MedNexus
2021年 · 第134卷第01期
出版日期 2021-01-05电子版 ￥0.00元
MedNexus
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- Editorial
- Consensus Statement
- Review Article
- Medical Progress
- Perspective
- Original Article
- Clinical Observation
- Technical Notes
- Correspondence
Editorial
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了解成人潜伏性自身免疫性糖尿病的漫长而曲折的道路Shuo-Ming Luo, Bing-Wen Liu, Wen-Feng Yin, Xia Li, Zhi-Guang Zhou
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001321
摘要
成人潜伏性自身免疫性糖尿病（LADA）描述了发展为表型2型糖尿病（T2D）但具有胰岛自身免疫标志物的患者亚组。LADA是1型糖尿病（T1D）的一种亚型还是一种独特的疾病仍有争议。取决于种族，LADA在表型T2D中占约1.5%至14.2%。它是成人中诊断的最常见的自身免疫性糖尿病形式，患病率比成人发病的T1D高3.3至12.2倍。[
Consensus Statement
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老年患者围手术期脑健康中国多学科专家共识综述Min Li, Tian-Long Wang, Dong-Xin Wang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001213
摘要
中国快速老龄化的人口给麻醉师带来了严峻的挑战。老年患者的合并症和功能下降增加了脑部并发症的风险，这可能导致长期发病率和术后总体生活质量下降。[
Review Article
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NLRP3炎症小体：高危生殖障碍的新治疗靶点？Feng Zhou, Chao Li, Song-Ying Zhang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001214
摘要
The NOD-like receptor protein 3 (NLRP3) inflammasome is a key regulator of the host’s immune response, and many immune and metabolic disorders are linked to its activation. This review aimed to investigate and clarify the relationship between this inflammasome and high-risk reproductive disorders. Papers cited here were retrieved from PubMed up to August 2020 using the keywords "NLRP3" or "NALP3" , "caspase-1" , "endometriosis" , "gestational diabetes" , "interleukin (IL)-18" , "IL-1β" , "pre-eclampsia (PE)" , "preterm birth" , "polycystic ovarian syndrome (PCOS)" , "recurrent spontaneous abortion (RSA)" , and combinations of these terms. The results show that NLRP3 inflammasome is associated with various high-risk reproductive disorders and many inflammatory factors are secreted during its activation, such as IL-1β induced during the development of endometriosis. PCOS is also associated with activation of the NLRP3 inflammasome, especially in overweight patients. It also participates in the pathogenesis of RSA and is activated in fetal membranes before preterm birth. The placentas of pregnant women with PE show higher expression of the NLRP3 inflammasome, and gestational diabetes mellitus occurs simultaneously with its activation. Current evidence suggest that the NLRP3 inflammasome plays an important role in female reproductive disorders. New treatment and management methods targeting it might help reduce the incidence of such disorders and improve neonatal outcomes.
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精氨酸代谢：胰腺癌治疗的潜在靶点Jin-Shou Yang, Cheng-Cheng Wang, Jiang-Dong Qiu, Bo Ren, Lei You
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001216
摘要
Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an extremely low survival rate of <9% in the United States. As a new hallmark of cancer, metabolism reprogramming exerts crucial impacts on PDAC development and progression. Notably, arginine metabolism is altered in PDAC cells and participates in vital signaling pathways. In addition, arginine and its metabolites including polyamine, creatine, agmatine, and nitric oxide regulate the proliferation, growth, autophagy, apoptosis, and metastasis of cancer cells. Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy. However, drug resistance develops during arginine depletion treatment, along with the re-expression of ASS1, metabolic dysfunction, and the appearance of anti-drug antibody. Additionally, arginase 1 exerts crucial roles in myeloid-derived suppressor cells, indicating its potential targeting by cancer immunotherapy. In this review, we introduce arginine metabolism and its impacts on PDAC cells. Also, we discuss the role of arginine metabolism in arginine deprivation therapy and immunotherapy for cancer.
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MAFLDvs.NAFLD：流行病学、病理生理学、诊断和药物治疗的共同特征和潜在变化Ying-Xin Xian, Jian-Ping Weng, Fen Xu
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001263
摘要
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, placing an increasing burden on human health. NAFLD is a complex multifactorial disease involving genetic, metabolic, and environmental factors. It is closely associated with metabolic syndrome, obesity, and type 2 diabetes, of which insulin resistance is the main pathophysiological mechanism. Over the past few decades, investigation of the pathogenesis, diagnosis, and treatments has revealed different aspects of NAFLD, challenging the accuracy of definition and therapeutic strategy for the clinical practice. Recently, experts reach a consensus that NAFLD does not reflect the current knowledge, and metabolic (dysfunction) associated fatty liver disease (MAFLD) is suggested as a more appropriate term. The new definition puts increased emphasis on the important role of metabolic dysfunction in it. Herein, the shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy of the newly defined MAFLD, as compared with the formerly defined NAFLD, are reviewed for updating our understanding.
Medical Progress
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溶酶体相关蛋白跨膜-4 β：一种具有多种功能的新型癌症治疗潜在生物标志物Xi-Chao Xu, Jian-Guo Feng, Li-Ling Tang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001021
摘要
LAPTM4B它是一种原癌基因，在癌症的进展中起着重要作用，包括临床分期和病理分级。[
Perspective
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补充维生素D对胰腺β细胞破坏和1型糖尿病的影响Xiao-Bo Hu, Ting-Ting Duan, Jun Liu, Gao-Lu Zhu, Zhao-Hui Cao, Shao-Long Feng
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001239
摘要
1型糖尿病(T1D)是一种器官特异性自身免疫性疾病，伴有胰腺β-细胞的丢失，其特征是胰岛素水平降低和血糖升高。[
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1型糖尿病的口服耐受治疗Rui-Feng Mao, Ying-Ying Chen, En-Jie Diao, Xin Chang, Zhen-Jing Chi, Ye-Fu Wang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001130
摘要
1型糖尿病(T1DM)是一种自身免疫性疾病，其特征在于T细胞介导的胰腺β细胞的破坏，这导致几乎完全丧失合成胰岛素的能力。[
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脂肪肥大：患病率、临床后果和发病机制Xiao-Han Xu, Vladmir Carvalho, Xiao-Hang Wang, Shan-Hu Qiu, Zi-Lin Sun
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000000970
摘要
胰岛素治疗有许多皮肤改变和皮肤相关的不良反应，脂肪肥大（LH）是其中最常见的。[
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2019冠状病毒病急诊心脏手术患者的预防和保护管理Fei Xiang, Nian-Guo Dong, Liang Tao, Jia-Hong Xia, Xin Chen
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001012
摘要
冠状病毒疾病2019（新冠肺炎）疫情最近使全球卫生服务面临越来越大的压力。对于已知新冠肺炎阳性或高度怀疑新冠肺炎感染的患者，尽管稳定的心血管疾病首选非手术治疗以减少暴露，但当主要问题危及生命且没有其他选择时，仍有必要进行紧急心脏手术。
Original Article
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快速城市化背景下中国长江平原血镉与维生素D水平的关系Chi Chen, Hao-Jie Zhang, Hua-Ling Zhai, Yi Chen, Bing Han, Qin Li, Fang-Zhen Xia, Ning-Jian Wang, Ying-Li Lu
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001068
摘要
Background:
China has experienced rapid urbanization in the past 30 years. We aimed to report blood cadmium level (BCL) in the rapidly urbanized Yangtze Plain of China, and explore the association between BCL and 25-hydroxyvitamin D (25(OH)D).
Methods:
Our data source was the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China) cross-sectional study (ChiCTR-ECS-14005052, www.chictr.org). We enrolled 3234 subjects from 12 villages in the Yangtze Plain. BCLs were measured by atomic absorption spectrometry. 25(OH)D was measured with a chemiluminescence assay.
Results:
A total of 2560 (79.2%) subjects were diagnosed with vitamin D deficiency. The median (interquartile range) BCL was 1.80 μg/L (0.60-3.42) for men and 1.40 μg/L (0.52-3.10) for women. In women, mean 25(OH)D concentrations were inversely associated with BCL (0.401, 95% confidence interval: -0.697 to -0.105 nmol/L lower with each doubling of the BCL) after adjustment for age, educational status, current smoking, body mass index, diabetes, and season. However, there was no significant difference in 25(OH)D across the BCL tertiles for men.
Conclusions:
BCL in Chinese residents in the Yangtze Plain were much higher than that in developed countries. An inverse association between BCL and 25(OH)D was found in general Chinese women after multivariable adjustment. Future prospective cohort and animal studies are warranted to resolve the direction and temporality of these relationships, and to elucidate the exact mechanisms involved.
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中国农村到城市移民的抵达年龄、移民持续时间和超重/肥胖之间的关系：彝族移民研究Ye Wang, Li Pan, Shao-Ping Wan, Huo-Wu-Li Yi, Fang Yang, Hui-Jing He, Zheng Li, Jia Zhang, Zheng-Ping Yong, Guang-Liang Shan
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000000973
摘要
Background:
Urbanization in China is rapidly proceeding, but rural-to-urban migration and its association with overweight and obesity is not well studied. This study aimed to explore the age at arrival, duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China.
Methods:
A cross-sectional study was conducted in rural and urban areas in 2015 in Sichuan province, China. Demographic characteristics, lifestyle factors, and anthropometry were collected. General linear regression models were used to assess the effect of duration of migration (1-10, 11-20, 21-30, and >30 years) on body mass index (BMI). Multi-variable logistic regression was used to examine the association between duration of migration and overweight/obesity (BMI ≥ 25 kg/m2).
Results:
A total of 3056 Yi people (1894 Yi farmers and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and other potential confounders, Yi migrants had 1.71 kg/m2 (95% confidence interval [CI]: 1.36-2.06) higher BMI and a 2.13-fold (95% CI: 1.71-2.65) higher risk of overweight/obesity than Yi farmers. In Yi migrants, stratified by age at arrival, no significant association between duration of migration and overweight/obesity was observed in those who were 0 to 20 years old at arrival. In comparison, in migrants >20 years old at arrival, compared with the reference group (1-10 years), long-term migration (>30 years) was found to be associated with overweight/obesity after adjustment (odds ratio: 1.85, 95% CI: 1.04-3.29).
Conclusions:
Yi migrants were observed to have greater risk of overweight/obesity than Yi farmers. In Yi migrants, the risk of overweight/obesity increased according to the duration of migration, especially in those who were older upon their arrival.
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基于立体脑电图的颞叶内侧和外侧癫痫研究Xiao-Ming Yan, Cui-Ping Xu, Yu-Ping Wang, Kai Ma, Tao Yu, Xiao-Hua Zhang, Xi Zhang, Run-Shi Gao, Guo-Jun Zhang, Yong-Jie Li
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001256
摘要
Background:
Patients with temporal lobe epilepsy (TLE) originating from different seizure onset zones had distinct electrophysiological characteristics and surgical outcomes. In this study, we aimed to investigate the relationship between the origin and prognosis of TLE, and the stereoelectroencephalography (SEEG) features.
Methods:
Thirty patients with TLE, who underwent surgical treatment in our functional neurosurgery department from January 2016 to December 2017, were enrolled in this study. All patients underwent anterior temporal lobectomy after an invasive preoperative evaluation with SEEG. Depending on the epileptic focus location, patients were divided into those with medial temporal lobe seizures (MTLS) and those with lateral temporal lobe seizures (LTLS). The Engel classification was used to evaluate operation effectiveness, and the Kaplan-Meier analysis was used to detect seizure-free duration.
Results:
The mean follow-up time was 25.7 ± 4.8 months. Effectiveness was 63.3% for Engel I (n = 19), 13.3% for Engel II, 3.3% for Engel III, and 20.0% for Engel IV. According to the SEEG, 60.0% (n = 18) had MTLS, and 40.0% (n = 12) had LTLS. Compared with the MTLS group, the operation age of those with LTLS was significantly greater (26.9 ± 6.9 vs. 29.9 ± 12.5 years, t = -0.840, P = 0.009) with longer epilepsy duration (11.9 ± 6.0 vs. 17.9 ± 12.1 years, t = -1.801, P = 0.038). Patients with MTLS had a longer time interval between ictal onset to seizure (67.3 ± 59.1 s vs. 29.3 ± 24.4 s, t = 2.017, P = 0.008). The most common SEEG ictal pattern was a sharp/spike-wave rhythm in the MTLS group (55.6%) and low-voltage fast activity in the LTLS group (58.3%). Compared with the LTLS group, patients with MTLS had a more favorable prognosis (41.7% vs. 77.8%, P = 0.049). Post-operative recurrence was more likely to occur within three months after the operation for both groups, and there appeared to be a stable longterm outcome.
Conclusion:
Patients with MTLS, who accounted for three-fifths of patients with TLE, showed a more favorable surgical outcome.
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动脉硬化闭塞症患者GRB2相关结合蛋白1的缺失促进宿主自噬Meng Ye, Xiang-Jiang Guo, Ke-Jia Kan, Qi-Hong Ni, Jia-Quan Chen, Han Wang, Xin Qian, Guan-Hua Xue, Hao-Yu Deng, Lan Zhang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001255
摘要
Background:
Arteriosclerosis obliterans (ASO) is a major cause of adult limb loss worldwide. Autophagy of vascular endothelial cell (VEC) contributes to the ASO progression. However, the molecular mechanism that controls VEC autophagy remains unclear. In this study, we aimed to explore the role of the GRB2 associated binding protein 1 (GAB1) in regulating VEC autophagy.
Methods:
In vivo and in vitro studies were applied to determine the loss of adapt protein GAB1 in association with ASO progression. Histological GAB1 expression was measured in sclerotic vascular intima and normal vascular intima. Gain- and loss-of-function of GAB1 were applied in VEC to determine the effect and potential downstream signaling of GAB1.
Results:
The autophagy repressor p62 was significantly downregulated in ASO intima as compared to that in healthy donor (0.80 vs. 0.20, t= 6.43, P < 0.05). The expression level of GAB1 mRNA (1.00 vs. 0.24, t= 7.41, P < 0.05) and protein (0.72 vs. 0.21, t = 5.97, P < 0.05) was significantly decreased in ASO group as compared with the control group. Loss of GAB1 led to a remarkable decrease in LC3II (1.19 vs. 0.68, t = 5.99, P < 0.05), whereas overexpression of GAB1 significantly led to a decrease in LC3II level (0.41 vs. 0.93, t= 7.12, P < 0.05). Phosphorylation levels of JNK and p38 were significantly associated with gain- and loss-of-function of GAB1 protein.
Conclusion:
Loss of GAB1 promotes VEC autophagy which is associated with ASO. GAB1 and its downstream signaling might be potential therapeutic targets for ASO treatment.
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上调环状RNA hsa_circ_01844诱导胶质母细胞瘤细胞凋亡并抑制增殖和迁移Jin-Xu Zhou, Ke-Fei Chen, Shuai Hu, Ji-Rong Dong, Hong-Xiang Wang, Xin Su, Yu-Hai Wang, Jun-Sheng Chu
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000000979
摘要
Background:
Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers, such as liver cancer, lung cancer, breast cancer, and others. The potential role of circular RNAs in glioblastoma, however, is still uncertain. In this study, we aimed to study the potential role of hsa_circ _01844 in glioblastoma.
Methods:
Using reverse transcription-polymerase chain reaction (RT-PCR) method, hsa_circ_01844 expression was measured in five glioblastoma samples and five normal brain samples. To evaluate the potential function of hsa_circ_01844 in glioblastoma, hsa_circ_01844 was overexpressed in glioblastoma cell lines (U251 and U87 cells). Using these two cell lines, in vitro experiments including the flow cytometry assay, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, Transwell assay, and cell apoptosis assay were performed to investigate the role of hsa_circ_01844 in glioblastoma. Student t test and one-way analysis of variance were used for statistical analysis.
Results:
The expression of circular RNA hsa_circ_01844 was lower in glioblastoma tissues when compared with the normal brain tissues by RT-PCR method (0.034 ± 0.036 vs. 1.630 ± 0.891, P < 0.001). Using two glioblastoma cell lines, we found that overexpression of hsa_circ_01844 in glioblastoma cells suppressed their proliferation, colony formation, migration, and increased the apoptotic rate compared with empty vector group and blank control group (all P < 0.05).
Conclusion:
Hsa_circ_01844 shows decreased expression in glioblastoma and its overexpression induces apoptosis and inhibits proliferation, migration, and invasion of glioblastoma cells.
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单核细胞趋化蛋白诱导蛋白1负调节哮喘气道炎症和粘液高分泌涉及γ-氨基丁酸A型受体信号通路体内和体外Guang-Ming Dai, Jia-Jia Wang, Zhi-Hong Chen, Ya-Juan Ran, Huo-Jin Deng, Ruo-Lin Mao, Tao Zhu
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001154
摘要
Background:
Mounting evidence, consistent with our previous study, showed that γ-aminobutyric acid type A receptor (GABAAR) played an indispensable role in airway inflammation and mucus hypersecretion in asthma. Monocyte chemotactic protein-inducing protein 1 (MCPIP1) was a key negative regulator of inflammation. Recent studies showed that inflammation was largely suppressed by enhanced MCPIP1 expression in many inflammatory diseases. However, the role and potential mechanism of MCPIP1 in airway inflammation and mucus hypersecretion in asthma were still not well studied. This study was to explore the role of MCPIP1 in asthmatic airway inflammation and mucus hypersecretion in both mice and BEAS-2B cells, and its potential mechanism.
Methods:
In vivo, mice were sensitized and challenged by ovalbumin (OVA) to induce asthma. Airway inflammation and mucus secretion were analyzed. In vitro, BEAS-2B cells were chosen. Interleukin (IL)-13 was used to stimulate inflammation and mucus hypersecretion in cells. MCPIP1 Lentiviral vector (LA-MCPIP1) and plasmid-MCPIP1 were used to up-regulate MCPIP1 in lung and cells, respectively. MCP-1, thymic stromal lymphopoietin (TSLP), mucin 5AC (MUC5AC), MCPIP1, and GABAARβ2 expressions were measured in both lung and BEAS-2B cells. Immunofluorescence staining was performed to observe the expression of GABAARβ2 in cells.
Results:
MCPIP1 was up-regulated by LA-MCPIP1 (P < 0.001) and plasmid-MCPIP1 (P < 0.001) in lung and cells, respectively. OVA-induced airway inflammation and mucus hypersecretion, OVA-enhanced MCP-1, TSLP, MUC5AC, and GABAARβ2 expressions, and OVA-reduced MCPIP1 were significantly blunted by LA-MCPIP1 in mice (all P < 0.001). IL-13-enhanced MCP-1, TSLP, MUC5AC, and GABAARβ2 expressions, and IL-13-reduced MCPIP1 were markedly abrogated by plasmid-MCPIP1 in BEAS-2B cells (all P < 0.001).
Conclusion:
The results of this study suggested that OVA and IL-13-induced airway inflammation and mucus hypersecretion were negatively regulated by MCPIP1 in both lung and BEAS-2B cells, involving GABAAR signaling pathway.
Clinical Observation
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卵泡刺激素分泌腺瘤患者不孕症的处理及长期随访Yun Ren, Jie-Jing Wang, Li-Na Wang, Ying Wang, Jie Qiao, Xiu-Mei Zhen, Hong-Bin Chi, Rong Li
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001059
摘要
卵泡刺激素（FSH）分泌腺瘤（FSHoma）是一种相对罕见的促性腺瘤。[
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胎儿无细胞DNA富集在无创产前筛查中的应用：来自中国东部单中心的经验Ying Lin, Dong Liang, Ping Hu, Hang Li, Chun-Yu Luo, Zheng-Feng Xu
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001112
摘要
对孕妇外周血的无细胞DNA（cfDNA）进行测序已成功应用于胎儿染色体非整倍体的产前筛查，称为非侵入性产前筛查（NIPS）。[
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2019年严重冠状病毒疾病的重症监护：一项来自中国低病死率省份的基于人群的研究Xue-Lian Liao, Hong Chen, Zhen Li, Bo Wang, Zhong-Wei Zhang, Wei-Min Li, Zong-An Liang, Jin Tang, Jian Wang, Rui Shi 等
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001187
摘要
2019冠状病毒病（COVID-19）大流行自爆发以来已影响全球超过2000万人，[
Technical Notes
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淋巴管造影在卵巢癌主动脉旁淋巴结切除术中的应用Zhen Xu, Lu Wang, Wu-Liang Wang
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001087
摘要
上皮性卵巢癌（EOC）是最常见的卵巢恶性肿瘤。2018年国际妇产科联合会（FIGO）指南推荐盆腔和主动脉旁淋巴结的选择性淋巴结切除术作为早期卵巢癌分期手术的一部分。[
Correspondence
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单节段Prestige LP颈椎间盘置换术中前路骨丢失的发生率和结果Xiao-Fei Wang, Yang Meng, Hao Liu, Bei-Yu Wang, Ying Hong
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001254
摘要
致编辑：全颈椎间盘置换（TDR）已被广泛用于治疗颈椎间盘退行性疾病（CDDD）。然而，许多研究报告了种植体相关并发症，包括种植体迁移、种植体下沉、异位骨化（HO）和前骨丢失（ABL）。ABL近年来受到了更多的关注；然而，这种现象仅在没有龙骨的颈椎人工椎间盘中被认识到，包括Bryan、Baguera-C、Discocerv和Mobi-C。[
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皮肤Rosai-Dorfman病的皮肤镜和反射共聚焦显微镜检查Xue Shen, Wen-Ju Wang, Zi-Yi Wang, Yong Cui
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001271
摘要
致编辑：Rosai-Dorfman病（RDD），又称窦组织细胞增生症伴巨大淋巴结病，是一种罕见的非朗格汉斯细胞组织细胞增生性疾病。RDD的特征是双侧颈部淋巴结肿大伴有结外受累，皮肤是最常见的受累器官。[
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头皮环状狼疮脂膜炎Hao Guo, Hong-Wei Yan, Xing-Hua Gao, Jiu-Hong Li
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000000959
摘要
致编辑：一名1岁男孩因进行性线性头皮脱发到我科就诊，已持续1个月。体格检查发现位于头皮右顶叶和枕叶区域的环状脱发斑块，宽度约为1.5 cm[
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司库奇尤单抗在中国人群中治疗银屑病疗效和安全性的真实世界研究Jing-Xin Zeng, Quan Luo, Ju Wen, Xin Tian, Xin Zhou, Wei Li, Ya-Ping Tang, San-Quan Zhang, Wei-Yu Liu, Hui-Lan Zhu 等
中华医学杂志英文版2021年 134卷 01期
DOI: 10.1097/CM9.0000000000001179
摘要
致编辑：银屑病是一种多基因遗传背景下由T淋巴细胞介导的慢性炎症增生性疾病。[
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