1986年 · 第99卷第05期

The microvascular vasomotion in the hamster dorsal skin fold window preparation had been continuously and dynamically observed and analysed. It was found that under normal conditions, the vaso-motor activity of arteriole propagated down-stream in a wave-like form. Anisodamine could enhance the arteriolar vasomotion.

The recent death of Hsien-I Chu in Tianjin has removed the last link with a period of historic importance in the growth of knowledge about metabolic bone disease. The work of Chu and his colleagues at Peking Union Medical College (PUMC), as it was then called, is now largely forgotten, but it can still provide some useful lessons and suggestions for present-day investigators. Many of the observations made at PUMC can be retrospectively explained in terms of current knowledge concerning vitamin D metabolism, but some of the questions raised remain unanswered.

A case of giant hairy nevus on the face involving the eyelid with orbital Schwannoma (neurilemoma) was seen in our hospital. No similar case has been found in the literature.

162 patients with menstrual dysfunction and genital anomalies underwent laparoscopy for assessment of gonadal function. Eight different morphologic types of gonads were observed; normal sized ovary with normal appearance, streak gonad, small ovary, atrophic ovary, sclerocystic ovary, ovotestis, mixed gonads, and gonadal tumor. Biopsies were obtained in 64, chromosomal analysis in 71, LH and FSH determinations in 151, and PRL in 32. Characteristic appearances and pathologic pictures were described. Correlation of clinical diagnosis with the type of gonads, biopsy results, karyotype and LH and FSH determinations was made. LH and FSH values were high in cases of streak gonads and atrophic ovaries. Laparoscopy plays a supplementary but important role in the assessment of gonadal function.

108 patients with intracranial arterio-venous malformation (AVM) were treated microsurgically, with a total AVM excision rate of 88%. Only one patient (0.92%) died. One of 14 patients (13.0%) was seriously crippled and the rest were slightly crippled. We used loupe instead of operative microscope, except in patients with small AVM. It was stressed that a set of good angiograms is essential before operation. The method for exposure of small and deeply seated AVMs and the principles for the management of acute hyperperfusion syndrome of the brain are presented.

Erythrocyte membrane Na++K+ ATPase activity was studied in 60 normal individuals of different ages and 34 patients with Duchenne type muscular dystrophy (DMD) or limb-girdle dystrophy. The results showed that Na++K+ ATPase activity was lower in normal children than in normal adults and ouabain exerted inhibitory action on Na++K+ ATPase activity. In DMD ATPase activity was much lower but ouabain inhibitory action was increased. In limb-girdle dystrophy ATPase was also lowered but ouabain inhibitory action was decreased in many cases.

A strain (named BJ-1) of hepatitis A virus (HAV) causing cytopathic effects (CPE) has been isolated in A549 cell cultures from a fecal specimen of an infant with hepatitis A. Hepatitis A antigen (HAAg) was detectable in about 50% of the cells by immunofluorescence (IF) assay. The viral antigenicity was specifically identified by monoclonal anti-HAV and chimpanzee reference antiserum to HAV (NIH). HAV particles in crystal arrangement were observed in cell cytoplasm by electron microscopy in ultrathin sections. The particles appeared both "empty" and "full". It was observed that many 27-30 nm virus particles were aggregated by convalescent human hepatitis A sera and chimpanzee HAV antisera observed by immune electron microscopic (IEM) examination. BJ-1 HAAg could be detected on day 34 after inoculation at the initial passage. The virus titers increased and the virus replication cycle shortened with serial passages. The highest TCID 50 was 10-5/0.1 ml and the shortest replication cycle 2-3 days. IF kit consisting of BJ-1 HAV infected A549 coverslip culture and sheep fluorescence antibody to human IgM were made to detect anti-HAV IgM. Comparing the BJ-1 IF with the Abbott EIA HAVAB-M kit, the coincidence rate was 98.4% (246/250).

The 3 major symptoms of Reiter's disease are urethritis, conjunctivitis and arthritis. Some cases are associated with psoriasis-like mucocutaneous 1esions. Reiter's disease with psoriasiform dermatosis is quite rare and has never been reported in China. This article reports 2 cases with mild and transient symptoms of urethritis and conjunctivitis which disappeared before hospitalization. The differentiation of such cases from psoriasis arthropathica is difficult because the clinical and histopathological pictures and X-ray findings of the two disorders arc similar and both have "seronegative" arthritis with no rheumatoid factors and high incidence of HLA B 27 antigens. However, the authors found that the skin microcirculation features were quite different in the two diseases and might be taken as one of the criteria for differential diagnosis.

This paper describes successful application of the introduction technic in subclavian venipuncture and insertion of permanent leads in a series of 75 cases. Three attempts to cannulate the subclavian vein were unsuccessful in the early 11 cases. A routine technic was followed in the later 64 consecutive cases with successful insertion of permanent leads through the subclavian vein. No serious complications were encountered in this series. Therefore, this technic is safe, relatively atraumatic, rapid and especially valuable for physiologic dual-chamber pacing.