MedNexus
2022年 · 第135卷第08期
出版日期 2022-04-20电子版 ￥0.00元
MedNexus
- 全部
- Editorial
- Consensus Statement
- Review Article
- Meta Analysis
- Original Article
- Clinical Observation
- Technical Notes
- Correspondence
- Corrigendum
Editorial
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中国慢性淋巴细胞白血病Robert Peter Gale
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001811
摘要
慢性淋巴细胞白血病（CLL）在中国汉族人中的发病率比主要为欧洲血统的人低10至20倍，相当于每10E+5人口/年的发病率为0.2至0.6vs.4.6每10E+5人口/年。[
Consensus Statement
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2021中国妊娠期原发性免疫性血小板减少症诊断与管理共识Xiaohui Zhang, Fangping Chen, Xiequn Chen, Yunfeng Cheng, Meiyun Fang, Jianming Feng, Haixia Fu, Hong Gao, Yue Han, Aili He 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002043
摘要
免疫性血小板减少症（ITP）是一种以孤立性血小板减少为特征的获得性疾病，是妊娠期血小板减少最常见的原因之一。患有严重血小板减少症的ITP妇女发生危及生命的产科并发症的风险增加。因此，我们就妊娠期ITP的诊断和管理建立了这一共识声明（详细信息可在补充文件http://links.lww.com/CM9/A978中获得）。
Review Article
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免疫治疗时代异基因造血干细胞移植在成人急性淋巴细胞白血病治疗中的作用Wei Sun, Xiaojun Huang
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001898
摘要
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the standard of care for adult acute lymphoblastic leukemia (ALL) patients. In recent years, with the continuous development of immunotherapy, such as chimeric antigen receptor T cells, blinatumomab, and inotuzumab ozogamicin, a series of vital clinical studies have confirmed its high response rate and favorable outcomes for ALL. Although the emergence of immunotherapy has expanded relapsed or refractory (r/r) ALL patients' opportunities to receive allo-HSCT, allo-HSCT is associated with potential challenges. In this review, the role of allo-HSCT in the treatment of adult ALL in the era of immunotherapy will be discussed.
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干细胞逆转衰老Le Chang, Weiwen Fan, Xinghua Pan, Xiangqing Zhu
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001984
摘要
As human life expectancy continues to increase and the birth rate continues to decline, the phenomenon of aging is becoming more prominent worldwide. Therefore, addressing the problems associated with global aging has become a current research focus. The main manifestations of human aging are structural degeneration and functional decline of aging tissues and organs, quality of life decline, decreased ability to resist diseases, and high incidence rates of a variety of senile degenerative diseases. Thus far, no ideal treatments have been found. Stem cell (SC) therapies have broad application prospects in the field of regenerative medicine due to the inherent biological characteristics of SCs, such as their plasticity, self-renewal, and multidirectional differentiation potential. Thus, SCs could delay or even reverse aging. This manuscript reviews the causes of human aging, the biological characteristics of SCs, and research progress on age reversal.
Meta Analysis
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脊柱关节炎患者生物和靶向药物感染风险：随机临床试验的荟萃分析Lidong Hu, Siliang Man, Xiaojian Ji, Yiwen Wang, Xingkang Liu, Jiaxin Zhang, Chuan Song, Jian Zhu, Feng Huang
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001928
摘要
Background:
Concerns exist regarding the risk of infections in patients with spondyloarthritis (SpA) treated with biologics. We assessed the risk of infections of biological and targeted drugs in patients with SpA by performing a meta-analysis based on randomized controlled trials (RCTs).
Methods:
A systematic literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and China Biology Medicine Disc for RCTs evaluating the risk of infections of biological therapy in patients with SpA from inception through August 9, 2021. We calculated a pooled Peto odds ratio (OR) for infections in biologics-treated patients vs. placebo patients. The risk of bias on the included RCTs was assessed by using the Cochrane Risk of Bias Tool.
Results:
In total, 62 studies were included in this meta-analysis. Overall, the risk of infection (Peto OR: 1.16, 95% confidence interval [CI]: 1.07-1.26, P < 0.001), serious infection (Peto OR: 1.65, 95% CI: 1.26-2.17, P < 0.001), upper respiratory tract infection (URTI) (Peto OR: 1.17, 95% CI: 1.04-1.32, P = 0.008), nasopharyngitis (Peto OR: 1.25, 95% CI: 1.10-1.42, P < 0.001), and Candida infection (Peto OR: 2.64, 95% CI: 1.48-4.71, P = 0.001) were increased in SpA patients treated with biologics compared with placebo. Sensitivity analysis based on biologics classes was conducted, and results demonstrated that compared with placebo, there was a higher risk of infection for tumor necrosis factor (TNF)-α inhibitors (Peto OR: 1.38, 95% CI: 1.13-1.68, P = 0.001) and interleukin (IL)-17 inhibitors (Peto OR: 1.55, 95% CI: 1.08-2.22, P = 0.018) in axial SpA, and for Janus kinase inhibitors in peripheral SpA (Peto OR: 1.39, 95% CI: 1.14-1.69, P = 0.001); higher risk of serious infection for IL-17 inhibitors in peripheral SpA (Peto OR: 3.46, 95% CI: 1.26-9.55, P = 0.016) and axial SpA (Peto OR: 2.01, 95% CI: 1.38-2.91, P < 0.001); higher risk of URTI for TNF-α inhibitors in axial SpA (Peto OR: 1.37, 95% CI: 1.05-1.78, P= 0.019), and for apremilast in peripheral SpA (Peto OR: 1.60, 95% CI: 1.08-2.36, P = 0.018); higher risk of nasopharyngitis for TNF-α inhibitors in axial SpA (Peto OR: 1.41, 95% CI: 1.05-1.90, P = 0.022) and peripheral SpA (Peto OR: 1.49, 95% CI: 1.09-2.05, P = 0.013), and for IL-17 inhibitors in axial SpA (Peto OR: 1.35, 95% CI: 1.01-1.82, P = 0.044); higher risk of herpes zoster for Janus kinase inhibitors in peripheral SpA (Peto OR: 2.18, 95% CI: 1.03-4.62, P = 0.043); higher risk of Candida infection for IL-17 inhibitors in peripheral SpA (Peto OR: 2.52, 95% CI: 1.31-4.84, P= 0.006).
Conclusions:
This meta-analysis shows that biological therapy in patients with SpA may increase the risk of infections, including serious infections, URTI, nasopharyngitis, and Candida infection, which should be paid attention to in our clinical practice.
Original Article
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c-Myc依赖性异质性核核糖核蛋白A1的过表达促进细胞增殖和抑制细胞凋亡凹口1-突变的慢性淋巴细胞白血病细胞Yixin Zou, Hanning Tang, Yi Miao, Huayuan Zhu, Li Wang, Lei Fan, Jianxin Fu, Wei Xu, Jianyong Li, Yi Xia
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002037
摘要
Background:
NOTCH1 mutation is an essential molecular biologic aberration in chronic lymphocytic leukemia (CLL). CLL patients with NOTCH1 mutation have shown an unfavorable survival and a poor response to chemoimmunotherapy. This study aims to present the mechanisms of adverse prognosis caused by NOTCH1 mutation from the perspective of the splicing factor heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1).
Methods:
The microarray data in Gene Expression Omnibus datasets were analyzed by bioinformatics and the function of hnRNPA1 was checked by testing the proliferation and apoptosis of CLL-like cell lines. Afterward, quantitative reverse transcription-polymerase chain reaction and Western blotting were applied to explore the relationship among NOTCH1, c-Myc, and hnRNPA1.
Results:
RNA splicing was found to play a vital part in NOTCH1-mutated CLL cells; hence, hnRNPA1 was selected as the focus of this study. Higher expression of hnRNPA1 validated in primary NOTCH1-mutated CLL samples could promote proliferation and inhibit apoptosis in CLL. The expression of hnRNPA1 increased when NOTCH1 signaling was activated by transfection with NOTCH1 intracellular domain (NICD)-overexpressed adenovirus vector and declined after NOTCH1 signaling was inhibited by NOTCH1-shRNA. Higher expression of c-Myc was observed in NICD-overexpressed cells and hnRNPA1 expression was downregulated after applying c-Myc inhibitor 10058-F4. Moreover, in NICD-overexpressed cells, hnRNPA1 expression decreased through c-Myc inhibition.
Conclusion:
Overexpression of c-Myc-dependent hnRNPA1 could promote proliferation and inhibit apoptosis in NOTCH1- mutated CLL cells, which might partly account for the poor prognosis of patients with NOTCH1 mutation.
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对于Ph高危B细胞急性淋巴细胞白血病，单倍体相合移植比HLA相合的同胞移植具有更好的移植物抗白血病效果Menglin Fan, Yu Wang, Ren Lin, Tong Lin, Fen Huang, Zhiping Fan, Yajing Xu, Ting Yang, Na Xu, Pengcheng Shi 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001852
摘要
Background:
Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.
Methods:
This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.
Results:
A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups (P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%; P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%; P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%; P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%; P= 0.041), respectively, in the HID and MSD groups.
Conclusion:
HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transplantation for Ph- high-risk B-ALL patients.
Trial registration:
ClinicalTrials.gov: NCT01883180, NCT02673008.
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单倍体相合造血干细胞移植可提高高危T细胞急性淋巴细胞白血病患儿首次完全缓解的长期生存率Yongzhan Zhang, Lu Bai, Yifei Cheng, Aidong Lu, Yu Wang, Jun Wu, Xiaohui Zhang, Yingxi Zuo, Lanping Xu, Yueping Jia 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001999
摘要
Background:
The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with high-risk (HR) T-cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under evaluation. Moreover, relapse is the main factor affecting survival. This study aimed to explore the effect of allo-HSCT (especially haploidentical HSCT [haplo-HSCT]) on improving survival and reducing relapse for HR childhood T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.
Methods:
A total of 74 newly diagnosed pediatric T-ALL patients between January 1, 2012 and June 30, 2018 were enrolled in this retrospective study. Patients were stratified into the low-risk chemotherapy cohort (n = 16), HR chemotherapy cohort (n = 31), and HR transplant cohort (n = 27). Characteristics, survival outcomes, and prognostic factors of all patients were then analyzed.
Results:
Patient prognosis in the HR chemotherapy cohort was significantly worse than that in the low-risk chemotherapy cohort (5-year overall survival [OS]: 58.5% vs. 100%, P = 0.003; 5-year event-free survival [EFS]: 54.1% vs. 83.4%, P = 0.010; 5-year cumulative incidence of relapse [CIR]: 45.2% vs. 6.3%, P = 0.011). In HR patients, allo-HSCT improved the 5-year EFS and CIR compared to that of chemotherapy (5-year EFS: 80.1% vs. 54.1%, P = 0.041; 5-year CIR: 11.6% vs. 45.2%, P = 0.006). The 5-year OS was higher in the HR transplant cohort than that in the HR chemotherapy cohort (81.0% vs. 58.5%, P = 0.084). Minimal residual disease re-emergence was an independent risk factor for 5-year OS, EFS, and CIR; age ≥10 years was an independent risk factor for OS and EFS; and high white blood cell count was an independent risk factor for EFS and CIR.
Conclusion:
Allo-HSCT, especially haplo-HSCT, could effectively reduce relapse of children with HR T-ALL in CR1.
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糖尿病促进胃癌淋巴结转移：15年单机构经验Xinhua Chen, Yuehong Chen, Tao Li, Weiqi Liang, Huilin Huang, Hongtao Su, Chuyang Sui, Yanfeng Hu, Hao Chen, Tian Lin 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001795
摘要
Background:
Previous studies have revealed that diabetes mellitus (DM) promotes disease progress of gastric cancer (GC). This study aimed to further investigating whether DM advanced lymph nodes (LNs) metastasis in GC.
Methods:
The clinicopathologic data of GC patients with >15 examined LN (ELN) between October 2004 and December 2019 from a prospectively maintained database were included. The observational outcomes included the number (N3b status) and anatomical distribution (N3 stations) of metastatic LN (MLN).
Results:
A total of 2142 eligible patients were included in the study between October 2004 and December 2019. N3 stations metastasis (26.8% in DM vs. 19.3% in non-DM, P = 0.026) and N3b status (18.8% in DM vs. 12.8% in non-DM, P = 0.039) were more advanced in the DM group, and multivariate logistic regression analyses confirmed that DM was an independent factor of developing N3 stations metastasis (odds ratio [OR] = 1.771, P= 0.011) and N3b status (OR= 1.752, P= 0.028). Also, multivariate analyses determined DM was independently associated with more MLN (β = 1.424, P = 0.047). The preponderance of N3 stations metastasis (DM vs. non-DM, T1-2: 2.2% vs. 4.9%, T3: 29.0% vs. 20.3%, T4a: 38.9% vs. 25.8%, T4b: 50.0% vs. 36.6%; ELN16-29: 8.6% vs. 10.4%, ELN30-44: 27.9% vs. 20.5%, ELN ≥ 45: 37.7% vs. 25.3%), N3b status (DM vs. non-DM, T1-2: 0% vs. 1.7%, T3: 16.1% vs. 5.1%, T4a: 27.8% vs. 19.1%, T4b: 44.0% vs. 28.0%; ELN16-29: 8.6% vs. 7.9%, ELN30-44: 18.0% vs. 11.8%, ELN ≥ 45: 26.4% vs. 17.3%), and the number of MLN (DM vs. non-DM, T1-2: 0.4 vs. 1.1, T3: 8.6 vs. 5.2, T4a: 9.7 vs. 8.6, T4b: 17.0 vs. 12.8; ELN16-29: 3.6 vs. 4.6, ELN30-44: 5.8 vs. 5.5, ELN ≥ 45: 12.0 vs. 7.7) of DM group increased with the advancement of primary tumor depth stage and raising of ELN.
Conclusions:
DM was an independent risk factor for promoting LN metastasis. The preponderance of LN involvement in the DM group was aggravated with the advancement of tumor depth.
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系统性红斑狼疮白质高信号病变特点及临床意义Qian Guo, Yang He, Xia Liu, Xuguang Gao, Jing Xu, Xue Li, Yue Sun, Yajuan Xiang, Ru Li, Zhanguo Li
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002074
摘要
Background:
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by complex and various clinical manifestations. The study aimed to analyze clinical features and cerebral magnetic resonance imaging (MRI) changes of hyperintense white matter (WM) lesions in SLE patients.
Methods:
This was a retrospective study based on a consecutive cohort of 1191 SLE patients; 273 patients for whom cerebral MRI data were available were enrolled to assess hyperintense WM lesions associated with SLE. Patients were assigned to two groups, ie, with or without hyperintense WM lesions. The MRI assessment showed that the hyperintense WM lesions could be classified into three categories: type A, periventricular hyperintense WM lesions; type B, subcortical hyperintense WM lesions; and type C, multiple discrete hyperintense WM lesions. The clinical and MRI characteristics were analyzed. Factors related to hyperintense WM lesions were identified by multivariate logistic regression analysis.
Results:
Among the 273 SLE patients with available cerebral MRI scans, 35.9% (98/273) had hyperintense WM lesions associated with SLE. The proportions of types A, B, and C were 54.1% (53/98), 11.2% (11/98), and 92.9% (91/98), respectively. Fifty-one percents of the patients showed an overlap of two or three types. Type C was the most common subgroup to be combined with other types. Compared with those without hyperintense WM lesions, the patients with hyperintense WM lesions were associated with neuropsychiatric SLE (NPSLE), lupus nephritis (LN), hypertension, and hyperuricemia (P = 0.002, P = 0.018, P = 0.045, and P = 0.036, respectively). Significantly higher rates of polyserous effusions and cardiac involvement were found in the patients with hyperintense WM lesions (P = 0.029 and P = 0.027, respectively), and these patients were more likely to present with disease damage (P < 0.001). In addition, the patients with hyperintense WM lesions exhibited a higher frequency of proteinuria (P = 0.009) and higher levels of CD8+ T cells (P = 0.005). In the multivariate logistic analysis, hyperuricemia and higher CD8+ T cells percentages were significantly correlated with hyperintense WM lesions in SLE patients (P= 0.019; OR 2.129, 95% confidence interval [CI] 1.313-4.006 and P < 0.001; OR 1.056, 95% CI 1.023-1.098, respectively).
Conclusions:
Hyperintense WM lesions are common in SLE patients and significantly associated with systemic involvement, including NPSLE, LN, polyserous effusions, cardiac involvement, and disease damage. Hyperuricemia and a higher number of CD8+ T cells were independent factors associated with hyperintense WM lesions in SLE.
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半面小体患者下颌骨的三维测量Meng Wang, Lai Gui
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002116
摘要
Background:
Hemifacial microsomia (HFM), which involves multiple sites with different levels of severity, is the second most common congenital craniofacial deformity after cleft lip and palate. However, three-dimensional (3D) measurements of mandibular deformities have not yet been studied in detail. The objective of this study is to investigate the method of 3D measurements of mandibular deformities in HFM patients.
Methods:
A total of 48 HFM patients were included in this study. All clinical treatment for patients was performed in the Plastic Surgery Hospital of the Chinese Academy of Medical Sciences at Peking Union Medical College from June 2006 to June 2020. The patients’ 3D computerized tomography scan data were processed using medical imaging software, following four iterative steps: 3D reconstruction, mirroring, differential analysis, and partition.
Results:
The characteristics of the mandibular bone in HFM patients are mainly presented as follows: (1) compared to the normal side, the part of the bone body that extends from the ascending ramus to the pogonion (Po-NB) is analyzed using a dynamic process: less fullness-fullness-more fullness; (2) absences were frequently observed among the angular zones, that is, the height of the ascending ramus is deficient.
Conclusions:
HFM is a complicated condition with numerous variations in clinical presentation. We employed both 3D image reconstruction and computerization image processing techniques to investigate asymmetrical mandibular deformity in HFM patients in detail and with great accuracy. This will be of great use to clinicians for disease management.
Clinical Observation
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评估中国重症监护病房护士新的重症监护超声培训计划Jianhua Sun, Yue Wang, Qing Zhang, Xin Li, Wei He, Yangong Chao, Xiaoting Wang, Dawei Liu, Critical Care Ultrasound Study Group (CCUSG)
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002033
摘要
重症监护超声（CCUS）在评估休克、呼吸衰竭和指导中心静脉通路方面至关重要。[
Technical Notes
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Y形分支脑室—腹腔分流术治疗成人多房性脑积水Xiaohui Ren, Chuanwei Yang, Xiangrong Li, Yong Cui, Yonggang Wang, Dali Sui, Zhongli Jiang, Song Lin
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001961
摘要
由于神经外科操作、出血、感染或肿瘤引起的多房性脑积水（MLH）在成人中并不常见，不能通过内窥镜开窗术或单侧脑室—腹膜分流术（VPS）轻松解决，目前还没有关于MLH手术策略的共识报道。治疗的目标是恢复被困心室间室之间的连通，[
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大食管裂孔疝合并难治性胃食管反流病的内镜治疗Haijing Zhang, Haiping Zhao, Mingxing Hou, Chunlu Jin, Rui Rui, Baiyinbatu Xie, Ying Li, Zhiguang Hu, Guanlan Liu, Feng Guo 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001838
摘要
食管裂孔疝（HH）通常与胃食管反流病（GERD）有关。HH会增加GERD的发病率。[
Correspondence
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基于单细胞RNA测序的新型冠状病毒RNA复发阳性新冠肺炎患者免疫学特征分析Bin Su, Ruya Sun, Lili Zhang, Jiaying Zhang, Xia Feng, Zhenhuan Cao, Wei Hou, Xianghua Guo, Qing Ge, Qinghua Cui 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001956
摘要
致编辑：自2019年12月爆发以来，严重急性呼吸综合征冠状病毒2（新型冠状病毒）已在全球范围内感染了>24亿人，导致>490万人死亡。为了了解新型冠状病毒感染的发病机制，已经在不同疾病阶段的冠状病毒疾病-2019（新冠肺炎）患者中构建了外周血单核细胞（PBMCs）的单细胞RNA测序（scRNA-seq）图谱。[
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星状神经节阻滞后处理通过抑制失血性休克和复苏后清醒大鼠的自噬改善肠屏障功能Zhonghua Li, Wendi Wang, Qi Sun, Tingjiao Suo, Jiayi Zhai, Huibo Du, Zhen’ao Zhao, Fulong Li, Chunyu Niu, Zigang Zhao
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001968
摘要
致编辑：失血性休克是一种以微循环功能障碍和低灌注为特征的临界病理过程，严重后果是细胞损伤和器官功能障碍。肠屏障功能障碍是失血性休克引起远处器官损伤的关键环节。星状神经节阻滞（SGB）预防性治疗可显著减少失血性休克诱导的肠屏障损伤。[
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脓毒症对自发性脑出血后远期预后的影响及危险因素Jie Lin, Minglian He, Binbin Tan, Xue Yang, Yuhong Li, Jishu Xian, Hua Feng, Yujie Chen
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001954
摘要
致编辑：自发性脑出血（sICH）是我国老年人急性脑血管病中发病率较高的一种，死亡率高，存活者有远期功能损害。然而，ICH后住院期间继发感染是否对远期功能产生负面影响仍存在争议。阿里等人[
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电视胸腔镜手术治疗肺部或纵隔不明确肿块在恶性血液病疗效评估中的应用Runhui Zheng, Guilin Peng, Xin Xu, Xiaodan Luo, Chunyan Wang
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001910
摘要
致编辑：恶性血液病治疗过程中胸部病变的发病率很高，除感染外，肿瘤复发或侵犯也很常见。由于血小板低和免疫力低下，经皮肺活检或支气管镜检查可能导致严重的咯血、气胸或感染，并且由于诊断不明确，治疗通常无效。即使当患者被诊断患有真菌疾病时，仅使用抗真菌药物也很难消除病变。电视辅助胸外科（VATS）是一种重要的外科手术，用于在微创环境中进行充分的疼痛缓解和镇静，允许在自主呼吸下进行胸部手术。[
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胃肠道癌症患者免疫治疗试验中免疫检查点抑制剂相关的心脏毒性Yiqun Li, Yanfeng Wang, Ning Li, Xinjun Liang, Shu Zhang, Qingxia Fan, Xianli Yin, Zhixiang Zhuang, Yunpeng Liu, Jingdong Zhang 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002054
摘要
致编辑：胃肠道（GI）癌是中国最常见的恶性肿瘤。[
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诺模图预测扩张型心肌病患者心房颤动Yangming Mao, Yanmin Liu, Jian Zhang, Yeqian Zhu, Xinguang Chen, Ling Sun, Yao Lu, Hongwu Chen, Weizhu Ju, Gang Yang 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001926
摘要
致编辑：扩张型心肌病（DCM）是一种病因不明的原发性心肌病。[
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非高危人群肺结节的治疗：来自中国真实世界前瞻性队列研究的初步证据Jing Ren, Feng Chen, Qing Liu, Yongzhao Zhou, Yue Cheng, Panwen Tian, Ye Wang, Yalun Li, Yanqi He, Dan Liu 等
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001848
摘要
致编辑：肺癌仍然是全球肿瘤相关死亡的最常见原因。低剂量计算机断层扫描（CT）筛查已被证明可以大大降低肺癌患者的死亡率。尽管不同指南推荐的筛查人群有所不同，但老年吸烟者始终是最重要的受试者。然而，已经发现相当一部分肺癌患者是年轻的，没有烟草消费。[
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预测接受治疗的患者的累积活产率体外受精(IVF)/卵胞浆内单精子注射(ICSI)治疗输卵管和男性不育：使用XGBoost的机器学习方法Zhiyan Chen, Duoduo Zhang, Jingran Zhen, Zhengyi Sun, Qi Yu
中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000001874
摘要
致编辑：面对世界范围内日益增加的不孕症，这十年见证了人工生殖技术（ART）的利用急剧上升。[
Corrigendum
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对杨涛等的更正。中国医学杂志2022；135：672-680.中华医学杂志英文版2022年 135卷 08期
DOI: 10.1097/CM9.0000000000002306
摘要
杨等人在2022年3月20日出版的文章中出现了出版商在排版过程中引入的印刷错误。[
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