospectively analyzed, and the follow-up with a range of 1 year to 20 years was conducted.
Results:
The cardiac lipomas were located in the right atrium (RA) or superior vena cava (SVC) in seven patients (35%) (RA in six patients and SVC in one patient), left ventricle in eight patients (40%) (left ventricular chamber in four patients and left ventricular subepicardium and myocardium in four patients), right ventricle in three patients (15%) (right ventricular chamber in one patient and right ventricular subepicardial layer and myocardium in two patients), subepicardial interventricular groove in one patient (5%), and pericardium in one patient (5%). Complete resection was achieved in 14 patients (70%), including seven patients with lipomas in the RA or SVC. Incomplete resection occurred in six patients (30%) with lipomas in the ventricles. No perioperative deaths occurred. Long-term follow-up was conducted for 19 patients (95%), including two (10%) who died. Both patients who died had lipomas incompletely resected due to ventricles involvement, and preoperative malignant arrhythmias persisted post-operatively.
Conclusions:
The complete resection rate was high, and the long-term prognosis was satisfactory in patients with cardiac lipomas that did not involve the ventricle. The complete resection rate was low in patients with cardiac lipomas in ventricles; and complications, including malignant arrhythmia, were common. Failure of complete resection and post-operative ventricular arrhythmia are correlated with post-operative mortality.
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冠状病毒疾病2019疫苗接种对癫痫患者癫痫发作的影响Xiqin Fang, Shan Qiao, Ranran Zhang, Tingting Yang, Zhihao Wang, Qingxia Kong, Meihua Sun, Jianhong Geng, Chunyan Fang, Yanxiu Chen 等
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002558
摘要
Background:
Given that seizures may be triggered by vaccination, this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy (PWE) after being vaccinated against coronavirus disease 2019 (COVID-19).
Methods:
This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in China. We divided the PWE into two groups as follows: (1) patients who developed seizures within 14 days of vaccination were assigned to the SAV (with seizures after vaccination) group; (2) patients who were seizure-free within 14 days of vaccination were assigned to the SFAV (seizure-free after vaccination) group. To identify potential risk factors for seizure reccurence, the binary logistic regression analysis was performed. Besides, 67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence, and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or withdrawal.
Results:
The study included a total of 407 patients; of which, 48 (11.8%) developed seizures within 14 days after vaccination (SAV group), whereas 359 (88.2%) remained seizure-free (SFAV group). The binary logistic regression analysis revealed that duration of seizure freedom (P < 0.001) and withdrawal from anti-seizure medications (ASMs) or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures (odds ratio= 7.384, 95% confidence interval = 1.732–31.488, P = 0.007). In addition, 32 of 33 patients (97.0%) who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination. A total of 92 (22.6%) patients experienced non-epileptic adverse reactions after vaccination. Binary logistic regression analysis results showed that vaccine did not significantly affect the recurrence rate of PWE who had the behavior of ASMs dose reduction or withdrawal (P = 0.143).
Conclusions:
PWE need protection from the COVID-19 vaccine. PWE who are seizure-free for >3 months before vaccination should be vaccinated. Whether the remaining PWE should be vaccinated depends on the local prevalence of COVID-19. Finally, PWE should avoid discontinuing ASMs or reducing their dosage during the peri-vaccination period.
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端粒酶介导的盆腔器官脱垂患者阴道壁成纤维细胞永生化Tao Guo, Ting Xie, Jinghe Lang, Zhijing Sun
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002278
摘要
Background:
Extracellular matrix (ECM) remodeling is the most important pathomechanism of pelvic organ prolapse (POP). Fibroblasts are the key to ECM regulation. The passaging capacity of human vaginal wall fibroblasts (hVWFs) is limited in vitro. Here, we aimed to immortalize hVWFs through the introduction of human telomerase reverse transcriptase (hTERT).
Methods:
Primary cells were derived from the vaginal wall tissue of patients with POP. Cellular senescence was detected via senescence-associated β-galactosidase staining. We employed a lentiviral transfection vector to stably express hTERT in hVWFs at passage 3, generating immortalized hVWFs (i-hVWFs). We then assessed cellular proliferation via the CCK-8 and EdU assays as well as cellular migration via wound healing assays. G-banded chromosome karyotypic analysis was performed to evaluate chromosomal karyotype stability. Finally, cellular tumorigenesis capacity was assessed in nude mice. A two-tailed Student’s t test was used to compare differences between the two groups.
Results:
Our results showed that senescence of primary hVWFs significantly increased from passage seven. From passage 11, hVWFs showed a significantly higher senescence percentage than i-hVWFs. During the continuous passage, i-hVWFs presented stability in proliferation, migration capacity, expression of ECM regulation-related genes, and chromosome karyotype. In vivo tumorigenesis was absent in i-hVWFs.
Conclusions:
The senescence of hVWFs significantly increased from the seventh passage, and we successfully used hTERT to immortalize hVWFs derived from patients with POP. Studies on POP that require a long-lived hVWF line will benefit from our technique.
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2008-2018年冠心病和高血压住院患者房颤患病率和临床特征的横断面研究Qian Xin, Sijin Zhang, Chi Wang, Siyu Yao, Cuijuan Yun, Yizhen Sun, Ziwei Hou, Miao Wang, Maoxiang Zhao, Lu Tian 等
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002471
摘要
Background:
The clinical characteristics of patients with the comorbidities of hypertension and coronary artery disease (HT-CAD) and atrial fibrillation (AF) are largely unknown. This study aimed to investigate the prevalence of AF in patients with HT-CAD and clinical characteristics of patients with both HT-CAD and AF.
Methods:
This cross-sectional study was conducted in Chinese People’s Liberation Army General Hospital in Beijing, China, and included 20,747 inpatients with HT-CAD with or without AF from August 2008 to July 2018. We examined the overall prevalence, clinical characteristics, comorbidity profiles, treatment patterns, and blood pressure (BP) control of patients with both HT-CAD and AF. Multivariate logistic regression was used to investigate the associations of cardiovascular risk factors with AF in patients with HT-CAD.
Results:
The overall prevalence of AF in patients with HT-CAD was 4.87% (1011/20,747), and this increased with age; to be specific, the prevalence in women and men increased from 0.78% (2/255) and 1.02% (26/2561) at the age of <50 years to 8.73% (193/2210) and 10.28 % (298/2900) at the age of ≥70 years, respectively. HT-CAD patients who had AF had a higher prevalence of cardiovascular-related comorbidities than those without AF. Multivariate logistic regression showed that age, gender (male), body mass index, heart failure, and chronic kidney disease were independently associated with the risk of AF in patients with HT-CAD. For those with both HT-CAD and AF, 73.49% (743/1011) had a CHA2DS2-VASc score of ≥4, and only about half of them had the BP controlled at <140/90 mmHg, which indicated a high risk of thromboembolism and stroke. The use of oral anticoagulation increased during the study period (10.00% [20/200] in 2008 to 2011 vs. 30.06% [159/529] in 2015 to 2018, P < 0.01), but remained at a relatively low level.
Conclusions:
AF is highly prevalent among patients with HT-CAD. Patients with both HT-CAD and AF have a higher prevalence of cardiovascular-related comorbidities, lower BP control rate, and lower use of oral anticoagulation.
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视力恢复对年龄相关性白内障患者步态和下肢运动学的影响Mingxin Ao, Huijuan Shi, Xuemin Li, Hongshi Huang, Yingfang Ao, Wei Wang
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002509
摘要
Background:
Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly; however, the mechanism needs to be explored intensively. The present study assessed the gait pattern after cataract surgery to investigate the effects of visual restoration on locomotion.
Methods:
The prospective study recruited 32 patients (70.1 ± 5.2 years) with bilateral age-related cataracts in the Department of Ophthalmology at Peking University Third Hospital from October 2016 to December 2019. The temporal-spatial gait parameters and kinematic parameters were measured by the Footscan system and inertial measurement units. Paired t-test was employed to compare data normally distributed and Wilcoxon rank-sum test for non-normally distributed.
Results:
After visual restoration, the walking speed increased by 9.3% (1.19 ± 0.40 m/s vs. 1.09 ± 0.34 m/s, P=0.008) and exhibited an efficient gait pattern with significant decrease in gait cycle (1.02 ± 0.08 s vs. 1.04 ± 0.07 s, P=0.012), stance time (0.66 ± 0.06 s vs. 0.68 ± 0.06 s, P=0.045), and single support time (0.36 ± 0.03 s vs. 0.37 ± 0.02 s, P=0.011). High amplitude of joint motion was detected in the sagittal plane in the left hip (37.6° ± 5.3° vs. 35.5° ± 6.2°, P=0.014), left thigh (38.0° ± 5.2° vs. 36.4° ± 5.8°, P=0.026), left shank (71.9° ± 5.7° vs. 70.1° ± 5.6°, P=0.031), and right knee (59.1° ± 4.8° vs. 56.4° ± 4.8°, P=0.001). The motor symmetry of thigh improved from 8.35 ± 5.30% to 6.30 ± 4.73% (P=0.042).
Conclusions:
The accelerated gait in response to visual restoration is characterized by decreased stance time and increased range of joint motion. Training programs for improving muscle strength of lower extremities might be helpful to facilitate the adaptation to these changes in gait.
Clinical Observation
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中国成人特应性皮炎的患病率和危险因素：一项基于全国人群的横断面研究Dandan Mao, Jiaqing Li, Shuoshuo Liu, Ping Liu, Jing Tian, Xiaojing Liu, Ruiqun Qi, Bingxue Bai, Yu Wang, Jianzhong Zhang
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002560
摘要
特应性皮炎（AD）又称特应性湿疹、湿疹、内源性湿疹、神经性皮炎，是一种发生于儿童、青少年和成人的慢性炎症性皮肤病。AD患者通常具有严重瘙痒，并且可能患有其他特应性疾病(例如，过敏性鼻炎、哮喘或过敏性结膜炎)。AD对患者的生活质量有着深远的影响。中国儿童AD的患病率已有报道。[
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肾移植患者早期改用低剂量钙调磷酸酶抑制剂联合西罗莫司疗效和安全性的多中心随机对照试验Xiang Zheng, Weijie Zhang, Hua Zhou, Ronghua Cao, Zhangfei Shou, Shuwei Zhang, Ying Cheng, Xuchun Chen, Chenguang Ding, Ning Li 等
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002604
摘要
虽然以钙调神经磷酸酶抑制剂（CNIs）为主的三联免疫抑制方案大大改善了肾移植的近期预后，但肾移植的远期预后并没有明显改善。CNIs相关肾毒性是影响移植物存活的主要危险因素。[
Correspondence
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MG7-Ag、hTERT和TFF2识别高危肠上皮化生并构成胃癌的预测模型Siran Wu, Xiaodong Qu, Na Wang, Luyao Zhang, Xingyu Zhao, Qiong Wu, Junye Liu, Yongquan Shi
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002518
摘要
致编辑：胃癌（GC）在全球和中国的发病率和死亡率均居第三位。[
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使用运动学对准技术的Oxford移动轴承单室膝关节置换术中轴承运动轨迹Xiaowei Sun, Feifan Lu, Wanshou Guo, Liming Cheng, Weiguo Wang, Qidong Zhang
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002052
摘要
致编辑：移动轴承脱位是接受牛津移动轴承单室膝关节置换术（Oxford MB UKA）的亚洲患者翻修的最常见原因，发生率高达7.9%。[
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基于超声心动图向量血流图测量中国健康成人左室流体动力学参数Sijia Wang, Lixue Yin, Anguo Luo, Zhengyang Wang, Shan Wang, Geqi Ding, Xiuzhang Lyu, Yunyou Duan, Qing Zhou, Mei Zhang 等
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002519
摘要
致编辑：由于临床上几乎没有建立具有广泛代表性、公认和标准化的超声心动图向量血流图（VFM）方法来观察和测量心腔内的血流，并且迄今为止还没有获得普遍接受的中国成人正常参考值，阻碍了该技术在临床上的进一步推广和应用。建立在临床实践中可以广泛接受的超声心动图VFM的正常参考值对于确定左心室（LV）腔内正常或异常的流体动力学状态具有重要意义。基于超声心动图VFM的多中心、大样本临床观察和定量研究是检验该技术实用性和可靠性的有效方法，有助于建立一种新颖、规范的基于VFM的超声心动图观察技术体系，用于心脏流体动力学的观察、分析和定量评价。在此基础上，可以建立中国健康成人左心室流体动力学的可靠正常VFM参考值。
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Effects of functional foods, nutraceuticals, and herbal products on pancreasAngela Saviano, Christian Zanza, Yaroslava Longhitano, Enrico Celestino Nista, Francesco Franceschi, Veronica Ojetti
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002396
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炎症相关外周血细胞和血脂水平与帕金森病相关Hong Jin, Lanxiang Wang, Yun Shen, Chengjie Mao, Jing Chen, Chunfeng Liu
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002397
摘要
致编辑：帕金森病（PD）是全球最常见的神经退行性疾病之一，也是最常见的运动障碍。PD发病机制已被证明与神经炎症和肠道炎症有关。C反应蛋白（CRP）水平升高与步态冻结和PD快速进展有关，尤其是在老年患者中。最近的研究表明，外周血中的免疫细胞也可能有助于PD的发病机制，为炎症和PD之间的关系提供了进一步的见解。[
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在全球新冠肺炎疫情的背景下，一种基于5G电信技术的新型心脏植入式电气设备植入过程中的非接触式远程询问系统Hong Zhang, Hai Gao, Xin Liu, Xijuan Mu, Xiaodong Shi
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000002069
摘要
致编辑：心脏植入式电气设备（CIED）是治疗和诊断几种不同类型的心律失常和心力衰竭的最有效方法。临床医生有必要评估器械的参数，以确保手术过程中的安全性和有效性。传统上，参数测试和编程由制造商的临床服务技术人员在导管室现场执行。然而，在冠状病毒病-2019（新冠肺炎）爆发后，制造商的临床服务技术人员不允许进入导管室和病房。解决参数测试和编程问题至关重要。一种基于中国电信5G数据传输模块和Merlin Programmer 3650软件版本20.1.1 rev3（美国明尼阿波利斯St.Jude Medical）的新型非接触式询问系统提供了一种有用的解决方案，在CIEDs植入期间无需与制造商的临床服务技术人员进行任何物理接触，并降低了新冠肺炎感染的风险。这种新颖的远程询问系统由一个名为5G cloud follow-up的异地设备安装远程询问（RI）软件、一个Abbott Merlin Patient Care system-3650程序员（版本20.1.1 rev3；St.Jude Medical，Minneapolis，USA）和一个位于安全数据中心的中央服务器组成[
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过去十年儿童适应症外药物使用：范围审查Yuyi Tang, Weiguo Li, Jing Liao, Xiaoqing Wang, Muna Baskota, Enmei Liu
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000001991
摘要
致编辑：标签外药物使用（OLDU）是指在标签上注明的年龄、适应症、体重、剂量、制剂或给药途径之外使用药物。由于缺乏儿科特异性药物信息，这是全球临床医生，尤其是儿科医生的主要关注点和常见做法。[
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应用依达拉奉减少老年髋关节置换患者围手术期神经认知障碍Yujing Yuan, Liujiazi Shao, Xin Luo, Fushan Xue
中华医学杂志英文版2023年 136卷 05期
DOI: 10.1097/CM9.0000000000001973
摘要
致编辑：通过一项随机对照试验，*和在[
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