1989年 · 第102卷第02期

The effects of edible black tree fungus (BFF) compared with aspirin on serum lipid level and experimental atherosclerosis and thrombosis in rabbits were studied. The results showed that total serum cholesterol and B-lipoprotein of the BTF group were significantly decreased (P<0.01) than the aspirin group and the group with neither BTF nor aspirin. There were less aortic atherosclerotic plaque and intramyocardial arterial lumen stenosis in the BTF group. The development of thrombus and platelet aggregation and thromboxane TXB2 level were inhibited both in the BTF and aspirin group (P<0.01). These findings indicate BTF may be used as a healthy food in preventing atherosclerosis and coronary heart disease, but its mechanism requires further investigation.

To investigate the effect of Calcium antagonists (Ca-An) with different tissue specificity in the development of hypertension and stroke in salt-loading SHRSP, three experiments were conducted. In experiment Ⅰ(1), 50 8-week-old male SHRSP were divided into three groups and given nifedipine (NF, 32mg/kg/day), menidipine (MN 32mg/kg/day) and placebo (control group) respectively. In the control group 83.3% (15/18) died of stroke and 17 showded renal vascular sclerosis. Their average lifespan was 84 days. NF and MN significantly reduced systolic blood pressure (SBP), and no stroke of renal vascular sclerosis developed. In experiment Ⅰ(2), 54 7-week-old male SHRSP were divided into three groups (18 in each group). They were treated with nimodipine (NM) 20 mg/kg/day, 2 mg/kg/day and placebo respectively. NM (20mg/kg/day) markedly lowered SBP and postponed the onset of stroke. Only 11% died in 17 weeks. NM (2mg/kg/day did not lower SBP but postpond the onset of stroke. In experiment Ⅱ(1), 29 10-week-old female SHRSP were divided into three groups: Group A was given NF 32mg/kg/day, group B was parathyoidectomized (PTX) and group C served as control. PTX group did not lower SBP but could postpone the onset of stroke. In experiment Ⅱ(2), 33 male SHRSP were divided into three groups and ticated as desctibed above in experiment Ⅱ(1) (11 in each group). Seven weeks after the experiment, the brain blood flow of NF group was significantly greater (67.5%) than that of the control and PTX groups. In experiment Ⅲ, 27 7-week-old male SHRSP were divided into three groups as described above in experiment Ⅰ(2). Two weeks after the treatment, significant difference was found in norepinephrine (NE)contents of the anterior hypothalamic region (AHR) between NM (20 mg/kg/day) group and control group (2 870 vs 2 304 pg/mg tissue). Our results show that Ca-An (nimodipine) can reverse the NE depletion by high salt in SHRSP, thus lower SBP and prevent stroke.

From October 1986 to June 1987, 6 patients received thumb reconstuctrion with free rib segments and big toe nail flaps. All of them had satisfactory results.

The duration of viremia in patients with epidemic hemorrhagic fever (EHF) was studied using immunofluorescence technique and cell culture assays. The duration of virus in plasma of EHF patients was about 1 week, which was concomitant with the febrile phase of the disease. Comparatively, the separation rate of viruses in peripheral blood mononuclear cells (PBMC) was greater (1.8 times) than in plasma, while the detected peak of EHF (in 4-7 days after onset of the disease) was found to be 2 or 3 days less than that of plasma, thus the detectable viremia was prolonged until the 8th to llth day of the disease. High titre EHF antibody of IgG, TgM was unable to neutralize the virus in human blood. The results revealed that a blood-cell-associated prolonged viremia is one of the characteristics of EHF infection.

344 patients with psoriasis vulgaris treated in Huashan Hospital, Shanghai were followed up for 7-30 years. 13% of them developed arthralgia and 2% had joint deformities. One patient developed erythroderma due to dexamethasone medication. Internal malignancy occurred in 2 patients (0.58%). The severity of the course of the disease was neither influenced by family history nor alcoholism, but was markedly influenced by the duration of illness and administration of anti-neoplastic drugs.

A cross-sectional study was conducted to examine the rate of cytomegalovirus (CMV) shedding through breast feeding and the rate of acquired infection by the infants. Among the 104 seropositive breast-feeding mothers, CMV was recovered in the milk in 19 cases, with a milk shedding rate of 18.3%. Isolation of CMV from the urine of the infants of the 188 seropositive mothers found 36 positive cases. Of the 36 cases, 15 0f 19 fed on CMV-positive milk were infected through breast-feeding, with an infection rate of 78.9%; 11 of the 85 fed on CMV-negative milk were infected, the infection rate being 12.9%; and 10 (11.9%) of 84 fed on cow's milk were infected. These demonstrate that the rate of infection in infants fed on virus~positive milk was significantly higher than those fed on virus-negative milk or cow's milk (P<0.005).

Using humoral immunity (γ-globulin 18 cases, IgG, IgA, IgM each 30 cases, CH50, C3, C4 each 29 cases and CIC 31 cases), cellular immunity (E-RFC 68 cases, As 30 cases, SmIg, SmIgG each 18 cases, IMIT 30 cases) and immunopathological manifestations (light microscope, fluorescence microscope, transmitted electron microscope each 7 cases) as indices, we studied the immunological changes of "progressing", "remittent" and "stabilized" groups of patients with thromboangiitis obliterans (TAO) in different stages. Humoral immunity indicated that γ-globulin, immune complex and IgG were all increased; cellular immunity indicated that the rate of T cells and suppressor cells was declined, while that of B cells was elevated. Immunopathologically, under light microscope all the layers of involved vessels were infiltrated with neutrophils, lymphocytes and monocytes; under flourescene and electron microscope, immune complexes were found in the involved vessel walls. Our preliminary results suggest that TAO is an autoimmune disease relevant to antigen-antibody complex.

β-endorphin-like immunoreactivity(β-ELI) was measured in the cerebrospinal fluid (CSF) of 36 patients with acute head injury and 12 controls. The mean values of β-ELI in CSF of controls and patients with moderate and severe acute head injury were 51.9±5.6 pg/ml, 110.5 pg/ml, and 173.8±20.1 pg/ml respectively, with significant difference between them (p<0.05). The results showed that β-ELI increased in CSF of acute head injury patients.

In 1985, we applied an arterialized vein stem free flap in 4 cases with success in 3. In making this flap the superficial vein with the covered skin of the limb was used. In operation the flap was inverted and the 2 ends of the vein stem were anastomosed with the artery of the recipient area. Rapid arterial blood flow not only provided blood supply to the flap, but through the "venous network shunt" and "tidal pressure difference of artery" maintained blood circulation of the flap. The details of technique and the changes of blood circulation after flap transfer are described, as are indications advantages and mechanism of blood circulation of the flap, and factors affecting the circulation.

Thallium-201 dipyridamole test (T1-201DT) has high sensitivity and specificity in the assessment of coronary disease (CAD), but is not always available. We proposed impedance cardiography DT (IDT) instead. To determine the characteristic changes of impedance cardiogram (ICG) in patients with typical angina and to compare with those in normal subjects, 37 subjects undergoing IDT were divided into 3 groups: typical angina (15), suspected chest pain (11) and normals (11). Dipyridamole (DP) was infused intravenously for over 10 minutes at a total dose of 0.75 mg/kg. Simultaneous recording of ECG, PCG, and ICG were repeated immediately 2 minutes and 4 minutes after infusion of DP, and immediately and 5 minutes after intravenous infusion of aminophylline. Eleven parameters, HR, SPRP, QZ/ZA2, HI, SV, CO, A wave, A/C, O wave, O/C, A+O/C were observed. Only in O/C and A+O/C there were changes of significant differences (P<0.01) between groups. Specificity was 100% (0/11 positive) in normals. Sensitivity was 80% (12/15 positive) in the angina group, but only 46.7% (7/15) with ECG. The characteristic changes in CAD patients during IDT were angina induced by DP, abnormal O wave on ICG and change from deep A wave to abnormal Owave. No serious complication occurred after IDT. Our results indicate that IDT is a simple, practical and valuable method for detecting CAD.