1984年 · 第97卷第02期

A (dz/dt) max and P-A interval are measured in 32 normal subjects (Group I), 32 ECG Ptf-V1 positive patients (Group II) and 32 coronary heart disease patients without positive Ptf-V1 (Group III). The mean values for a (dz/dt) max in the 3 groups are 0.48±0.28, 0.69±0.39 and 0.82±0.33Ω/sec. The mean P-A interval values are 108.77±28.21, 144.69±41.58 and 149.06±21.76 msec. In normals the aged phenomenon of A wave is found but not the P-A interval. The abnormal A (dz/dt) max and P-A interval in the impedance cardiogram (ICG) may reflect left atrial overload and/or impaired left atrial conduction system and may also indirectly reflect left ventricular dysfunction. A preliminary approach to the relationship of the P-A interval and Ptf-V1 is made.

This paper reports os calcis fracture treated by percutaneous poking reduction and internal fixation. 106 cases were treated this way. The early results were exceUenrt and good in 46 and 25 respectively and the late results excellent in 24 and good in 21. The treatment is described in detail.

Experimentally, early X-ray signs and pathologic changes appear almost simultaneously in rickets. In the active and repair stages of the disease X-rays can correctly reflect, the most basic pathologic changes. Bone microangiographic studies show that the leading cause of intraosteal capillary distribution changes in different stages is primarily incomplete calcification of the ground substance of the hypertrophic cartilage cells which impedes blood vessel bone formation. We consider that classification of early stage experimental rickets into mild, moderate and severe, and of repair stage experimental rickets into initial repair, manifest repair and reconstruction and healing is applicable to rickets in children.

Neutrophil alkaline phosphatase (NAP) activity was estimated by Kaplow's cytochemical method in 36 cases of malignant histiocytosis and compared with that in 29 normal subjects and 180 patients with various diseases. The mean rate of positive reactions to the NAP stain was 27.5% and the score of NAP-positive cells was 36.5 in 29 normal subjects with no difference between the male and female. The corresponding figures for the malignant histiocytosis patients were l.4% and 2 being completely negative in 27 of them (75%). The NAP activity was significantly lower in malignant histiocytosis than in normal subjects and various other diseases (p<0.01). Hence its estimation of NAP activity is of value in differentiating malignant histiocytosis from a number of disorders characterized by a similar clinical picture and the presence of bizarre histiocytes and erythrophagocytosis in the bone marrow.

Gentamicin ototoxicity is studied in 10 guinea pigs at 70 mg/kg/day for 22 days. The results are quite different from those of our first study, there are no animal exhaustion or deaths throughout the experiment. Hearing acuity was examined by auricular reflex, and cortical electrical response tests and velstibular function by rotatory test. Physiological examinations have proved that gentamicin damages not only vestibular function but also hearing ability. Observing the cochlea we found that gentamicin ototoxicity is due mainly to destruction of the cochler basal turn. Corti's organ may also disappear. The pathological changes of the 2nd, 3rd and apical turns are mainly sensory hair cell decimation. These findings correspond with the clinical signs of high tone hearing loss in experimental animals. Outer hair cell damage is more severe than that of inner hair cells. In some there is complete disappearance of the first and second rows of outer hair cells. Organ of Corti damage causes sensory neural deafness. Therefore clinicians should be wary when using gentamicin. Being kidney toxic, it should also be used with care in those with kidney diseases.

From July 1973 to January 1980, 80 patients of primary tongue carcinoma were treated by cryosurgery 77 had squamous cell carcinoma and the other 3 other types of malignant tumors. TNM clinical classification shows T1 27 patients, T2 51 and T3 2. The diameter of the tumors ranged from 0.7 to 3.5 cm. 77 patients were treated in the outpatient clinic under acupuncture or local anesthesia. One month after disappearance of the primary lesion, 32 patients underwent radical or prophylactic neck dissection. All patients were followed up for 6 months to 7 years. After cryotherapy, the primary lesion disappeared in 76 (95%) patients and 4 were not controlled. The 3- and 5-year survival rates were 72%(23/32) and 75%(9/12). The recurrence rate in this series was 11%(9/80). Cryosurgery in tongue carcinoma is effective, safe, economical and convenient.

This paper traces the changes in cholelithiasis in Tianjin during the past 30 years, these changes in characteristics of gallstone may be attributed to the decrease of biliary ascariasis and changes in diet. Living standards and health knowledge may also cause differences, in stones of urban and rural patients and in those found in patients engaged in mental or physical labor.

Macrotia is seldom seen. We encountered a case in our hospital, and it is here reported.

The serum C1q levels of 42 acute infectious hepatitis (AIH), 51 chronic infectious hepatitis (CIH) cases and 100 normal controls are determined by using sensitive rocket immunoelectrophoresis. The mean control value is 168.08±84.70 μg/ml, those of AIH and CIH are low (p<0.001). The significance of these findings is discussed.

1,330 autopsies performed at the Pathology Department of this hospital during 1958-1981, including 415 newborns, are studied. Among the 371 cases of congenital anomalies (110 newborns), 173 were congenital cardiovascular anomalies (66 newborns), a 13% morbidity forming 46.5% of all congenital anomalies seen. The 66 newborns were 60% of all neonatal congenital anomalies and 38.2% of all cardiovascular anomalies. Fetal stage diagnosis and early termination of pregnancy when necessary is the treatment of choice.