MedNexus
2022年 · 第135卷第17期
出版日期 2022-09-05电子版 ￥0.00元
MedNexus
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- Review Article
- Original Article
- Clinical Observation
- Technical Notes
- Correspondence
- Corrigendum
Review Article
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微小RNA在直肠癌放疗中的作用机制Lili Zhu, Mojin Wang, Na Chen, Yujie Zhang, Tao Xu, Wen Zhuang, Shuomeng Xiao, Lei Dai
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002139
摘要
Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.
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铁下垂及其在急性胰腺炎中的新作用Hongyao Li, Yujie Lin, Ling Zhang, Jing Zhao, Peiwu Li
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002096
摘要
Acute pancreatitis (AP) is a common and potentially life-threatening pancreatic inflammatory disease. Although it is usually self-limiting, up to 20% of patients will develop into severe AP. It may lead to systemic inflammatory response syndrome and multiple organ dysfunction, affecting the lungs, kidneys, liver, heart, etc. Surviving patients usually have sequelae of varying degrees, such as chronic hyperglycemia after AP (CHAP), pancreatic exocrine insufficiency, and chronic pancreatitis. Lacking specific target treatments is the main reason for high mortality and morbidity, which means that more research on the pathogenesis of AP is needed. Ferroptosis is a newly discovered regulated cell death (RCD), originally described in cancer cells, involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids, and a caspase-independent RCD. It is closely related to neurological diseases, myocardial infarction, ischemia/reperfusion injury, cancer, etc. Research in the past years has also found the effects of ferroptosis in AP, pancreatic cancer, and AP complications, such as acute lung injury and acute kidney injury. This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP, trying to provide new insight into the pathogenesis and treatment of AP, facilitating the development of better-targeted drugs.
Original Article
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中美原发性肝癌发病率时间趋势比较：2019年全球疾病负担的年龄-时期-队列分析Zhiyong Zou, Zuofeng Zhang, Ce Lu, Hui Wang
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001980
摘要
Background:
China and the United States (US) ranked first and third in terms of new liver cancer cases and deaths globally in 2020. Therefore, a comprehensive assessment of trends in the incidence of primary liver cancer with four major etiological factors between China and the US during the past 30 years with age-period-cohort (APC) analyses is warranted.
Methods:
Data were obtained from the Global Burden of Disease 2019, and period/cohort relative risks were estimated by APC modeling from 1990 to 2019.
Results:
In 2019, there were 211,000 new liver cancer cases in China and 28,000 in the US, accounting for 39.4% and 5.2% of global liver cancer cases, respectively. For China, the age-standardized incidence rate (ASIR) consecutively decreased before 2005 but increased slightly since then, whereas the ASIR continuously increased in the US. Among the four etiological factors of liver cancer, the fastest reduction in incidence was observed in hepatitis B virus-related liver cancer among Chinese women, and the fastest increase was in nonalcoholic steatosis hepatitis (NASH)-related liver cancer among American men. The greatest reduction in the incidence of liver cancer was observed at the age of 53 years in Chinese men (-5.2%/year) and 33 years in Chinese women (-6.6%/year), while it peaked at 58 years old in both American men and women (4.5%/year vs. 2.8%/year). Furthermore, the period risks of alcohol- and NASH-related liver cancer among Chinese men have been elevated since 2013. Simultaneously, leveled-off period risks were observed in hepatitis C viral-related liver cancer in both American men and women.
Conclusions:
Currently, both viral and lifestyle factors have been and will continue to play an important role in the time trends of liver cancer in both countries. More tailored and efficient preventive strategies should be designed to target both viral and lifestyle factors to prevent and control liver cancer.
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接受经动脉化疗栓塞的不可切除肝细胞癌患者肝肺综合征的患病率和预后影响：一项前瞻性队列研究He Zhao, Jiaywei Tsauo, Xiaowu Zhang, Huaiyuan Ma, Ningna Weng, Zhengqiang Yang, Xiao Li
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002034
摘要
Background:
To determine the prevalence and prognostic impact of hepatopulmonary syndrome (HPS) in patients with unresectable hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).
Methods:
Fifty-four patients with unresectable HCC undergoing TACE between December 2014 and December 2015 were prospectively screened for HPS and were followed up for a maximum of 2 years or until the end of this prospective study.
Results:
Nineteen of the 54 (35.2%) patients were considered to have HPS, including one (5.3%) with severe HPS, nine (47.4%) with moderate HPS, and nine (47.4%) with mild HPS. The median overall survival (OS) was 10.1 (95% confidence interval [CI], 3.9–16.3) months for patients with HPS and 15.1 (95% CI, 7.3–22.9) months for patients without HPS, which is not a significant difference (P = 0.100). The median progression-free survival was also not significantly different between patients with and without HPS (5.2 [95% CI, 0–12.8] vs. 8.4 [95% CI, 3.6–13.1] months; P = 0.537). In the multivariable Cox regression analyses, carbon monoxide diffusing capacity (hazard ratio [HR] = 1.033 [95% CI, 1.003–1.064]; P = 0.028) and Child-Pugh class (HR = 1.815 [95% CI, 1.011–3.260]; P = 0.046) were identified to be the independent prognostic factors of OS.
Conclusion:
Mild or moderate HPS is common in patients with unresectable HCC undergoing TACE, but it does not seem to have a significant prognostic impact.
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1990-2019年中国乙型肝炎肝病死亡率趋势：全球疾病负担研究结果Guiying Cao, Jue Liu, Min Liu
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002331
摘要
Background:
Hepatitis B is a viral infection that attacks the liver and can cause both potentially life-threatening acute and chronic liver disease. China has the world’s largest burden of hepatitis B and is considered to be a major contributor toward the goal of World Health Organization (WHO) of eliminating hepatitis B virus (HBV) as a global health threat by 2030. This study aimed to analyze data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to determine the trends in mortality of liver disease due to hepatitis B in China between 1990 and 2019 and the gap with the WHO’s goal.
Methods:
Annual deaths and age-standardized mortality rates (ASMRs) of liver disease due to hepatitis B in China between 1990 and 2019 were collected from GBD 2019. We calculated the percentage changes in deaths and estimated annual percentage changes (EAPCs) of ASMRs of liver disease due to hepatitis B.
Results:
In China, deaths of total liver disease due to hepatitis B decreased by 29.13% from 229 thousand in 2016 to 162 thousand in 2019, and ASMR decreased by an average of 4.92% (95% confidence interval [CI]: 4.45–5.39%) per year in this period. For the spectrum of liver disease due to hepatitis B, deaths decreased by 74.83%, 34.71%, and 23.34% for acute hepatitis, cirrhosis and other chronic liver diseases, and liver cancer from 1990 to 2019, respectively, and ASMRs of acute hepatitis (EAPC = –7.63; 95% CI: –8.25, –7.00), cirrhosis and other chronic liver diseases (EAPC= –4.15; 95% CI: –4.66, –3.65), and liver cancer (EAPC = –5.17; 95% CI: –6.00, –4.33) decreased between 1990 and 2019. The proportions of older adults aged ≥70 years among all deaths of the spectrum of liver disease due to hepatitis B increased from 1990 to 2019. Deaths of liver cancer due to hepatitis B increased by 7.05% from 2015 to 2019.
Conclusions:
Although a favorable trend in the mortality of liver disease due to hepatitis B was observed between 1990 and 2019, China still faces challenges in achieving the WHO’s goal of eliminating HBV as a public threat by 2030. Therefore, efforts to increase the coverage of diagnosis and treatment of liver disease due to hepatitis B, especially of liver cancer due to hepatitis B, are warranted in China.
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1990年至2019年儿童和青少年非运输意外伤害死亡率的全球趋势和地区差异：2019年全球疾病负担研究结果Yunfei Liu, Yanhui Dong, Xiaojin Yan, Ning Ma, Jiajia Dang, Jingshu Zhang, Panliang Zhong, Luo Li, Zhiyong Zou, Yi Song 等
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002315
摘要
Background:
Non-transport unintentional injuries (NTUIs) are major public concerns, especially among children and adolescents in low- and middle-income countries. With environmental and cognitive changes, a recent systematic description of global trends and regional differences concerning NTUIs is urgently needed for the global agenda of relevant policy-making and intervention target findings.
Methods:
We used mortality, population, and socio-demographic-index (SDI) data from Global Burden of Disease 2019 to analyze the trends of NTUIs mortality. We applied the slope index of inequality (SII) and relative index of inequality (RII) to measure the absolute and relative inequality between countries and territories. The concentration curve and concentration index (CI) were also used to measure the inequality. We conducted a sensitivity analysis to make our findings credible.
Results:
In 2019, there were 205,000 deaths due to NTUIs among children and adolescents aged 5 to 24 years, which decreased from 375,000 in 1990. In 2019, the age-standardized mortality rate (ASMR) was 8.13 per 100,000, ranging from the lowest in the Netherlands (0.90 per 100,000) to the highest in the Solomon Islands (29.34 per 100,000). The low-middle SDI group had the highest ASMR of NTUIs, while the low SDI group had the slowest decrease. After excluding the death caused by "exposure to forces of nature" and "other unintentional injuries" , drowning accounted for the most deaths in almost every SDI group, gender, and age group, but the major causes of death varied in different subgroups. For example, animal contact was a major cause in low and low-middle SDI groups but less in high SDI groups, while high and high-middle SDI groups had a higher proportion of deaths for foreign body and poisonings. The SII showed a declining trend, but the RII and CI did not, which might indicate that inequality was persistent. Similar results were found in the sensitivity analysis.
Conclusions:
Despite the declining trend of the mortality rate and the narrowing gap between countries, there were still a large number of children and adolescents dying from NTUIs, and those experiencing social-economic disadvantages remained at high mortality. Embedding the prevention of NTUIs into sustainable development goals might contribute to the progress of reducing death and inequalities, which ensures that no one is left behind.
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2013-2018年中国心血管疾病死亡率的时间趋势及其对预期寿命增长的贡献Xue Xia, Yue Cai, Xiang Cui, Ruixian Wu, Fangchao Liu, Keyong Huang, Xueli Yang, Xiangfeng Lu, Shiyong Wu, Dongfeng Gu
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002082
摘要
Backgrounds:
Cardiovascular disease (CVD) remains the leading cause of deaths nationwide. However, little is understood about its temporal trend and corresponding influence on longevity improvements. We aimed to describe the updated tendency in CVD mortality and to quantify its impact on life expectancy (LE) increase in China.
Methods:
All-cause mortality rates were calculated with population sizes from the National Bureau of Statistics and death counts from the National Health Commission. We estimated CVD mortality rates by allocating age- and sex-based mortality envelopes to each CVD subtype based on its proportion derived from the Disease Surveillance Points system. The probability of CVD premature deaths and LE were calculated with life tables and we adopted Arriaga’s method to quantitate age- and cause-specific contributions to LE gains.
Results:
During 2013 to 2018, the age-standardized mortality rate of CVD decreased from 289.69 (95% confidence interval [CI]: 289.03, 290.35)/100,000 to 272.37 (95%CI: 271.81, 272.94)/100,000, along with a decline in probability of CVD premature deaths from 9.05% (95%CI: 9.02%, 9.09%) to 8.13% (95%CI: 8.10%, 8.16%). The gap in CVD mortality across sexes expanded with more remarkable declines in females, especially for those aged 15 to 64 years. Among major subtypes, the probability of premature deaths from hemorrhage stroke declined fastest, while improvements of ischemic stroke and ischemic heart disease were limited, and there was an increase in stroke sequelae. LE in China reached 77.04 (95%CI: 76.96, 77.12) years in 2018 with an increase of 1.38 years from 2013. Of the total LE gains, 21.15% (0.29 years) were attributed to reductions of CVD mortality in the overall population, mostly driven by those aged >65 years.
Conclusions:
The general process in reducing CVD mortality has contributed to longevity improvements in China. More attention should be paid to prevention and control of atherosclerotic CVD and stroke sequelae, especially for the elderly. Working-age males also deserve additional attention due to inadequate improvements.
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肿瘤诊断的多样性和异质性：晚期乳腺癌转移再活检的真实世界研究Huimin Lv, Limin Niu, Mengwei Zhang, Huiai Zeng, Shengnan Zhao, Min Yan
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001969
摘要
Background:
Re-biopsy of metastasis in advanced breast cancer (ABC) has become an international convention to assist the diagnosis and evaluation of tumor heterogeneity. This study aimed to detect diagnostic diversity and inconsistencies among estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression levels between primary and metastatic lesions.
Methods:
We conducted a retrospective analysis of 1670 cases of ABC patients who had undergone at least one lesion re-biopsy from January 2010 to December 2018. The pathological diagnosis of biopsies, distribution of biopsy sites, and severe puncture complications at each site were collected. In addition, the inconsistency rates and related factors of ER, PR, and HER2 expression between primary and metastatic lesions were analyzed fully considering patients’ demographic profiles and disease characteristics.
Results:
In total, 1670 cases of breast cancer (BC) patients diagnosed by pathology underwent one to four biopsies of recurrences or metastases in different sites or at different stages during the rescue treatment, producing 2019 histopathological specimens which were analyzed in the study. Pathological diagnosis showed that eight patients had benign pathological diagnoses, 11 patients had second primary malignant tumors but without recurrences of breast cancer, and 17 patients had pathologically confirmed breast cancer recurrences combined with second primary cancer. In 1173 patients who presented ER, PR, and HER2 expressions in primary and metastatic lesions, the inconsistency rates of ER, PR, and HER2 were 17.5% (205/1173), 31.3% (367/1173), and 13.9% (163/1173), respectively. The multivariate analysis showed that the age at the onset of breast cancer or adjuvant endocrine therapy was an independent factor affecting changes in PR expression level. Except one liver puncture with local hemorrhage and two lung punctures with hemopneumothorax, no other severe puncture complications occurred in 1950 non-surgical rebiopsies.
Conclusions:
The pathological diagnosis of metastasis re-biopsy of ABC was diverse, and the ER, PR, and HER2 expression levels were inconsistent between primary and metastatic lesions. Therefore, more attention should be paid to perform biopsies of relapsed and metastatic breast cancers routinely in clinical practice.
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男性性激素结合球蛋白与肾功能的关系：SPECT-China研究结果Haojie Zhang, Chi Chen, Xuan Zhang, Yuying Wang, Heng Wan, Yi Chen, Wen Zhang, Fangzhen Xia, Yingli Lu, Ningjian Wang
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002046
摘要
Background:
The association between sex hormone-binding globulin (SHBG) and renal function has rarely been reported in men. We aimed to investigate the above association in a community-based Chinese population.
Methods:
A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors, which is a population-based study conducted from 2014 to 2016 in Eastern China. The estimated glomerular filtration rate (eGFR) was calculated according to the chronic kidney disease Epidemiology Collaboration equation. Low eGFR was defined as eGFR <60 mL·min-1·1.73 m-2.
Results:
After adjusting for age, smoking, metabolic factors, and testosterone, through increasing quartiles of SHBG, a significantly positive association between SHBG quartiles and eGFR was detected in men (Q1 vs. Q4, β -2.53, 95% confidence interval -3.89,-1.17, Ptrend < 0.001). Compared with the highest quartile of SHBG, SHBG in the lowest quartile was associated with 96% higher odds of low eGFR (odds ratio 1.96, 95% confidence interval 1.10, 3.48) in the model after full adjustment. According to the stratified analyses, the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged ≥60 years old, waist circumference <90 cm, diabetes (no), hypertension (yes), dyslipidemia (no), and nonalcoholic fatty liver disease (no).
Conclusions:
Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics, lifestyle, metabolic-related risk factors, and testosterone. Large prospective cohort and basic mechanistic studies are warranted in the future.
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MicroRNA-20a-5p靶向调节人肝细胞癌上皮-间质转化RUNX3Xianjue Wang, Ping Wei, Ling Yang, Fangyuan Liu, Xin Tong, Xiaoyu Yang, Liya Su
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001975
摘要
Background:
MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aimed to study the role of miR-20a-5p in HCC and its downstream molecular mechanisms.
Methods:
We used real-time polymerase chain reaction to detect the expression of miR-20a-5p and runt-related transcription factor 3 (RUNX3) in HCC and paraneoplastic tissue, transfected Huh7 and highly metastatic human hepatocellular carcinoma (MHCC97H) cells. A live cell workstation was used to observe the proliferation and migration of transfected cells. The invasiveness of transfected cells was verified by Transwell assay. Cell apoptosis was detected by flow cytometry. The expression levels of proteins after transfection were measured using simple western immunoblot measurements. Gene expression profiles between HCC and normal samples were obtained from The Cancer Genome Atlas. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were processed by the database for annotation, visualization and integrated discovery. Potential target genes of miR-20a-5p were predicted to further investigate how miR-20a-5p regulates epithelial-mesenchymal transition (EMT) in HCC.
Results:
MiR-20a-5p was significantly highly expressed in HCC tissues, and overexpression of miR-20a-5p significantly promoted HCC cell proliferation, migration, and invasion and inhibited apoptosis in vitro. The protein expression of E-cadherin was decreased and that of vimentin was increased after overexpression of miR-20a-5p in HCC cells. We discovered the intersection of genes from miRDB, miR TarBase, and TargetScan, obtained 397 target genes and finally focused on RUNX3. RUNX3 was not only reduced in HCC specimens but also drastically reduced in HCC cells overexpressing miR-20a-5p. RUNX3 expression decreased with elevated miR-20a-5p, which activated downstream EMT signaling and promoted cell proliferation, migration, and invasion.
Conclusions:
Since RUNX3 is involved in EMT in HCC, as proven by previous research, our findings provide further evidence for a novel regulatory pathway comprising the miR-20a/RUNX3/EMT axis that upregulates EMT signaling and enhances the migration of HCC cells.
Clinical Observation
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支气管镜热蒸汽消融对不均匀性肺气肿患者的疗效和三维通气/灌注单光子发射计算机断层扫描/计算机断层扫描肺叶定量：一项来自中国的前瞻性试点研究Wenjun Zhu, Yuchen Zhang, Felix J.F. Herth, Dan Liu, Hui Zhu, Jingyu Shi, Chujie Zhang, Gongshun Tang, Fengming Luo
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002013
摘要
慢性阻塞性肺病（COPD）的特征是肺气肿和气流受限，是全世界发病率和死亡率的主要原因之一。内镜肺减容术（ELVR）是一种微创技术，适用于严重过度充气和晚期肺气肿患者。迄今为止，研究最多的ELVR形式是瓣膜植入，即在肺气肿肺叶的所有节段中放置瓣膜。然而，在存在叶间侧支通气（CV）的情况下，瓣膜置换不能实现足够的肺容量减少。[
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m7G RNA调节因子在胰腺癌中的作用及预后表现Qihang Yuan, Jie Ren, Xu Chen, Yantong Dong, Dong Shang
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002179
摘要
胰腺癌（PAAD）是全球内分泌癌死亡的主要原因，给公众健康带来负担。新出现的证据表明，PAAD的形成是一个极其复杂的多基因参与和多阶段进化的生物学过程。[
Technical Notes
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椎/锁骨下动脉血管成形术中球囊支持栓塞保护技术Hao Liu, Daqiao Guo, Bin Chen, Junhao Jiang, Yun Shi, Tao Ma, Changpo Lin, Zhihui Dong, Weiguo Fu
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002256
摘要
后循环卒中的发病率和死亡率很高，占缺血性卒中的20%，大约25%发生在椎动脉和/或基底动脉狭窄的患者中。[
Correspondence
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顺行股总动脉入路Shenton线确定股动脉分叉的临床应用Hui Zhao, Liang Zhao, Fuxian Zhang, Hao Wang, Jie Zhang, Changbao Yan, Peiqiang Geng, Yanyang Wang, Zongheng Gu, Dafang Liu 等
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001873
摘要
致编辑：股总动脉是外科手术最受欢迎的穿刺通路。股深动脉和股浅动脉分叉处的股总动脉远端难以识别，尤其是血管外科医生行顺行股动脉穿刺治疗同侧下肢动脉病变时。许多研究报道了在X射线上解剖定位股骨头的方法。在此，我们介绍一个解剖学标志——Shenton线，它是指正常骨盆正位片上连接股骨颈内外侧缘和耻骨下缘的弧线。
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组蛋白去乙酰化酶8通过H3K9乙酰化调节哮喘小鼠NF-κ B相关炎症Yuan Ren, Menglu Li, Shiyao Bai, Xinming Su
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001963
摘要
致编辑：支气管哮喘是一种呼吸系统疾病，其病理特征主要包括气道炎症、气道重塑和气道高反应性的改变。哮喘发作时，大量炎症基因被激活，炎症介质表达增加，最终导致气道高反应性和重塑。核因子-κ B（NF-κ B）由Rel家族的转录活性二聚体组成，与哮喘发作时炎症基因的表达密切相关。
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全因死亡率的流行病学特征回顾COVID-19阴云下的院外死亡Linfeng Li, Weidong Yan, Yongqing Wang, Dezhi Chen, Yuanchang Qiao, Min Liu, Bin Cong, Libing Yun
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002146
摘要
致编辑：冠状病毒疾病2019（新冠肺炎）已迅速成为一种巨大的全球感染，并带来了广泛的健康后果，包括由于持续传播而导致的大量死亡。[
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止血剂在微创肾部分切除术中是否有效和安全？Qiong Guo, Yifei Lin, Chenyang Zhang, Fangqun Leng, Youlin Long, Yifan Cheng, Liu Yang, Liang Du, Jin Huang, Ga Liao
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001992
摘要
致编辑：肾细胞癌（RCC）是成人最常见的十大癌症之一。[
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之间的关联CYP2C9、VORC1、VDR、和APOE中国心脏瓣膜置换患者华法林维持和初始抗凝反应的基因型Xiaoye Li, Zi Wang, Zhiyan Liu, Limin Xia, Qianzhou Lyu
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002016
摘要
致编辑：对于机械和生物人工心脏瓣膜置换患者，根据指南推荐维生素K拮抗剂（VKA）治疗。有效和安全的华法林治疗需要持续监测凝血酶原时间和国际标准化比值（INR）水平，以调整华法林的剂量。
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从肿瘤学家的角度关注抗癌治疗诱导的心脏毒性Binliang Liu, Yanfeng Wang, Dan Lyu, Fei Ma
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002133
摘要
致编辑：癌症和心血管（CV）疾病与世界上最大的发病率和死亡率相关，它们通过一些共同的风险因素相互关联。[
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2型糖尿病合并胆石症患者肠道菌群的变化Jiajia Chen, Linlin Yan, Xingfan Ma, Ping Yuan, Fan Zhao, Zihan Han, Jingshan Liu, Wenbo Wang, Donghai Zhou, Hongyu Zhao 等
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002102
摘要
致编辑：2型糖尿病（T2D）和胆石症都是患病率较高的常见病。在中国，T2D患病率为0.9%[
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维持性血液透析患者血小板形态学指标与尿毒症瘙痒的关系Zhen Ai, Qixia Lei, Naya Huang, Xiaoqing Ye, Raoping Wang, Yuanwen Xu, Wei Chen
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002107
摘要
致编辑：尿毒症性瘙痒是一种常见且令人痛苦的并发症，影响>65%接受维持性血液透析（MHD）的患者。尿毒症瘙痒的强度与MHD患者的抑郁、睡眠障碍、生活质量下降和死亡率增加相关；然而，尿毒症瘙痒症的发病机制知之甚少，目前没有有效的治疗方法。[
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通过生物信息学分析鉴定脓毒症诱导免疫抑制过程中中性粒细胞差异表达基因和信号通路Yongxin Zheng, Zhihui Zhang, Yongbo Huang, Jinping Wang, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000001878
摘要
致编辑：脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍。脓毒症严重扰乱免疫稳态，并通过直接改变负责稳态的效应细胞的寿命、产生和功能来损害先天和适应性免疫。[
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苯磺酸瑞马唑仑用于重症监护病房术后患者镇静：一项I期、开放标签、剂量探索研究Yun Tang, Xiaobo Yang, Huaqing Shu, Yuan Yu, Jiqian Xu, Shangwen Pan, Xiaojing Zou, Shiying Yuan, You Shang
中华医学杂志英文版2022年 135卷 17期
DOI: 10.1097/CM9.0000000000002243
摘要
致编辑：苯磺酸瑞马唑仑是一种新型、超短效苯二氮卓类药物，起效和抵消特征迅速且可预测，无蓄积和延长效应，且不依赖于器官消除。[
Corrigendum
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勘误表：炎症介导的酪蛋白激酶2-相互作用蛋白-1对间充质干细胞成骨的年龄依赖性影响中华医学杂志英文版2022年 135卷 17期
DOI: 10.3760/cma.j.issn.0366-6999.2022.17.101
摘要
在最初的文章发表之后，[
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