1987年 · 第100卷第10期

We recorded sinus node electrogram (SNE) in 10 of 11 patients with sick sinus syndrome (SSS) by a new method, which could increase the success rate of stable SNE (91%). Their direct sinoatrial conduction times (SACTd) were significantly longer than those without SSS. According to SNE, two types of I degree S-A block in 9, and special type of II degree S-A block in 1 of 10 patients were diagnosed.

Isolated mucosal epithelial cells from surgically resected gastric cancer in the human stomach from high- and low-incidence areas in Fujian Province arc studied. Following short-term culture in vitro, the mucosal tissue was exposed to ultraviolet for 25 minuntes and then cultured in the presence of (3H) TdR and hydrourea. The unscheduled DNA synthesis (UDS) was assessed using hydrexylapatite column chromatography and liquid scintillation counting set and the cpm/µg DNA was determined as an indirect measure of DNA damage repair. This study shows that DNA repair in gastric mucosal cells in the high cancer incidence area group is significantly lower than that in the low cancer incidence Area group. This may play a role in gastric cancer induction.

Six patients with stage II or stage III essential hypertension aged 35-65 years on a diet of 150 mEq Na, 60 mEq K per day entered the study. α-huruan atrial natriuretic peptide. ( α-hANP) was administered intravenously within 3 minutes to each patient. ECG, BP, HR and left heart function (by nuclear stethoscope) were recorded. Urine samples were collected every 15 minutes and venous blood drawn 30 minutes before and 8, 25, 60 and 120 minutes after α-hANP injection. Urinary volume, specific gravity, pH, protein, urinary Na and K, and creatinine contents were measured. Plasma renin activity (PRA), angiotension II (PAII), aldosterone (PAC) and arginine vasopression (AVP) were measured by radioimmunoassay. Plasma norepinephrine (PNE) and epinephrine (PE) were measured by modified fluorometric method. Other parameters included body weight, blood gas, serum Na, K, creatinine and urea nitrogen. The results showed a statistically significant in crease of urine volume, UNa, UK, UCr, a fall in BP and an improvement in cardiac function, accompanied by HR increase after α-hANP. PRA, PAC and AVP were also affected at different time intervals.

We have examined the extent of glycophorin (GP) polymorphism in normal and abnormal human red cell membranes using immunoblotting technics and the following probes: Polyclonal anti-α GP that detects α and δ GP; antiserum to the C-terminal fragment of α GP (residues 82-131) that detects δ GP and all others that differ from α GP in the C-terminal region; and M and N specific monoclonal antibodies detecting the N-terminal octapeptide that specify M and N serological phenotypes. Red cells from 41 Central African normals displayed an invariant profile among all but 5. The invariant profile consisted of monomer and dimer of (M,N) GP and of δ (S,s) GP, γ GP and two other minor components, one of which had not been described before. The five abnormal profiles included two Central Africans with lack of δ GP, most likely S-s-U- serological phenotype which has a 4.9% incidence among them. In three other black individuals differences in the γ GP observed were not previously reported. α GP of all individuals reacted with M and N specific antibodies in accordance with their serologically determined M and N phenotypes, and in all individuals δ GP reacted with the N-specific monoclonal antibody. Only one case of sickle cell disease out of 54 Caucasian and black hematological patients showed a variant GP band (band 3a), the others had all normal pro files, including red cells from whole blood or density-defined fractions in Hb SS patients. Our impression is that GP polymorphism is infrequent among Caucasians but comparatively frequent among Central Africans. Moreover, immunoblotting technics confirmed the presence of Stα glycophorins in the erythrocytes of 5 members from a Japanese family.

From January 1960 to May 1985, 28 cases had undergone reoperation for liver cancer. Hepatectomy was performed twice or thrice in 17, extirpation of extrahepatic metastases after curative lobectomy in 4 and removal of giant tumors by two stage operation in 7 following hepatic artery ligation or intraoperative embolization as a pretreatment. The 1-, 3-, 5-year survival rates after the first operation were 96.4%, 77.8%, and 62.2% respectively, while the 1-, 2, 3-year survival rate after the second operation was 60.8%, 55.0% and 44.0% respectively. The preliminary results of reoperation are thus encouraging. The indications for reintervention, types of operation, timing of the second laparotomy for resection of a relatively large tumor, prophylactic measures against tumor recurrence and metastases and evaluation of reoperation arc discussed.

A survey and analysis of 208 801 deliveries in 16 hospitals in the Beijing-Tianjin Area discloses birth defects (BD) of 58 categories in the period of 1970-1984. The overall BD prevalence rates varied from 8.7‰ to 17.2‰. They were significantly higher in rural than in urban and suburban areas. The 6 leading BD were: CNS defects, other skeletomuscular defects, cleft lip and/or cleft palate, GI tract/abdominal wall defects, reduction deformity/other limb defects and polydactyly and syndactyly. Twelve common BD with prevalence rates higher than 0.2‰ were: spina bifida, anencephalus, hydrocephaly, varus and vulgus deformity of the foot, cleft lip and cleft palate, cleft lip alone, cleft palate alone, omphalocele/gastroschisis, other abdominal wall defects, polydactyly and deformity of multiple systems. Most common was neural tube defects which were surprising by as high as 6.6‰. The male-to-female ratio of birth defects was 0.82, but those of individual categories varied considerably. Data from 10 hospitals show that seasonal variations of both overall BD and CNS defects have the same pattern, peaking in October. Seasonal distribution of BD in the cities, countryside, overall BD and some individual defects all differ.

Phage group 2 type 55/71 coagulase-positive staphylococci isolated from a 13 day-old infant patient with typical staphylococcal scalded skin syndrome (SSSS), produced skin exfoliation in newborn mice exactly the same as in human beings. In our experiment the optimal organism dosage was 9×l06-7. Mouse age was an important factor, newborn mice 2-8 days old almost all developed experimental SSSS. Mice above 12 days of age gave negative responses except for some local inflammatory reaction, nodules or abscesses at the site of inoculation. The subcutaneous route of inoculation was superior to the in traperitoneal route. Nonphage group 2 staphylococci failed to produce SSSS in mice of any age. Our experiment further proves the correctness of Melish's SSS work.

Thymolipoma is a rare, benign tumor of the thymus, which frequently presents as an asymptomatic mediastinal mass found on a routine chest roentgenogram. Because not all clinicians are aware of this entity, the diagnosis is easily missed. This is a case in which the chest radiograph strongly suggested pericardial cyst. At thoracotomy a thymolipoma weighing 1000 g was resected. Thymolipoma should be considered in the differential diagnosis of anterior mediastinal tumors.

Based on the results of previous ncuroepidemiologic studies and the present one in 6 cities of China, the authors suggest the following major risk factors for epilepsy in developing countries: Age, less than 10 years old; and more than 50 years old; sex, males more than females; race, blacks more than whites; poor health care in prenatal and perinatal period; head trauma; poor socioeconomic status; first-degree epileptic relatives; and other conditions such as diseases of the central nervous system, illnesses of gravid women, febrile convulsions, and maternal age at parturition.

Holoprosencephaly is a rare defect in the formation of midline structures resulting in a rare spectrum of disordered organogenesis of the prosencephalon, often associated with facial anomalies. In this article a case of holoprosencephaly is described and its etiology, embryology, classification, pathology, and prognosis are briefly discussed.